4.6 Editorial Material

microRNA Bioinformatics

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A Transcription Regulatory Sequence in the 5′ Untranslated Region of SARS-CoV-2 Is Vital for Virus Replication with an Altered Evolutionary Pattern against Human Inhibitory MicroRNAs

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Summary: This study reveals a distinct pattern of evolution in the leader sequence of SARS-CoV-2 and identifies several microRNAs with stable binding energy against coronaviruses, including hsa-MIR-5004-3p which targets both SARS and SARS-CoV-2 with reduced stability in the latter. Lack of innate human inhibitory microRNAs binding to the leader sequence of SARS-CoV-2 may contribute to its high replication in infected human cells.
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