The Major Stilbene Compound Accumulated in the Roots of a Resistant Variety of Phoenix dactylifera L. Activates Proteasome for a Path in Anti-Aging Strategy

The main objective of the present study is to estimate, through differential analysis, various biological activities of total phenolics content in alcoholic extracts of three date palm varieties sensitive or resistant to Fusarium oxysporum. sp Albidinis. Here, stilbene products with antioxidant and bioactive capacities were evidenced in resistant variety Taabdount (TAAR). Furthermore, the methanolic fraction of the TAAR-resistant date palm variety contains a significant product, determined by LC-MS/MS and 1H, 13C NMR, belonging to the family of hydroxystilbenes, which exhibits antioxidant capacities, inhibits the mushroom tyrosinase activity, and activates and exerts a protective effect on hypochlorite-induced damage in 20S proteasome of human dermal fibroblast aged cells. Altogether, the present results indicate that hydroxystilbene present in resistant Phoenix dactylifera L. should be studied to understand the way that the stilbene could exert anti-aging ability.

Automated summary

The main objective of this study is to estimate the biological activities of total phenolics content in alcoholic extracts of date palm varieties sensitive or resistant to Fusarium oxysporum.sp Albidinis through differential analysis. Stilbene products with antioxidant and bioactive capacities were found in the resistant variety Taabdount (TAAR). Additionally, the methanolic fraction of the TAAR-resistant date palm variety contains a significant hydroxystilbene compound, which exhibits antioxidant capacities, inhibits tyrosinase activity, and protects against hypochlorite-induced damage in human dermal fibroblast aged cells. The presence of hydroxystilbene in resistant Phoenix dactylifera L. suggests its potential as an anti-aging compound.