4.7 Article

Anisotropic Contraction in a Magnetically Hard but Mechanically Ultra-Soft Foam for Precise Drug Delivery

期刊

ADVANCED MATERIALS TECHNOLOGIES
卷 8, 期 4, 页码 -

出版社

WILEY
DOI: 10.1002/admt.202201255

关键词

anisotropic contraction; drug deliveries; hard magnetic foams; low actuating magnetic fields; magnetodeformational effects; porous structures; shape morphing

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Hard magnetic soft materials (HMSMS) have attracted intensive attention in soft robots due to their untethered, rapid and reversible actuation, as well as large shape changes. However, previous studies have mainly focused on shape morphing, neglecting contraction deformation which could be useful in precise drug delivery. In this study, an anisotropic contraction in a porous structure called hard magnetic foam (HMF) is reported, which has the advantage of being mechanically ultra-soft but magnetically hard. By adjusting the magnetic fields directions, the relationship between magnetodeformational effect and magnetic body-force can be regulated to achieve maximum contraction or negligible deformation. HMF is also utilized for precision drug delivery with no leakage, adjustable drug release rate, and no residue after leaving.
Hard magnetic soft materials (HMSMS) have been recently intensively explored in soft robots, owing to its native advantages such as untethered, rapid and reversible actuation, as well as large shape changes. However, in the existing studies, HMSMS is majorly applied by a magnetic field to produce bending, folding, and even twisting, that is, shape morphing, to realize multimodal locomotion. Meanwhile, such as contraction deformation, which may be employed in precise drug delivery, has been neglected in a long term. Here, an anisotropic contraction in a porous structure, hard magnetic foam (HMF), which is mechanically ultra-soft (with a shear modulus of 4.5 kPa) but magnetically hard (with a residual magnetic flux density of 12 mT), is reported. The investigation of HMF structures indicates that anisotropic contraction is dominated by the magnetodeformational effect and the magnetic body-force against support constraint. By adjusting the magnetic fields directions, the relationship between these two factors can be regulated to achieve a maximum contraction of 43% (synergy) or negligible deformation (antagonism). Finally, HMF is utilized to realize precision drug delivery since it has the advantages of no leakage during moving, precisely adjustable drug release rate (from 0.008 to 0.62 mL min(-1)), and no residues after leaving.

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