Analysis of prognostic factors and construction of prognostic models for triple-positive breast cancer

Article Oncology

The impact of young age at diagnosis (age <40 years) on prognosis varies by breast cancer subtype: A US SEER database analysis

Hee Jeong Kim et al.

Summary: Women under 40 years old are at increased risk for developing breast cancer and have worse prognoses. This study found that young age is independently associated with worse outcomes in HR-positive, lower grade disease.

BREAST (2022)

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Article Oncology

Establishment and verification of a nomogram for predicting survival in patients with triple-positive breast cancer

Xingguang Wang et al.

Summary: This study analyzed the factors affecting the prognosis of TPBC patients and constructed a prediction model using a sufficient sample size from the SEER database. The model accurately predicted the individual survival of patients, helping clinicians identify high-risk patients and develop personalized treatment plans.

ANNALS OF TRANSLATIONAL MEDICINE (2022)

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Article Oncology

Breast-Conserving Therapy is Associated with Improved Survival Compared with Mastectomy for Early-Stage Breast Cancer: A Propensity Score Matched Comparison Using the National Cancer Database

Erica Wrubel et al.

Summary: A study comparing breast-conserving therapy (BCT) with mastectomy for early-stage breast cancer found that BCT was associated with superior overall survival. This survival advantage was consistent for both stage I and stage II disease subgroups.

ANNALS OF SURGICAL ONCOLOGY (2021)

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Article Oncology

Cancer Statistics, 2021

Rebecca L. Siegel et al.

Summary: Every year, the American Cancer Society projects the numbers of new cancer cases and deaths in the United States, with the latest data showing a significant decline in lung cancer mortality, while prostate cancer mortality has plateaued and breast and colorectal cancer mortality have slowed. Improvements in treatment have accelerated progress against lung cancer, leading to a record drop in overall cancer mortality.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Oncology

Recommendations from the European Commission Initiative on Breast Cancer for multigene testing to guide the use of adjuvant chemotherapy in patients with early breast cancer, hormone receptor positive, HER-2 negative

Paolo Giorgi Rossi et al.

Summary: Using 21-RS for lymph node-negative women may provide larger benefits for those at higher risk of recurrence, while using 70-GS for women at high clinical risk is recommended, with 70-GS not recommended for those at low clinical risk.

BRITISH JOURNAL OF CANCER (2021)

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Review Clinical Neurology

Decision curve analysis to evaluate the clinical benefit of prediction models

Andrew J. Vickers et al.

Summary: Decision curve analysis is a valuable method for evaluating the clinical value of prediction models in orthopedics. By comparing the net benefit and threshold probability of prediction models, their clinical value can be determined. Decision curves help draw conclusions on the clinical value of prediction models.

SPINE JOURNAL (2021)

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Review Medicine, General & Internal

Capecitabine for hormone receptor-positive versus hormone receptor-negative breast cancer

Siao-Nge Hoon et al.

Summary: This review examined the efficacy of capecitabine in hormone receptor-positive and -negative breast cancer patients across different treatment scenarios. Results showed heterogeneity in the effect of capecitabine in the metastatic setting, while improvements were seen in progression-free survival for hormone receptor-positive cancers in the adjuvant setting. Adverse effects such as diarrhea and hand-foot syndrome were noted across all treatment scenarios.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2021)

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Article Oncology