期刊
CELLS
卷 11, 期 23, 页码 -出版社
MDPI
DOI: 10.3390/cells11233758
关键词
NLRP3; microbiota; intestinal mucosal immunity; inflammasome
类别
资金
- Special Funds for People's Livelihood Research Medical and Health Project of Shanghai
- [PKJ2019-Y22]
This article discusses the crucial role of the NLRP3 inflammasome in maintaining gut microbiota homeostasis, gut health, and immune system stability.
The inflammasome is a platform for inflammatory signaling, and the NLRP3 inflammasome recognizes stimuli in vitro and in vivo, and releases inflammatory cytokines that trigger inflammation and pyroptosis. In the gut, the NLRP3 inflammasome is a key sensor for protecting the body from damage and exogenous pathogens. It plays a fundamental role in maintaining the stability of the gut's immune system. We focus on the role of NLRP3 as a key node in maintaining the homeostasis of gut microbiota which has not been fully highlighted in the past; gut microbiota and innate immunity, as well as the NLRP3 inflammasome, are discussed in this article.
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