期刊
CELLS
卷 11, 期 23, 页码 -出版社
MDPI
DOI: 10.3390/cells11233781
关键词
subarachnoid hemorrhage; TLR4; brain injury; cerebrospinal fluid; inflammatory response
类别
资金
- Postgraduate Education Reform and Quality Improvement Project of Henan Province
- Postgraduate Cultivating Innovation and Quality Improvement Action Plan of Henan University
- Henan Provincial Science and Technology Research Project
- [YJS2022KC30]
- [YJSJG2022XJ059]
- [222102310251]
Subarachnoid hemorrhage (SAH) is a common clinical neurological emergency with a relatively high incidence and often leads to severe adverse prognoses. Inflammatory response plays an important role in early nerve injury in SAH, with Toll-like receptor 4 (TLR4) playing a vital role in the inflammatory transduction pathway.
Subarachnoid hemorrhage (SAH) is one of the common clinical neurological emergencies. Its incidence accounts for about 5-9% of cerebral stroke patients. Even surviving patients often suffer from severe adverse prognoses such as hemiplegia, aphasia, cognitive dysfunction and even death. Inflammatory response plays an important role during early nerve injury in SAH. Toll-like receptors (TLRs), pattern recognition receptors, are important components of the body's innate immune system, and they are usually activated by damage-associated molecular pattern molecules. Studies have shown that with TLR 4 as an essential member of the TLRs family, the inflammatory transduction pathway mediated by it plays a vital role in brain injury after SAH. After SAH occurrence, large amounts of blood enter the subarachnoid space. This can produce massive damage-associated molecular pattern molecules that bind to TLR4, which activates inflammatory response and causes early brain injury, thus resulting in serious adverse prognoses. In this paper, the process in research on TLR4-mediated inflammatory response mechanism in brain injury after SAH was reviewed to provide a new thought for clinical treatment.
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