Effects of Dimerization, Dendrimerization, and Chirality in p-BthTX-I Peptide Analogs on the Antibacterial Activity and Enzymatic Inhibition of the SARS-CoV-2 PLpro Protein

Article Hematology

A snake venom-analog peptide that inhibits SARS-CoV-2 and papain-like protease displays antithrombotic activity in mice arterial thrombosis model, without interfering with bleeding time

Ruben Siedlarczyk Nogueira et al.

Summary: The peptide (p-BthTX-I)(2) K demonstrates antithrombotic activity by prolonging coagulation time, inhibiting platelet aggregation, and extending time to arterial thrombosis. However, it does not prolong bleeding time in the mouse model.

THROMBOSIS JOURNAL (2023)

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Review Pharmacology & Pharmacy

Advances in the development of antimicrobial peptides and proteins for inhaled therapy

Yuncheng Wang et al.

Summary: Antimicrobial peptides and proteins play an increasingly important role in treating multidrug-resistant bacterial infections. Inhalation delivery of these agents can effectively increase local drug concentration in the lungs and reduce systemic toxicity. Targeted formulation strategies are needed to improve stability and inhalability of different antimicrobial peptides and proteins, as well as their combination with other antimicrobial agents. However, research on inhalable formulations of these agents is still underexplored, which is a crucial area for clinical translation.

ADVANCED DRUG DELIVERY REVIEWS (2022)

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Article Pharmacology & Pharmacy

Antimicrobial Proteins: Structure, Molecular Action, and Therapeutic Potential

Mohamed Hassan et al.

Pharmaceutics (2022)

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Review Pharmacology & Pharmacy

Recent insights for the emerging COVID-19: Drug discovery, therapeutic options and vaccine development

Yuefei Zhu et al.

Summary: The global outbreak of COVID-19 has posed a serious threat to humanity, requiring a more in-depth understanding of the epidemic and the development of rational containment strategies. While there is currently no specific antiviral therapy, rapid detection technology and promising treatment methods have been helpful.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

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Article Pharmacology & Pharmacy

The revitalization of antimicrobial peptides in the resistance era

Yuan Liu et al.

Summary: The antibiotic resistance crisis is escalating, leading to the need for alternative strategies. Antimicrobial peptides show promise as antibacterial substances due to their low propensity to acquire resistance.

PHARMACOLOGICAL RESEARCH (2021)

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Review Microbiology

Review: Lessons Learned From Clinical Trials Using Antimicrobial Peptides (AMPs)

Gabrielle S. Dijksteel et al.

Summary: Antimicrobial peptides show potential as alternatives to antibiotics, but face challenges in clinical implementation. To improve the success rate of AMPs in clinical trials, strategies need to be developed, emphasizing lessons learned from these trials.

FRONTIERS IN MICROBIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Linear and Branched Forms of Short Antimicrobial Peptide-IRK Inhibit Growth of Multi Drug Resistant Staphylococcus aureus Isolates from Mastitic Cow Milk

Purnima Gogoi et al.

Summary: Linear and branched forms of the antimicrobial peptide IRK showed different levels of antibacterial activity against Staphylococcus aureus and MRSA, with decreased activity but increased hemolytic activity as branching increased. Structural changes due to multimerization may have contributed to this change in biological activity.

INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS (2021)

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Article Biochemistry & Molecular Biology

Non-Toxic Dimeric Peptides Derived from the Bothropstoxin-I Are Potent SARS-CoV-2 and Papain-like Protease Inhibitors

Marjorie C. L. C. Freire et al.

Summary: This study reported on antiviral peptides and their derivatives against SARS-CoV-2, showing strong inhibitory activities with low cytotoxicity. These peptides inhibited viral enzyme activities, indicating that they are promising prototypes for the discovery and development of new drugs against SARS-CoV-2.

MOLECULES (2021)

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Article Pharmacology & Pharmacy

Understanding the mechanism of action of peptide (p-BthTX-I)2 derived from C-terminal region of phospholipase A2 (PLA2)-like bothropstoxin-I on Gram-positive and Gram-negative bacteria

Norival Alves Santos-Filho et al.

Summary: The peptide derived from the C-terminal region of the myotoxin BthTX-I showed different mechanisms of action against Gram-negative (E. coli) and Gram-positive (S. aureus) bacteria, indicating its potential as a prototype for new antimicrobial drugs.

TOXICON (2021)

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Article Chemistry, Multidisciplinary

Advances on chemically modified antimicrobial peptides for generating peptide antibiotics

Samilla B. Rezende et al.

Summary: Antimicrobial peptides (AMPs) are seen as promising molecules against antibiotic-resistant bacterial infections, but face limitations such as enzymatic degradation, chemical/physical instability, and toxicity towards healthy human cells in clinical trials. To improve their therapeutic potential, chemical modifications like peptidomimetic approaches are promising strategies to fine-tune AMPs.

CHEMICAL COMMUNICATIONS (2021)

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Review Chemistry, Multidisciplinary

The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions

Bee Ha Gan et al.

Summary: Bacterial infections caused by 'superbugs' are on the rise globally, with traditional antibiotics becoming less effective, posing a risk of entering a post-antibiotic era. Antimicrobial peptides (AMPs) have garnered attention for their clinical potential as a new class of antibiotics to combat antimicrobial resistance. This review discusses various aspects of AMPs, including their physicochemical properties, mechanisms of action, and chemical synthesis strategies for developing novel AMPs.

CHEMICAL SOCIETY REVIEWS (2021)

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Review Chemistry, Multidisciplinary