期刊
CELLS
卷 11, 期 24, 页码 -出版社
MDPI
DOI: 10.3390/cells11244102
关键词
cannabinoids; cannabinoid receptors; endocannabinoid system; atopic dermatitis; allergic contact dermatitis; dermatomyositis; fibrosis; inflammation; pruritus; psoriasis; systemic sclerosis; wound healing
类别
资金
- German Research Foundation (DFG) [HI 813/9-1]
- European Social Fund [ESF/14-BM-A55-0002/18]
- Ministry of Education, Science, and Culture of Mecklenburg-Vorpommern, Germany
- Federal Ministry of Education and Research (BMBF), Germany [03ZZ0928A, 03ZZ0933A]
The endocannabinoid system plays a role in various skin functions and has potential therapeutic applications in the treatment of skin diseases, including inflammatory, fibrotic, and pruritic conditions.
The endocannabinoid system has been shown to be involved in various skin functions, such as melanogenesis and the maintenance of redox balance in skin cells exposed to UV radiation, as well as barrier functions, sebaceous gland activity, wound healing and the skin's immune response. In addition to the potential use of cannabinoids in the treatment and prevention of skin cancer, cannabinoid compounds and derivatives are of interest as potential systemic and topical applications for the treatment of various inflammatory, fibrotic and pruritic skin conditions. In this context, cannabinoid compounds have been successfully tested as a therapeutic option for the treatment of androgenetic alopecia, atopic and seborrhoeic dermatitis, dermatomyositis, asteatotic and atopic eczema, uraemic pruritis, scalp psoriasis, systemic sclerosis and venous leg ulcers. This review provides an insight into the current literature on cannabinoid compounds as potential medicines for the treatment of skin diseases.
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