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Apelin-36 mediates neuroprotective effects by regulating oxidative stress, autophagy and apoptosis in MPTP-induced Parkinson's disease model mice
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Elabela/Toddler and apelin bind differently to the apelin receptor
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FASEB JOURNAL (2020)
Apelin protects auditory cells from cisplatin-induced toxicity in vitro by inhibiting ROS and apoptosis
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Apelin-13 Inhibits Methylglyoxal-Induced Unfolded Protein Responses and Endothelial Dysfunction via Regulating AMPK Pathway
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Obesity and triple-negative-breast-cancer: Is apelin a new key target?
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JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)
ELABELA ameliorates hypoxic/ischemic-induced bone mesenchymal stem cell apoptosis via alleviation of mitochondrial dysfunction and activation of PI3K/AKT and ERK1/2 pathways
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STEM CELL RESEARCH & THERAPY (2020)
Apelin-13 Protects Dopaminergic Neurons against Rotenone-Induced Neurotoxicity through the AMPK/mTOR/ULK-1 Mediated Autophagy Activation
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
microRNA-182 Negatively Influences the Neuroprotective Effect of Apelin Against Neuronal Injury in Epilepsy
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NEUROPSYCHIATRIC DISEASE AND TREATMENT (2020)
Multifunctional APJ Pathway Promotes Ovarian Cancer Progression and Metastasis
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MOLECULAR CANCER RESEARCH (2019)
Protective role of Apelin-13 on amyloid β25-35-induced memory deficit; Involvement of autophagy and apoptosis process
Samaneh Aminyavari et al.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2019)
Apelin-13 attenuates early brain injury following subarachnoid hemorrhage via suppressing neuronal apoptosis through the GLP-1R/PI3K/Akt signaling
Yao Liu et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)
Elabela protects against podocyte injury in mice with streptozocin-induced diabetes by associating with the PI3K/Akt/mTOR pathway
Yixian Zhang et al.
PEPTIDES (2019)
Effects of Apelin on Left Ventricular-Arterial Coupling and Mechanical Efficiency in Rats with Ischemic Heart Failure
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DISEASE MARKERS (2019)
Apelin affects the mouse aging urinary peptidome with minimal effects on kidney
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SCIENTIFIC REPORTS (2019)
Apelin-13 Protects PC12 Cells Against Methamphetamine-Induced Oxidative Stress, Autophagy and Apoptosis
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NEUROCHEMICAL RESEARCH (2019)
Apelin-13/APJ system attenuates early brain injury via suppression of endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation and oxidative stress in a AMPK-dependent manner after subarachnoid hemorrhage in rats
Weilin Xu et al.
JOURNAL OF NEUROINFLAMMATION (2019)
Apelin-13 attenuates ER stress-mediated neuronal apoptosis by activating Gαi/Gαq-CK2 signaling in ischemic stroke
Fei Wu et al.
EXPERIMENTAL NEUROLOGY (2018)
Elabela, a newly discovered APJ ligand: Similarities and differences with Apelin
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PEPTIDES (2018)
ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice
Lena Ho et al.
SCIENCE (2017)
Expression of apelin and apelin receptor (APJ) in porcine ovarian follicles and in vitro effect of apelin on steroidogenesis and proliferation through APJ activation and different signaling pathways
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THERIOGENOLOGY (2017)
ELABELA-APJ axis protects from pressure overload heart failure and angiotensin II-induced cardiac damage
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CARDIOVASCULAR RESEARCH (2017)
Apela exhibits isoform- and headgroup-dependent modulation of micelle binding, peptide conformation and dynamics
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BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2017)
Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension
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CIRCULATION (2017)
Apelin (APLN) and Apelin Receptor (APLNR) in Human Ovary: Expression, Signaling, and Regulation of Steroidogenesis in Primary Human Luteinized Granulosa Cells
Jennifer Roche et al.
BIOLOGY OF REPRODUCTION (2016)
Apelin-13 administration protects against ischaemia/reperfusion-mediated apoptosis through the FoxO1 pathway in high-fat diet-induced obesity
Frederic Boal et al.
BRITISH JOURNAL OF PHARMACOLOGY (2016)
Discovery and Structure-Activity Relationship of a Bioactive Fragment of ELABELA that Modulates Vascular and Cardiac Functions
Alexandre Murza et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Apelin-13 Protects PC12 Cells from Corticosterone-Induced Apoptosis Through PI3K and ERKs Activation
Yunjun Zou et al.
NEUROCHEMICAL RESEARCH (2016)
The neuroprotective effect of apelin-13 in a mouse model of intracerebral hemorrhage
Haijun Bao et al.
NEUROSCIENCE LETTERS (2016)
Apelin-13 protects against apoptosis by activating AMP-activated protein kinase pathway in ischemia stroke
Yi Yang et al.
PEPTIDES (2016)
Quantitative imaging reveals real-time Pou5f3-Nanog complexes driving dorsoventral mesendoderm patterning in zebrafish
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ELIFE (2016)
Effects of apelin on proliferation and apoptosis in rat ovarian granulosa cells
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CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY (2016)
Downregulation of apelin in the human placental chorionic villi from preeclamptic pregnancies
Liliya M. Yamaleyeva et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2015)
An Apela RNA-Containing Negative Feedback Loop Regulates p53-Mediated Apoptosis in Embryonic Stem Cells
Mangmang Li et al.
CELL STEM CELL (2015)
ELABELA Is an Endogenous Growth Factor that Sustains hESC Self-Renewal via the PI3K/AKT Pathway
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CELL STEM CELL (2015)
Apela Regulates Fluid Homeostasis by Binding to the APJ Receptor to Activate Gi Signaling
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JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Central action of ELABELA reduces food intake and activates arginine vasopressin and corticotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus
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Apelin Protects Primary Rat Retinal Pericytes from Chemical Hypoxia-Induced Apoptosis
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JOURNAL OF OPHTHALMOLOGY (2015)
Elabela-Apelin Receptor Signaling Pathway is Functional in Mammalian Systems
Zhi Wang et al.
SCIENTIFIC REPORTS (2015)
The effects of water immersion and restraint stress on the expressions of apelin, apelin receptor (APJR) and apoptosis rate in the rat heart
Ismail Ustunel et al.
ACTA HISTOCHEMICA (2014)
Effect of apelin on mitosis, apoptosis and DNA repair enzyme OGG 1/2 expression in intestinal cell lines IEC-6 and Caco-2
Hanna Antushevich et al.
FOLIA HISTOCHEMICA ET CYTOBIOLOGICA (2014)
Apelin Attenuates Oxidative Stress in Human Adipocytes
Aung Than et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Apelin-13 protects the brain against ischemia/reperfusion injury through activating PI3K/Akt and ERK1/2 signaling pathways
Yi Yang et al.
NEUROSCIENCE LETTERS (2014)
Toddler: An Embryonic Signal That Promotes Cell Movement via Apelin Receptors
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SCIENCE (2014)
Apelin promotes lymphangiogenesis and lymph node metastasis
Judit Berta et al.
ONCOTARGET (2014)
ELABELA: A Hormone Essential for Heart Development Signals via the Apelin Receptor
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DEVELOPMENTAL CELL (2013)
Apelin-13 regulates proliferation, migration and survival of retinal Muller cells under hypoxia
Qiang Lu et al.
DIABETES RESEARCH AND CLINICAL PRACTICE (2013)
The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis
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JOURNAL OF ENDOCRINOLOGY (2013)
Apelin-36, a potent peptide, protects against ischemic brain injury by activating the PI3K/Akt pathway
Qin Gu et al.
NEUROCHEMISTRY INTERNATIONAL (2013)
Effects of Weight Loss and Exercise on Apelin Serum Concentrations and Adipose Tissue Expression in Human Obesity
Joanna Krist et al.
OBESITY FACTS (2013)
International Union of Basic and Clinical Pharmacology. LXXXVIII. G Protein-Coupled Receptor List: Recommendations for New Pairings with Cognate Ligands
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Apelin-13 increases myocardial progenitor cells and improves repair postmyocardial infarction
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AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2012)
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JOURNAL OF BIOCHEMISTRY (2012)
Apelin-13 Protects the Brain Against Ischemic Reperfusion Injury and Cerebral Edema in a Transient Model of Focal Cerebral Ischemia
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JOURNAL OF MOLECULAR NEUROSCIENCE (2012)
Protective effect of apelin on cultured rat bone marrow mesenchymal stem cells against apoptosis
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STEM CELL RESEARCH (2012)
Apelin-13 protects the heart against ischemia-reperfusion injury through inhibition of ER-dependent apoptotic pathways in a time-dependent fashion
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AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2011)
Apelin Decreases Lipolysis via G(q), G(i), and AMPK-Dependent Mechanisms
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Apelin and insulin resistance: Another arrow for the quiver?
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JOURNAL OF DIABETES (2011)
Apelin suppresses apoptosis of human vascular smooth muscle cells via APJ/PI3-K/Akt signaling pathways
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AMINO ACIDS (2010)
The fate of the internalized apelin receptor is determined by different isoforms of apelin mediating differential interaction with β-arrestin
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)
Neuroprotective effect of the endogenous neural peptide apelin in cultured mouse cortical neurons
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EXPERIMENTAL CELL RESEARCH (2010)
Apelin and APJ receptor expression in granulosa and theca cells during different stages of follicular development in the bovine ovary: Involvement of apoptosis and hormonal regulation
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ANIMAL REPRODUCTION SCIENCE (2009)
[Pyr1]Apelin-13 Identified as the Predominant Apelin Isoform in the Human Heart Vasoactive Mechanisms and Inotropic Action in Disease
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HYPERTENSION (2009)
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MOLECULAR AND CELLULAR ENDOCRINOLOGY (2009)
Apelin protects heart against ischemia/reperfusion injury in rat
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PEPTIDES (2009)
Reciprocal regulation of plasma apelin and vasopressin by osmotic stimuli
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JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2008)
Paracrine and autocrine mechanisms of apelin signaling govern embryonic and tumor angiogenesis
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DEVELOPMENTAL BIOLOGY (2007)
Apelin stimulates proliferation and suppresses apoptosis of mouse osteoblastic cell line MCM-E1 via JNK and PI3-K/Akt signaling pathways
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PEPTIDES (2007)
Apelin suppresses apoptosis of human osteoblasts
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APOPTOSIS (2007)
Apelin, the ligand for the endothelial G-protein-coupled receptor, APJ, is a potent angiogenic factor required for normal vascular development of the frog embryo
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DEVELOPMENTAL BIOLOGY (2006)
The apj receptor is expressed in pancreatic islets and its ligand, apelin, inhibits insulin secretion in mice
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REGULATORY PEPTIDES (2005)
Apelin, orexin-A and leptin plasma levels in morbid obesity and effect of gastric banding
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REGULATORY PEPTIDES (2005)
Apelin, a newly identified adipokine up-regulated by insulin and obesity
J Boucher et al.
ENDOCRINOLOGY (2005)
Apelin (65-77) activates p70 S6 kinase and is mitogenic for umbilical endothelial cells
B Masri et al.
FASEB JOURNAL (2004)
Apelin, a potent diuretic neuropeptide counteracting vasopressin actions through inhibition of vasopressin neuron activity and vasopressin release
N De Mota et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Cell-cell fusion and internalization of the CNS-based, HIV-1 co-receptor, APJ
NM Zhou et al.
VIROLOGY (2003)
Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility
I Szokodi et al.
CIRCULATION RESEARCH (2002)
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S Taheri et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)
Apelin (65-77) activates extracellular signal-regulated kinases via a PTX-sensitive G protein
B Masri et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)
Physiological role of a novel neuropeptide, apelin, and its receptor in the rat brain
A Reaux et al.
JOURNAL OF NEUROCHEMISTRY (2001)
Molecular properties of apelin: tissue distribution and receptor binding
Y Kawamata et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2001)
Apelin peptides block the entry of human immunodeficiency virus (HIV)
MX Zou et al.
FEBS LETTERS (2000)
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