4.6 Review

The evolving role of radiation in pancreatic cancer

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Elective Target Coverage for Pancreatic Cancer: When Less Does Not Clearly Achieve More

Michael D. Chuong et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2022)

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Neoadjuvant Chemoradiotherapy Versus Upfront Surgery for Resectable and Borderline Resectable Pancreatic Cancer: Long-Term Results of the Dutch Randomized PREOPANC Trial

Eva Versteijne et al.

Summary: This study investigates the impact of neoadjuvant chemoradiotherapy on the survival of patients with resectable and borderline resectable pancreatic cancer. The results demonstrate that neoadjuvant chemoradiotherapy improves overall survival compared to upfront surgery in these patients.

JOURNAL OF CLINICAL ONCOLOGY (2022)

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Pancreatic Stereotactic Body Radiation Therapy With or Without Hypofractionated Elective Nodal Irradiation

Jacob A. Miller et al.

Summary: Through a retrospective study on pancreatic SBRT treatment, it was found that the addition of elective nodal irradiation (ENI) to pancreatic SBRT can reduce locoregional progression, but it does not improve survival. The combination treatment has a certain impact on acute toxicity, but late and serious toxicity remain similar.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2022)

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Efficacy of Preoperative mFOLFIRINOX vs mFOLFIRINOX Plus Hypofractionated Radiotherapy for Borderline Resectable Adenocarcinoma of the Pancreas The A021501 Phase 2 Randomized Clinical Trial

Matthew H. G. Katz et al.

Summary: This randomized clinical trial found that treatment with neoadjuvant modified FOLFIRINOX alone was associated with favorable overall survival (OS) in patients with borderline resectable pancreatic ductal adenocarcinoma (PDAC) compared with treatment with modified FOLFIRINOX plus hypofractionated radiotherapy. Therefore, modified FOLFIRINOX represents a reference regimen in this setting.

JAMA ONCOLOGY (2022)

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Association of survival with stereotactic body radiation therapy following induction chemotherapy for unresected locally advanced pancreatic cancer

Sung Jun Ma et al.

Summary: The study showed that using SBRT following iC may improve survival for LAPC patients compared to CFRT, based on analysis of NCDB data.

JOURNAL OF RADIOTHERAPY IN PRACTICE (2022)

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Delta radiomics analysis of Magnetic Resonance guided radiotherapy imaging data can enable treatment response prediction in pancreatic cancer

M. R. Tomaszewski et al.

Summary: This study demonstrates the potential of using quantitative image analysis in MRgRT for predicting treatment response in PDAC patients. The change in histogram skewness during treatment was found to be significantly associated with progression free survival, suggesting it could serve as a predictive biomarker for RT response. Additionally, stability analysis revealed a wide distribution of feature sensitivities to region of interest delineation, highlighting the importance of robust feature selection in radiomic studies for MRgRT.

RADIATION ONCOLOGY (2021)

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Risk Adapted Ablative Radiotherapy After Intensive Chemotherapy for Locally Advanced Pancreatic Cancer

Gabriella Rossi et al.

Summary: The study evaluated the efficacy of a Risk-Adapted Ablative Radiotherapy (RAdAR) approach in patients with locally advanced pancreatic cancer, and the results indicated that RAdAR approach is an effective radiation treatment strategy for selected patients, representing a promising therapeutic option in a multimodality treatment regimen.

FRONTIERS IN ONCOLOGY (2021)

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Nanotechnology for Boosting Cancer Immunotherapy and Remodeling Tumor Microenvironment: The Horizons in Cancer Treatment

Shan Gao et al.

Summary: Immunotherapy utilizing the human immune system against cancer has become a mainstream strategy, with the potential to eliminate tumors and treat metastasis and recurrence. The development of nanotechnology has enabled the application of nanomaterials in cancer immunotherapy, offering significant potential for improving treatment efficacy. Nanotechnology-based immunotherapy aims to produce effective anti-tumor immune responses and enhance tumor immune defense by modulating the immune suppression mechanism in the tumor microenvironment.

ACS NANO (2021)

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Impact of Adjuvant Chemoradiotherapy on Survival of Resected Pancreatic Adenocarcinoma Cancer: A Surveillance, Epidemiology and End Results (SEER) Analysis

Xiaomao Shi et al.

Summary: The study found that adjuvant CRT may improve the overall survival of postoperative pancreatic cancer patients compared to adjuvant CT. Survival benefit was more significant in female patients, T3 stage patients, and lymph nodes positive patients.

FRONTIERS IN ONCOLOGY (2021)

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The tumour microenvironment in pancreatic cancer - clinical challenges and opportunities

Won Jin Ho et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

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Biological determinants of radioresistance and their remediation in pancreatic cancer

Parthasarathy Seshacharyulu et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2017)