☆ 4.6 Review

MALDI Mass Spectrometry Imaging: A Potential Game-Changer in a Modern Microbiology

CELLS (2022)

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Article Parasitology

Spatial visualization of drug uptake and distribution in Fasciola hepatica using high-resolution AP-SMALDI mass spectrometry imaging

Carolin M. Morawietz et al.

Summary: Understanding drug penetration, distribution, and metabolization in parasites is essential for drug efficacy. Recently, matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) has been used to visualize the distribution patterns of drug compounds in blood flukes and liver flukes. This technique provides high spatial resolution and has the potential to contribute to preclinical drug discovery in liver fluke research.

PARASITOLOGY RESEARCH (2022)

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Article Biochemical Research Methods

Changes in the lipid profile of hamster liver after Schistosoma mansoni infection, characterized by mass spectrometry imaging and LC-MS/MS analysis

Katja R. Wiedemann et al.

Summary: This study identified and studied infection markers in the livers of hamsters infected with the parasitic Schistosoma mansoni using LC-MS/MS technology, and matched these markers to specific anatomical structures using high-resolution MALDI MSI.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2022)

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Article Food Science & Technology

Mass spectrometry imaging and its potential in food microbiology

Yuchen Zou et al.

Summary: This article briefly introduces the technology of mass spectrometry imaging (MSI) and covers some interesting topics regarding sample preparations. It describes successful applications of MSI in disciplines similar to food microbiology and provides perspectives on how MSI could benefit food microbiology and the challenges it may face.

INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY (2022)

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Article Biochemical Research Methods

Evaluation of 6 MALDI-Matrices for 10 ?m Lipid Imaging and On-Tissue MSn with AP-MALDI-Orbitrap

Tina B. Angerer et al.

Summary: Mass spectrometry imaging is a technique used to localize and identify lipids in tissue samples. By utilizing an AP-MALDI source coupled to an Orbitrap Elite, lipid locations and structures can be determined with high mass resolution spectra and cellular spatial resolution. Different MALDI matrices and treatment protocols have varying effects on the lipid coverage and signal intensity in positive and negative ion modes.

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2022)

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Article Biochemical Research Methods

Mapping the Influence of the Gut Microbiota on Small Molecules across the Microbiome Gut Brain Axis

Heather Hulme et al.

Summary: Microbes have significant effects on the levels of neurotransmitters and their precursors in the brain. Antibiotic treatment does not cause significant changes in these metabolites in the brain.

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2022)

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Article Microbiology

One Cell at a Time: Advances in Single-Cell Methods and Instrumentation for Discovery in Aquatic Microbiology

Vesna Grujcic et al.

Summary: Studying aquatic microbes from a single-cell perspective has become an important theme, and the observation of heterogeneity in activity levels within microbial populations requires the development of new methods. Despite the challenges in method development, it has contributed significantly to research in the field.

FRONTIERS IN MICROBIOLOGY (2022)

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Review Spectroscopy

What are we imaging? Software tools and experimental strategies for annotation and identification of small molecules in mass spectrometry imaging

Gerard Baquer et al.

Summary: This review discusses experimental strategies and bioinformatics tools for annotating and identifying compounds in MSI experiments. It covers the influence of sample preparation and acquisition process on annotation and identification, reviews twelve software tools, and offers perspectives on current needs in the MSI community.

MASS SPECTROMETRY REVIEWS (2022)

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Review Biology

Mass Spectrometry Imaging Spatial Tissue Analysis toward Personalized Medicine

Juliana P. L. Goncalves et al.

Summary: Novel profiling methodologies are revolutionizing the field of diagnostics and therapeutics, enabling more precise and personalized healthcare. Mass spectrometry imaging and other techniques provide molecular level information directly from tissues, aiding in understanding aberrant cellular behavior and disease characterization.

LIFE-BASEL (2022)

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Review Biotechnology & Applied Microbiology

The Exploration of Microbial Natural Products and Metabolic Interaction Guided by Mass Spectrometry Imaging

Hao Li et al.

Summary: Mass spectrometric imaging (MSI) is an impressive technology that provides mass spectra data and spatial distribution of analytes simultaneously. MSI has been widely used in various fields due to its accuracy and high resolution. This review focuses on the applications of MSI in exploring microbial natural products (NPs) and metabolic interaction, particularly NPs from marine microbes. The review also discusses the challenges and future prospects in this field.

BIOENGINEERING-BASEL (2022)

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Review Chemistry, Analytical

Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) for in situ analysis of endogenous small molecules in biological samples

Huihui Liu et al.

Summary: This paper provides an overview of the importance of endogenous small molecules in biological processes and their relevance to various diseases. It highlights the use of matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) as a powerful tool for analyzing small molecules in situ. The paper discusses the workflow, applications, challenges, and future directions of MALDI-MSI for small molecule analysis.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2022)

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Review Virology

A How to Guide: Clinical Population Test Development and Authorization of MALDI-ToF Mass Spectrometry-Based Screening Tests for Viral Infections

Ray K. Iles et al.

Summary: Applying MALDI-ToF mass spectrometry as a clinical diagnostic test for viruses is fundamentally different from its application for bacteria, fungi, and other micro-organisms due to variations in systems biology, viral protein characteristics, and quantification methods. Overcoming analytical challenges in developing clinical MALDI-ToF mass spectrometry tests for virus, particularly human pathogenic enveloped viruses, includes sample enrichment, virus envelope disruption, optimal matrix formulation, optimal MALDI ToF MS performance, and optimal spectral data processing/bioinformatics. The instrument operating settings need to be optimized to match the nature of viral-specific proteins, and the procedures for the technique must meet legal and operational requirements for high-throughput clinical testing. Regulatory authorities often require application of CLIA laboratory developed test (LDT) criteria for clinical MALDI ToF mass spectrometry due to its novelty and lack of standardized comparisons with authorized technology tests.

VIRUSES-BASEL (2022)

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Editorial Material Microbiology

Discrimination of Escherichia coli, Shigella flexneri, and Shigella sonnei using lipid profiling by MALDI-TOF mass spectrometry paired with machine learning

Jade Pizzato et al.

Summary: This study demonstrated the potential of lipid profiling using MALDI-TOF MS in the negative ion mode coupled with machine learning to differentiate between Escherichia coli and Shigella spp.

MICROBIOLOGYOPEN (2022)

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Article Biochemistry & Molecular Biology

Viral Biomarker Detection and Validation Using MALDI Mass Spectrometry Imaging (MSI)

Matthew B. O'Rourke et al.

Summary: In this study, a hybrid bioinformatic/image-based method was developed for the identification and validation of viral biomarkers. This method leverages the power of mass spectrometry imaging and provides confident identifications for viral proteins without requiring MS/MS.

PROTEOMES (2022)

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Article Microbiology

Identification of Adult Fasciola spp. Using Matrix-Assisted Laser/Desorption Ionization Time-of-Flight (MALDI-TOF) Mass Spectrometry

Issa Sy et al.

Summary: Fascioliasis is caused by Fasciola gigantica and Fasciola hepatica. Traditional diagnostic methods have low accuracy, while molecular diagnostics such as MALDI-TOF MS are more reliable. A study developed and validated an in-house database for species-specific identification of Fasciola using MALDI-TOF MS, showing promising results for accurate identification of medically relevant liver flukes.

MICROORGANISMS (2021)

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Article Pharmacology & Pharmacy

Quantitative MALDI mass spectrometry imaging for exploring cutaneous drug delivery of tofacitinib in human skin

Anne Mette Handler et al.

Summary: In this study, HPLC-MS/MS and MALDI-MSI were used to analyze drug penetration in the skin, revealing the impact of different formulations on drug release and retention in the skin, with C1 showing the highest retention of tofacitinib and the gel and C2 demonstrating higher permeation.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2021)

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Review Immunology

Detection of Species-Specific Lipids by Routine MALDI TOF Mass Spectrometry to Unlock the Challenges of Microbial Identification and Antimicrobial Susceptibility Testing

Vera Solntceva et al.

Summary: MALDI-TOF mass spectrometry has revolutionized clinical microbiology diagnostics by delivering accurate identification of microorganisms through the detection of proteins and lipids. Lipid modifications play a crucial role in both the rapid detection of pathogens and the determination of their drug susceptibility.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

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Article Biochemical Research Methods

High-resolution AP-SMALDI MSI as a tool for drug imaging in Schistosoma mansoni

Annika S. Mokosch et al.

Summary: Imatinib shows high efficacy against Schistosoma mansoni in vitro, mainly affecting the intestinal integrity in males and females. AP-SMALDI MSI is a useful method for studying the uptake, tissue distribution, and metabolization of imatinib in schistosomes, with potential applications for investigating other antiparasitic compounds and their metabolites in parasites.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2021)

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Article Oncology

Cancer Tissue Classification Using Supervised Machine Learning Applied to MALDI Mass Spectrometry Imaging

Paul Mittal et al.

Summary: The study demonstrated the potential of mass spectrometry-based imaging combined with machine learning in accurately distinguishing colorectal tumors and predicting lymph node metastasis in endometrial cancer, thus providing important guidance for cancer treatment.

CANCERS (2021)

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Article Medicine, General & Internal

Investigation of MALDI-TOF Mass Spectrometry for Assessing the Molecular Diversity of Campylobacter jejuni and Comparison with MLST and cgMLST: A Luxembourg One-Health Study

Maureen Feucherolles et al.

Summary: The study evaluated the potential of MALDI-TOF MS in pre-screening genetic diversity of C. jejuni, demonstrating high accuracy in predicting CCs, STs, and CTs with protein profiles. The random forest algorithm showed a sensitivity and specificity of up to 97.5% in predicting different STs.

DIAGNOSTICS (2021)

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Article Biochemical Research Methods

Infrared MALDI Mass Spectrometry with Laser-Induced Postionization for Imaging of Bacterial Colonies

Eike U. Brockmann et al.

Summary: UV-MALDI-MSI is a powerful tool for visualizing bacterial metabolites in microbial colonies and biofilms. The use of a pulsed IR laser without prior matrix coating allowed for efficient extraction of analytes, utilizing water or glycerol for energy deposition and ionization. This approach provided enhanced detection of small molecules and bacterial phospholipids, demonstrating potential as a new tool for microbial mass spectrometry imaging.

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2021)

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Review Immunology

Host/microbiota interactions in health and diseases-Time for mucosal microbiology!

Noemie Daniel et al.

Summary: In the past 20 years, a new research field has emerged outlining the importance of the microbiota in health and diseases. Inappropriate host-microbiota interactions have been shown to trigger chronic inflammatory diseases, with the mucosa-associated microbiota playing a key role in chronic intestinal inflammation and associated disease states. Expanding research in mucosal microbiology presents both challenges and promises in understanding the mechanisms behind these relationships.

MUCOSAL IMMUNOLOGY (2021)

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Article Microbiology

Identification of Metabolically Quiescent Leishmania mexicana Parasites in Peripheral and Cured Dermal Granulomas Using Stable Isotope Tracing Imaging Mass Spectrometry

Joachim Kloehn et al.

Summary: The study reveals the presence of metabolically quiescent and active sub populations of Leishmania mexicana in dermal granulomas, with both granuloma core and surrounding collagen-rich mesothelium harboring different parasite populations. The lack of miltefosine accumulation in cured lesion tissue may contribute to drug failure and nonsterile cure, highlighting the importance of understanding the metabolic heterogeneity of parasites in host-pathogen interactions.

MBIO (2021)

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Article Multidisciplinary Sciences

Connecting structure and function from organisms to molecules in small-animal symbioses through chemo-histo-tomography

Benedikt Geier et al.

Summary: We developed a new method CHEMHIST to connect anatomical structure and metabolic function in millimeter-sized symbiotic animals, addressing the limited understanding of metabolic interactions between these animals. By combining MSI and micro-CT, we successfully correlated the distribution of metabolites with the 3D histology of the animals, providing a methodological groundwork for understanding the roles of these symbiotic animals in ecosystem functioning.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Multidisciplinary Sciences

Peak learning of mass spectrometry imaging data using artificial neural networks

Walid M. Abdelmoula et al.

Summary: This study demonstrates the application of artificial intelligence in mining Mass Spectrometry Imaging (MSI) data to reveal biologically relevant metabolomic and proteomic information acquired from different mass spectrometry platforms. By utilizing a fully connected variational autoencoder, the researchers developed the msiPL method to learn and visualize the underlying non-linear spectral manifold in MSI data, uncovering biologically relevant clusters of tissue anatomy and tumor heterogeneity in various tissue types.

NATURE COMMUNICATIONS (2021)

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Article Microbiology

Revisiting Species Identification within the Enterobacter cloacae Complex by Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry

Alexandre Godmer et al.

Summary: MALDI-TOF MS is commonly used in clinical microbiology labs for pathogen identification, but faces limitations, especially in uncertain identification of ECC species like E. hormaechei. By utilizing an online database combined with high-performance MSI software, substantial improvements in species-level identification of ECC isolates can be achieved.

MICROBIOLOGY SPECTRUM (2021)

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Article Microbiology

Evaluating Different Storage Media for Identification of Taenia saginata Proglottids Using MALDI-TOF Mass Spectrometry

Tabea P. Wendel et al.

Summary: Taenia saginata, a helminth causing taeniasis in humans and cysticercosis in cattle, requires a species-specific diagnosis for effective management. Traditional diagnostic methods lack sensitivity and the ability to differentiate it from similar species. MALDI-TOF MS shows promise as an accurate technique for identification of T. saginata through protein spectra.

MICROORGANISMS (2021)

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Review Medical Laboratory Technology

Cellular resolution in clinical MALDI mass spectrometry imaging: the latest advancements and current challenges

Klara Scupakova et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2020)

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Letter Infectious Diseases

Antimicrobial resistance classification using MALDI-TOF-MS is not that easy: lessons from vancomycin-resistant Enterococcus faecium

M. Brackmann et al.

CLINICAL MICROBIOLOGY AND INFECTION (2020)

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Article Microbiology

Spatial metabolomics of in situ host-microbe interactions at the micrometre scale

Benedikt Geier et al.

NATURE MICROBIOLOGY (2020)

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Review Medicine, General & Internal

Bioinformatics and Computational Tools for Next-Generation Sequencing Analysis in Clinical Genetics

Rute Pereira et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Article Infectious Diseases

Tissue- and sex-specific lipidomic analysis of Schistosoma mansoni using high-resolution atmospheric pressure scanning microprobe matrix-assisted laser desorption/ionization mass spectrometry imaging

Patrik Kadesch et al.

PLOS NEGLECTED TROPICAL DISEASES (2020)

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Editorial Material Infectious Diseases

Digitalization, clinical microbiology and infectious diseases

A. Egli

CLINICAL MICROBIOLOGY AND INFECTION (2020)

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Review Infectious Diseases

Digital microbiology

A. Egli et al.

CLINICAL MICROBIOLOGY AND INFECTION (2020)

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Article Biochemical Research Methods

Considerations for MALDI-Based Quantitative Mass Spectrometry Imaging Studies

Fernando Tobias et al.

JOURNAL OF PROTEOME RESEARCH (2020)

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Article Chemistry, Analytical

On-Tissue Derivatization of Lipopolysaccharide for Detection of Lipid A Using MALDI-MSI

Hyojik Yang et al.

ANALYTICAL CHEMISTRY (2020)

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Article Biology

A micrometer-scale snapshot on phototroph spatial distributions: mass spectrometry imaging of microbial mats in Octopus Spring, Yellowstone National Park

Lars Woermer et al.

GEOBIOLOGY (2020)

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Article Food Science & Technology

Laser Ablation Remote-Electrospray Ionisation Mass Spectrometry (LARESI MSI) Imaging-New Method for Detection and Spatial Localization of Metabolites and Mycotoxins Produced by Moulds

Justyna Szulc et al.

TOXINS (2020)

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Article Veterinary Sciences

Targeting Kinases in Fasciola hepatica: Anthelminthic Effects and Tissue Distribution of Selected Kinase Inhibitors

Carolin M. Morawietz et al.

FRONTIERS IN VETERINARY SCIENCE (2020)

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Article Microbiology

Bringing SEM and MSI Closer Than Ever Before: Visualizing Aspergillus and Pseudomonas Infection in the Rat Lungs

Tereza Jurikova et al.

JOURNAL OF FUNGI (2020)

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Review Infectious Diseases

Bacterial Biofilm and its Role in the Pathogenesis of Disease

Lene K. Vestby et al.

ANTIBIOTICS-BASEL (2020)

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Article Infectious Diseases

Rapid one-step protein extraction method for the identification of mycobacteria using MALDI-TOF MS

Suwatchareeporn Rotcheewaphan et al.

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE (2019)

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Article Multidisciplinary Sciences

Viscosin-like lipopeptides from frog skin bacteria inhibit Aspergillus fumigatus and Batrachochytrium dendrobatidis detected by imaging mass spectrometry and molecular networking

Christian Martin H et al.

SCIENTIFIC REPORTS (2019)

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Article Microbiology

In plaque-mass spectrometry imaging of a bloom-forming alga during viral infection reveals a metabolic shift towards odd-chain fatty acid lipids

Guy Schleyer et al.

NATURE MICROBIOLOGY (2019)

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Review Pharmacology & Pharmacy

Applications of MALDI mass spectrometry imaging for pharmacokinetic studies during drug development

Masanobu Nishidate et al.

DRUG METABOLISM AND PHARMACOKINETICS (2019)

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Review Parasitology

MALDI-TOF mass spectrometry as a diagnostic tool in human and veterinary helminthology: a systematic review

Maureen Feucherolles et al.

PARASITES & VECTORS (2019)

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Review Biochemical Research Methods

An update on the routine application of MALDI-TOF MS in clinical microbiology

Martin Welker et al.

EXPERT REVIEW OF PROTEOMICS (2019)

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Article Biochemical Research Methods

Identification performance of MALDI-ToF-MS upon mono- and bi-microbial cultures is cell number and culture proportion dependent

Christoph Mortelmaier et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2019)

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Article Biochemical Research Methods

Transmission-mode MALDI-2 mass spectrometry imaging of cells and tissues at subcellular resolution

M. Niehaus et al.

NATURE METHODS (2019)

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Article Chemistry, Analytical

Advanced Methods for MALDI-MS Imaging of the Chemical Communication in Microbial Communities

Eike Ulrich Brockmann et al.

ANALYTICAL CHEMISTRY (2019)

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Review Computer Science, Artificial Intelligence

Object Detection With Deep Learning: A Review

Zhong-Qiu Zhao et al.

IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS (2019)

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Review Microbiology

MALDI-TOF Mass Spectrometry and Specific Biomarkers: Potential New Key for Swift Identification of Antimicrobial Resistance in Foodborne Pathogens

Maureen Feucherolles et al.

MICROORGANISMS (2019)

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Article Biochemical Research Methods

MALDI MS Imaging at Acquisition Rates Exceeding 100 Pixels per Second

Antonin Bednarik et al.

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2019)

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Article Microbiology

Imaging Mass Spectrometry and Proteome Analysis of Marek's Disease Virus-Induced Tumors

V. Pauker et al.

MSPHERE (2019)

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Article Biochemistry & Molecular Biology

Mass Spectrometry Uncovers the Role of Surfactin as an Interspecies Recruitment Factor

Tal Luzzatto-Knaan et al.

ACS CHEMICAL BIOLOGY (2019)

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Review Spectroscopy

Characterization of microbial mixtures by mass spectrometry

Todd R. Sandrin et al.

MASS SPECTROMETRY REVIEWS (2018)

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Article Chemistry, Analytical

Visualization of Mycobacterial Biomarkers and Tuberculosis Drugs in Infected Tissue by MALDI-MS Imaging

Landry Blanc et al.

ANALYTICAL CHEMISTRY (2018)

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Article Immunology

MALDI-TOF MS identification of ticks of domestic and wild animals in Algeria and molecular detection of associated microorganisms

Mehdi Boucheikhchoukh et al.

COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES (2018)

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Article Microbiology

Evaluation of the Vitek MS v3.0 Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry System for Identification of Mycobacterium and Nocardia Species

Barbara A. Body et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2018)

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Article Parasitology

MALDI-TOF MS as a new tool for the identification of Dientamoeba fragilis

Adriana Calderaro et al.

PARASITES & VECTORS (2018)

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Article Infectious Diseases

Detection of Bartonella spp. in fleas by MALDI-TOF MS

Basma El Hamzaoui et al.

PLOS NEGLECTED TROPICAL DISEASES (2018)

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Article Chemistry, Analytical

Direct MALDI-TOF MS Identification of Bacterial Mixtures

Yi Yang et al.

ANALYTICAL CHEMISTRY (2018)

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Article Biochemical Research Methods

MALDI mass spectrometry imaging and in situ microproteomics of Listeria monocytogenes biofilms

Tiago Santos et al.

JOURNAL OF PROTEOMICS (2018)

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Article Endocrinology & Metabolism

High-Resolution Tissue Mass Spectrometry Imaging Reveals a Refined Functional Anatomy of the Human Adult Adrenal Gland

Na Sun et al.

ENDOCRINOLOGY (2018)

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Review Chemistry, Analytical

Mass Spectrometry Imaging: A Review of Emerging Advancements and Future Insights

Amanda Rae Buchberger et al.

ANALYTICAL CHEMISTRY (2018)

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Review Chemistry, Multidisciplinary

Mass Spectrometry Imaging of Complex Microbial Communities

Sage J. B. Dunham et al.

ACCOUNTS OF CHEMICAL RESEARCH (2017)

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Article Biochemical Research Methods

Atmospheric pressure MALDI mass spectrometry imaging of tissues and cells at 1.4-μm lateral resolution

Mario Kompauer et al.

NATURE METHODS (2017)

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Article Microbiology

Validation of a New Web Application for Identification of Fungi by Use of Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry

A. C. Normand et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2017)

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Article Multidisciplinary Sciences

Host-based lipid inflammation drives pathogenesis in &ITFrancisella&IT infection

Alison J. Scott et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Article Biochemistry & Molecular Biology

Imaging with Mass Spectrometry of Bacteria on the Exoskeleton of Fungus-Growing Ants

Erin Gemperline et al.

ACS CHEMICAL BIOLOGY (2017)

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Review Biochemistry & Molecular Biology

MALDI-TOF MS in the Microbiology Laboratory: Current Trends

Soeren Schubert et al.

CURRENT ISSUES IN MOLECULAR BIOLOGY (2017)

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Review Pathology

Third generation sequencing technologies applied to diagnostic microbiology: benefits and challenges in applications and data analysis

Enrico Lavezzo et al.

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS (2016)

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Article Biochemical Research Methods

A one-step matrix application method for MALDI mass spectrometry imaging of bacterial colony biofilms

Bin Li et al.

JOURNAL OF MASS SPECTROMETRY (2016)

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Article Biochemical Research Methods

Characterization of Bacillus subtilis Colony Biofilms via Mass Spectrometry and Fluorescence Imaging

Tong Si et al.

JOURNAL OF PROTEOME RESEARCH (2016)

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Article Biochemical Research Methods

Matrix Recrystallization for MALDI-MS Imaging of Maize Lipids at High-Spatial Resolution

Maria Emilia Duenas et al.

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2016)

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Article Endocrinology & Metabolism

Where imaging mass spectrometry stands: here are the numbers

Andrew Palmer et al.

METABOLOMICS (2016)

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Review Biochemical Research Methods

The use of MALDI-MSI in the investigation of psychiatric and neurodegenerative disorders: A review

Klaus Oliver Schubert et al.

PROTEOMICS (2016)

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Article Biochemical Research Methods

Visualizing fungal metabolites during mycoparasitic interaction by MALDI mass spectrometry imaging

Matthias Holzlechner et al.

PROTEOMICS (2016)

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Article Multidisciplinary Sciences

The innate immune protein calprotectin promotes Pseudomonas aeruginosa and Staphylococcus aureus interaction

Catherine A. Wakeman et al.

NATURE COMMUNICATIONS (2016)

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Article Chemistry, Analytical

Phospholipid Topography of Whole-Body Sections of the Anopheles stephensi Mosquito, Characterized by High-Resolution Atmospheric-Pressure Scanning Microprobe Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging

Saleh M. Khalil et al.

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Article Biotechnology & Applied Microbiology

Comparative genomics and metabolic profiling of the genus Lysobacter

Irene de Bruijn et al.

BMC GENOMICS (2015)

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Article Biochemical Research Methods

Brain Region-Specific Dynamics of On-Tissue Protein Digestion Using MALDI Mass Spectrometry Imaging

Bram Heijs et al.

JOURNAL OF PROTEOME RESEARCH (2015)

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Article Biochemical Research Methods

Mass Spectrometry Analysis of Pseudomonas aeruginosa Treated with Azithromycin

Vanessa V. Phelan et al.

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2015)

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Article Biochemical Research Methods

Homogeneous Matrix Deposition on Dried Agar for MALDI Imaging Mass Spectrometry of Microbial Cultures

Thomas Hoffmann et al.

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2015)

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Article Medicine, Research & Experimental

MALDI Imaging mass spectrometry: current frontiers and perspectives in pathology research and practice

Michaela Aichler et al.

LABORATORY INVESTIGATION (2015)

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Article Multidisciplinary Sciences

Thiopeptide antibiotics stimulate biofilm formation in Bacillus subtilis

Rachel Bleich et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Article Immunology

Mycobacterial envelope lipids fingerprint from direct MALDI-TOF MS analysis of intact bacilli

Gerald Larrouy-Maumus et al.

TUBERCULOSIS (2015)

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Review Microbiology

MALDI-TOF mass spectrometry: an emerging technology for microbial identification and diagnosis

Neelja Singhal et al.

FRONTIERS IN MICROBIOLOGY (2015)

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Review Chemistry, Analytical

Mass Spectrometry Imaging of Biomolecular Information

Bernhard Spengler

ANALYTICAL CHEMISTRY (2015)

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Article Chemistry, Analytical

MALDI-guided SIMS: Multiscale Imaging of Metabolites in Bacterial Biofilms

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