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Aptamers as Smart Ligands for Targeted Drug Delivery in Cancer Therapy

PHARMACEUTICS (2022)

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Review Chemistry, Multidisciplinary

Directed Evolution of Aptamer Discovery Technologies

Diana Wu et al.

Summary: This article introduces four techniques developed in the laboratory to accelerate the discovery of high-quality aptamer reagents. These techniques include particle display, multiparametric particle display, click chemistry-based particle display, and non-natural aptamer array platform. The application of these techniques makes aptamer technology more accessible, efficient, and robust.

ACCOUNTS OF CHEMICAL RESEARCH (2022)

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Article Chemistry, Multidisciplinary

Biomimetic Nanoerythrosome-Coated Aptamer-DNA Tetrahedron/Maytansine Conjugates: pH-Responsive and Targeted Cytotoxicity for HER2-Positive Breast Cancer

Wenjuan Ma et al.

Summary: DNA materials have been used as nanocarriers for targeted cancer therapy, but their short half-life and low bioavailability hinder their clinical translation. This study developed a HER2-targeted DNA-aptamer-modified DNA tetrahedron/DM1 conjugate, and applied a biomimetic camouflage to enhance drug delivery and tumor-stimulated drug release. The hybrid erythrosome-based nanoparticles exhibited superior inhibition of HER2-positive cancer.

ADVANCED MATERIALS (2022)

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Article Chemistry, Applied

Carboxylated chitosan-mediated improved efficacy of mesoporous silica nanoparticle-based targeted drug delivery system for breast cancer therapy

Garima Lohiya et al.

Summary: In this study, a chitosan-coated nanoparticle was developed for targeting breast cancer cells, showing higher cellular uptake and cytotoxicity compared to non-targeted nanoparticles. The chitosan coating provided pH-responsiveness and endo/lysosomal escape ability to the nanoparticles, enhancing the efficacy of anticancer drug delivery.

CARBOHYDRATE POLYMERS (2022)

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Article Pharmacology & Pharmacy

Aptamer-conjugated gold nanoparticles for targeted paclitaxel delivery and photothermal therapy in breast cancer

Jamileh Kadkhoda et al.

Summary: This study successfully developed a targeted photothermal therapy with a multifunctional drug delivery platform. The Mucin1 (MUC1) aptamer-modified poly (ethylene glycol)-gold nanoparticle system loaded with Paclitaxel (PTX) showed selective cytotoxicity towards MUC1-positive breast cancer cells and exhibited excellent cellular uptake ability when combined with near-infrared (NIR) irradiation. The synergistic effect of PTX/PEG-AuNPs@antiMUC1 was observed, leading to increased cell death compared to either photothermal therapy or chemotherapy alone. Protein expression analysis confirmed the potential of this synergistic combinational system in cancer therapy.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2022)

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Article Chemistry, Multidisciplinary

Aptamers Entirely Built from Therapeutic Nucleoside Analogues for Targeted Cancer Therapy

Lijuan Zhu et al.

Summary: Aptamer-drug conjugates (ApDCs) are a promising drug delivery system for targeted cancer therapy. However, the conventional ApDC has limited drug loading capacity. To address this challenge, researchers have developed drugtamers, whole drug-constituted DNA-like oligomers, which have 100% drug loading ratio, active targeting capability, and enzyme-mediated release of active therapeutics.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

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Review Instruments & Instrumentation

Exploring the role of mesoporous silica nanoparticle in the development of novel drug delivery systems

Senitta Stephen et al.

Summary: Mesoporous silica nanoparticles (MSN) offer advantages such as high drug loading efficiency and suitability for functionalization, making them attractive for delivering therapeutic agents in the treatment of various diseases. Recent research has expanded their application to deliver a range of compounds, from small chemicals to large peptides or proteins, for combating complex diseases.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2022)

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Article Nanoscience & Nanotechnology

Simultaneous Imaging of Dual microRNAs in Cancer Cells through Catalytic Hairpin Assembly on a DNA Tetrahedron

Chun Hong Li et al.

Summary: Simultaneous detection and imaging of two miRNAs was achieved using a DTN probe, showing great potential for improving detection accuracy.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Review Radiology, Nuclear Medicine & Medical Imaging

Advances in aptamer-based nuclear imaging

Wenyu Song et al.

Summary: This review highlights recent advances in aptamer-based nuclear imaging and compares aptamer tracers with other biogenic probes. The fundamental properties of aptamer-based radiotracers are discussed, along with potential directions to improve their imaging performance. Despite the translational obstacles, aptamers are expected to become a versatile tool for cancer nuclear imaging in the near future.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2022)

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Review Biochemistry & Molecular Biology

A comprehensive review on polysaccharides with hypolipidemic activity: Occurrence, chemistry and molecular mechanism

Pratap Kalita et al.

Summary: The translation discusses the challenging future of natural product research and the potential therapeutical benefits of natural polysaccharides. It highlights the various health benefits of these polysaccharides and their potential applications in anticancer, antiviral, immunomodulatory, antimicrobial, anticoagulant, anti-inflammatory, antidiabetic, antioxidant, and antitumor activities. The review focuses on the hypolipidemic activity of polysaccharides, their sources, structural characteristics, chemistry, biological activity, and probable mode of action.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Review Agriculture, Multidisciplinary

Recent Advances of Stimuli-Responsive Polysaccharide Hydrogels in Delivery Systems: A Review

Yunzhen Zhang et al.

Summary: Hydrogels obtained from natural polymers, with excellent biocompatibility and environmental friendliness, can be used as smart active substance delivery systems. They can respond to external stimuli by changing their volume phase and structure, potentially playing a role in gut microbiota modulation and regulating the gut-brain axis.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022)

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Article Chemistry, Multidisciplinary

ATP-Triggered Intracellular In Situ Aggregation of a Gold-Nanoparticle-Equipped Triple-Helix Molecular Switch for Fluorescence Imaging and Photothermal Tumor Therapy

Yao Jiang et al.

Summary: In this study, a nanoscale probe was constructed for tumor imaging and photothermal therapy (PTT) by utilizing MUC1 aptamer-guided targeting and ATP-induced aggregation of nanoparticles. The designed nanoscale probe shows promising applications in tumor imaging and PTT.

LANGMUIR (2022)

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Article Multidisciplinary Sciences

Targeting lung cancer cells with MUC1 aptamer-functionalized PLA-PEG nanocarriers

Shima Shahrad et al.

Summary: MUC1 aptamer-functionalized PLA-PEG nanocarriers were prepared at various w/w ratios and evaluated for their physiochemical properties, drug release kinetics, cytotoxicity, and antitumor activity. Targeted nanocarriers at a w/w ratio of 10:1 demonstrated significantly higher apoptosis rates in MUC1-overexpressing cancer cells compared to non-targeted and free drug forms, suggesting their potential as a promising drug delivery system for targeted therapy.

SCIENTIFIC REPORTS (2022)

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Review Medicine, Research & Experimental

Organ-restricted delivery through stimuli-responsive nanocarriers for lung cancer therapy

Yirivinti Hayagreeva Dinakar et al.

Summary: This article discusses the application of stimuli-responsive nanocarriers in treating lung cancer, including endogenous stimuli-responsive nanocarriers and exogenous stimuli-responsive nanocarriers. These applications help to enhance existing properties and achieve organ-restricted drug delivery.

LIFE SCIENCES (2022)

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Article Nanoscience & Nanotechnology

Self-Assembly of a Multifunction DNA Tetrahedron for Effective Delivery of Aptamer PL1 and Pcsk9 siRNA Potentiate Immune Checkpoint Therapy for Colorectal Cancer

Wenjing Guo et al.

Summary: Compared with traditional single therapy, nanomedicine has advanced the development of multimodal combination treatments for various cancers. This study utilizes advanced DNA nanotechnology to create intelligent multifunctional biomaterials for the treatment of colorectal cancer. The results demonstrate that this approach effectively inhibits tumor growth and enhances immune cell targeting of cancer cells.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Chemistry, Applied

Multifunctional magnetic nanoparticles for MRI-guided co-delivery of erlotinib and L-asparaginase to ovarian cancer

Seraj Mohaghegh et al.

Summary: The study developed magnetic nanoparticles (MNPs) as targeted drug delivery and non-invasive MRI contrast agents in ovarian cancer cells, showing synergistic therapeutic effects. The size, morphology, functional groups, and magnetic properties of the nanoparticles were characterized. The cellular uptake of the nanoparticles with MUC16 overexpression and the signal intensity changes in tumor sites were evaluated using MR images and flow cytometry. The findings suggest the potential of the nanoparticles as an image-guided co-drug delivery system for ovarian cancer.

JOURNAL OF MICROENCAPSULATION (2022)

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Review Polymer Science

Natural Polysaccharide-Based Nanodrug Delivery Systems for Treatment of Diabetes

Aijun Qiu et al.

Summary: Natural polysaccharides are considered as ideal candidates for novel drug delivery systems due to their good biocompatibility, biodegradability, low immunogenicity, renewable source and easy modification. They have been widely used in the design of nanocarriers, especially in the field of biomedicine.

POLYMERS (2022)

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Article Chemistry, Multidisciplinary

Fluorescence Detection of Cancer Stem Cell Markers Using a Sensitive Nano-Aptamer Sensor

Jie Ding et al.

Summary: A novel fluorescence turn-on nano-aptamer sensor was designed for quantifying CD133, which achieved enhanced fluorescence signals of quantum dots through the hybridization between aptamers and ssRNA. The sensor demonstrated specificity, precision, and accuracy in detecting CD133 in lung cancer cells.

FRONTIERS IN CHEMISTRY (2022)

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Article Chemistry, Analytical

Molecularly Imprinting-Aptamer Techniques and Their Applications in Molecular Recognition

Qingqing Zhou et al.

Summary: Molecular imprinting-aptamer techniques combine the advantages of molecular imprinting and aptamer technology, offering higher stability, binding affinity, and selectivity. This review introduces the development of these techniques and explains the mechanism of MIP-aptamer formation. Challenges in preparing MIP-aptamer are discussed, and applications in disease diagnosis, environmental analysis, and food safety are summarized.

BIOSENSORS-BASEL (2022)

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Article Nanoscience & Nanotechnology

Cell-Membrane-Anchored DNA Logic-Gated Nanoassemblies for In Situ Extracellular Bioimaging

Hangsheng Gong et al.

Summary: Elevated extracellular levels of K+ and ATP in the tumor microenvironment can be used as biomarkers for early cancer detection and tumor localization. This study develops an intelligent DNA nanoassembly controlled by a logic circuit for precise targeting of the TME.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Chemistry, Analytical

An entropy-driven three-dimensional multipedal-DNA walker for ultrasensitive detection of cancer cells

Hong Jiang et al.

Summary: In this study, a simple fluorescent signal amplification biosensor based on an entropy-driven three-dimensional DNA walker was developed for highly sensitive detection of cancer cells. The biosensor showed excellent selectivity and sensitivity, and has great potential for early diagnosis and clinical treatment of cancer.

ANALYTICA CHIMICA ACTA (2022)

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Article Chemistry, Medicinal

PEGylated solid lipid nanoparticles functionalized by aptamer for targeted delivery of docetaxel in mice bearing C26 tumor

Zahra Shakib et al.

Summary: In this study, PEGylated solid lipid nanoparticles modified with anti-nucleolin aptamers were used to target nucleolin receptors on colorectal cancer cells. The results showed that these targeted nanoparticles had high DTX entrapment efficiency and exhibited efficient tumor inhibitory characteristics in a murine carcinoma model.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2022)

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Article Chemistry, Multidisciplinary

A covalently conjugated branched DNA aptamer cluster-based nanoplatform for efficiently targeted drug delivery

Runze Li et al.

Summary: This study presents a nanoplatform based on branched DNA aptamer clusters for efficient targeted drug delivery. The covalently conjugated branched DNA aptamer cluster-modified DNA tetrahedron demonstrates highly targeted cellular uptake, resulting in selective inhibition of tumor cell proliferation after loading the chemotherapeutic drug.

NANOSCALE (2022)

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Article Materials Science, Biomaterials

Gold nanorods/tetrahedral DNA composites for chemo-photothermal therapy

Ziyun He et al.

Summary: In this study, a nanocomposite based on gold nanorods and DNA nanostructures was developed for chemo-photothermal combinational therapy in cancer treatment. The nanocomposite exhibited targeted anticancer activity and high efficiency.

REGENERATIVE BIOMATERIALS (2022)

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Review Biochemistry & Molecular Biology

Recent Nanocarrier Approaches for Targeted Drug Delivery in Cancer Therapy

Rohit Bhatia et al.

Summary: Nanocarrier systems have the ability to recognize tumor cells and deliver therapeutic agents in fixed proportions, causing minimal harm to healthy cells. They have improved bioavailability and long retention in the blood, enhancing their potency. Recent advancements in nanocarrier systems include mesoporous silica nanoparticles, metal organic frameworks, and quantum dots.

CURRENT MOLECULAR PHARMACOLOGY (2021)

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Review Chemistry, Analytical

SELEX-based DNA Aptamer Selection: A Perspective from the Advancement of Separation Techniques

Shingo Saito

Summary: This review discusses the advancements in separation techniques for SELEX-based aptamer selection developed in this decade, including CE, microfluidic chip, solid phase, and FACS-based SELEX among others.

ANALYTICAL SCIENCES (2021)

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Review Medicine, Research & Experimental

Focally amplified long non-coding RNA in epithelial cancer as a potential biomarker and therapeutic target

Yahya H. Hobani

Summary: FALEC, an upregulated lncRNA in multiple cancer types, acts as an oncogene through various mechanisms such as competitively binding miRNAs and regulating signaling pathways. Its potential as a biomarker for human cancers has been identified, highlighting the need for further studies to explore its diagnostic and prognostic performance in liquid biopsy samples and its development as a clinically utilizable prognostic cancer biomarker and molecular therapeutic target.

BIOMARKERS IN MEDICINE (2021)

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Article Engineering, Biomedical

Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy

Boyi Niu et al.

Summary: Glutathione (GSH) plays a crucial role in cellular antioxidative system, particularly in cancer cells, where a high level of GSH is essential for scavenging ROS and detoxifying xenobiotics. Depletion of GSH has been shown to enhance the efficacy of various therapies such as ROS-based therapy, ferroptosis, and chemotherapy. This review comprehensively discusses the importance of GSH depletion in cancer therapy and various strategies employed to achieve it.

BIOMATERIALS (2021)

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Article Medicine, Research & Experimental

Oligonucleotide aptamers: Recent advances in their screening, molecular conformation and therapeutic applications

Xueran Xiao et al.

Summary: Aptamers are single stranded oligonucleotides with specific recognition and binding ability to target molecules. They have advantages of low molecular weight, easy modification and high stability. Aptamers play important roles in promoting food safety, monitoring the environment, basic research, and have great potential in clinical diagnosis and therapeutic drugs.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Review Chemistry, Applied

Chemical synthesis of polysaccharide-protein and polysaccharide-peptide conjugates: A review

Yang Zhou et al.

Summary: Polysaccharide-protein conjugates have advantages such as increased solubility, improved emulsion properties, prolonged circulation time, reduced immunogenicity, and enhanced selectivity for targeting specific tissues compared to native peptides and proteins.

CARBOHYDRATE POLYMERS (2021)

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Article Biochemistry & Molecular Biology

Aptamer-Aptamer Chimera for Targeted Delivery and ATP-Responsive Release of Doxorubicin into Cancer Cells

Ezaldeen Esawi et al.

Summary: The study developed a chimera consisting of two aptamers to selectively deliver doxorubicin into cancer cells and release the drug inside cells. Results demonstrate the selective uptake of the chimera into cancer cells, successful delivery of doxorubicin to targeted cells, inhibition of cancer cell growth, and reduced cytotoxicity on normal cells, indicating the potential of the AS1411-ATP aptamer chimera as an innovative drug delivery system for improved therapeutic efficacy with decreased off-target cytotoxicity.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Nanoscience & Nanotechnology

Potential of Nanocarrier-Based Drug Delivery Systems for Brain Targeting: A Current Review of Literature

Badriyah Shadid Alotaibi et al.

Summary: The emergence of nanotechnologies, such as nanocarriers and nanotherapeutics, has revolutionized treatment strategies with more efficacious drug delivery systems, particularly for targeting brain diseases. Various nanocarrier-based composites have been developed for drug targeting towards brain cells, with ongoing advancements in technologies and research in this area.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Review Oncology

Fascin actin-bundling protein 1 in human cancer: Promising biomarker or therapeutic target?

Hongliang Liu et al.

Summary: Fascin actin-bundling protein 1 (FSCN1) is a highly conserved protein that has been found to be overexpressed in various human cancers, where it is associated with aggressive clinical progression, poor prognosis, and survival outcomes. The upregulation of FSCN1 in cancer cells is linked to tumor growth, migration, invasion, and metastasis, making it a potential therapeutic target and biomarker for multiple cancer types.

MOLECULAR THERAPY-ONCOLYTICS (2021)

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Review Oncology

The role of the tumor microbe microenvironment in the tumor immune microenvironment: bystander, activator, or inhibitor?

Jiayao Ma et al.

Summary: The tumor microbe microenvironment modulates the tumor immune microenvironment in various ways, acting as an immune activator, inhibitor, or bystander, and involving multiple potential mechanisms. Modulation strategies of the tumor microbe microenvironment may enhance the efficacy of immunotherapy and reduce adverse effects of checkpoint inhibitors, but there are still key questions awaiting answers in this field.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Biotechnology & Applied Microbiology

Improving anti-cancer drug delivery performance of magnetic mesoporous silica nanocarriers for more efficient colorectal cancer therapy

Sonia Iranpour et al.

Summary: By designing a novel DDS based on magnetic mesoporous silica core-shell nanoparticles, incorporating gold gatekeepers, PEG, and aptamer, the study successfully achieved targeted drug delivery to colorectal cancer cells. The targeted nanocarriers showed higher cytotoxicity and cellular uptake, indicating the efficacy of aptamer as a targeting agent. In vivo results in a humanized mouse model demonstrated enhanced drug accumulation at the tumor site, tumor growth inhibition, and reduced adverse side effects.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Review Education, Scientific Disciplines

Targeted Drug Delivery System: Advantages, Carriers and Strategies

Kousalya Prabahar et al.

Summary: Drug targeting is a novel drug delivery system that delivers medication to specific target sites to enhance efficacy and reduce side effects. It retains and transports the intact drug until reaching the target site, allowing for therapeutic action in diseased organs while minimizing impact on healthy organs.

INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH (2021)

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Review Biochemistry & Molecular Biology

Overview of the Therapeutic Potential of Aptamers Targeting Coagulation Factors

Max Liu et al.

Summary: Aptamers are single-stranded DNA or RNA sequences that exhibit high specificity and affinity in binding target molecules. They are non-immunogenic, easier to synthesize and modify, and can bind targets with greater affinity, making them a promising therapeutic candidate for treating various conditions. Active research is ongoing in developing aptamers to target blood coagulation factors, with potential applications in treating cardiovascular diseases, blood disorders, and cancers. Although no aptamers targeting blood coagulation factors have been approved for clinical use, several have shown promise in clinical trials and preclinical studies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Nanoscience & Nanotechnology

Aptamer-Targeted Calcium Phosphosilicate Nanoparticles for Effective Imaging of Pancreatic and Prostate Cancer

Thomas Abraham et al.

Summary: Aptamer-targeted nanoparticles loaded with imaging agents showed enhanced detection of pancreatic and prostate tumors in vivo and ex vivo. The specific interaction with CCK-B receptors allows for well-distributed distribution of the tumor-targeted nanoparticles in the tumor matrix, improving early cancer detection.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Review Pharmacology & Pharmacy

Tumor microenvironment as a therapeutic target in cancer

Yi Xiao et al.

Summary: This article summarizes the current progress in targeting the tumor microenvironment in both drug development and clinical trials, emphasizing the challenges in intervening in the tumor microenvironment and discussing strategies to maximize therapeutic benefits. New technologies and approaches to better understand the tumor microenvironment are explored in this context.

PHARMACOLOGY & THERAPEUTICS (2021)

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Review Gastroenterology & Hepatology

Gastrointestinal cancers in China, the USA, and Europe

Yumo Xie et al.

Summary: Gastrointestinal cancers, including colorectal cancer, gastric cancer, and esophageal cancer, are a major global medical and economic burden. While esophageal and gastric cancers are common in developing countries, colorectal cancer is predominant in Western countries. However, a shift in the major GI-cancer type is occurring in economically transitioning countries.

GASTROENTEROLOGY REPORT (2021)

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Review Pharmacology & Pharmacy

Natural gum polysaccharides as efficient tissue engineering and drug delivery biopolymers

Arun Koyyada et al.

Summary: The usage of plant origin natural gum polysaccharides in various biomedical applications is steadily rising due to their unique properties like biocompatibility, biodegradability, and cytocompatibility. These polysaccharides are beneficial in tissue engineering applications as they exhibit exceptional properties compared to other biomaterials. Ongoing research in nanotechnology and polysaccharides has shown potential for improving drug delivery and cell proliferation in scaffold fabrication.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021)

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Article Materials Science, Biomaterials

Aptamer and Peptide-Modified Lipid-Based Drug Delivery Systems in Application of Combined Sequential Therapy of Hepatocellular Carcinoma

Lv Jianghong et al.

Summary: This study demonstrated that aptamer/peptide-modified lipid-based drug delivery systems, A54-PEG-SLN/OXA and A15-PEG-SLN/SAL, could specifically target carcinoma cells and had a significant antitumor effect when used sequentially.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2021)

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Article Chemistry, Multidisciplinary

CLEC3B Identified as a Potential Lung Cancer Biomarker in Serum by Aptamer-Capture Technology

Yuanbin Guo et al.

Summary: A novel lung cancer biomarker, CLEC3B, was identified in this study, which showed potential for early diagnosis and therapy of lung cancer. Various experiments confirmed the specificity and selectivity of CLEC3B, indicating its potential clinical application value.

CHEMISTRYSELECT (2021)

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Review Chemistry, Multidisciplinary

Nano-scale delivery: A comprehensive review of nano-structured devices, preparative techniques, site-specificity designs, biomedical applications, commercial products, and references to safety, cellular uptake, and organ toxicity

Ahmed A. H. Abdellatif et al.

Summary: This review focuses on the preparation of nano-structured delivery devices from biodegradable and biocompatible natural and synthetic polymers, metals, metal oxides, and other compounds. Various nano-entities such as nanoparticles, liposomes, hydrogels, dendrimers, and carbon-based nano-entities have been produced using different preparative techniques. The review outlines developments in design, structural specifications, preparative strategies, chemo-biological interfacing, and applications of nanomaterials in biomedical fields.

NANOTECHNOLOGY REVIEWS (2021)

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Article Nanoscience & Nanotechnology

An Aptamer-Modified DNA Tetrahedron-Based Nanogel for Combined Chemo/Gene Therapy of Multidrug-Resistant Tumors

Wantao Tang et al.

Summary: DNA-based nanogels have been used as a platform for combined chemo/gene therapy of multidrug-resistant tumors in this study, showing efficient targeted cellular internalization and stimuli-responsive release. The incorporation of aptamer and disulfide bridges in the design of DNA-based nanogels enables targeted drug delivery and combined tumor therapy, providing a new strategy for intelligent drug delivery.

ACS APPLIED BIO MATERIALS (2021)

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Article Materials Science, Biomaterials

PEG-poly(amino acid)s/EpCAM aptamer multifunctional nanoparticles arrest the growth and metastasis of colorectal cancer

Yingru Zhang et al.

Summary: A new targeted nanoparticle drug carrier system, EpCAM-TSIIA-NPs, is reported in this study, which has higher cytotoxicity, better water solubility, and superior targeting ability, effectively suppressing tumor proliferation and metastasis. EpCAM-TSIIA-NPs can enhance the expression of APC and axin, stabilize the beta-catenin destruction complex, and inhibit tumor occurrence and progression by blocking nuclear activities of beta-catenin.

BIOMATERIALS SCIENCE (2021)

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Article Materials Science, Biomaterials

Targeted delivery and controlled release of doxorubicin to cancer cells by smart ATP-responsive Y-shaped DNA structure-capped mesoporous silica nanoparticles

Elnaz Bagheri et al.

Summary: In this study, a dual-receptor doxorubicin-targeted delivery system based on mesoporous silica nanoparticles modified with mucine-1 and ATP aptamers was developed, showing high drug loading capacity and ATP-responsive release behavior for enhanced anticancer efficacy. The smart platform exhibited superior tumor accumulation and growth inhibitory effects in vivo, indicating its potential for cancer treatment.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Cell Biology

Hybrid nanoreservoirs based on dextran-capped dendritic mesoporous silica nanoparticles for CD133-targeted drug delivery

Mahsa Zahiri et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

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Review Oncology

The utilization of saliva as an early diagnostic tool for oral cancer: microRNA as a biomarker

J. S. Ghizoni et al.

CLINICAL & TRANSLATIONAL ONCOLOGY (2020)

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Review Environmental Sciences

Magnetic nanoparticles for hyperthermia in cancer treatment: an emerging tool

Jobin Jose et al.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2020)

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Review Nanoscience & Nanotechnology

Aptamers as Versatile Ligands for Biomedical and Pharmaceutical Applications

Baozhang Guan et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Review Pharmacology & Pharmacy

Magnetic nanocarriers: Emerging tool for the effective targeted treatment of lung cancer

Janani Sadhasivam et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2020)

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Article Dentistry, Oral Surgery & Medicine

Role of CD44 in tumor-initiating cells of salivary gland pleomorphic adenoma: More than a surface biomarker

Shukun Shen et al.

ORAL DISEASES (2020)

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Article Oncology

Aptamer-Conjugated Superparamagnetic Ferroarabinogalactan Nanoparticles for Targeted Magnetodynamic Therapy of Cancer

Olga S. Kolovskaya et al.

CANCERS (2020)

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Review Pathology

Update on urine as a biomarker in cancer: a necessary review of an old story

Wei Zhang et al.

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS (2020)

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Review Biochemistry & Molecular Biology

Aptamers, the Nucleic Acid Antibodies, in Cancer Therapy

Zhaoying Fu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Engineering, Biomedical

Synthesis of combinatorial Janus nanoparticles based on EpCAM-PEG/PCL for targeted therapy of human colorectal adenocarcinoma

Somayeh Khezrian et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2020)

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Article Chemistry, Multidisciplinary

MUC1 Aptamer-Capped Mesoporous Silica Nanoparticles for Navitoclax Resistance Overcoming in Triple-Negative Breast Cancer

Gema Vivo-Llorca et al.

CHEMISTRY-A EUROPEAN JOURNAL (2020)

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Article Engineering, Biomedical

Tumor microenvironment (TME)-activatable circular aptamer-PEG as an effective hierarchical-targeting molecular medicine for photodynamic therapy

Yu Yang et al.

BIOMATERIALS (2020)

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Review Oncology

Expression and function of epithelial cell adhesion molecule EpCAM: where are we after 40 years?

Olivier Gires et al.

CANCER AND METASTASIS REVIEWS (2020)

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Article Nanoscience & Nanotechnology

Gint4.T-Modified DNA Tetrahedrons Loaded with Doxorubicin Inhibits Glioma Cell Proliferation by Targeting PDGFRβ

Feng Wang et al.

NANOSCALE RESEARCH LETTERS (2020)

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Review Biochemistry & Molecular Biology

Molecular and Cellular Complexity of Glioma. Focus on Tumour Microenvironment and the Use of Molecular and Imaging Biomarkers to Overcome Treatment Resistance

Silvia Valtorta et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Biochemistry & Molecular Biology

Aptamers against Immunoglobulins: Design, Selection and Bioanalytical Applications

Zsofia Bognar et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Engineering, Biomedical

Construction of Aptamer-siRNA Chimera/PEI/5-FU/Carbon Nanotube/Collagen Membranes for the Treatment of Peritoneal Dissemination of Drug-Resistant Gastric Cancer

Wen Chen et al.

ADVANCED HEALTHCARE MATERIALS (2020)

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Review Oncology

MicroRNAs: potential biomarkers for diagnosis and prognosis of different cancers

Prakash Chand Sharma et al.

TRANSLATIONAL CANCER RESEARCH (2020)

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Cell-mediated targeting drugs delivery systems

Hongli Yu et al.

DRUG DELIVERY (2020)

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Review Nanoscience & Nanotechnology

Chemically Modified Aptamers in Biological Analysis

Ruichen Shen et al.

ACS APPLIED BIO MATERIALS (2020)

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Review Biochemistry & Molecular Biology

Ligand-Targeted Delivery of Photosensitizers for Cancer Treatment

Piotr Gierlich et al.

MOLECULES (2020)

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Comparing Conventional Chemotherapy to Chronomodulated Chemotherapy for Cancer Treatment: Protocol for a Systematic Review

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JMIR RESEARCH PROTOCOLS (2020)

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DNA-Based Nanomedicine with Targeting and Enhancement of Therapeutic Efficacy of Breast Cancer Cells

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ACS APPLIED MATERIALS & INTERFACES (2019)

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Viewing the Emphasis on State-of-the-Art Magnetic Nanoparticies: Synthesis, Physical Properties, and Applications in Cancer Theranostics

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CURRENT PHARMACEUTICAL DESIGN (2019)

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Smart Mesoporous Silica Nanoparticles for Protein Delivery

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NANOMATERIALS (2019)

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Article Pharmacology & Pharmacy

CD30 aptamer-functionalized PEG-PLGA nanoparticles for the superior delivery of doxorubicin to anaplastic large cell lymphoma cells

Xiao Luo et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

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Review Biochemistry & Molecular Biology

Giutathione, an Antioxidant Tripeptide: Dual Roles in Carcinogenesis and Chemoprevention

Arunaksharan Narayanankutty et al.

CURRENT PROTEIN & PEPTIDE SCIENCE (2019)

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Article Medicine, Research & Experimental

EpCAM Aptamer-Functionalized Cationic Liposome-Based Nanoparticles Loaded with miR-139-5p for Targeted Therapy in Colorectal Cancer

Yuyu Zhao et al.

MOLECULAR PHARMACEUTICS (2019)

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Article Chemistry, Analytical

Image-guided cancer therapy using aptamer-functionalized cross-linked magnetic-responsive Fe3O4@carbon nanoparticles

Changhong Zhao et al.

ANALYTICA CHIMICA ACTA (2019)

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Review Biochemistry & Molecular Biology

Nucleic acid aptamers in diagnosis of colorectal cancer

Yaghoub Ahmadyousefi et al.

BIOCHIMIE (2019)

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The Many Facets of Tumor Heterogeneity: Is Metabolism Lagging Behind?

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CANCERS (2019)

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Aptamer/photosensitizer hybridized mesoporous MnO2 based tumor cell activated ROS regulator for precise photodynamic therapy of breast cancer

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COLLOIDS AND SURFACES B-BIOINTERFACES (2019)

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Pegylated magnetic mesoporous silica nanoparticles decorated with AS1411 Aptamer as a targeting delivery system for cytotoxic agents

Ramin Sakhtianchi et al.

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY (2019)

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Article Nanoscience & Nanotechnology

An Efficient Cell-Targeting Drug Delivery System Based on Aptamer-Modified Mesoporous Silica Nanoparticles

Yang Yang et al.

NANOSCALE RESEARCH LETTERS (2019)

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A Nanocarrier System for Mitochondrial Delivery Targeted to a Pancreatic Beta Cell

Yuma Yamada

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN (2019)

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Anti-MUC1/CD44 Dual-Aptamer-Conjugated Liposomes for Cotargeting Breast Cancer Cells and Cancer Stem Cells

Dong-Min Kim et al.

ACS APPLIED BIO MATERIALS (2019)

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Screening of Oligonucleotide Aptamers and Application in Detection of Pesticide and Veterinary Drug Residues

Zou Xue-Mei et al.

CHINESE JOURNAL OF ANALYTICAL CHEMISTRY (2019)

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Biology and clinical relevance of EpCAM

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CELL STRESS (2019)

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AS1411 aptamer-modified theranostic liposomes co-encapsulating manganese oxide nano-contrast agent and paclitaxel for MRI and therapy of cancer

Jingjing Li et al.

RSC ADVANCES (2019)

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Dendrimer nanohybrid carrier systems: an expanding horizon for targeted drug and gene delivery

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DRUG DISCOVERY TODAY (2018)

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A dual-targeting DNA tetrahedron nanocarrier for breast cancer cell imaging and drug delivery

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TALANTA (2018)

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CD133-targeted delivery of self-assembled PEGylated carboxymethylcellulose-SN38 nanoparticles to colorectal cancer

Mona Alibolandi et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2018)

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A basic insight into aptamer-drug conjugates (ApDCs)

Wenjing Xuan et al.

BIOMATERIALS (2018)

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Article Biotechnology & Applied Microbiology

Dual targeting delivery of miR-328 by functionalized mesoporous silica nanoparticles for colorectal cancer therapy

Yang Li et al.

NANOMEDICINE (2018)

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CD44 is overexpressed and correlated with tumor progression in gallbladder cancer

Yuting He et al.

CANCER MANAGEMENT AND RESEARCH (2018)

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Dual-modified cationic liposomes loaded with paclitaxel and survivin siRNA for targeted imaging and therapy of cancer stem cells in brain glioma

Xiyang Sun et al.

DRUG DELIVERY (2018)

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Article Chemistry, Medicinal

MUC1 aptamer-conjugated mesoporous silica nanoparticles effectively target breast cancer cells

Mohammad Yahya Hanafi-Bojd et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2018)

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Review Biochemistry & Molecular Biology

Recent Advances in SELEX Technology and Aptamer Applications in Biomedicine

Zhenjian Zhuo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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TRAIL, Wnt, Sonic Hedgehog, TGFβ, and miRNA Signalings Are Potential Targets for Oral Cancer Therapy

Ammad Ahmad Farooqi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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EpCAM aptamer-functionalized polydopamine-coated mesoporous silica nanoparticles loaded with DM1 for targeted therapy in colorectal cancer

Yang Li et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

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Article Nanoscience & Nanotechnology

SL2B aptamer and folic acid dual-targeting DNA nanostructures for synergic biological effect with chemotherapy to combat colorectal cancer

Pengchao Sun et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

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Photo-controlled aptamers delivery by dual surface gold-magnetic nanoparticles for targeted cancer therapy

Zhao Jian et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2017)

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Article Biotechnology & Applied Microbiology

PLGA nanoparticles with CD133 aptamers for targeted delivery and sustained release of propranolol to hemangioma

Xiaonan Guo et al.

NANOMEDICINE (2017)

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Article Nanoscience & Nanotechnology

MUC1 aptamer-capped mesoporous silica nanoparticles for controlled drug delivery and radio-imaging applications

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NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2017)

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Osteotropic nanoscale drug delivery systems based on small molecule bone-targeting moieties

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NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2017)

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Aptamer-based assay of biomolecules: Recent advances in electro-analytical approach

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TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2017)

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Integration of intracellular telomerase monitoring by electrochemiluminescence technology and targeted cancer therapy by reactive oxygen species

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CHEMICAL SCIENCE (2017)

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Expression of CD133 in endometrial cancer cells and its implications

Dah-Ching Ding et al.

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Peroxiredoxin-4 as a potential biomarker of early gastric cancer screened by Cell-SELEX

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TRANSLATIONAL CANCER RESEARCH (2017)

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Recent progress on nanoparticle-based drug delivery systems for cancer therapy

Yanru Xin et al.

CANCER BIOLOGY & MEDICINE (2017)

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DNA-spheres decorated with magnetic nanocomposites based on terminal transfer reactions for versatile target detection and cellular targeted drug delivery

Yingshu Guo et al.

CHEMICAL COMMUNICATIONS (2017)

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Heralding a new paradigm in 3D tumor modeling

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BIOMATERIALS (2016)

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EpCAM aptamer-functionalized mesoporous silica nanoparticles for efficient colon cancer cell-targeted drug delivery

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EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2016)

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Article Pharmacology & Pharmacy

Specific targeting delivery to MUC1 overexpressing tumors by albumin-chitosan nanoparticles conjugated to DNA aptamer

Mehdi Esfandyari-Manesh et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2016)

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Review Clinical Neurology

The role of CD44 in glioblastoma multiforme

Kelly L. Mooney et al.

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Adapting conventional cancer treatment for immunotherapy

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Carbohydrate-based amphiphilic nano delivery systems for cancer therapy

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NANOSCALE (2016)

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Amino Acid Metabolism Abnormity and Microenvironment Variation Mediated Targeting and Controlled Glioma Chemotherapy

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Aptamers as smart ligands for nano-carriers targeting

Ahad Mokhtarzadeh et al.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2016)

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Article Oncology

Aptamer-guided DNA tetrahedron as a novel targeted drug delivery system for MUC1-expressing breast cancer cells in vitro

Bindong Dai et al.

ONCOTARGET (2016)

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Article Oncology

CD109 is identified as a potential nasopharyngeal carcinoma biomarker using aptamer selected by cell-SELEX

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ONCOTARGET (2016)

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Review Biochemistry & Molecular Biology

Development of Cell-SELEX Technology and Its Application in Cancer Diagnosis and Therapy

Man Chen et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

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Aptamer-modified PLGA nanoparticle delivery of triplex forming oligonucleotide for targeted prostate cancer therapy

J. Jiao et al.

NEOPLASMA (2016)

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Article Engineering, Biomedical

Specific aptamer-conjugated mesoporous silica-carbon nanoparticles for HER2-targeted chemo-photothermal combined therapy

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ACTA BIOMATERIALIA (2015)

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Article Engineering, Biomedical

Dual-stimuli responsive hyaluronic acid-conjugated mesoporous silica for targeted delivery to CD44-overexpressing cancer cells

Qinfu Zhao et al.

ACTA BIOMATERIALIA (2015)

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Current approaches in SELEX: An update to aptamer selection technology

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BIOTECHNOLOGY ADVANCES (2015)

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Aptamers as a novel tool for diagnostics and therapy

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INVESTIGATIONAL NEW DRUGS (2015)

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Applications of Magnetic Nanoparticles in Targeted Drug Delivery System

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Article Nanoscience & Nanotechnology

Mesoporous silica nanoparticles in drug delivery and biomedical applications

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NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2015)

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Aptamers: Active Targeting Ligands for Cancer Diagnosis and Therapy

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THERANOSTICS (2015)

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Design Strategies and Applications of Circulating Cell-Mediated Drug Delivery Systems

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ACS BIOMATERIALS SCIENCE & ENGINEERING (2015)

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Review Materials Science, Biomaterials

Design Strategies and Applications of Circulating Cell-Mediated Drug Delivery Systems

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ACS BIOMATERIALS SCIENCE & ENGINEERING (2015)

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Review Chemistry, Multidisciplinary

The Biological Applications of Inorganic Nanoparticle Drug Carriers

Mei-Xia Zhao et al.

CHEMNANOMAT (2015)

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Article Biochemical Research Methods

Functionalizing Liposomes with anti-CD44 Aptamer for Selective Targeting of Cancer Cells

Walhan Alshaer et al.

BIOCONJUGATE CHEMISTRY (2015)

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Article Chemistry, Multidisciplinary

Chitosan as a Sustainable Organocatalyst: A Concise Overview

Abdelkrim El Kadib

CHEMSUSCHEM (2015)

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Article Engineering, Biomedical

Nucleolin-targeting liposomes guided by aptamer AS1411 for the delivery of siRNA for the treatment of malignant melanomas

Liyu Li et al.

BIOMATERIALS (2014)

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Article Oncology

Expression of CD133 in the cytoplasm is associated with cancer progression and poor prognosis in gastric cancer

Kousuke Hashimoto et al.

GASTRIC CANCER (2014)

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Article Oncology

Comparison of nucleostemin gene expression in CD133+and CD133-cell population in colon cancer cell line HT29

Noosha Zia-Jahromi et al.

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS (2014)

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Article Nutrition & Dietetics

Mitochondrial reactive oxygen species accelerate gastric cancer cell invasion

Masato Tamura et al.

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION (2014)

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Review Chemistry, Analytical

Smart Materials Based on DNA Aptamers: Taking Aptasensing to the Next Level

Emily Mastronardi et al.

SENSORS (2014)

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Review Materials Science, Multidisciplinary

Aptamer-conjugated nanomaterials for specific cancer cell recognition and targeted cancer therapy

Qiaoling Liu et al.

NPG ASIA MATERIALS (2014)

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Review Medicine, General & Internal

Drug-targeting methodologies with applications: A review

Clement Kleinstreuer et al.

WORLD JOURNAL OF CLINICAL CASES (2014)

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Article Oncology

Clinicopathological significance of CD133 in lung cancer: A meta-analysis

Yaoxi Tan et al.

MOLECULAR AND CLINICAL ONCOLOGY (2014)

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Article Pharmacology & Pharmacy

Applications of Mesoporous Materials as Excipients for Innovative Drug Delivery and Formulation

Shou-Cang Shen et al.

CURRENT PHARMACEUTICAL DESIGN (2013)

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Review Chemistry, Multidisciplinary

Smart ligand: Aptamer-mediated targeted delivery of chemotherapeutic drugs and siRNA for cancer therapy

Xin Li et al.

JOURNAL OF CONTROLLED RELEASE (2013)

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Article Chemistry, Multidisciplinary

Aptamer conjugated theragnostic multifunctional magnetic nanoparticles as a nanoplatform for pancreatic cancer therapy

Balasubramanian Sivakumar et al.

RSC ADVANCES (2013)

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Article Oncology

Cancer stem cell-like characteristics of a CD133(+) subpopulation in the J82 human bladder cancer cell line

Peng Huang et al.

MOLECULAR AND CLINICAL ONCOLOGY (2013)

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Article Oncology

Characterization of the conversion between CD133+ and CD133- cells in colon cancer SW620 cell line

Jian-Ming Feng et al.

CANCER BIOLOGY & THERAPY (2012)

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Article Oncology

Cell cycle analysis of the CD133 and CD133 - cells isolated from human colorectal cancer

Marjan Gharagozloo et al.

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS (2012)

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Article Engineering, Biomedical

Polyvalent Mesoporous Silica Nanoparticle-Aptamer Bioconjugates Target Breast Cancer Cells

Le-Le Li et al.

ADVANCED HEALTHCARE MATERIALS (2012)

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Review Biochemistry & Molecular Biology

Recent Developments in Protein and Cell-Targeted Aptamer Selection and Applications

Jun Liu et al.

CURRENT MEDICINAL CHEMISTRY (2011)

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Article Biochemistry & Molecular Biology

In vitro selected RNA aptamer recognizing glutathione induces ROS-mediated apoptosis in the human breast cancer cell line MCF 7

Jyoti Bala et al.

RNA BIOLOGY (2011)

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Article Gastroenterology & Hepatology

Upregulated CD133 expression in tumorigenesis of colon cancer cells

Zhi-Li Yang et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2011)

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Review Pharmacology & Pharmacy

Receptor Mediated Tumor Targeting: An Emerging Approach for Cancer Therapy

Chandana Mohanty et al.

CURRENT DRUG DELIVERY (2011)

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Article Chemistry, Multidisciplinary

Aptamer-Based Tumor-Targeted Drug Delivery for Photodynamic Therapy

Yen-An Shieh et al.

ACS NANO (2010)

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Article Otorhinolaryngology

Chemiluminescence assay of reactive oxygen species in laryngeal cancer

T. Baglam et al.

JOURNAL OF LARYNGOLOGY AND OTOLOGY (2010)

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Article Nanoscience & Nanotechnology

Doxorubicin-loaded solid lipid nanoparticles to overcome multidrug resistance in cancer therapy

Keon Wook Kang et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2010)

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Review Biotechnology & Applied Microbiology

Aptamers as therapeutics

Anthony D. Keefe et al.

NATURE REVIEWS DRUG DISCOVERY (2010)

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Review Pharmacology & Pharmacy

Magnetic nanoparticles and targeted drug delivering

Jana Chomoucka et al.

PHARMACOLOGICAL RESEARCH (2010)

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Review Pharmacology & Pharmacy

Detection of VEGF(165) Using an Aptamer Affinity Probe in Microchip Capillary Electrophoresis

Maojun Gong et al.

CURRENT PHARMACEUTICAL ANALYSIS (2009)

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Review Pharmacology & Pharmacy

Ligand-based targeted therapy for cancer tissue

Manasi Das et al.

EXPERT OPINION ON DRUG DELIVERY (2009)

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Article Biochemistry & Molecular Biology

Epigenetic regulation of CD133 and tumorigenicity of CD133+ovarian cancer cells

T. Baba et al.

ONCOGENE (2009)

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Review Biochemistry & Molecular Biology

RNA Aptamers to Translational Components

Yoshikazu Nakamura et al.

TRANSLATIONAL CONTROL IN HEALTH AND DISEASE (2009)

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Review Chemistry, Multidisciplinary

A review of stimuli-responsive nanocarriers for drug and gene delivery

Srinivas Ganta et al.

JOURNAL OF CONTROLLED RELEASE (2008)

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Review Biochemical Research Methods

Methods developed for SELEX

Subash Chandra Bose Gopinath

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2007)

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Article Oncology

Frequent high-level expression of the immunotherapeutic target Ep-CAM in colon, stomach, prostate and lung cancers

P Went et al.

BRITISH JOURNAL OF CANCER (2006)

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Review Oncology

Nutrient and antioxidant modulation of apoptosis in gastric and colon cancer cells

Geoffrey M. Matthews et al.

CANCER BIOLOGY & THERAPY (2006)

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Review Nanoscience & Nanotechnology

Role of nanotechnology in targeted drug delivery and imaging: a concise review

Otilia M. Koo et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2005)

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Article Multidisciplinary Sciences

A tenascin-C aptamer identified by tumor cell SELEX: Systematic evolution of ligands by exponential enrichment

DA Daniels et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

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