4.6 Review

Rechallenge with anti-EGFR therapy to extend the continuum of care in patients with metastatic colorectal cancer

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Summary: This study investigated the efficacy of cetuximab plus avelumab rechallenge in metastatic colorectal cancer patients and explored the predictive role of baseline neutrophil-to-lymphocyte ratio (NLR). The results showed that in patients without RAS/BRAF mutations, NLR <3 was significantly associated with improved overall survival. This finding may provide a potential non-invasive predictive biomarker for cetuximab plus avelumab rechallenge activity.

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