Neurotrophic Factors in Health and Disease

Editorial Material Cell Biology

Putting Cells in Motion: Advantages of Endogenous Boosting of BDNF Production

Elvira Brattico et al.

Summary: Physical exercise, such as sports or musical activities, can modulate brain functions and have positive effects on mood regulation, well-being, memory, and cognitive preservation. Exercise can increase BDNF levels, promoting the growth of neurons and synapses, benefiting memory, learning, and higher cognitive functions.

CELLS (2021)

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Article Cell Biology

Nerve Growth Factor Neutralization Promotes Oligodendrogenesis by Increasing miR-219a-5p Levels

Rossella Brandi et al.

Summary: NGF regulates oligodendrogenesis and myelination by modulating miR-219a-5p levels, with NGF deprivation leading to increased expression of miR-219a-5p and enhanced oligodendrocyte differentiation.

CELLS (2021)

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Article Cell Biology

Social Defeat Stress during Early Adolescence Confers Resilience against a Single Episode of Prolonged Stress in Adult Rats

Giulia Federica Mancini et al.

Summary: The study found that early exposure to social stress influences rats' ability to cope with subsequent challenges in life, and rats experiencing early adversity may exhibit resilience or vulnerability to different types of stressors, impacting emotional and cognitive capabilities differently.

CELLS (2021)

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Article Cell Biology

Transcriptional Profiles of Cell Fate Transitions Reveal Early Drivers of Neuronal Apoptosis and Survival

Giovanna Morello et al.

Summary: Neuronal apoptosis and survival are regulated at the transcriptional level. By studying the key genes and regulatory factors involved in these processes, a core set of 175 genes showing opposite expression trends at the intersection of apoptosis and survival was identified. Transcription regulatory network analysis revealed the action of nine upstream transcription factors, with five of them potentially serving as drug targets.

CELLS (2021)

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Article Cell Biology