4.6 Article

The prognosis of bladder cancer is affected by fatty acid metabolism, inflammation, and hypoxia

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Biochemistry & Molecular Biology

Pyroptosis, a target for cancer treatment?

Ying Huang et al.

Summary: Pyroptosis is a newly discovered form of programmed cell death mediated by the gasdermin protein that is closely related to cancer. It has complex effects on cancer development, including inhibition of cancer cell viability, impacts on the invasion and migration of cancer cells, improvement of antitumor immunity, and enhancement of chemotherapy sensitivity.

APOPTOSIS (2022)

Article Oncology

Hypoxia signaling: Challenges and opportunities for cancer therapy

Mircea Ivan et al.

Summary: This review focuses on new pharmacological agents that exploit tumor hypoxia or interfere with hypoxia signaling and discusses strategies to maximize their therapeutic impact.

SEMINARS IN CANCER BIOLOGY (2022)

Article Multidisciplinary Sciences

Copper induces cell death by targeting lipoylated TCA cycle proteins

Peter Tsvetkov et al.

Summary: Copper is an essential cofactor for all organisms, but excessive copper can lead to cell death. We found that copper-dependent cell death mechanism is different from known mechanisms, and it is related to mitochondrial respiration. Copper directly binds to lipoylated components of the tricarboxylic acid cycle, causing protein aggregation and loss of iron-sulfur cluster proteins, ultimately leading to cell death.

SCIENCE (2022)

Review Oncology

Fatty Acid Metabolism and Cancer Immunotherapy

Yuting Luo et al.

Summary: This review provides an update on the latest findings concerning the impacts of FA metabolism reprogramming on the phenotypes and functions of immune cells in tumor-related immune responses. The combinatorial interventions of FA metabolism are also summarized, which can improve the effects of current immunotherapies.

CURRENT ONCOLOGY REPORTS (2022)

Review Urology & Nephrology

European Association of Urology Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2020 Guidelines

J. Alfred Witjes et al.

Summary: This article presents the updated European Association of Urology guidelines for muscle-invasive and metastatic bladder cancer, providing practical evidence-based recommendations and consensus statements on clinical management. The guidelines cover a broad scope and incorporate the latest research findings and results from consensus meetings.

EUROPEAN UROLOGY (2021)

Review Biochemistry & Molecular Biology

Chronic and Cycling Hypoxia: Drivers of Cancer Chronic Inflammation through HIF-1 and NF-κB Activation: A Review of the Molecular Mechanisms

Jan Korbecki et al.

Summary: This paper discusses the mechanisms and effects of chronic low-grade inflammation caused by chronic hypoxia and cycling hypoxia in malignant tumors, as well as their impact on the tumor microenvironment and cell recruitment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Biochemistry & Molecular Biology

Natural Products with Activity against Lung Cancer: A Review Focusing on the Tumor Microenvironment

Yue Yang et al.

Summary: Despite the progress made in lung cancer research, targeting the tumor microenvironment (TME) remains a challenge. Natural products play a crucial role in cancer therapy, and research on TME is essential for developing more effective treatments.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Oncology

High Tumor Mutational Burden in Rare and Complex EGFR Mutant Non-Small Cell Lung Cancer

A. Mo et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2021)

Review Oncology

Immune Checkpoint Inhibitors for the Treatment of Bladder Cancer

Antonio Lopez-Beltran et al.

Summary: Several immune checkpoint inhibitors have been approved for the treatment of patients with metastatic urothelial carcinoma, showing promising efficacy in first-line or second-line therapy. PD-L1 expression may be a predictive factor for response to ICIs. Anti-PD-1 and PD-L1 antibodies have demonstrated durable responses in some mUC patients.

CANCERS (2021)

Review Oncology

The diversity and breadth of cancer cell fatty acid metabolism

Shilpa R. Nagarajan et al.

Summary: Tumor cellular metabolism has distinguishing features that enhance biomass synthesis and maintain cellular homeostasis through complex interactions between cell-intrinsic and cell-extrinsic factors. Fatty acid metabolism plays a crucial role in tumorigenesis by supporting processes like membrane biosynthesis, energy production, and signaling intermediates generation.

CANCER & METABOLISM (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Oncology

Characterization of the fatty acid metabolism in colorectal cancer to guide clinical therapy

Chengsheng Ding et al.

Summary: The study investigated the role of fatty acid metabolism in colorectal cancer (CRC) and established a prognostic risk score model based on fatty acid metabolism-related genes. The model can predict the prognosis of CRC patients and guide effective immunotherapy regimens.

MOLECULAR THERAPY-ONCOLYTICS (2021)

Review Oncology

Induction of Pyroptosis: A Promising Strategy for Cancer Treatment

Lei Wang et al.

Summary: Pyroptosis is a lytic pro-inflammatory type of programmed cell death that has a complex relationship with cancer. It can provide a comfortable environment for tumor proliferation as inflammatory cell death, but excessive activation can also inhibit the development of tumor cells.

FRONTIERS IN ONCOLOGY (2021)

Article Oncology

Metabolic adaptation in hypoxia and cancer

Felipe Paredes et al.

Summary: The focus of cells' adaptation to hypoxia is the transcription factor HIF1α, which promotes tumor development by affecting cellular metabolism. In addition to hypoxia, metabolic inhibition also influences HIF1α stability and activity, promoting glycolytic metabolism in cancer cells to support growth and proliferation.

CANCER LETTERS (2021)

Review Oncology

The Complex Network between Inflammation and Colorectal Cancer: A Systematic Review of the Literature

Rossana Percario et al.

Summary: Colorectal cancer is a common malignant pathology with multifactorial etiology, and inflammation has been identified as a significant contributor. This study systematically reviewed literature on the strong link between inflammation and colorectal cancer, identifying multiple inflammation pathways and anti-tumorigenic molecules that could have diagnostic, clinical, and therapeutic implications in cancer prevention and treatment.

CANCERS (2021)

Review Oncology

Metabolic Modifications, Inflammation, and Cancer Immunotherapy

Sihao Zheng et al.

Summary: In recent years, there has been increasing research on metabolic modifications in cancer immunotherapy, focusing on the roles of glycosylation and palmitoylation in the tumor microenvironment. Targeting these metabolic modifications in immune checkpoints and inflammation presents an attractive therapeutic strategy to improve individualized therapy responses.

FRONTIERS IN ONCOLOGY (2021)

Article Oncology

METTL1-m7G-EGFR/EFEMP1 axis promotes the bladder cancer development

Xiaoling Ying et al.

Summary: The study reveals that METTL1 is highly expressed in bladder cancer (BC) and correlates with poor patient prognosis. Silencing METTL1 inhibits proliferation, migration, and invasion of BC cells by altering the expression of certain target genes, such as EGFR/EFEMP1, through m(7)G tRNA modification. Forced expression of EGFR/EFEMP1 partially rescues the effects of METTL1 deletion on BC cells, highlighting the potential therapeutic targets in BC treatment.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

Article Oncology

A 4-gene-based hypoxia signature is associated with tumor immune microenvironment and predicts the prognosis of pancreatic cancer patients

Jianfeng Ding et al.

Summary: The study established a hypoxia risk model using mRNA expression profiles from TCGA and GEO databases, which could be used to predict prognosis and demonstrate the immune microenvironment in PAC. The higher hypoxia risk score was associated with poorer prognosis and an immunosuppressive microenvironment in PAC patients.

WORLD JOURNAL OF SURGICAL ONCOLOGY (2021)

Editorial Material Biochemistry & Molecular Biology

m7G tRNA modification reveals new secrets in the translational regulation of cancer development

Olga Katsara et al.

MOLECULAR CELL (2021)

Article Oncology

Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of urothelial cancer

Matthew D. Galsky et al.

Summary: Immunotherapies play a significant role in the treatment of urothelial cancer, with a focus on selecting the right agents and treatment scheduling while considering patient management. A panel of experts has developed a clinical practice guideline to provide guidance for healthcare professionals treating patients with urothelial cancer.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Article Oncology

Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of breast cancer

Leisha A. Emens et al.

Summary: In recent years, the use of immune checkpoint inhibitors in combination with chemotherapy for advanced/metastatic TNBC has shown efficacy, leading to FDA approval and expanding treatment options for patients. Questions remain regarding optimal chemotherapy backbone, patient selection, and treatment strategies, highlighting the importance of further research and guidance for healthcare providers.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Article Oncology

Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of hepatocellular carcinoma

Tim F. Greten et al.

Summary: The standard of care for advanced HCC has been transformed by the combination of immunotherapy and anti-VEGF therapy, showing improved overall survival rates. The use of immunotherapy in later stages of treatment has been proven safe and effective, with ongoing research focusing on novel combinations of ICI and TKI for earlier intervention in HCC treatment.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Review Oncology

Immune Checkpoint Inhibitors in Urothelial Bladder Cancer: State of the Art and Future Perspectives

Giandomenico Roviello et al.

Summary: Urothelial bladder cancer is a deadly disease with poor prognosis, but immunotherapy has shown promising results in clinical settings. FDA-approved ICIs have opened up new treatment options for bladder cancer, and further research is needed to explore the future potential of immunotherapy.

CANCERS (2021)

Review Genetics & Heredity

The epitranscriptome beyond m6A

David Wiener et al.

Summary: This Perspective reviews efforts to map six different RNA modifications and how they differ from N-6-methyladenosine. The authors discuss technical and analytical challenges of characterizing the epitranscriptome and provide their conclusions on the abundance and distribution of these modifications. The article highlights commonalities and differences among the modifications in comparison to m(6)A, speculating on their origins and functional abilities over evolutionary timescales.

NATURE REVIEWS GENETICS (2021)

Review Oncology

Reprogramming of fatty acid metabolism in cancer

Nikos Koundouros et al.

BRITISH JOURNAL OF CANCER (2020)

Article Oncology

Timing of adjuvant chemotherapy and overall survival following radical cystectomy

Joshua S. Jue et al.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2020)

Article Oncology

Treatment of muscle-invasive and advanced bladder cancer in 2020

Vaibhav G. Patel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

Review Immunology

Inflammation and Cancer: Triggers, Mechanisms, and Consequences

Florian R. Greten et al.

IMMUNITY (2019)

Article Biochemistry & Molecular Biology

Toll-like receptor mediated inflammation requires FASN-dependent MYD88 palmitoylation

Young-Chan Kim et al.

NATURE CHEMICAL BIOLOGY (2019)

Review Immunology

A review on the role of M2 macrophages in bladder cancer; pathophysiology and targeting

Laleh Sharifi et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2019)

Article Biochemistry & Molecular Biology

m6A modification suppresses ocular melanoma through modulating HINT2 mRNA translation

Ruobing Jia et al.

MOLECULAR CANCER (2019)

Article Genetics & Heredity

Tumor mutational load predicts survival after immunotherapy across multiple cancer types

Robert M. Samstein et al.

NATURE GENETICS (2019)

Article Biochemistry & Molecular Biology

Maftools: efficient and comprehensive analysis of somatic variants in cancer

Anand Mayakonda et al.

GENOME RESEARCH (2018)

Article Genetics & Heredity

Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden

Zachary R. Chalmers et al.

GENOME MEDICINE (2017)

Review Medicine, Research & Experimental

Hypoxia-inducible factors: a central link between inflammation and cancer

Daniel Triner et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Review Biotechnology & Applied Microbiology

A survey of best practices for RNA-seq data analysis

Ana Conesa et al.

GENOME BIOLOGY (2016)

Article Statistics & Probability

Regularization Paths for Cox's Proportional Hazards Model via Coordinate Descent

Noah Simon et al.

Journal of Statistical Software (2015)

Review Biochemistry & Molecular Biology

Mechanisms for copper acquisition, distribution and regulation

Byung-Eun Kim et al.

NATURE CHEMICAL BIOLOGY (2008)

Review Oncology

Hypoxia signalling through mTOR and the unfolded protein response in cancer

Bradly G. Wouters et al.

NATURE REVIEWS CANCER (2008)