期刊
FRONTIERS IN ONCOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2022.1072701
关键词
Osteosarcoma; ubiquitination; deubiquitination; post-translation modification; cell signals
类别
资金
- Youth Science and Technology Talent Program of Changzhou Health and Family Planning Commission
- Changzhou SciTech Program
- Youth Talent Development Plan of Changzhou Health Commission
- [QN202106]
- [QN202007]
- [CJ20210085]
- [CZQM2020047]
Surgical resection remains the mainstream treatment for osteosarcoma, and early diagnosis and distal metastasis are difficult issues in the treatment of this disease. Ubiquitination, as an emerging posttranslational modification, has been found to be closely related to the development of osteosarcoma. This review describes the cellular functions and molecular mechanisms of ubiquitination in osteosarcoma.
Although some advances have been made in the treatment of osteosarcoma in recent years, surgical resection remains the mainstream treatment. Initial and early diagnosis of osteosarcoma could be very difficult to achieve due to the insufficient sensitivity for the means of examination. The distal metastasis of osteosarcoma also predicts the poor prognosis of osteosarcoma. In order to solve this series of problems, people begin to discover a new method of diagnosing and treating osteosarcoma. Ubiquitination, as an emerging posttranslational modification, has been shown to be closely related to osteosarcoma in studies over the past decades. In general, this review describes the cellular functions and molecular mechanisms of ubiquitination during the development of osteosarcoma.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据