The Role of Oxytocin in Abnormal Brain Development: Effect on Glial Cells and Neuroinflammation

Article Neurosciences

Mapping the Plasticity of Morphology, Molecular Properties and Function in Mouse Primary Microglia

Xue Jiang et al.

Summary: Microglia display diverse phenotypes with different plasticity in response to different stimuli, which is important for maintaining homeostasis in the brain.

FRONTIERS IN CELLULAR NEUROSCIENCE (2022)

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Article Neurosciences

Whole-Brain Wiring Diagram of Oxytocin System in Adult Mice

Seoyoung Son et al.

Summary: This study provides a comprehensive mapping of Oxt neurons in the whole brain of adult male and female mice, revealing the anatomical connectivity and relationship with Oxtr expression in different hypothalamic regions, shedding light on the distinct functions of Oxt signaling in the brain.

JOURNAL OF NEUROSCIENCE (2022)

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Article Neurosciences

Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain

Samuel E. Marsh et al.

Summary: Enzymatic dissociation during single-cell sequencing experiments can lead to aberrant gene expression, especially in microglia. A validated protocol is presented to preserve in vivo transcriptional profiles and cell-type diversity and yield. Similar gene expression changes are observed in postmortem human brain tissue, and these changes can be induced by exposure to elevated temperatures ex vivo.

NATURE NEUROSCIENCE (2022)

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Article Neurosciences

Oxytocin receptor expression patterns in the human brain across development

Jaroslav Rokicki et al.

Summary: Oxytocin plays a vital role in social behavior and homeostatic processes through its impact on gene expression in the brain. The developmental trajectory of OXTR gene expression is still unclear, but this study demonstrates distinct patterns in both human and macaque brains, and identifies a gene network associated with psychiatric illness and body composition phenotypes.

NEUROPSYCHOPHARMACOLOGY (2022)

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Article Clinical Neurology

Identification of oxytocin expression in human and murine microglia

Yuko Maejima et al.

Summary: The study found expression of oxytocin in microglia, suggesting that oxytocin may regulate the release of inflammatory cytokines from microglia in a paracrine/autocrine manner.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2022)

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Article Neurosciences

Microglia states and nomenclature: A field at its crossroads

Rosa C. Paolicelli et al.

NEURON (2022)

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Review Neurosciences

Emerging role of astrocytes in oxytocin-mediated control of neural circuits and brain functions

Angel Baudon et al.

Summary: The neuropeptide oxytocin has been studied for its effects on physiology, neuronal circuits, and behaviors, particularly sociality. Recent studies have shown the existence and importance of astroglial oxytocin receptors in various brain regions. The role of astrocytic oxytocin receptors in neuromodulation and integrated brain functions still needs further investigation.

PROGRESS IN NEUROBIOLOGY (2022)

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Review Neurosciences

Missing pieces in decoding the brain oxytocin puzzle: Functional insights from mouse brain wiring diagrams

Steffy B. Manjila et al.

Summary: This review integrates the brain wide connectivity of Oxt neurons and their downstream circuits with OxtR expression in mice. It categorizes Oxt connected brain regions into three functional modules that regulate internal state, somatic visceral, and cognitive response, each containing three neural circuits processing distinct behavioral effects.

FRONTIERS IN NEUROSCIENCE (2022)

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Article Biology

Endogenous oxytocin exerts anti-nociceptive and anti-inflammatory effects in rats

Haruki Nishimura et al.

Summary: The analgesic effect of oxytocin is mediated through its receptor and contributes to the anti-nociception and anti-inflammatory response. A transgenic rat line expressing hM3Dq and mCherry in oxytocin neurons was generated and demonstrated that oxytocin activates specific neurons and attenuates hyperalgesia. This analgesic effect is abolished by oxytocin receptor antagonist.

COMMUNICATIONS BIOLOGY (2022)

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Article Cell Biology

A dorsal CA2 to ventral CA1 circuit contributes to oxytocinergic modulation of long-term social recognition memory

Tsung-Chih Tsai et al.

Summary: This study reveals the crucial role of oxytocin receptor signaling in the dorsal hippocampus CA2 region in governing the persistence of long-term social recognition memory (SRM). By investigating the neural circuitry involved, the researchers identify the connection from dorsal CA2 to ventral CA1 as necessary for the formation of long-term SRM.

JOURNAL OF BIOMEDICAL SCIENCE (2022)

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Article Nanoscience & Nanotechnology

Oxytocin Nanogels Inhibit Innate Inflammatory Response for Early Intervention in Alzheimer?s Disease

Caihua Ye et al.

Summary: Researchers developed oxytocin-loaded angiopep-2-modified chitosan nanogels (AOC NGs) to inhibit microglial activation and reduce neuroinflammation in the early stage of Alzheimer's disease. The nanogels successfully crossed the blood-brain barrier and effectively slowed disease progression, prevented cognitive impairment, and delayed hippocampal atrophy in mice.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Clinical Neurology

Neonatal amygdala resting-state functional connectivity and socio-emotional development in very preterm children

Dana Kanel et al.

Summary: Very preterm children are more likely to have difficulties in socio-emotional processing, possibly due to changes in the development of the limbic system. This study found that the resting-state functional connectivity of the amygdala at term-equivalent age is associated with socio-emotional outcomes in childhood.

BRAIN COMMUNICATIONS (2022)

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Article Psychology, Developmental

NICU music therapy effects on maternal mental health and preterm infant's emotional arousal

Ambra Palazzi et al.

Summary: The study showed that music therapy has positive effects on both preterm infants and their mothers, reducing maternal anxiety and depression levels and promoting growth and recovery in preterm infants. Music therapy can also improve maternal emotional health and help reduce the length of hospitalization for preterm infants.

INFANT MENTAL HEALTH JOURNAL (2021)

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Article Immunology

Astrocyte-derived CCL7 promotes microglia-mediated inflammation following traumatic brain injury

Jianqin Xue et al.

Summary: This study revealed the important role of astrocyte-derived CCL7 in promoting microglia-mediated inflammation after TBI, suggesting CCL7 could serve as a potential therapeutic strategy for attenuating TBI by inhibiting microglial activation.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Review Endocrinology & Metabolism

The oxytocin system and early-life experience-dependent plastic changes

Tatsushi Onaka et al.

Summary: Early-life experiences, including affiliative tactile stimuli, can impact social and emotional behavior in adulthood. Oxytocin plays a role in early-life stages, but the mechanisms behind its effects are not fully understood. Affiliative tactile stimuli and early-life adverse stimuli affect the oxytocin-oxytocin receptor system differently, with potential implications for social and emotional behavior in adulthood.

JOURNAL OF NEUROENDOCRINOLOGY (2021)

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Review Immunology

The semantics of microglia activation: neuroinflammation, homeostasis, and stress

Samuel C. Woodburn et al.

Summary: Microglia are increasingly recognized as critical regulators of neuronal function and behavior in neuroscience. Research has shifted focus from their classical immune functions in pathological contexts to neuro-immune interactions in the absence of disease, injury, or infection. Standard methods to study and define microglial phenotype and function are being developed to facilitate the development of microglia-directed therapeutics in psychiatric and neurological diseases.

JOURNAL OF NEUROINFLAMMATION (2021)

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Article Neurosciences

Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents

Jerome Wahis et al.

Summary: This study reveals a morphologically distinct subpopulation of astrocytes expressing OT receptors in the central amygdala of mice and rats, mediating the anxiolytic and positive reinforcement effects of OT. It challenges the traditional belief that OT exclusively acts on neurons, highlighting the essential role of astrocytes in modulating emotional states under normal and chronic pain conditions.

NATURE NEUROSCIENCE (2021)

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Article Nutrition & Dietetics

Impact of Fetal Growth Restriction on the Neonatal Microglial Proteome in the Rat

Manuela Zinni et al.

Summary: The study found that IUGR induced by LPD significantly affects the development and proteome of microglial cells. Proteins associated with fetal growth, inflammation, immune response, and oxidative stress were significantly enriched or upregulated in LPD microglia at P1 and P4. Additionally, differences in protein expression were observed between control and LPD microglia during postnatal development.

NUTRIENTS (2021)

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Review Neurosciences

Endogenous Oxytocin Levels in Autism-A Meta-Analysis

Matthijs Moerkerke et al.

Summary: The meta-analysis showed that children with ASD have lower levels of endogenous OT compared to neurotypical controls, but this difference seems to disappear in adolescent and adult populations. Differences in OT levels between individuals with and without ASD were mainly present in studies with male participants, highlighting the need for more research using homogeneous methods.

BRAIN SCIENCES (2021)

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Article Cell Biology

Microglial identity and inflammatory responses are controlled by the combined effects of neurons and astrocytes

Paul S. Baxter et al.

Summary: Neurons and astrocytes cooperate to promote microglial ramification and induce the expression of signature genes, while repressing infection- and injury-associated gene sets. This influence is mediated through TGF-beta 2 signaling and helps limit the feedback effects of inflammation on neurons and astrocytes.

CELL REPORTS (2021)

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Article Neurosciences

Neuronal Representation of Locomotion During Motivated Behavior in the Mouse Anterior Cingulate Cortex

Sachuriga et al.

Summary: In this study, researchers investigated how individual and ensembles of ACC neurons temporally represent information for locomotion and behavioral outcomes during a self-paced locomotor reward-based task in mice. They found that more than two-fifths of the neurons showed phasic activity related to locomotion or the reward behavior, with some neurons exhibiting significant differences in firing rate depending on the behavioral outcome. By utilizing a demixed principal component analysis, the ACC population activity was separated into components representing locomotion and previous/future outcomes, demonstrating the dynamic integration of motor and behavioral inputs by ACC neurons during goal-directed behaviors.

FRONTIERS IN SYSTEMS NEUROSCIENCE (2021)

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Article Neurosciences

Experimental cerebral palsy causes microstructural brain damage in areas associated to motor deficits but no spatial memory impairments in the developing rat

E. F. Sanches et al.

Summary: The study described brain damage and behavioral alterations in a CP model induced by maternal inflammation, perinatal anoxia, and postnatal sensorimotor restriction. Results showed long-term brain microstructural alterations and locomotor impairments in experimental CP, providing new evidence to understand CP pathophysiological mechanisms and guide further research for neuroprotective and neurorehabilitative strategies in CP patients.

BRAIN RESEARCH (2021)

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Article Clinical Neurology

Repeated oxytocin prevents central sensitization by regulating synaptic plasticity via oxytocin receptor in a chronic migraine mouse model

Yunfeng Wang et al.

Summary: Our study demonstrated that repeated intranasal administration of OT can alleviate hyperalgesia in CM mice and prevent central sensitization. OT treatment inhibited the overexpression of phosphorylated NR2B and synaptic-associated proteins in the TNC, restoring abnormal synaptic structure. The protective effect of OT is mediated through OTR and involves downregulation of the AC1/PKA/pCREB signaling pathway.

JOURNAL OF HEADACHE AND PAIN (2021)

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Review Endocrinology & Metabolism

The multiple faces of the oxytocin and vasopressin systems in the brain

Valery Grinevich et al.

Summary: Traditionally, hypothalamic neuroendocrine cells were classified into magnocellular and parvocellular neurons for hormone release and brain circuit regulation purposes respectively. However, recent studies show these classic projections are outdated, with oxytocin and vasopressin released in the brain from dendrites and distant axon varicosities to modulate information transfer through conventional synapses.

JOURNAL OF NEUROENDOCRINOLOGY (2021)

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Article Biochemistry & Molecular Biology

Oxytocin administration in neonates shapes hippocampal circuitry and restores social behavior in a mouse model of autism

Alessandra Bertoni et al.

Summary: This study elucidated the co-expression of Magel2 and oxytocin receptor in hippocampal regions, demonstrating social memory deficits in Magel2(tm1.1Mus)-deficient mice. The research further revealed that oxytocin administration can restore the deficits and impact the development of the GABAergic system and phosphorylation modifications of KCC2.

MOLECULAR PSYCHIATRY (2021)

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Article Neurosciences

Neuroinflammatory astrocyte subtypes in the mouse brain

Philip Hasel et al.

Summary: This study investigated the transcriptome changes of mouse cortical astrocytes after an acute inflammatory stimulus, revealing rapid and drastic changes over time. By sequencing thousands of astrocytes at single-cell resolution, it was shown that inflammation causes a widespread response with distinct subtypes undergoing inflammatory transitions with defined transcriptomic profiles. Spatial transcriptomics and in situ hybridization were used to attribute specific inflammation-induced reactive astrocyte sub-states to certain brain regions.

NATURE NEUROSCIENCE (2021)

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Article Multidisciplinary Sciences

Maternal speech decreases pain scores and increases oxytocin levels in preterm infants during painful procedures

Manuela Filippa et al.

Summary: This study found that the mother's voice can effectively alleviate pain in preterm infants and is associated with the release of endogenous oxytocin. Vocal contact may serve as a promising protective mechanism during early painful interventions.

SCIENTIFIC REPORTS (2021)

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Article Geriatrics & Gerontology

The Unfolded Protein Response in Immune Cells as an Emerging Regulator of Neuroinflammation

Dominique Fernandez et al.

Summary: Immune surveillance is crucial for maintaining the homeostasis of a healthy brain, with microglia playing a key role in this process and in neurodegenerative diseases.

FRONTIERS IN AGING NEUROSCIENCE (2021)

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Review Neurosciences

Diversity of Axonal and Dendritic Contributions to Neuronal Output

Jean-Marc Goaillard et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2020)

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Article Multidisciplinary Sciences

Quantitative cellular-resolution map of the oxytocin receptor in postnatally developing mouse brains

Kyra T. Newmaster et al.

NATURE COMMUNICATIONS (2020)

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Review Medicine, General & Internal

Hypothalamic Neuropeptide Brain Protection: Focus on Oxytocin

Maria Antonietta Panaro et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Article Neurosciences

Oxytocin induces long-lasting adaptations within amygdala circuitry in autism: a treatment-mechanism study with randomized placebo-controlled design

Kaat Alaerts et al.

NEUROPSYCHOPHARMACOLOGY (2020)

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Review Immunology

Interaction of Microglia and Astrocytes in the Neurovascular Unit

Li-rong Liu et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Immunology

Crosstalk Between Astrocytes and Microglia: An Overview

Agata Matejuk et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Neurosciences

CD49f Is a Novel Marker of Functional and Reactive Human iPSC-Derived Astrocytes

Lilianne Barbar et al.

NEURON (2020)

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Article Behavioral Sciences

Central but not peripheral oxytocin administration reduces risk-based decision-making in male rats

Danielle N. Tapp et al.

HORMONES AND BEHAVIOR (2020)

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Article Multidisciplinary Sciences

Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model

Kevin A. Guttenplan et al.

NATURE COMMUNICATIONS (2020)

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Article Multidisciplinary Sciences

Distinct dynamics of social motivation drive differential social behavior in laboratory rat and mouse strains

Shai Netser et al.

NATURE COMMUNICATIONS (2020)

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Article Neurosciences

Longitudinal study of neonatal brain tissue volumes in preterm infants and their ability to predict neurodevelopmental outcome

L. Gui et al.

NEUROIMAGE (2019)

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Article Neurosciences

Mitochondria, Oxytocin, and Vasopressin: Unfolding the Inflammatory Protein Response

Evan A. Bordt et al.

NEUROTOXICITY RESEARCH (2019)

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Article Multidisciplinary Sciences

Oxytocin pathway gene networks in the human brain

Daniel S. Quintana et al.

NATURE COMMUNICATIONS (2019)

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Article Biochemistry & Molecular Biology

Attenuation of Oxytocin and Serotonin 2A Receptor Signaling through Novel Heteroreceptor Formation

Barbara Chruscicka et al.

ACS CHEMICAL NEUROSCIENCE (2019)

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Article Neurosciences

An Exploratory Examination of Neonatal Cytokines and Chemokines as Predictors of Autism Risk: The Early Markers for Autism Study

Luke S. Heuer et al.

BIOLOGICAL PSYCHIATRY (2019)

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Article Neurosciences

A Fear Memory Engram and Its Plasticity in the Hypothalamic Oxytocin System

Mazahir T. Hasan et al.

NEURON (2019)

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Article Cell Biology

Oxytocin Suppresses Inflammatory Responses Induced by Lipopolysaccharide through Inhibition of the eIF-2α-ATF4 Pathway in Mouse Microglia

Takayuki Inoue et al.

CELLS (2019)

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Article Immunology

Serum cytokine levels in children with spectrum autism disorder: Differences in pro- and anti-inflammatory balance

Natalia Karolina Kordulewska et al.

JOURNAL OF NEUROIMMUNOLOGY (2019)

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Article Psychiatry

A meta-analysis of pro-inflammatory cytokines in autism spectrum disorders: Effects of age, gender, and latitude

Amene Saghazadeh et al.

JOURNAL OF PSYCHIATRIC RESEARCH (2019)

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Article Clinical Neurology

Decreased microglial Wnt/β-catenin signalling drives microglial pro-inflammatory activation in the developing brain

Juliette Van Steenwinckel et al.

BRAIN (2019)

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Article Neurosciences

Oxytocin receptor agonist reduces perinatal brain damage by targeting microglia

Jerome Mairesse et al.

GLIA (2019)

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Article Immunology

Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes

Timothy R. Hammond et al.

IMMUNITY (2019)

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Article Neurosciences

Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing

Qingyun Li et al.

NEURON (2019)

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Article Nursing

Parent Engagement Correlates With Parent and Preterm Infant Oxytocin Release During Skin-to-Skin Contact

Dorothy Vittner et al.

ADVANCES IN NEONATAL CARE (2019)

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Review Psychology, Multidisciplinary

Pain, Parental Involvement, and Oxytocin in the Neonatal Intensive Care Unit

Manuela Filippa et al.

FRONTIERS IN PSYCHOLOGY (2019)

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Article Neurosciences

Combined fetal inflammation and postnatal hypoxia causes myelin deficits and autism-like behavior in a rat model of diffuse white matter injury

Erik van Tilborg et al.

GLIA (2018)

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Article Neurosciences

Conditional Deletion of Hippocampal CA2/CA3a Oxytocin Receptors Impairs the Persistence of Long-Term Social Recognition Memory in Mice

Yu-Ting Lin et al.

JOURNAL OF NEUROSCIENCE (2018)

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Article Obstetrics & Gynecology

The global epidemiology of preterm birth

Joshua P. Vogel et al.

BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY (2018)

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Review Clinical Neurology

Neurologic Consequences of Preterm Birth

Margie A. Ream et al.

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2018)

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Article Biochemistry & Molecular Biology

The risk of neurodevelopmental disorders at age 10 years associated with blood concentrations of interleukins 4 and 10 during the first postnatal month of children born extremely preterm

Alan Leviton et al.

CYTOKINE (2018)

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Article Pharmacology & Pharmacy

Oxytocin inhibited stress induced visceral hypersensitivity, enteric glial cells activation, and release of proinflammatory cytokines in maternal separated rats

Shaoxian Xu et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2018)

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Review Neurosciences

Molecular Mechanisms of Oxytocin Signaling at the Synaptic Connection

Jan Bakos et al.

NEURAL PLASTICITY (2018)

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Article Medicine, Research & Experimental

Oxytocin improves animal behaviors and ameliorates oxidative stress and inflammation in autistic mice

Yu Wang et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Review Neurosciences

Oxytocin and Vasopressin, and the GABA Developmental Shift During Labor and Birth: Friends or Foes?

Yehezkel Ben-Ari

FRONTIERS IN CELLULAR NEUROSCIENCE (2018)

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Article Neurosciences

Oxytocin Enhancement of Emotional Empathy: Generalization Across Cultures and Effects on Amygdala Activity

Yayuan Geng et al.

FRONTIERS IN NEUROSCIENCE (2018)

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Article Neurosciences

Neonatal Oxytocin Treatment Ameliorates Autistic-Like Behaviors and Oxytocin Deficiency in Valproic Acid-Induced Rat Model of Autism

Yu-Chuan Dai et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2018)

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Article Nursing

Increase in Oxytocin From Skin-to-Skin Contact Enhances Development of Parent-Infant Relationship

Dorothy Vittner et al.

BIOLOGICAL RESEARCH FOR NURSING (2018)

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Article Clinical Neurology

Gestational age and gender influence on executive control and its related neural structures in preterm-born children at 6 years of age

Sebastien Urben et al.

CHILD NEUROPSYCHOLOGY (2017)

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Article Neurosciences

Oxytocin and Serotonin Brain Mechanisms in the Nonhuman Primate

Arthur Lefevre et al.

JOURNAL OF NEUROSCIENCE (2017)

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Article Multidisciplinary Sciences

Neurotoxic reactive astrocytes are induced by activated microglia

Shane A. Liddelow et al.

NATURE (2017)

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Review Pharmacology & Pharmacy

The Action Radius of Oxytocin Release in the Mammalian CNS: From Single Vesicles to Behavior

Bice Chini et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2017)

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Article Multidisciplinary Sciences

Increased striatal activity in adolescence benefits learning

S. Peters et al.

NATURE COMMUNICATIONS (2017)

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Article Multidisciplinary Sciences

Oxytocin stimulates hippocampal neurogenesis via oxytocin receptor expressed in CA3 pyramidal neurons

Yu-Ting Lin et al.

NATURE COMMUNICATIONS (2017)

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Article Multidisciplinary Sciences

Hippocampal oxytocin receptors are necessary for discrimination of social stimuli

Tara Raam et al.

NATURE COMMUNICATIONS (2017)

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Review Neurosciences

The Immune System, Cytokines, and Biomarkers in Autism Spectrum Disorder

Anne Masi et al.

NEUROSCIENCE BULLETIN (2017)

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Article Neurosciences

Oxytocin Rapidly Changes Astrocytic GFAP Plasticity by Differentially Modulating the Expressions of pERK 1/2 and Protein Kinase A

Ping Wang et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2017)

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Article Biochemistry & Molecular Biology

Neonatal maternal separation delays the GABA excitatory-to-inhibitory functional switch by inhibiting KCC2 expression

Minami Furukawa et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

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Article Physiology

Dendritic Release of Neurotransmitters

Mike Ludwig et al.

COMPREHENSIVE PHYSIOLOGY (2017)

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Review Pediatrics

Suboptimal bonding impairs hormonal, epigenetic and neuronal development in preterm infants, but these impairments can be reversed

D. Kommers et al.

ACTA PAEDIATRICA (2016)

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Article Biochemistry & Molecular Biology

Prenatal minocycline treatment alters synaptic protein expression, and rescues reduced mother call rate in oxytocin receptor-knockout mice

Shinji Miyazaki et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

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Review Neurosciences

Assembling the Puzzle: Pathways of Oxytocin Signaling in the Brain

Valery Grinevich et al.

BIOLOGICAL PSYCHIATRY (2016)

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Article Obstetrics & Gynecology

Social reasoning abilities in preterm and full-term children aged 5-7 years

Fleur Lejeune et al.

EARLY HUMAN DEVELOPMENT (2016)

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Article Behavioral Sciences

Are age and sex differences in brain oxytocin receptors related to maternal and infanticidal behavior in naive mice?

Daniel E. Olazabal et al.

HORMONES AND BEHAVIOR (2016)

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Review Neurosciences

The search for true numbers of neurons and glial cells in the human brain: A review of 150 years of cell counting

Christopher S. von Bartheld et al.

JOURNAL OF COMPARATIVE NEUROLOGY (2016)

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Article Endocrinology & Metabolism

Sex Differences in the Embryonic Development of the Central Oxytocin System in Mice

S. Tamborski et al.

JOURNAL OF NEUROENDOCRINOLOGY (2016)

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Article Immunology

Oxytocin inhibits lipopolysaccharide-induced inflammation in microglial cells and attenuates microglial activation in lipopolysaccharide-treated mice

Lin Yuan et al.

JOURNAL OF NEUROINFLAMMATION (2016)

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Article Medicine, General & Internal

Global, regional, and national causes of under-5 mortality in 2000-15: an updated systematic analysis with implications for the Sustainable Development Goals

Li Liu et al.

LANCET (2016)

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Article Neurosciences

A New Population of Parvocellular Oxytocin Neurons Controlling Magnocellular Neuron Activity and Inflammatory Pain Processing

Marina Eliava et al.

NEURON (2016)

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Article Multidisciplinary Sciences

New tools for studying microglia in the mouse and human CNS

Mariko L. Bennett et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Article Anatomy & Morphology

Altered Amygdala Development and Fear Processing in Prematurely Born Infants

Anca Liliana Cismaru et al.

FRONTIERS IN NEUROANATOMY (2016)

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Article Cell Biology

The Timing of the Excitatory-to-Inhibitory GABA Switch Is Regulated by the Oxytocin Receptor via KCC2

Marianna Leonzino et al.

CELL REPORTS (2016)

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Review Neurosciences

The Role of Hypothalamic Neuropeptides in Neurogenesis and Neuritogenesis

Jan Bakos et al.

NEURAL PLASTICITY (2016)

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Article Cell Biology

An overview of the oxytocin-oxytocin receptor signaling network

Oishi Chatterjee et al.

JOURNAL OF CELL COMMUNICATION AND SIGNALING (2016)

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Article Neurosciences

An Early Postnatal Oxytocin Treatment Prevents Social and Learning Deficits in Adult Mice Deficient for Magel2, a Gene Involved in Prader-Willi Syndrome and Autism

Hamid Meziane et al.

BIOLOGICAL PSYCHIATRY (2015)

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Article Genetics & Heredity

An Evolutionarily Conserved Switch in Response to GABA Affects Development and Behavior of the Locomotor Circuit of Caenorhabditis elegans

Bingjie Han et al.

GENETICS (2015)

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Article Neurosciences

Microglial P2X7 receptor in the hypothalamic paraventricular nuclei contributes to sympathoexcitatory responses in acute myocardial infarction rat

Dongshu Du et al.

NEUROSCIENCE LETTERS (2015)

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Article Clinical Neurology

The Breadth and Type of Systemic Inflammation and the Risk of Adverse Neurological Outcomes in Extremely Low Gestation Newborns

Karl C. K. Kuban et al.

PEDIATRIC NEUROLOGY (2015)

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Review Biology

Multiple signalling modalities mediated by dendritic exocytosis of oxytocin and vasopressin

Mike Ludwig et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2015)

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Article Multidisciplinary Sciences

Neural mechanisms of social decision-making in the primate amygdala

Steve W. C. Chang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Article Psychiatry

A pilot double-blind placebo-controlled trial of pioglitazone as adjunctive treatment to risperidone: Effects on aberrant behavior in children with autism

Ali Ghaleiha et al.

PSYCHIATRY RESEARCH (2015)

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Review Anatomy & Morphology

Ontogenesis of oxytocin pathways in the mammalian brain: late maturation and psychosocial disorders

Valery Grinevich et al.

FRONTIERS IN NEUROANATOMY (2015)

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Article Genetics & Heredity

An Evolutionarily Conserved Switch in Response to GABA Affects Development and Behavior of the Locomotor Circuit of Caenorhabditis elegans

Bingjie Han et al.

GENETICS (2015)

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Article Medicine, General & Internal

Altered Microglia in the Amygdala Are Involved in Anxiety-related Behaviors of a Copy Number Variation Mouse Model of Autism

Tomoko Shigemori et al.

JOURNAL OF NIPPON MEDICAL SCHOOL (2015)

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Review Neurosciences

Developmental Perspectives on Oxytocin and Vasopressin

Elizabeth A. D. Hammock

NEUROPSYCHOPHARMACOLOGY (2015)

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Article Biochemistry & Molecular Biology

Brain damage of the preterm infant: new insights into the role of inflammation

Juliette Van Steenwinckel et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2014)

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Article Clinical Neurology

Risk of cerebral palsy in relation to pregnancy disorders and preterm birth: a national cohort study

Havard Tronnes et al.

DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY (2014)

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Article Obstetrics & Gynecology

Emotional and effortful control abilities in 42-month-old very preterm and full-term children

Arnaud Witt et al.

EARLY HUMAN DEVELOPMENT (2014)

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Article Neurosciences

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

Ye Zhang et al.

JOURNAL OF NEUROSCIENCE (2014)

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Article Neurosciences

Oxytocin mediates early experience-dependent cross-modal plasticity in the sensory cortices

Jing-Jing Zheng et al.

NATURE NEUROSCIENCE (2014)

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Article Multidisciplinary Sciences

Functional Neuroanatomy of Executive Function after Neonatal Brain Injury in Adults Who Were Born Very Preterm

Anastasia K. Kalpakidou et al.

PLOS ONE (2014)

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Article Neurosciences

Modeling Transformations of Neurodevelopmental Sequences across Mammalian Species

Alan D. Workman et al.

JOURNAL OF NEUROSCIENCE (2013)

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Article Multidisciplinary Sciences

Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin

Guel Doelen et al.

NATURE (2013)

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Review Neurosciences

Brain development in rodents and humans: Identifying benchmarks of maturation and vulnerability to injury across species

Bridgette D. Semple et al.

PROGRESS IN NEUROBIOLOGY (2013)

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Article Endocrinology & Metabolism

Oxytocin mediates rodent social memory within the lateral septum and the medial amygdala depending on the relevance of the social stimulus: Male juvenile versus female adult conspecifics

Michael Lukas et al.

PSYCHONEUROENDOCRINOLOGY (2013)

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Article Neurosciences

Celecoxib as adjunctive treatment to risperidone in children with autistic disorder: a randomized, double-blind, placebo-controlled trial

Mahtab Asadabadi et al.

PSYCHOPHARMACOLOGY (2013)

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Article Behavioral Sciences

Oxytocin receptor ligand binding in embryonic tissue and postnatal brain development of the C57BL/6J mouse

Elizabeth A. D. Hammock et al.

FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2013)

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Review Public, Environmental & Occupational Health

Born Too Soon: The global epidemiology of 15 million preterm births

Hannah Blencowe et al.

REPRODUCTIVE HEALTH (2013)

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Review Neurosciences

Autism spectrum disorder in children born preterm-role of exposure to perinatal inflammation

Suzanne J. Meldrum et al.

FRONTIERS IN NEUROSCIENCE (2013)

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Review Clinical Neurology

Inflammation during fetal and neonatal life: Implications for neurologic and neuropsychiatric disease in children and adults

Henrik Hagberg et al.

ANNALS OF NEUROLOGY (2012)

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Review Endocrinology & Metabolism

Oxytocin and Vasopressin Agonists and Antagonists as Research Tools and Potential Therapeutics

M. Manning et al.

JOURNAL OF NEUROENDOCRINOLOGY (2012)

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Article Neurosciences

Dopamine neurons in the ventral tegmental area fire faster in adolescent rats than in adults

James E. McCutcheon et al.

JOURNAL OF NEUROPHYSIOLOGY (2012)

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Article Neurosciences

Evoked Axonal Oxytocin Release in the Central Amygdala Attenuates Fear Response

H. Sophie Knobloch et al.

NEURON (2012)

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Article Nursing

Music Therapy Research in the NICU: An Updated Meta-Analysis

Jayne Standley

NEONATAL NETWORK (2012)

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Article Clinical Neurology

Systemic Inflammation Disrupts the Developmental Program of White Matter

Geraldine Favrais et al.

ANNALS OF NEUROLOGY (2011)

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Review Medicine, Research & Experimental

Cross talk between activation of microglia and astrocytes in pathological conditions in the central nervous system

W. Liu et al.

LIFE SCIENCES (2011)

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Article Multidisciplinary Sciences

Spatio-temporal transcriptome of the human brain

Hyo Jung Kang et al.

NATURE (2011)

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Article Multidisciplinary Sciences

Oxytocin Selectively Gates Fear Responses Through Distinct Outputs from the Central Amygdala

Daniele Viviani et al.

SCIENCE (2011)

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Article Clinical Neurology

Oxytocin Mediates Social Neuroprotection After Cerebral Ischemia

Kate Karelina et al.

STROKE (2011)

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Article Psychology, Developmental

QUALITY OF ATTACHMENT, PERINATAL RISK, AND MOTHER-INFANT INTERACTION IN A HIGH-RISK PREMATURE SAMPLE

Laura Udry-Jorgensen et al.

INFANT MENTAL HEALTH JOURNAL (2011)

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Review Clinical Neurology

Preterm birth and neurodevelopmental outcome: a review

Carla Arpino et al.

CHILDS NERVOUS SYSTEM (2010)

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Article Biochemistry & Molecular Biology

A single postnatal injection of oxytocin rescues the lethal feeding behaviour in mouse newborns deficient for the imprinted Magel2 gene

Fabienne Schaller et al.

HUMAN MOLECULAR GENETICS (2010)

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Article Neurosciences

Oxytocin Enhances Amygdala-Dependent, Socially Reinforced Learning and Emotional Empathy in Humans

Rene Hurlemann et al.

JOURNAL OF NEUROSCIENCE (2010)

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Article Multidisciplinary Sciences

Genetic dissection of an amygdala microcircuit that gates conditioned fear

Wulf Haubensak et al.

NATURE (2010)

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Review Clinical Neurology

Double-blind placebo-controlled trial of pentoxifylline added to risperidone: Effects on aberrant behavior in children with autism

Shahin Akhondzadeh et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2010)

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Article Endocrinology & Metabolism

An Interaction of Oxytocin Receptors with Metabotropic Glutamate Receptors in Hypothalamic Astrocytes

J. Kuo et al.

JOURNAL OF NEUROENDOCRINOLOGY (2009)

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Article Neurosciences

Evidence That Oxytocin Exerts Anxiolytic Effects via Oxytocin Receptor Expressed in Serotonergic Neurons in Mice

Masahide Yoshida et al.

JOURNAL OF NEUROSCIENCE (2009)

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Review Clinical Neurology

Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances

Joseph J. Volpe

LANCET NEUROLOGY (2009)

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Article Neurosciences

Oxytocin attenuates affective evaluations of conditioned faces and amygdala activity

Predrag Petrovic et al.

JOURNAL OF NEUROSCIENCE (2008)

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Article Clinical Neurology

A dual role of the NF-κB pathway in neonatal hypoxic-ischemic brain damage

Cora H. Nijboer et al.

STROKE (2008)

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Article Neurosciences

Interaction of extracellular signal-regulated protein kinase 1/2 with actin cytoskeleton in Supraoptic oxytocin neurons and astrocytes: Role in burst firing

Yu-Feng Wang et al.

JOURNAL OF NEUROSCIENCE (2007)

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Article Biochemistry & Molecular Biology

Stimuli and consequences of dendritic release of oxytocin within the brain

I. D. Neumann

BIOCHEMICAL SOCIETY TRANSACTIONS (2007)

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Article Behavioral Sciences

Sex differences in oxytocin and vasopressin: Implications for autism spectrum disorders?

C. Sue Carter

BEHAVIOURAL BRAIN RESEARCH (2007)

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Review Neurosciences

Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

Michelle L. Block et al.

NATURE REVIEWS NEUROSCIENCE (2007)

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Article Multidisciplinary Sciences

Maternal oxytocin triggers a transient inhibitory switch in GABA signaling in the fetal brain during delivery

Roman Tyzio et al.

SCIENCE (2006)

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Review Neurosciences

Dendritic peptide release and peptide-dependent behaviours

M Ludwig et al.

NATURE REVIEWS NEUROSCIENCE (2006)

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Review Neurosciences

Cerebral palsy

Michael V. Johnston et al.

NEUROMOLECULAR MEDICINE (2006)

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Article Neurosciences

Brain oxytocin correlates with maternal aggression: Link to anxiety

OJ Bosch et al.

JOURNAL OF NEUROSCIENCE (2005)

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Article Multidisciplinary Sciences

Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala

D Huber et al.

SCIENCE (2005)

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Article Geriatrics & Gerontology

Importance of MAPK pathways for microglial pro-inflammatory cytokine IL-1β production

SH Kim et al.

NEUROBIOLOGY OF AGING (2004)

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Article Neurosciences

Quantitative analysis of perinatal rodent oligodendrocyte lineage progression and its correlation with human

A Craig et al.

EXPERIMENTAL NEUROLOGY (2003)

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Article Immunology

Hormonal regulation of cytokine release by human fetal membranes at term gestation:: effects of oxytocin, hydrocortisone and progesterone on tumour necrosis factor-α and transforming growth factor-β 1 output

A Zicari et al.

JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2002)

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Article Neurosciences

Neurons modulate oxytocin receptor expression in rat cultured astrocytes:: Involvement of TGF-β and membrane components

P Mittaud et al.

GLIA (2002)

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Review Physiology

The Oxytocin Receptor System: Structure, function, and regulation

G Gimpl et al.

PHYSIOLOGICAL REVIEWS (2001)

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Article Neurosciences

LPS-induced Fos expression in oxytocin and vasopressin neurons of the rat hypothalamus

W Matsunaga et al.

BRAIN RESEARCH (2000)

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The Role of Oxytocin in Abnormal Brain Development: Effect on Glial Cells and Neuroinflammation

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