MicroRNAs in Cancer and Cardiovascular Disease

Although cardiac tumor formation is rare, accumulating evidence suggests that the two leading causes of deaths, cancers, and cardiovascular diseases are similar in terms of pathogenesis, including angiogenesis, immune responses, and fibrosis. These similarities have led to the creation of new exciting field of study called cardio-oncology. Here, we review the similarities between cancer and cardiovascular disease from the perspective of microRNAs (miRNAs). As miRNAs are well-known regulators of translation by binding to the 3 '-untranslated regions (UTRs) of messenger RNAs (mRNAs), we carefully dissect how a specific set of miRNAs are both oncomiRs (miRNAs in cancer) and myomiRs (muscle-related miRNAs). Furthermore, from the standpoint of similar pathogenesis, miRNAs categories related to the similar pathogenesis are discussed; namely, angiomiRs, Immune-miRs, and fibromiRs.

Automated summary

Although rare, cardiac tumor formation shares similarities in terms of pathogenesis with cancers and cardiovascular diseases, including angiogenesis, immune responses, and fibrosis. This has led to the emergence of the field of cardio-oncology. This review explores the similarities between cancer and cardiovascular disease from the perspective of microRNAs (miRNAs). In particular, it examines a specific set of miRNAs that act as both oncomiRs (miRNAs in cancer) and myomiRs (muscle-related miRNAs), as well as different categories of miRNAs related to similar pathogenesis.