Influence of SARS-CoV-2 on Adult Human Neurogenesis

Review Microbiology

COVID-19: comprehensive review on mutations and current vaccines

Ananda Vardhan Hebbani et al.

Summary: Viral outbreaks, particularly the COVID-19 pandemic, pose a persistent threat to humanity. Prevention, early detection, and effective treatment are crucial in curbing the spread of the virus.

ARCHIVES OF MICROBIOLOGY (2022)

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Article Immunology

IL-1 reprogramming of adult neural stem cells limits neurocognitive recovery after viral encephalitis by maintaining a proinflammatory state

Allison L. Soung et al.

Summary: In viral encephalitis, continued astrocyte inflammasome-mediated production of IL-113 is maintained by IL-1R1 signaling in neural stem cells, preventing synapse repair and promoting spatial learning deficits.

BRAIN BEHAVIOR AND IMMUNITY (2022)

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Letter Medicine, General & Internal

Long-term neuropsychiatric outcomes in COVID-19 survivors: A 1-year longitudinal study

Raul Mendez et al.

JOURNAL OF INTERNAL MEDICINE (2022)

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Article Cell & Tissue Engineering

The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS route for SARS-CoV-2

Susanne Krasemann et al.

Summary: Neurological complications are common in COVID-19. This study reveals that SARS-CoV-2 can enter the brain through the blood-brain barrier and cause increased interferon signaling. In vitro experiments show that SARS-CoV-2 can infect BCECs and replicate, with the virus being transported across the barrier. This process can be inhibited by specific antibodies or inhibitors.

STEM CELL REPORTS (2022)

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Article Neurosciences

Association of COVID-19 with New-Onset Alzheimer's Disease

Lindsey Wang et al.

Summary: This retrospective cohort study found that COVID-19 infection is associated with an increased risk of Alzheimer's disease, particularly in older adults and women.

JOURNAL OF ALZHEIMERS DISEASE (2022)

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Review Cell Biology

The Adverse Outcome Pathway Framework Applied to Neurological Symptoms of COVID-19

Helena T. Hogberg et al.

Summary: This review organizes available knowledge on the neurobiological mechanisms of COVID-19, identifies four AOPs leading to neurological adverse outcomes, and discusses factors influencing the impact of COVID-19 on neurological AOPs. The use of the AOP framework helps visualize core pathways and shared mechanisms.

CELLS (2022)

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Article Medicine, General & Internal

Short-term neuropsychiatric outcomes and quality of life in COVID-19 survivors

R. Mendez et al.

Summary: The study found that COVID-19 survivors shortly after hospital discharge showed a high prevalence of neurocognitive impairment, psychiatric morbidity, and poor quality of life. Female gender was more likely to be associated with psychiatric morbidity, while delirium and psychiatric morbidity were related to neurocognitive impairment.

JOURNAL OF INTERNAL MEDICINE (2021)

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Article Neurosciences

Frequency and profile of objective cognitive deficits in hospitalized patients recovering from COVID-19

Abhishek Jaywant et al.

Summary: Most COVID-19 patients who require acute rehabilitation prior to discharge exhibit cognitive impairment, with deficits commonly seen in working memory, set-shifting, divided attention, and processing speed. Interventions targeting attention and executive dysfunctions may be beneficial for this population.

NEUROPSYCHOPHARMACOLOGY (2021)

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Letter Clinical Neurology

Assessing Brain Capillaries in Coronavirus Disease 2019

David W. Nauen et al.

JAMA NEUROLOGY (2021)

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Article Clinical Neurology

COVID-19 neuropathology at Columbia University Irving Medical Center/New York Presbyterian Hospital

Kiran T. Thakur et al.

Summary: Many patients with SARS-CoV-2 infection exhibit neurological signs and symptoms, but autopsy results show that most brains have low levels of detectable virus and it does not correlate with the histopathological alterations.

BRAIN (2021)

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Review Biochemistry & Molecular Biology

Potential drug targets of SARS-CoV-2: From genomics to therapeutics

Anas Shamsi et al.

Summary: The emergence of SARS-CoV-2 has posed a global threat due to the continuous rise in COVID-19 cases. The complex mechanism of the virus pathogenesis hinders the development of effective therapeutics, but in-depth analysis of the genome architecture and pathogenesis may lead to potential treatment options.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Cell & Tissue Engineering

SARS-CoV-2 targets glial cells in human cortical organoids

Courtney L. McMahon et al.

Summary: Researchers used human stem cell-derived brain organoids to study how SARS-CoV-2 infects brain tissue and found that glial cells and cells of the choroid plexus were preferentially targeted, while neurons were not infected. The expression of angiotensin-converting enzyme 2 was detected in infected cells, but viral replication and cell death did not occur, indicating that this model serves as a feasible platform to study the cellular effects of SARS-CoV-2 infection in brain tissue.

STEM CELL REPORTS (2021)

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Review Clinical Neurology

Neuropathological findings from COVID-19 patients with neurological symptoms argue against a direct brain invasion of SARS-CoV-2: A critical systematic review

Giuseppe Cosentino et al.

Summary: Neuropathological studies in COVID-19 patients reveal that neurological symptoms are associated with brain inflammatory reactions and hypoxic-ischemic damage rather than neuronal viral load. Older individuals are more likely to experience neurological symptoms.

EUROPEAN JOURNAL OF NEUROLOGY (2021)

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Review Biology

COVID-19 and central nervous system interplay: A big picture beyond clinical manifestation

Sutapa Som Chaudhury et al.

Summary: The COVID-19 pandemic caused by SARS-CoV-2 presents a significant threat globally, with infected individuals displaying a range of clinical symptoms. The involvement of the central nervous system in disease progression is crucial, with its immunological responses and interactions with other major organs not fully understood.

JOURNAL OF BIOSCIENCES (2021)

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Article Biochemistry & Molecular Biology

Federated learning for predicting clinical outcomes in patients with COVID-19

Ittai Dayan et al.

Summary: Federated learning, a method for training artificial intelligence algorithms while protecting data privacy, was used to predict future oxygen requirements of symptomatic patients with COVID-19 using data from 20 different institutes globally. The study showed improved predictive accuracy and generalizability, setting the stage for wider applications in healthcare.

NATURE MEDICINE (2021)

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Article Neurosciences

Neuropathological analysis of the brains of fifty-two patients with COVID-19

Teresa Wierzba-Bobrowicz et al.

Summary: This study reported neuropathological changes in brains of patients infected with CoV-2 coronavirus, showing vascular lesions and inflammatory process characteristic of the infection. Damage of vessel walls and morphological feature of the damage to the blood-brain barrier were observed, along with lymphocytic and microglial infiltrates.

FOLIA NEUROPATHOLOGICA (2021)

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Article Medicine, General & Internal

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China

Dawei Wang et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Letter Biology

Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission

Xintian Xu et al.

SCIENCE CHINA-LIFE SCIENCES (2020)

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Article Biochemistry & Molecular Biology

Glecaprevir and Maraviroc are high-affinity inhibitors of SARS-CoV-2 main protease: possible implication in COVID-19 therapy

Anas Shamsi et al.

BIOSCIENCE REPORTS (2020)

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Review Cardiac & Cardiovascular Systems

Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System Celebrating the 20th Anniversary of the Discovery of ACE2

Mahmoud Gheblawi et al.

CIRCULATION RESEARCH (2020)

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Article Infectious Diseases

A first case of meningitis/encephalitis associated with SARS-Coronavirus-2

Takeshi Moriguchi et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2020)

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Article Clinical Neurology

Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China

Ling Mao et al.

JAMA NEUROLOGY (2020)

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Letter Medicine, General & Internal

Neurologic Features in Severe SARS-CoV-2 Infection

Julie Helms et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Editorial Material Clinical Neurology

Guillain-Barre syndrome related to COVID-19 infection

Paola Alberti et al.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2020)

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Article Clinical Neurology

Microvascular injury and hypoxic damage: emerging neuropathological signatures in COVID-19

Zane Jaunmuktane et al.

ACTA NEUROPATHOLOGICA (2020)

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Editorial Material Surgery

Unforeseen consequences of the COVID pandemic

John Bucuvalas et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2020)

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Review Medicine, General & Internal

Review on the coronavirus disease (COVID-19) pandemic: Its outbreak and current status

Dalia Almaghaslah et al.

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE (2020)

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Review Biochemistry & Molecular Biology

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): a review

Wei Feng et al.

MOLECULAR CANCER (2020)

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Article Cell & Tissue Engineering

Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism Predominates in Choroid Plexus Epithelium

Fadi Jacob et al.

CELL STEM CELL (2020)

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Article Environmental Sciences

COVID-19: Disease, management, treatment, and social impact

Imran Ali et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2020)

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Article Virology

Identification of high-affinity inhibitors of SARS-CoV-2 main protease: Towards the development of effective COVID-19 therapy

Taj Mohammad et al.

VIRUS RESEARCH (2020)

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Article Clinical Neurology

Arterial and venous strokes in the setting of COVID-19

Mohammed F. Kananeh et al.

JOURNAL OF CLINICAL NEUROSCIENCE (2020)

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Article Virology

Infection of Brain Organoids and 2D Cortical Neurons with SARS-CoV-2 Pseudovirus

Sang Ah Yi et al.

VIRUSES-BASEL (2020)

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Article Medicine, General & Internal

Cerebral Micro-Structural Changes in COVID-19 Patients - An MRI-based 3-month Follow-up Study

Yiping Lu et al.

ECLINICALMEDICINE (2020)

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Review Geriatrics & Gerontology

TGF-β Signaling: A Therapeutic Target to Reinstate Regenerative Plasticity in Vascular Dementia?

Mahesh Kandasamy et al.

AGING AND DISEASE (2020)

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Review Psychiatry

Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study

Aravinthan Varatharaj et al.

LANCET PSYCHIATRY (2020)

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Editorial Material Cell & Tissue Engineering

Is Alzheimer's Disease a Neurogenesis Disorder?

Se Hoon Choi et al.

CELL STEM CELL (2019)

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Article Multidisciplinary Sciences

Activating newborn neurons suppresses depression and anxiety-like behaviors

Elif Tunc-Ozcan et al.

NATURE COMMUNICATIONS (2019)

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Article Immunology

Astrocytes decrease adult neurogenesis during virus-induced memory dysfunction via IL-1

Charise Garber et al.

NATURE IMMUNOLOGY (2018)

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Review Neurosciences

Neurologic Alterations Due to Respiratory Virus Infections

Karen Bohmwald et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2018)

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Article Cell & Tissue Engineering

Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth

Hengli Tang et al.

CELL STEM CELL (2016)

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Review Biochemistry & Molecular Biology

Adult neurogenesis in Parkinson's disease

Franz Marxreiter et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2013)

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Review Biochemistry & Molecular Biology

Interleukin-6, a Major Cytokine in the Central Nervous System

Maria Erta et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2012)

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Review Neurosciences

Hippocampal Neurogenesis, Cognitive Deficits and Affective Disorder in Huntington's Disease

Mark I. Ransome et al.

NEURAL PLASTICITY (2012)

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Article Neurosciences

Tis21 Expression Marks Not Only Populations of Neurogenic Precursor Cells but Also New Postmitotic Neurons in Adult Hippocampal Neurogenesis

Alessio Attardo et al.

CEREBRAL CORTEX (2010)

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Review Clinical Neurology

Regulation of adult neurogenesis by stress, sleep disruption, exercise and inflammation: Implications for depression and antidepressant action

P. J. Lucassen et al.

EUROPEAN NEUROPSYCHOPHARMACOLOGY (2010)

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Article Multidisciplinary Sciences

Impaired Adult Neurogenesis in the Dentate Gyrus of a Triple Transgenic Mouse Model of Alzheimer's Disease

Jose J. Rodriguez et al.

PLOS ONE (2008)

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Review Biology

Neural stem cells: involvement in adult neurogenesis and CNS repair

Hideyuki Okano et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2008)

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Article Clinical Neurology

Neurogenesis after transient global ischemia in the adult hippocampus visualized by improved retroviral vector

R Tanaka et al.

STROKE (2004)

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Article Neurosciences

Transient expression of doublecortin during adult neurogenesis

JP Brown et al.

JOURNAL OF COMPARATIVE NEUROLOGY (2003)

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Article Multidisciplinary Sciences

Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants

L Santarelli et al.

SCIENCE (2003)

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Influence of SARS-CoV-2 on Adult Human Neurogenesis

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