Dysregulation of FBW7 in malignant lymphoproliferative disorders

The ubiquitin-proteasome system (UPS) is involved in various aspects of cell processes, including cell proliferation, differentiation, and cell cycle progression. F-box and WD repeat domain-containing protein 7 (FBW7), as a key component of UPS proteins and a critical tumor suppressor in human cancers, controls proteasome-mediated degradation by ubiquitinating oncoproteins such as c-Myc, Mcl-1, cyclin E, and Notch. It also plays a role in the development of various cancers, including solid and hematological malignancies, such as T-cell acute lymphoblastic leukemia, diffuse large B-cell lymphoma, and multiple myeloma. This comprehensive review emphasizes the functions, substrates, and expression of FBW7 in malignant lymphoproliferative disorders.

Automated summary

This review focuses on the functions, substrates, and expression of FBW7 in malignant lymphoproliferative disorders. FBW7, as a key component of UPS proteins and a critical tumor suppressor, plays an important role in controlling protein degradation and the development of various cancers.