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Equilibria of complexes in the aqueous cobalt(II)-N-(2-hydroxybenzyl) phenylalanine system and their biological activity compared to analogous Schiff base structures

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DOI: 10.1016/j.csbj.2023.01.035

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Cobalt(II) complex; Schiff base; Stability constant; UV; Vis spectroscopy; Antimicrobial activity; Anticancer activity

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Due to their excellent prospects in biological applications, Schiff bases and their complexes have attracted continuous interest. This study investigated the formation of four cobalt(II) complexes with the reduced Schiff base PhAlaSal in alkaline aqueous solution using pH-metry. The results confirmed the proposed species model through UV-Vis and ESI-MS studies. The Schiff base and its complexes showed antimicrobial abilities and cytotoxicity against cancer cells, with N-(2-hydroxybenzyl)phenylalanine demonstrating higher efficacy but also higher cytotoxicity than N-(2-hydroxybenzyl)alanine, while AlaSal showed low cytotoxicity for fibroblasts and high toxicity for gastric adenocarcinoma epithelial cells at bacteriostatic concentration.
Due to their excellent prospects in biological applications, Schiff bases and their complexes are a source of continuing interest. The present study examines the formation of four cobalt(II) complexes with the re-duced Schiff base N-(2-hydroxybenzyl)phenylalanine (PhAlaSal) in alkaline aqueous solution by pH-metry. UV-Vis and ESI-MS studies confirmed the model of proposed species. Kinetic analysis indicated that the single-and bi-ligand cobalt(II) complexes transitioned from octahedral to tetrahedral structures. The Schiff base and its complexes detected under physiological pH were tested for antimicrobial abilities and com-pared with analogous structures of the Schiff base derivative, N-(2-hydroxybenzyl)alanine (AlaSal). The ability of these structures to influence cell growth was tested on L929 mouse fibroblasts and on cervix and gastric adenocarcinoma cancer cell lines. N-(2-hydroxybenzyl)phenylalanine demonstrates greater anti-microbial efficacy than N-(2-hydroxybenzyl)alanine but also higher cytotoxicity; however, it is nonetheless effective against cancer cells. In turn, AlaSal demonstrates low cytotoxicity for fibroblasts and high cyto-toxicity for gastric adenocarcinoma epithelial cells at bacteriostatic concentration for Helicobacter pylori and Candida strains. The presence of these microorganisms in the gastric milieu supports the development of gastritis and gastric cancer; AlaSal therapy may be simultaneously effective against both. Due to their cy-totoxicity, Schiff base complexes are not suitable for use against fungal and bacterial infections, but may effectively prevent cancer cell growth. Data availability: Data will be made available on request.(c) 2023 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology. This is an open access article under the CC BY license (http://creative-commons.org/licenses/by/4.0/).

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