Reduced MHC Class I and II Expression in HPV-Negative vs. HPV-Positive Cervical Cancers

Review Oncology

Research on the influence of APOBEC family on the occurrence, diagnosis, and treatment of various tumors

Jing Yang et al.

Summary: This article reviews the mechanism of APOBECs and their impact on tumor occurrence, development, diagnosis, and treatment, providing a theoretical basis for future tumor treatment.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2023)

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Article Biochemistry & Molecular Biology

Amateur antigen-presenting cells in the tumor microenvironment

Laurel B. Darragh et al.

Summary: Presentation of tumor antigens is a crucial step in generating an effective antitumor immune response. Recent evidence suggests that besides professional antigen-presenting cells, other cells in the tumor microenvironment are also capable of presenting tumor antigens, potentially playing a significant role in priming an antitumor immune response. This new perspective on antigen presentation supports the development of novel immunotherapies to enhance T cell priming.

MOLECULAR CARCINOGENESIS (2022)

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Article Immunology

Dissecting the Single-Cell Transcriptome Network of Immune Environment Underlying Cervical Premalignant Lesion, Cervical Cancer and Metastatic Lymph Nodes

Chunbo Li et al.

Summary: This study used single-cell RNA sequencing to describe the composition and functional status of immune cells and mesenchymal cells during cervical cancer progression. The results showed distinct cell subpopulations at different stages of cervical cancer, with high-grade intraepithelial neoplasia exhibiting a low, recently activated tumor microenvironment, tumor tissue displaying an immunosuppressive state, and metastatic lymph node showing an early activated phase of immune response.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Microbiology

The HPV Induced Cancer Resource (THInCR): a Suite of Tools for Investigating HPV-Dependent Human Carcinogenesis

Mikhail Salnikov et al.

Summary: HPVs are highly infectious viruses that cause common sexually transmitted infections. They alter gene expression and cell growth to create a favorable environment for viral replication, which can also contribute to human carcinogenesis. The Cancer Genome Atlas (TCGA) has provided a comprehensive dataset for studying the role of HPV in cancer. The HPV Induced Cancer Resource (THInCR) is a suite of web-based tools that utilize TCGA data to investigate HPV-induced cancers and their impact on gene expression, gene methylation, patient survival, and immune features.

MSPHERE (2022)

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Review Medicine, General & Internal

False Negative Results in Cervical Cancer Screening-Risks, Reasons and Implications for Clinical Practice and Public Health

Anna Macios et al.

Summary: False negative results in cervical cancer screening pose serious risks to women, and they can be caused by various factors, including misinterpretation, clearance of HPV genetic material, and errors in histological interpretation, sampling, and laboratory procedures.

DIAGNOSTICS (2022)

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Article Medicine, General & Internal

HPV-Positive and -Negative Cervical Cancers Are Immunologically Distinct

Andris M. Evans et al.

Summary: HPV-negative cervical cancers have distinct disease phenotypes and immune characteristics compared to HPV-positive cervical cancers. They also exhibit a higher expression of potential neoantigens.

JOURNAL OF CLINICAL MEDICINE (2022)

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Article Medicine, General & Internal

CD74 and HLA-DRA in Cervical Carcinogenesis: Potential Targets for Antitumour Therapy

Carol K. Balakrishnan et al.

Summary: CD74 and HLA-DRA gene and protein expressions show an upregulation trend in the progression of cervical cancer. CD74 may promote cervical carcinogenesis via oncogenic signaling mechanisms, while the upregulation of HLA-DRA is associated with stronger immunogenicity, making it a promising biomarker for developing immunotherapies.

MEDICINA-LITHUANIA (2022)

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Review Oncology

Cytotoxic CD8+T cells in cancer and cancer immunotherapy

Hans Raskov et al.

Summary: The functions and interactions between the innate and adaptive immune systems play a crucial role in anticancer immunity. Cytotoxic T cells with CD8 as the most effective effectors in the anticancer immune response form the basis of successful cancer immunotherapies. Advancements in genetically modified or synthetic receptors on cytotoxic T cells are being developed for future cancer treatment. Combinatory regimens may optimize treatment effects and reduce adverse events in cancer therapy.

BRITISH JOURNAL OF CANCER (2021)

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Article Oncology

APOBEC: A molecular driver in cervical cancer pathogenesis

Sundaramoorthy Revathidevi et al.

Summary: Cervical cancer, a common cancer in women, is primarily caused by HPV infection. Apart from genetic and epigenetic factors, the APOBEC3 family plays a crucial role in the molecular pathogenesis of cancer, including inducing tumor mutations through DNA editing mechanisms.

CANCER LETTERS (2021)

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Review Biochemistry & Molecular Biology

The MHC Class II Transactivator CIITA: Not (Quite) the Odd-One-Out Anymore among NLR Proteins

Jorge Alfonso Leon Machado et al.

Summary: CIITA is the master regulator of MHC class II gene expression, functioning as a non-DNA-binding activator through interactions with the MHC enhanceosome complex. In addition to its role in MHC-II gene regulation, CIITA also plays important roles in cancer, viral restriction, and inhibition of virus replication.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Oncology

Human papillomavirus-independent cervical cancer

Andreina Fernandes et al.

Summary: This review provides an overview of HPV-independent cervical cancer, evaluating diagnostic techniques, molecular profiles, and clinical outcomes. HPV-independent tumors have distinct molecular characteristics, higher proliferative activity, and generally worse oncological outcomes.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Review Oncology

Human Papillomavirus-Negative Cervical Cancer: A Comprehensive Review

Biyuan Xing et al.

Summary: HPV-negative cervical cancers, predominantly adenocarcinomas, pose challenges in diagnosis and management due to unclear etiology and possible false negative results. It is important to pay greater attention to these cases as they are often diagnosed at advanced stages with poor prognoses.

FRONTIERS IN ONCOLOGY (2021)

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Article Biotechnology & Applied Microbiology

Integrated analysis of virus and host transcriptomes in cervical cancer in Asian and Western populations

Qiongzi Qiu et al.

Summary: Race may play a role in influencing vulnerability to HPV variants and cervical cancer prevalence. Integrated analysis of virus and host transcriptomes reveals differences in tumor subtypes and immune infiltration between populations, shedding light on racial disparities in HPV-associated cervical cancers.

GENOMICS (2021)

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Review Oncology

Molecular Pathology of Human Papilloma Virus-Negative Cervical Cancers

Hiroshi Yoshida et al.

Summary: Although cervical cancer is primarily caused by HPV infection, some cases test negative for HPV. True HPV-negative cancers are more common in certain adenocarcinoma subtypes, and have different pathological progression and pathogenesis compared to HPV-associated cervical cancers.

CANCERS (2021)

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Article Medicine, General & Internal

Pembrolizumab for Persistent, Recurrent, or Metastatic Cervical Cancer

N. Colombo et al.

Summary: Adding pembrolizumab to chemotherapy significantly improves progression-free and overall survival in patients with persistent, recurrent, or metastatic cervical cancer when compared to placebo. Anemia and neutropenia are the most common grade 3 to 5 adverse events.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Review Virology

The Not-So-Good, the Bad and the Ugly: HPV E5, E6 and E7 Oncoproteins in the Orchestration of Carcinogenesis

Om Basukala et al.

Summary: Infection with HPV begins with viral particles accessing basal cells in the epidermis through potential skin microtraumas. While HPV infections are typically cleared within 2 to 3 weeks by the host's immune response, persistent infections and compromised immune systems can lead to malignancy. Despite the strong association of HPV infection with cancer, therapeutic interventions against HPV-induced cancers remain a challenge, emphasizing the necessity for focused translational research.

VIRUSES-BASEL (2021)

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Article Oncology

Genomic Characterization and Therapeutic Targeting of HPV Undetected Cervical Carcinomas

Fiona J. Ruiz et al.

Summary: Persistent HPV infection is a known driver of cervical carcinogenesis, but the significance of HPV undetected (HPVU) cervical cancer has been debated. This study demonstrates that HPVU status can serve as a predictive biomarker of poor patient response to standard treatments and suggests personalized treatment plans for such patients. Palbociclib emerges as a promising alternative treatment for HPVU cervical cancer patients.

CANCERS (2021)

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Article Medicine, Research & Experimental

HPV transcript expression affects cervical cancer response to chemoradiation

Fiona J. Ruiz et al.

Summary: Persistent HPV infection is the main cause of cervical cancer, and patients with cervical tumors containing HPV genotypes other than HPV 16 have worse survival outcomes after CRT. High levels of E6*I and E6 expression may represent novel biomarkers of CRT efficacy.

JCI INSIGHT (2021)

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Article Obstetrics & Gynecology

HPV-negative Tumors in a Swedish Cohort of Cervical Cancer

Malin Kaliff et al.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY (2020)

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Article Oncology

Phase II evaluation of nivolumab in the treatment of persistent or recurrent cervical cancer (NCT02257528/NRG-GY002)

Alessandro D. Santin et al.

GYNECOLOGIC ONCOLOGY (2020)

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Article Cell Biology

High Levels of Class I Major Histocompatibility Complex mRNA Are Present in Epstein-Barr Virus-Associated Gastric Adenocarcinomas

Farhad Ghasemi et al.

CELLS (2020)

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Article Oncology

Molecular and pathological basis ofHPV-negative cervical adenocarcinoma seen in a global study

David Jenkins et al.

INTERNATIONAL JOURNAL OF CANCER (2020)

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Review Biology

T cell costimulation, checkpoint inhibitors and anti-tumor therapy

Dipankar Nandi et al.

JOURNAL OF BIOSCIENCES (2020)

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Article Pathology

Loss of MHC Class I Expression in HPV-associated Cervical and Vulvar Neoplasia A Potential Mechanism of Resistance to Checkpoint Inhibition

Megan E. Dibbern et al.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2020)

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Article Biotechnology & Applied Microbiology

Preferential expression of a HPV genotype in invasive cervical carcinomas infected by multiple genotypes

A. C. Brant et al.

GENOMICS (2020)

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Article Biochemistry & Molecular Biology

HPV E2, E4, E5 drive alternative carcinogenic pathways in HPV positive cancers

Shuling Ren et al.

ONCOGENE (2020)

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Article Multidisciplinary Sciences

High MHC-II expression inEpstein-Barr virus-associated gastric cancers suggests that tumor cells serve an important role in antigen presentation

Farhad Ghasemi et al.

SCIENTIFIC REPORTS (2020)

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Article Biochemistry & Molecular Biology

The regulatory network behind MHC class I expression

Marlieke L. M. Jongsma et al.

MOLECULAR IMMUNOLOGY (2019)

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Review Genetics & Heredity

What to do with HLA-DO/H-2O two decades later?

Robin Welsh et al.

IMMUNOGENETICS (2019)

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Article Oncology

Efficacy and Safety of Pembrolizumab in Previously Treated Advanced Cervical Cancer: Results From the Phase II KEYNOTE-158 Study

Hyun Cheol Chung et al.

JOURNAL OF CLINICAL ONCOLOGY (2019)

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Article Oncology

Safety and Efficacy of Nivolumab Monotherapy in Recurrent or Metastatic Cervical, Vaginal, or Vulvar Carcinoma: Results From the Phase I/II CheckMate 358 Trial

R. Wendel Naumann et al.

JOURNAL OF CLINICAL ONCOLOGY (2019)

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Article Immunology

Frequent Loss of IRF2 in Cancers Leads to Immune Evasion through Decreased MHC Class I Antigen Presentation and Increased PD-L1 Expression

Barry A. Kriegsman et al.

JOURNAL OF IMMUNOLOGY (2019)

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Article Oncology

APOBEC mutagenesis is tightly linked to the immune landscape and immunotherapy biomarkers in head and neck squamous cell carcinoma

Daniel L. Faden et al.

ORAL ONCOLOGY (2019)

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Article Oncology

High Level Expression of MHC-II in HPV plus Head and Neck Cancers Suggests that Tumor Epithelial Cells Serve an Important Role as Accessory Antigen Presenting Cells

Steven F. Gameiro et al.

CANCERS (2019)

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Article Oncology

LBA62Efficacy and safety of nivolumab (Nivo) + ipilimumab (Ipi) in patients (pts) with recurrent/metastatic (R/M) cervical cancer: Results from CheckMate 358

R W Naumann et al.

ANNALS OF ONCOLOGY (2019)

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Review Oncology

Biological Consequences of MHC-II Expression by Tumor Cells in Cancer

Margaret L. Axelrod et al.

CLINICAL CANCER RESEARCH (2019)

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Article Immunology

Protective association of HLA-DRB113:02, HLA-DRB104:06, and HLA-DQB1*06:04 alleles with cervical cancer in a Korean population

Hyoeun Shim et al.

HUMAN IMMUNOLOGY (2019)

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Review Cell Biology

CD8+ cytotoxic T lymphocytes in cancer immunotherapy: A review

Bagher Farhood et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Review Biotechnology & Applied Microbiology

Approaches to treat immune hot, altered and cold tumours with combination immunotherapies

Jerome Galon et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

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Review Oncology

The evolving landscape of biomarkers for checkpoint inhibitor immunotherapy

Jonathan J. Havel et al.

NATURE REVIEWS CANCER (2019)

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Article Multidisciplinary Sciences

Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy

Diego Chowell et al.

SCIENCE (2018)

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Article Oncology

A Randomized Phase 2 Study of ADXS11-001 Listeria monocytogenes-Listeriolysin O Immunotherapy With or Without Cisplatin in Treatment of Advanced Cervical Cancer

Partha Basu et al.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2018)

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Article Oncology

Major Histocompatibility Complex Class II and Programmed Death Ligand 1 Expression Predict Outcome After Programmed Death 1 Blockade in Classic Hodgkin Lymphoma

Margaretha G. M. Roemer et al.

JOURNAL OF CLINICAL ONCOLOGY (2018)

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Article Cell Biology

MHC proteins confer differential sensitivity to CTLA-4 and PD-1 blockade in untreated metastatic melanoma

Scott J. Rodig et al.

SCIENCE TRANSLATIONAL MEDICINE (2018)

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Review Biochemistry & Molecular Biology

The HPV E6/E7 Oncogenes: Key Factors for Viral Carcinogenesis and Therapeutic Targets

Karin Hoppe-Seyler et al.

TRENDS IN MICROBIOLOGY (2018)

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Article Oncology

Association of Ipilimumab With Safety and Antitumor Activity in Women With Metastatic or Recurrent Human Papillomavirus-Related Cervical Carcinoma

Stephanie Lheureux et al.

JAMA ONCOLOGY (2018)

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Review Immunology

Epithelial MHC Class II Expression and Its Role in Antigen Presentation in the Gastrointestinal and Respiratory Tracts

Jonathan E. Wosen et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Oncology

Treatment-naive HPV plus head and neck cancers display a T-cell-inflamed phenotype distinct from their HPV- counterparts that has implications for immunotherapy

Steven F. Gameiro et al.

ONCOIMMUNOLOGY (2018)

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Letter Oncology

Human papillomavirus E5 protein, the undercover culprit of tumorigenesis

Nima Hemmat et al.

INFECTIOUS AGENTS AND CANCER (2018)

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Article Virology

Human papillomavirus genotype and prognosis of cervical cancer: Favorable survival of patients with HPV16-positive tumors

Mamiko Onuki et al.

PAPILLOMAVIRUS RESEARCH (2018)

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Review Immunology

CD4+ T cell help in cancer immunology and immunotherapy

Jannie Borst et al.

NATURE REVIEWS IMMUNOLOGY (2018)

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Meeting Abstract Oncology

A prospective phase II trial of the listeria-based human papillomavirus immunotherpay axalimogene filolisbac in second- and third-line metastatic cervical cancer: A NRG oncology group trial

W. Huh et al.

GYNECOLOGIC ONCOLOGY (2017)

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Article Oncology

Impact of genetic variations and transcriptional alterations of HLA class I genes on cervical cancer pathogenesis

Damayanti Das Ghosh et al.

INTERNATIONAL JOURNAL OF CANCER (2017)

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Article Oncology

Safety and Efficacy of Pembrolizumab in Advanced, Programmed Death Ligand 1-Positive Cervical Cancer: Results From the Phase Ib KEYNOTE-028 Trial

Jean-Sebastien Frenel et al.

JOURNAL OF CLINICAL ONCOLOGY (2017)

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Article Multidisciplinary Sciences

Structure of the human MHC-I peptide-loading complex

Andreas Blees et al.

NATURE (2017)

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Article Multidisciplinary Sciences

Integrated genomic and molecular characterization of cervical cancer

Robert D. Burk et al.

NATURE (2017)

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Article Virology

Analysis of Class I Major Histocompatibility Complex Gene Transcription in Human Tumors Caused by Human Papillomavirus Infection

Steven F. Gameiro et al.

VIRUSES-BASEL (2017)

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Article Multidisciplinary Sciences

Resistance to checkpoint blockade therapy through inactivation of antigen presentation

Moshe Sade-Feldman et al.

NATURE COMMUNICATIONS (2017)

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Article Oncology

Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer

Scott Gettinger et al.

CANCER DISCOVERY (2017)

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Article Oncology

Human papillomavirus dysregulates the cellular apparatus controlling the methylation status of H3K27 in different human cancers to consistently alter gene expression regardless of tissue of origin

Steven F. Gameiro et al.

ONCOTARGET (2017)

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Article Oncology

Identification and characterization of HPV- independent cervical cancers

Carolyn E. Banister et al.

ONCOTARGET (2017)

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Article Oncology

Association of HLA-DRB1, HLA-DQB1 Polymorphisms with HPV 16 E6 Variants among Young Cervical Cancer Patients in China

Yan Hu et al.

JOURNAL OF CANCER (2017)

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Review Biochemistry & Molecular Biology

NF-kappa B signaling in inflammation

Ting Liu et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2017)

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Article Infectious Diseases

Independent prognostic role of human papillomavirus genotype in cervical cancer

Dong Hang et al.

BMC INFECTIOUS DISEASES (2017)

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Review Immunology

Present Yourself! By MHC Class I and MHC Class II Molecules

Kenneth L. Rock et al.

TRENDS IN IMMUNOLOGY (2016)

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Article Multidisciplinary Sciences

Melanoma-specific MHC-II expression represents a tumour-autonomous phenotype and predicts response to anti-PD-1/PD-L1 therapy

Douglas B. Johnson et al.

NATURE COMMUNICATIONS (2016)

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Article Oncology

Expression of the MHC Class II Pathway in Triple-Negative Breast Cancer Tumor Cells Is Associated with a Good Prognosis and Infiltrating Lymphocytes

Andres Forero et al.

CANCER IMMUNOLOGY RESEARCH (2016)

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Article Genetics & Heredity

Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism

Zheng Hu et al.

NATURE GENETICS (2015)

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Review Virology

Human papillomavirus molecular biology and disease association

John Doorbar et al.

REVIEWS IN MEDICAL VIROLOGY (2015)

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Review Oncology

Link between chronic inflammation and human papillomavirus-induced carcinogenesis

Jose Verissimo Fernandes et al.

ONCOLOGY LETTERS (2015)

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Article Obstetrics & Gynecology

HPV-negative carcinoma of the uterine cervix: a distinct type of cervical cancer with poor prognosis

L. Rodriguez-Carunchio et al.

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2015)

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Review Immunology

The ins and outs of MHC class II-mediated antigen processing and presentation

Paul A. Roche et al.

NATURE REVIEWS IMMUNOLOGY (2015)

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Article Education, Scientific Disciplines

T cell responses: naive to memory and everything in between

Nathan D. Pennock et al.

ADVANCES IN PHYSIOLOGY EDUCATION (2013)

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Article Genetics & Heredity

Histone deacetylase inhibitor AR-42 enhances E7-specific CD8+ T cell-mediated antitumor immunity induced by therapeutic HPV DNA vaccination

Sung Yong Lee et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2013)

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Article Oncology

Genome-wide Association Study of Susceptibility Loci for Cervical Cancer

Dan Chen et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2013)

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Article Virology

The papillomavirus E7 proteins

Ann Roman et al.

VIROLOGY (2013)

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Article Virology

Papillomavirus E6 oncoproteins

Scott B. Vande Pol et al.

VIROLOGY (2013)

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Review Immunology

Molecular mechanisms of T cell co-stimulation and co-inhibition

Lieping Chen et al.

NATURE REVIEWS IMMUNOLOGY (2013)

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Review Immunology

CD4(+)T Cells: Differentiation and Functions

Rishi Vishal Luckheeram et al.

CLINICAL & DEVELOPMENTAL IMMUNOLOGY (2012)

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Article Oncology

Human papillomavirus types in 115,789 HPV-positive women: A meta-analysis from cervical infection to cancer

Peng Guan et al.

INTERNATIONAL JOURNAL OF CANCER (2012)

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Review Immunology

Intrinsic antiviral immunity

Nan Yan et al.

NATURE IMMUNOLOGY (2012)

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Review Immunology

CD8+ T Cells: Foot Soldiers of the Immune System

Nu Zhang et al.

IMMUNITY (2011)

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Article Oncology

Expression of Macrophage Migration Inhibitory Factor and CD74 in Cervical Squamous Cell Carcinoma

Rong-jie Cheng et al.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2011)

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Article Biochemistry & Molecular Biology

Identification of Key Amino Acid Residues That Determine the Ability of High Risk HPV16-E7 to Dysregulate Major Histocompatibility Complex Class I Expression

Corina Heller et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

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Article Virology

High-Risk Human Papillomaviruses Repress Constitutive Kappa Interferon Transcription via E6 To Prevent Pathogen Recognition Receptor and Antiviral-Gene Expression

Jeanette Reiser et al.

JOURNAL OF VIROLOGY (2011)

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Article Oncology

Down-Regulation of HLA Class I Antigen in Human Papillomavirus Type 16 E7 Expressing HaCaT Cells Correlate With TAP-1 Expression

Wei Li et al.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2010)

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Article Oncology

Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study

Silvia de Sanjose et al.

LANCET ONCOLOGY (2010)

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Article Immunology

Association between human leukocyte antigen class II alleles and human papillomavirus-mediated cervical cancer in Indian women

Indu Kohaar et al.

HUMAN IMMUNOLOGY (2009)

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Review Immunology

MHC class I antigen presentation: learning from viral evasion strategies

Ted H. Hansen et al.

NATURE REVIEWS IMMUNOLOGY (2009)

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Article Oncology

Association of antigen processing machinery and HLA class I defects with clinicopathological outcome in cervical carcinoma

Akash M. Mehta et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2008)

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Article Biochemistry & Molecular Biology

Genital transmission of HPV in a mouse model is potentiated by nonoxynol-9 and inhibited by carrageenan

Jeffrey N. Roberts et al.

NATURE MEDICINE (2007)

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Article Immunology

Human leukocyte antigen class II alleles and risk of cervical cancer in China

Yuping Wu et al.

HUMAN IMMUNOLOGY (2007)

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Article Immunology

Tumor cell expression of HLA-DM associates with a Th1 profile and predicts improved survival in breast carcinoma patients

Sharon A. Oldford et al.

INTERNATIONAL IMMUNOLOGY (2006)

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Article Oncology

E5 protein of human papillomavirus 16 downregulates HLA class I and interacts with the heavy chain via its first hydrophobic domain

G. Hossein Ashrafi et al.

INTERNATIONAL JOURNAL OF CANCER (2006)

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Article Oncology

Differential MHC class II component expression in HPV-positive cervical cancer cells:: Implication for immune surveillance

I Zehbe et al.

INTERNATIONAL JOURNAL OF CANCER (2005)

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Review Immunology

Regulation of MHC class II gene expression by the class II transactivator

W Reith et al.

NATURE REVIEWS IMMUNOLOGY (2005)

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Review Immunology

Transcriptional regulation of the MHC class II antigen presentation pathway

JM Boss et al.

CURRENT OPINION IN IMMUNOLOGY (2003)

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Article Immunology

Human leukocyte antigen class II and cervical cancer risk: A population-based study

MM Madeleine et al.

JOURNAL OF INFECTIOUS DISEASES (2002)

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Article Biochemistry & Molecular Biology

Alterations of HLA class I and II antigen expression in preinvasive, invasive and metastatic cervical cancers

KS Ryu et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2001)

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Article Oncology

HLA class II alleles associated with infection by HPV16 in cervical cancer in situ

AH Beskow et al.

INTERNATIONAL JOURNAL OF CANCER (2001)

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Article Oncology

Human papillomavirus and prognosis of invasive cervical cancer: A population-based study

SM Schwartz et al.

JOURNAL OF CLINICAL ONCOLOGY (2001)

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Article Biochemistry & Molecular Biology

Transcriptional regulation of the major histocompatibility complex (MHC) class I heavy chain, TAP1 and LMP2 genes by the human papillomavirus (HPV) type 6b, 16 and 18 E7 oncoproteins

NT Georgopoulos et al.

ONCOGENE (2000)

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Article Biochemistry & Molecular Biology

Inactivation of interferon regulatory factor-1 tumor suppressor protein by HPV E7 oncoprotein - Implication for the E7-mediated immune evasion mechanism in cervical carcinogenesis

JS Park et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

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Reduced MHC Class I and II Expression in HPV-Negative vs. HPV-Positive Cervical Cancers

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