Evaluation of Pharmacokinetic and Toxicological Parameters of Arnica Tincture after Dermal Application In Vivo

Article Biochemistry & Molecular Biology

In Vitro Metabolism of Helenalin Acetate and 11α,13-Dihydrohelenalin Acetate: Natural Sesquiterpene Lactones from Arnica

Franziska M. Juergens et al.

Summary: Arnica tincture is a herbal medicinal preparation with anti-inflammatory activity that can be used for the treatment of blunt injuries and rheumatic muscle and joint complaints. Recent research has shown that it can cure cutaneous Leishmaniasis. In vitro metabolism experiments have provided a detailed understanding of the metabolism of Arnica tincture's main bioactive constituents, suggesting low levels of toxicity after dermal absorption.

METABOLITES (2022)

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Article Pharmacology & Pharmacy

Dermal Absorption of Sesquiterpene Lactones from Arnica Tincture

Franziska M. Juergens et al.

Summary: Arnica tincture is a traditional herbal medicine used for treating blunt injuries and is currently being investigated for its potential use in the treatment of cutaneous leishmaniasis. This study provides detailed information on the dermal absorption of Arnica tincture, particularly its bioactive constituents called sesquiterpene lactones (STLs). The results show that within 48 hours, a majority of the STLs from Arnica tincture were absorbed into the skin, but a significant portion could not be extracted from the skin and were irreversibly bound to skin proteins. Additionally, fluorescence microscopic images revealed the accumulation of a fluorescent derivative of STLs in the epidermis.

PHARMACEUTICS (2022)

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Article Chemistry, Medicinal

Therapeutic Efficacy of Arnica in Hamsters with Cutaneous Leishmaniasis Caused by Leishmania braziliensis and L. tropica

Sara M. Robledo et al.

Summary: Arnica montana flower preparations have potential therapeutic effects against Leishmaniasis, with high in vitro activity against two common Leishmania species and no cytotoxicity for human cells.

PHARMACEUTICALS (2022)

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Article Nutrition & Dietetics

Coffee Silverskin Extract: Nutritional Value, Safety and Effect on Key Biological Functions

Amaia Iriondo-DeHond et al.

NUTRIENTS (2019)

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Article Medicine, General & Internal

Leishmaniasis: clinical syndromes and treatment

B. S. McGwire et al.

QJM-AN INTERNATIONAL JOURNAL OF MEDICINE (2014)

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Article Parasitology

NATURAL SESQUITERPENE LACTONES ARE ACTIVE AGAINST LEISHMANIA MEXICANA

Patricia A. Barrera et al.

JOURNAL OF PARASITOLOGY (2008)

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Article Plant Sciences

In vitro behaviour of sesquiterpene lactones and sesquiterpene lactone-containing plant preparations in human blood, plasma and human serum albumin solutions

S Wagner et al.

PLANTA MEDICA (2004)

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Evaluation of Pharmacokinetic and Toxicological Parameters of Arnica Tincture after Dermal Application In Vivo

相关参考文献

In Vitro Metabolism of Helenalin Acetate and 11α,13-Dihydrohelenalin Acetate: Natural Sesquiterpene Lactones from Arnica

Dermal Absorption of Sesquiterpene Lactones from Arnica Tincture

Therapeutic Efficacy of Arnica in Hamsters with Cutaneous Leishmaniasis Caused by Leishmania braziliensis and L. tropica

Coffee Silverskin Extract: Nutritional Value, Safety and Effect on Key Biological Functions

Leishmaniasis: clinical syndromes and treatment

NATURAL SESQUITERPENE LACTONES ARE ACTIVE AGAINST LEISHMANIA MEXICANA

In vitro behaviour of sesquiterpene lactones and sesquiterpene lactone-containing plant preparations in human blood, plasma and human serum albumin solutions

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