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MHC Class II Presentation in Autoimmunity

CELLS (2023)

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Article Immunology

Association of HLA-DRB1 Alleles with Rheumatic Fever and Rheumatic Heart Disease: A Meta-analysis

Maheshkumar Poomarimuthu et al.

Summary: This study investigated the association between HLA class II genes and RF/RHD through meta-analysis. The results suggest that the increased frequency of HLA-DRB1*07 allele and the decreased frequency of HLA-DRB1*15 allele may play a crucial role in the pathogenesis of RF/RHD. However, there was no significant difference in the frequency of HLA-DQB1 alleles between RF/RHD patients and controls.

IMMUNOLOGICAL INVESTIGATIONS (2022)

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Review Biochemistry & Molecular Biology

Multiple sclerosis and myelin basic protein: insights into protein disorder and disease

Vebjorn Martinsen et al.

Summary: MBP is an abundant protein in CNS myelin and is studied in relation to the pathogenesis of MS. While its direct role as a primary antigen in human MS is unclear, MBP and its functions in myelin formation and maintenance are linked to the disease. This molecule demonstrates the complex relationship between normal nervous system development and neurodegenerative disease.

AMINO ACIDS (2022)

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Article Rheumatology

Key interactions in the trimolecular complex consisting of the rheumatoid arthritis-associated DRB1*04:01 molecule, the major glycosylated collagen II peptide and the T-cell receptor

Changrong Ge et al.

Summary: This study characterizes the autoantigen-presenting function of DRB1*04:01 and investigates T-cell responses to a specific peptide in patients with rheumatoid arthritis, revealing the importance of glycosylation of lysine residues in T-cell recognition.

ANNALS OF THE RHEUMATIC DISEASES (2022)

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Article Endocrinology & Metabolism

Upregulation of HLA class II in pancreatic beta cells from organ donors with type 1 diabetes

Estefania Quesada-Masachs et al.

Summary: This study characterized and quantified the expression of HLA class II in human pancreatic tissue, showing that HLA-II can be expressed by pancreatic beta cells from patients with type 1 diabetes. It also demonstrated that this upregulation can be induced in vitro in healthy isolated human islets or reaggregated human islets by treatment with proinflammatory cytokines. The findings support a role for HLA-II in type 1 diabetes pathogenesis as potential targets for autoreactive CD4(+) lymphocytes.

DIABETOLOGIA (2022)

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Article Immunology

Protective HLA Alleles Recruit Biased and Largely Similar Antigen-Specific T Cell Repertoires across Different Outcomes in HIV Infection

Dan Koning et al.

Summary: CD8(+) T cells play a significant role in controlling untreated HIV infection. HLA-B*27 and B*57 are associated with delayed HIV disease progression, but the specific factors providing superior immunity against HIV are unclear. This study found that there were no differences in TCR diversity between progressors and slow progressors, and both HLA alleles recruited biased T cell repertoires. These findings suggest that progressors and slow progressors have highly similar T cell repertoires in terms of TCR diversity, usage, and cross-reactivity.

JOURNAL OF IMMUNOLOGY (2022)

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Article Medicine, Research & Experimental

Blocking I-Ag7 class II major histocompatibility complex by drug-like small molecules alleviated Sjogren's syndrome in NOD mice

Shivai Gupta et al.

Summary: This study proposes a novel therapeutic approach for SjS by blocking MHC class II I-Ag-7 antigen presentation in NOD mice. The results demonstrate that treating NOD mice with TATD or 8-Azaguanine can alleviate SjS symptoms and reduce the severity of the disease.

LIFE SCIENCES (2022)

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Article Biochemical Research Methods

Tuning DO:DM Ratios Modulates MHC Class II Immunopeptidomes

Niclas Olsson et al.

Summary: This study investigates the effects of DO:DM ratios on peptide presentation by creating a panel of HLA-DR4-expressing APC lines and analyzing over 10,000 unique DR4-presented peptides. The findings provide insights into the characteristics that influence peptide presentation and have implications for HLA-II prediction algorithms and research strategies.

MOLECULAR & CELLULAR PROTEOMICS (2022)

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Article Multidisciplinary Sciences

Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM

Tobias Lanz et al.

Summary: Multiple sclerosis (MS) is an autoimmune disease where autoreactive lymphocytes attack the central nervous system. Epstein-Barr virus (EBV) infection has been linked to MS, with molecular mimicry between EBV nuclear antigen 1 (EBNA1) and central nervous system protein GlialCAM. EBNA1 immunization exacerbates disease in MS mouse models and anti-EBNA1 and anti-GlialCAM antibodies are prevalent in MS patients, providing a mechanistic link between MS and EBV and guiding the development of new MS therapies.

NATURE (2022)

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Article Immunology

A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection

Evangelos Andreakos et al.

Summary: SARS-CoV-2 infections can vary greatly between individuals, with some being asymptomatic while others experience life-threatening disease. While 20% of critical COVID-19 cases are due to inborn errors or autoantibodies, the genetic and immunological factors for resistance to infection itself remain unknown. Studies have shown that autosomal recessive deficiencies in certain genes or enzymes can confer resistance to diseases, suggesting a potential strategy for identifying individuals naturally resistant to SARS-CoV-2 infection.

NATURE IMMUNOLOGY (2022)

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Article Immunology

Repertoire analyses reveal T cell antigen receptor sequence features that influence T cell fate

Kaitlyn A. Lagattuta et al.

Summary: Raychaudhuri and colleagues identified intrinsic features of T cell antigen receptors (TCRs) that govern the development of regulatory T cells. They found that the interaction between TCRs and self-peptides presented via major histocompatibility complex (MHC) plays a role in determining the regulatory phenotype of T cells. The study also revealed the importance of specific regions and genes in the TCR for regulating T cell activation.

NATURE IMMUNOLOGY (2022)

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Article Biochemistry & Molecular Biology

Ancestral SARS-CoV-2-specific T cells cross-recognize the Omicron variant

Yu Gao et al.

Summary: This study found that SARS-CoV-2 spike-specific CD4(+) and CD8(+) T cells induced by prior infection or BNT162b2 vaccination provide extensive immune coverage against the Omicron variant. Additionally, T cells induced by BNT162b2 vaccination exhibit higher cross-reactivity to the Omicron variant compared to T cells induced by prior SARS-CoV-2 infection.

NATURE MEDICINE (2022)

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Review Immunology

Impact of Antigen Presentation Mechanisms on Immune Response in Autoimmune Hepatitis

Rossella Fasano et al.

Summary: The liver is a tolerogenic organ that can induce immune tolerance against self-antigens. However, autoimmune liver diseases can disrupt this tolerance due to genetic predisposition, environmental factors, and imbalance in regulatory mechanisms. Liver cells, including conventional and unconventional antigen presenting cells (APCs), present self-antigens to T cells, leading to altered immune responses, liver injury, and inflammation. Understanding the impact of antigen presentation and the role of immune cells in liver inflammation could aid in the development of novel therapeutic strategies for autoimmune liver diseases.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Immunology

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-Specific T Cells and Antibodies in Coronavirus Disease 2019 (COVID-19) Protection: A Prospective Study

Ivan A. Molodtsov et al.

Summary: In a prospective study involving 5340 individuals, the researchers found that both humoral and cellular responses to COVID-19 are closely related to the level of protection against infection. Individuals with both antibody and T-cell responses had the lowest incidence of COVID-19. Antibody response alone provided a significant level of protection, while T-cell response alone only offered intermediate protection.

CLINICAL INFECTIOUS DISEASES (2022)

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Article Immunology

A dormant T-cell population with autoimmune potential exhibits low self-reactivity and infiltrates islets in type 1 diabetes

Yuelin Kong et al.

Summary: The contribution of low-affinity T cells to autoimmunity has been understudied due to limitations in detection methods. Our study found a population of low-affinity T cells in the pancreatic islets of prediabetic NOD mice, which exhibited reduced reactivity to self-tissue and minimal effector function but induced rapid diabetes upon transfer. These cells had transcriptional characteristics of central memory T cells and relied on TCR affinity to shape their phenotype and function. Our findings suggest that low-affinity T cells may play an important role in long-term chronic autoimmunity.

EUROPEAN JOURNAL OF IMMUNOLOGY (2022)

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Article Biochemistry & Molecular Biology

Self-Antigens Targeted by Regulatory T Cells in Type 1 Diabetes

Angela M. Mitchell et al.

Summary: Despite progress in understanding the mechanisms behind autoimmune diseases, there is limited knowledge about protective mechanisms against these diseases. In the case of type 1 diabetes, pathogenic T cells that destroy pancreatic islets are well understood, but the immune-mediated mechanisms that contribute to protection against this disease are not fully elucidated. One potential protective mechanism involves regulatory CD4 T cells that suppress immune responses by recognizing self-peptides from islets. This review summarizes current knowledge about the antigenic self-peptides recognized by Tregs in the context of type 1 diabetes.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Genetics & Heredity

HLA autoimmune risk alleles restrict the hypervariable region of T cell receptors

Kazuyoshi Ishigaki et al.

Summary: Genetic analyses provide evidence supporting the central hypothesis that HLA alleles influence T cell receptor composition and increase the risk of autoimmune diseases.

NATURE GENETICS (2022)

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Review Endocrinology & Metabolism

Persistent coxsackievirus B infection and pathogenesis of type 1 diabetes mellitus

Magloire Pandoua Nekoua et al.

Summary: This review highlights the role of persistent enterovirus infections in triggering islet autoimmunity and type 1 diabetes mellitus (T1DM), and discusses the potential of vaccination or antiviral therapies in preventing T1DM onset.

NATURE REVIEWS ENDOCRINOLOGY (2022)

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Article Multidisciplinary Sciences

Citrullination of glucokinase is linked to autoimmune diabetes

Mei-Ling Yang et al.

Summary: This study implicates the citrullination of glucokinase in autoimmune diabetes inflammation, triggering autoimmunity and affecting glucokinase biological functions. The study also identifies glucokinase as a Type 1 diabetes biomarker, providing new insights into how inflammation drives post-translational modifications and affects beta cell metabolism.

NATURE COMMUNICATIONS (2022)

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Article Multidisciplinary Sciences

A systematic review and meta-analysis of HLA class II associations in patients with IgG4 autoimmunity

Anja Panhuber et al.

Summary: Autoimmune diseases caused by pathogenic IgG4 subclass autoantibodies may be influenced by genetic factors such as HLA-DQB1*05, HLA-DRB1*14 alleles, and the HLA-DQB1*05-DRB1*14 haplotype. Conversely, the HLA-DRB1*13 allele may offer protection against IgG4 autoimmunity.

SCIENTIFIC REPORTS (2022)

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Article Clinical Neurology

Markers of Epstein-Barr virus and Human Herpesvirus-6 infection and multiple sclerosis clinical progression

Chunrong Tao et al.

Summary: This study found that higher levels of HHV-6 IgG were associated with increased risk of conversion to multiple sclerosis and relapse. However, the association with EBV was relatively limited.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2022)

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Article Multidisciplinary Sciences

Alterations in SARS-CoV-2 Omicron and Delta peptides presentation by HLA molecules

Stepan Nersisyan et al.

Summary: The presentation of viral peptides derived from Omicron, Delta, and Wuhan variants of SARS-CoV-2 were analyzed, showing destructive effects of Omicron mutations on specific peptide binding and significant reduction in peptide binding for a specific HLA class I allele in the Delta variant. Overall, most HLA alleles and haplotypes were not significantly affected by the mutations, indicating the maintenance of effective T-cell immunity against Omicron and Delta variants.

PEERJ (2022)

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Review Immunology

Gut Microbial Antigenic Mimicry in Autoimmunity

Nahir Garabatos et al.

Summary: The composition of the gut microbiota is closely related to the development of various autoimmune diseases, including inflammatory bowel disease and multiple sclerosis. Antigenic mimicry and the impact on effector and regulatory T cells are important mechanisms involved in this process.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Immunology

HLA-G and the MHC Cusp Theory

Bruna Miglioranza Scavuzzi et al.

Summary: Human leukocyte antigens (HLA) are important genetic risk factors in many diseases, but the mechanisms underlying their associations remain unclear. The MHC Cusp theory posits that in addition to antigen presentation, MHC codes for allele-specific molecules that can trigger MHC-associated diseases through interactions with receptors. Empirical evidence has supported this theory in several HLA-Class II-associated autoimmune diseases.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Multidisciplinary Sciences

Abrogation of self-tolerance by misfolded self-antigens complexed with MHC class II molecules

Hui Jin et al.

Summary: Specific MHC class II alleles are strongly associated with susceptibility to autoimmune diseases. This study found that autoantibodies in patients with Graves' disease preferentially recognize TSHR complexed with MHC class II molecules of Graves' disease risk alleles. It suggests that aberrant TSHR transported by MHC class II molecules is the target of autoantibodies produced in Graves' disease.

SCIENCE ADVANCES (2022)

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Article Biochemistry & Molecular Biology

Molecular Mimicry of the Rheumatoid Arthritis-Related Immunodominant T-Cell Epitope within Type II Collagen (CII260-270) by the Bacterial L-Asparaginase

Dzhemal Moten et al.

Summary: This study investigated the pathogenesis of rheumatoid arthritis (RA) by exploring the molecular mimicry mechanism. It found that the bacterial peptide L-ASNase67-81 can mimic the immunodominant T-cell epitope CII259-273, activate specific T cells, and induce cytokine production in cells from RA patients.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Multidisciplinary Sciences

A gut microbial peptide and molecular mimicry in the pathogenesis of type 1 diabetes

Khyati Girdhar et al.

Summary: This article investigates the potential role of Parabacteroides distasonis in the pathogenesis of type 1 diabetes (T1D). The study found that a peptide sequence from P. distasonis can activate T cells from T1D patients and nonobese diabetic mice. Colonization of the mouse colon with P. distasonis accelerates the development of T1D and elicits an immune response.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

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Article Immunology

Gut microbiota in systemic lupus erythematosus: A fuse and a solution

Yanfei Chen et al.

Summary: Gut commensals play a crucial role in shaping the host immune system and have a significant impact on human health. In the context of systemic lupus erythematosus (SLE), the gut microbiota and their metabolites have been implicated in the development and progression of the disease through various mechanisms. Modulating the gut microbiota has the potential to be a promising neoadjuvant therapy for SLE.

JOURNAL OF AUTOIMMUNITY (2022)

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Article Immunology

Antigen-specific depletion of CD4 + T cells by CAR T cells reveals distinct roles of higher- and lower-affinity TCRs during autoimmunity

Jaeu Yi et al.

Science Immunology (2022)

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Article Immunology

Attenuated immune control of Epstein-Barr virus in humanized mice is associated with the multiple sclerosis risk factor HLA-DR15

Hana Zdimerova et al.

Summary: The immune responses to Epstein-Barr virus (EBV) infection along with the main genetic risk factor HLA-DR15 are shown to synergize in increasing the likelihood of developing multiple sclerosis (MS) sevenfold. The study observed elevated activation of both CD4(+) and CD8(+) T cells in HLA-DR15 donor-reconstituted humanized mice, even when compared to those carrying HLA-DR4 which is associated with other autoimmune diseases. Despite the higher immune activation, EBV viral loads were less well controlled in the context of HLA-DR15, and CD4(+) T cell clones demonstrated cross-reactivity towards allogeneic target cells and an MS autoantigen.

EUROPEAN JOURNAL OF IMMUNOLOGY (2021)

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Article Biochemistry & Molecular Biology

Impact of Posttranslational Modification in Pathogenesis of Rheumatoid Arthritis: Focusing on Citrullination, Carbamylation, and Acetylation

Eui-Jong Kwon et al.

Summary: Rheumatoid arthritis (RA) is triggered by a complex interplay of genetic, environmental, and immunologic factors, with posttranslational modifications and cell death mechanisms playing a role in the disease's pathogenesis. Certain microbial infections may induce autoantigens, while anti-modified protein antibodies are crucial in prediction, diagnosis, and prognosis of RA. Smoking is associated with both PTMs and AMPAs in RA development, although evidence linking smoking to the generation of AMPAs is currently lacking.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Medicine, General & Internal

Relation between Epstein-Barr virus infection and Multiple Sclerosis

Aisha Yassin Abdul-Ghaffar et al.

QJM-AN INTERNATIONAL JOURNAL OF MEDICINE (2021)

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Article Multidisciplinary Sciences

T-cell responses to hybrid insulin peptides prior to type 1 diabetes development

Angela M. Mitchell et al.

Summary: In type 1 diabetes, T-cell responses to hybrid insulin peptides (HIPs) may precede clinical symptoms and be associated with disease progression.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Multidisciplinary Sciences

HLA-DRB1 allelic epitopes that associate with autoimmune disease risk or protection activate reciprocal macrophage polarization

Vincent van Drongelen et al.

Summary: This study demonstrates differential macrophage activation by HLA-DRB1 alleles associated with autoimmune disease risk or protection, resulting in polarization of pro-inflammatory and anti-inflammatory macrophages. The findings reveal a previously unrecognized mechanism of differential immune modulation by short HLA-DRB1-coded allelic epitopes independent of antigen presentation, shedding new light on the mechanistic basis of HLA-disease association.

SCIENTIFIC REPORTS (2021)

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Review Virology

The Potential Role of COVID-19 in the Pathogenesis of Multiple Sclerosis-A Preliminary Report

Noothan J. Satheesh et al.

Summary: COVID-19 caused by SARS-CoV-2 affects the lungs and can enter the central nervous system, potentially leading to neurological complications such as encephalitis and encephalopathy. The virus may also trigger the development of Multiple Sclerosis (MS) as a secondary disease, similar to the increase in Parkinson's disease cases after the Spanish Flu in 1918.

VIRUSES-BASEL (2021)

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Article Medicine, Research & Experimental

Shared recognition of citrullinated tenascin-C peptides by T and B cells in rheumatoid arthritis

Jing Song et al.

Summary: This study confirms cit-TNC as an autoantigen targeted by autoreactive CD4(+) T cells and autoantibodies in patients with RA, and suggests that coinciding epitopes recognized by both CD4(+) T cells and B cells may amplify autoimmunity and promote the development of RA.

JCI INSIGHT (2021)

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Review Immunology

Multiple Sclerosis and SARS-CoV-2: Has the Interplay Started?

Gianmarco Bellucci et al.

Summary: There is a long-standing association between MS and viral infections, with the novel Coronavirus, SARS-CoV-2, having a significant impact on the immune system that echoes several aspects of MS pathobiology. Studying COVID-19 in people with MS has helped clinicians adjust therapeutic strategies, and efforts are being made for SARS-CoV-2 vaccination campaigns in this population.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

Enhanced influenza A H1N1 T cell epitope recognition and cross-reactivity to protein-O-mannosyltransferase 1 in Pandemrix-associated narcolepsy type 1

A. Vuorela et al.

Summary: NT1, a severe sleep disorder, is strongly associated with the HLA type DQB1*0602 and its incidence increases among children vaccinated with Pandemrix. Children vaccinated with Pandemrix develop T and B cell autoimmunity against protein-O-mannosyltransferase 1 through cross-reactivity, suggesting POMT1 as a potential autoantigen in NT1.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Nine residues in HLA-DQ molecules determine with susceptibility and resistance to type 1 diabetes among young children in Sweden

Lue Ping Zhao et al.

Summary: Using deep learning of DQ residue sequences, critical residues and motifs associated with T1D were uncovered on HLA-DQ molecules, including susceptibility and resistance associations. These residues, located on alpha and beta chains, play significant roles in the risk and protection against T1D.

SCIENTIFIC REPORTS (2021)

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Article Biochemistry & Molecular Biology

Peculiarities of the Presentation of the Encephalitogenic MBP Peptide by HLA-DR Complexes Providing Protection and Predisposition to Multiple Sclerosis

A. E. Mamedov et al.

Summary: Predisposition to multiple sclerosis is influenced by various factors, with genetics playing a significant role, especially HLA class II genes. The HLA-DRB1*01 allele group has been found to provide protection against MS in the Russian population. Research showed that the myelin peptide binds to protective HLA-DR1 and predisposing HLA-DR15 at a lower rate compared to viral peptides.

ACTA NATURAE (2021)

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Review Immunology

Antigen-Specific Regulatory T Cell Therapy in Autoimmune Diseases and Transplantation

Claudia Selck et al.

Summary: Regulatory T (Treg) cells are a diverse population of immunosuppressive T cells with therapeutic potential for treating autoimmune diseases and graft rejection. Antigen-specific Treg cells have shown to be more effective in disease-specific regulation, but face challenges such as the identification of disease-relevant antigens and the stability of cells post-transfer.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

The shared susceptibility epitope of HLA-DR4 binds citrullinated self-antigens and the TCR

Jia Jia Lim et al.

Summary: This study demonstrates the role of HLA-DR4 SE in the development of rheumatoid arthritis, showing that it not only presents antigens but also directly interacts with TCRs. The interaction between HLA-DR4 and the T cell repertoire may play a role in the pathogenesis of RA.

SCIENCE IMMUNOLOGY (2021)

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Review Immunology

Major histocompatibility complex (MHC) class I and class II proteins: impact of polymorphism on antigen presentation

Esam Abualrous et al.

Summary: MHC loci are highly diverse in vertebrate genomes, with thousands of gene variants existing in the human population. Understanding the unique peptide binding profiles of MHC alleles and their interactions with regulators can lead to personalized immune modulation strategies for HLA-associated diseases.

CURRENT OPINION IN IMMUNOLOGY (2021)

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Meeting Abstract Endocrinology & Metabolism

A Human Gut Commensal, Parabacteroides Distasonis, Enhances Type 1 Diabetes Autoimmunity via Molecular Mimicry

Khyati Girdhar et al.

DIABETES (2021)

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Article Multidisciplinary Sciences

T cell receptor recognition of hybrid insulin peptides bound to HLA-DQ8

Mai T. Tran et al.

Summary: This study demonstrates how TRBV5+ T cell receptors are inclined to recognize hybrid peptides bound to HLA-DQ8 in patients with type 1 diabetes, potentially through a 'polarised' mechanism.

NATURE COMMUNICATIONS (2021)

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Article Immunology

Characterization of Human CD4 T Cells Specific for a C-Peptide/C-Peptide Hybrid Insulin Peptide

Timothy A. Wiles et al.

Summary: This study provides an in-depth characterization of the CD4 T cell response to C-peptide/C-peptide HIP (HIP11) in human T1D, identifying HIP11-specific TCRs in T1D patients and donors, and confirming the presence of HIP11 in human islets. These findings lay the foundation for further understanding the role of CD4 T cell responses to HIPs in human T1D.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Biochemistry & Molecular Biology

Impact of Posttranslational Modification in Pathogenesis of Rheumatoid Arthritis: Focusing on Citrullination, Carbamylation, and Acetylation

Eui-Jong Kwon et al.

Summary: Rheumatoid arthritis is influenced by genetic, environmental, and immunological factors, with protein posttranslational modifications, cell death mechanisms, and autoantigenicity playing crucial roles in its pathogenesis. Microbial infections can induce autoantigens, while anti-modified protein antibodies are important for prediction, diagnosis, and prognosis. Smoking is associated with both posttranslational modifications and anti-modified protein antibodies in RA, although evidence of smoking inducing their generation is lacking.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Immunology

Distinct editing functions of natural HLA-DM allotypes impact antigen presentation and CD4+ T cell activation

Miguel Alvaro-Benito et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2020)

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Review Immunology

Regulatory T Cells and Human Disease

Shimon Sakaguchi et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 38 (2020)

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Review Immunology

The etiology of rheumatoid arthritis

Hans Ulrich Scherer et al.

JOURNAL OF AUTOIMMUNITY (2020)

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Article Biochemistry & Molecular Biology

HLA-DM catalytically enhances peptide dissociation by sensing peptide?MHC class II interactions throughout the peptide-binding cleft

Eduardo Reyes-Vargas et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

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Article Immunology

Increased islet antigen-specific regulatory and effector CD4+ T cells in healthy individuals with the type 1 diabetes-protective haplotype

Xiaomin Wen et al.

SCIENCE IMMUNOLOGY (2020)

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Article Endocrinology & Metabolism

Hybrid Insulin Peptides Are Recognized by Human T Cells in the Context of DRB1*04:01

David Arribas-Layton et al.

DIABETES (2020)

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Article Immunology

Protective Allele for Multiple Sclerosis HLA-DRB1*01:01 Provides Kinetic Discrimination of Myelin and Exogenous Antigenic Peptides

Azad Mamedov et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Immunology

MHC Restriction: Where Are We Now?

Pirooz Zareie et al.

VIRAL IMMUNOLOGY (2020)

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Article Immunology

The MHC-II peptidome of pancreatic islets identifies key features of autoimmune peptides

Xiaoxiao Wan et al.

NATURE IMMUNOLOGY (2020)

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Article Biochemistry & Molecular Biology

Genetic gateways to COVID-19 infection: Implications for risk, severity, and outcomes

Monojit Debnath et al.

FASEB JOURNAL (2020)

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Review Cell Biology

Revisiting nonclassical HLA II functions in antigen presentation: Peptide editing and its modulation

Miguel Alvaro-Benito et al.

HLA (2020)

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Article Chemistry, Multidisciplinary

Myelin Basic Protein Phospholipid Complexation Likely Competes with Deimination in Experimental Autoimmune Encephalomyelitis Mouse Model

Anddre Osmar Valdivia et al.

ACS OMEGA (2020)

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Article Biochemistry & Molecular Biology

HLA-DR15 Molecules Jointly Shape an Autoreactive T Cell Repertoire in Multiple Sclerosis

Jian Wang et al.

CELL (2020)

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Article Endocrinology & Metabolism

Next-Generation HLA Sequence Analysis Uncovers Seven HLA-DQ Amino Acid Residues and Six Motifs Resistant to Childhood Type 1 Diabetes

Lue Ping Zhao et al.

DIABETES (2020)

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Article Biochemistry & Molecular Biology

Exhaustive Search of the Receptor Ligands by the CyCLOPS (Cytometry Cell-Labeling Operable Phage Screening) Technique

Irina A. Ishina et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Gut microorganisms act together to exacerbate inflammation in spinal cords

Eiji Miyauchi et al.

NATURE (2020)

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Review Cell Biology

Coreceptors and TCR Signaling - the Strong and the Weak of It

Alexander M. Morch et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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A biomimetic five-module chimeric antigen receptor (5MCAR) designed to target and eliminate antigen-specific T cells

Shio Kobayashi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Endocrinology & Metabolism

HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of Islet β-Cells From Donors With Type 1 Diabetes

Mark A. Russell et al.

DIABETES (2019)

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Review Immunology

Human FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer

James B. Wing et al.

IMMUNITY (2019)

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Review Rheumatology

HLA associations in inflammatory arthritis: emerging mechanisms and clinical implications

Robert Busch et al.

NATURE REVIEWS RHEUMATOLOGY (2019)

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Review Endocrinology & Metabolism

Rationally designed small molecules to prevent type 1 diabetes

David A. Ostrov et al.

CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY (2019)

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Article Cell Biology

HIV Controllers Exhibit Effective CD8+ T Cell Recognition of HIV-1-Infected Non-activated CD4+ T Cells

Blandine Monel et al.

CELL REPORTS (2019)

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Article Microbiology

Pathogenic Autoreactive T and B Cells Cross-React with Mimotopes Expressed by a Common Human Gut Commensal to Trigger Autoimmunity

William E. Ruff et al.

CELL HOST & MICROBE (2019)

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Article Endocrinology & Metabolism

Hybrid Insulin Peptides Are Autoantigens in Type 1 Diabetes

Rocky L. Baker et al.

DIABETES (2019)

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Article Immunology

A temporal thymic selection switch and ligand binding kinetics constrain neonatal Foxp3+ Treg cell development

Brian D. Stadinski et al.

NATURE IMMUNOLOGY (2019)

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Article Multidisciplinary Sciences

A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity

Joshua D. Ooi et al.

NATURE COMMUNICATIONS (2019)

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Article Multidisciplinary Sciences

Molecular mimicry between Anoctamin 2 and Epstein-Barr virus nuclear antigen 1 associates with multiple sclerosis risk

Katarina Tengvall et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Review Virology

Viruses and Autoimmunity: A Review on the Potential Interaction and Molecular Mechanisms

Maria K. Smatti et al.

VIRUSES-BASEL (2019)

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Article Multidisciplinary Sciences

Genetic risk for autoimmunity is associated with distinct changes in the human gut microbiome

Jordan T. Russell et al.

NATURE COMMUNICATIONS (2019)

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Article Endocrinology & Metabolism

Epitope Stealing as a Mechanism of Dominant Protection by HLA-DQ6 in Type 1 Diabetes

Menno van Lummel et al.

DIABETES (2019)

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Article Biochemical Research Methods

Identification of Hybrid Insulin Peptides (HIPs) in Mouse and Human Islets by Mass Spectrometry

T. Aaron Wiles et al.

JOURNAL OF PROTEOME RESEARCH (2019)

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Article Biochemical Research Methods

HLA-DO Modulates the Diversity of the MHC-II Self-peptidome

Padma P. Nanaware et al.

MOLECULAR & CELLULAR PROTEOMICS (2019)

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Article Biochemistry & Molecular Biology

Loading Rate of Exogenous and Autoantigenic Determinants on Major Histocompatibility Complex Class II Mediates Resistance to Multiple Sclerosis

A. E. Mamedov et al.

DOKLADY BIOCHEMISTRY AND BIOPHYSICS (2019)

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Article Endocrinology & Metabolism

CD4 T Cells Reactive to Hybrid Insulin Peptides Are Indicators of Disease Activity in the NOD Mouse

Rocky L. Baker et al.

DIABETES (2018)

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Article Medicine, Research & Experimental

Methyldopa blocks MHC class II binding to disease-specific antigens in autoimmune diabetes

David A. Ostrov et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

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Article Multidisciplinary Sciences

T cells specific for post-translational modifications escape intrathymic tolerance induction

Bruno Raposo et al.

NATURE COMMUNICATIONS (2018)

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Article Immunology

Quantification of HLA-DM-Dependent Major Histocompatibility Complex of Class II Immunopeptidomes by the Peptide Landscape Antigenic Epitope Alignment Utility

Miguel Alvaro-Benito et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Microbiology

Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota

Jane A. Mullaney et al.

MICROBIOME (2018)

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Article Immunology

Rapid CLIP dissociation from MHC II promotes an unusual antigen presentation pathway in autoimmunity

Yoshinaga Ito et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2018)

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Article Multidisciplinary Sciences

T cells in patients with narcolepsy target self-antigens of hypocretin neurons

Daniela Latorre et al.

NATURE (2018)

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Article Biochemistry & Molecular Biology

Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis

Ana Mendanha Falcao et al.

NATURE MEDICINE (2018)

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Autoimmunity to hypocretin and molecular mimicry to flu in type 1 narcolepsy

Guo Luo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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Article Immunology

IFN gamma-Induced MHC Class II Expression on Islet Endothelial Cells Is an Early Marker of Insulitis but Is Not Required for Diabetogenic CD4(+) T Cell Migration

Nicholas A. Scott et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Immunology

Peptidomic analysis of type 1 diabetes associated HLA-DQ molecules and the impact of HLA-DM on peptide repertoire editing

Zemin Zhou et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2017)

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Article Multidisciplinary Sciences

Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells

Joshua D. Ooi et al.

NATURE (2017)

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Article Multidisciplinary Sciences

Protective major histocompatibility complex allele prevents type 1 diabetes by shaping the intestinal microbiota early in ontogeny

Michael Silverman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Article Immunology

Divergent immunomodulation capacity of individual Myelin Peptides-components of liposomal Therapeutic against Multiple sclerosis

Vilena V. Ivanova et al.

FRONTIERS IN IMMUNOLOGY (2017)

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Article Medicine, General & Internal

Genetic risk factors for type 1 diabetes

Flemming Pociot et al.

LANCET (2016)

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Article Immunology

Tolerance is established in polyclonal CD4+ T cells by distinct mechanisms, according to self-peptide expression patterns

Deepali Malhotra et al.

NATURE IMMUNOLOGY (2016)

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Article Clinical Neurology

CD206-Targeted Liposomal Myelin Basic Protein Peptides in Patients with Multiple Sclerosis Resistant to First-Line Disease-Modifying Therapies: A First-in-Human, Proof-of-Concept Dose-Escalation Study

Alexey Belogurov et al.

NEUROTHERAPEUTICS (2016)

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Review Immunology

T Cell Antigen Receptor Recognition of Antigen-Presenting Molecules

Jamie Rossjohn et al.

ANNUAL REVIEW OF IMMUNOLOGY VOL 33 (2015)

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Article Immunology

Mouse pancreatic beta cells express MHC class II and stimulate CD4+ T cells to proliferate

Yuxing Zhao et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2015)

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Article Immunology

T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex

Dennis X. Beringer et al.

NATURE IMMUNOLOGY (2015)

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Article Endocrinology & Metabolism

Recognition of Posttranslationally Modified GAD65 Epitopes in Subjects With Type 1 Diabetes

John W. McGinty et al.

DIABETES (2014)

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Article Multidisciplinary Sciences

Autoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes

Junbao Yang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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Review Immunology

Pathways of Antigen Processing

Janice S. Blum et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 31 (2013)

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Article Immunology

Composition of the HLA- DR- associated human thymus peptidome

Javier A. Collado et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2013)

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Article Biochemistry & Molecular Biology

Liposome-encapsulated peptides protect against experimental allergic encephalitis

Alexey A. Belogurov et al.

FASEB JOURNAL (2013)

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Article Immunology

Dendritic Cell-Dependent In Vivo Generation of Autoregulatory T Cells by Antidiabetogenic MHC Class II

Sue Tsai et al.

JOURNAL OF IMMUNOLOGY (2013)

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Article Multidisciplinary Sciences

Antidiabetogenic MHC class II promotes the differentiation of MHC-promiscuous autoreactive T cells into FOXP3+ regulatory T cells

Sue Tsai et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

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Review Immunology

HLA-DO and its role in MHC class II antigen presentation

Yuri O. Poluektov et al.

FRONTIERS IN IMMUNOLOGY (2013)

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Article Immunology

A Broad Range of Self-Reactivity Drives Thymic Regulatory T Cell Selection to Limit Responses to Self

Hyang-Mi Lee et al.

IMMUNITY (2012)

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Article Multidisciplinary Sciences

Crystal structure of a complete ternary complex of T-cell receptor, peptide-MHC, and CD4

Yiyuan Yin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

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Article Biochemistry & Molecular Biology

Structure of a TCR with high affinity for self-antigen reveals basis for escape from negative selection

Yiyuan Yin et al.

EMBO JOURNAL (2011)

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Article Biochemistry & Molecular Biology

Combinatorial antibody library from multiple sclerosis patients reveals antibodies that cross-react with myelin basic protein and EBV antigen

Alexander G. Gabibov et al.

FASEB JOURNAL (2011)

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Article Immunology

T Cell Receptor Signaling Is Limited by Docking Geometry to Peptide-Major Histocompatibility Complex

Jarrett J. Adams et al.

IMMUNITY (2011)

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Article Immunology

A highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHC

Dhruv K. Sethi et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2011)

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Article Immunology

Register shifting of an insulin peptide-MHC complex allows diabetogenic T cells to escape thymic deletion

James F. Mohan et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2011)

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Article Multidisciplinary Sciences

Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse

Frances Crawford et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

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Article Immunology

Contribution of Myelin Autoantigen Citrullination to T Cell Autoaggression in the Central Nervous System

Antonio Carrillo-Vico et al.

JOURNAL OF IMMUNOLOGY (2010)

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Article Multidisciplinary Sciences

Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection

Andrej Kosmrlj et al.

NATURE (2010)

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Article Multidisciplinary Sciences

Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register

Brian D. Stadinski et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

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The Major Genetic Determinants of HIV-1 Control Affect HLA Class I Peptide Presentation

Florencia Pereyra et al.

SCIENCE (2010)

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Article Immunology

Thymocyte deletion can bias Treg formation toward low-abundance self-peptide

Cristina Cozzo Picca et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2009)

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Article Biochemical Research Methods

Naturally Presented Peptides on Major Histocompatibility Complex I and II Molecules Eluted from Central Nervous System of Multiple Sclerosis Patients

Nicolas Fissolo et al.

MOLECULAR & CELLULAR PROTEOMICS (2009)

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Article Immunology

EBNA1-specific T cells from patients with multiple sclerosis cross react with myelin antigens and co-produce IFN-γ and IL-2

Jan D. Luenemann et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2008)

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Article Immunology

Thyroglobulin peptides associate in vivo to HLA-DR in autoimmune thyroid glands

Laia Muixi et al.

JOURNAL OF IMMUNOLOGY (2008)

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Article Immunology

Recognition and degradation of myelin basic protein peptides by serum autoantibodies: Novel biomarker for multiple sclerosis

Alexey A. Belogurov et al.

JOURNAL OF IMMUNOLOGY (2008)

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Article Multidisciplinary Sciences

Positioning of autoimmune TCR-Ob.2F3 and TCR-Ob.3D1 on the MBP85-99/HLA-DR2 complex

Zenichiro Kato et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

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Article Rheumatology

Resting CD4(+) effector memory T cells are precursors of bystander-activated effectors: a surrogate model of rheumatoid arthritis synovial T-cell function

Fionula M. Brennan et al.

ARTHRITIS RESEARCH & THERAPY (2008)

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Review Endocrinology & Metabolism

Recognition of thyroglobulin by T cells: The role of iodine

George Carayanniotis

THYROID (2007)

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Article Immunology

Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'

Dan Feng et al.

NATURE IMMUNOLOGY (2007)

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Article Medicine, Research & Experimental

Priming and effector dependence on insulin B:9-23 peptide in NOD islet autoimmunity

Maki Nakayama et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

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Article Immunology

The insulin-specific T cells of nonobese diabetic mice recognize a weak MHC-binding segment in more than one form

Matteo G. Levisetti et al.

JOURNAL OF IMMUNOLOGY (2007)

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Article Multidisciplinary Sciences

Aberrant MHC class II expression in mouse joints leads to arthritis with extraarticular manifestations similar to rheumatoid arthritis

Satoshi Kanazawa et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

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Review Immunology

MHC class II proteins and disease: a structural perspective

EY Jones et al.

NATURE REVIEWS IMMUNOLOGY (2006)

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Article Immunology

High level of cross-reactivity in influenza virus hemagglutinin-specific CD4+T-cell response: Implications for the initiation of autoimmune response in multiple sclerosis

S Markovic-Plese et al.

JOURNAL OF NEUROIMMUNOLOGY (2005)

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Article Immunology

The insulin A-chain epitope recognized by human T cells is posttranslationally modified

SI Mannering et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2005)

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Article Immunology

T cell mimicry and epitope specificity of cross-reactive T cell clones from rheumatic heart disease

NMJ Ellis et al.

JOURNAL OF IMMUNOLOGY (2005)

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Article Biochemistry & Molecular Biology

Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule

YL Li et al.

EMBO JOURNAL (2005)

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Article Immunology

Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor

M Hahn et al.

NATURE IMMUNOLOGY (2005)

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Article Virology

Diabetes acceleration or prevention by a coxsackievirus B4 infection: Critical requirements for both interleukin-4 and gamma interferon

DV Serreze et al.

JOURNAL OF VIROLOGY (2005)

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Article Immunology

Cutting edge: The conversion of arginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1*0401 MHC class II molecule

JA Hill et al.

JOURNAL OF IMMUNOLOGY (2003)

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Article Immunology

Duration and strength of extracellular signal-regulated kinase signals are altered during positive versus negative thymocyte selection

S Mariathasan et al.

JOURNAL OF IMMUNOLOGY (2001)

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Upregulation of transcription factors controlling MHC expression in multiple sclerosis lesions

SJP Gobin et al.

GLIA (2001)

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Cytomegalovirus in autoimmunity: T cell crossreactivity to viral antigen and autoantigen glutamic acid decarboxylase

HS Hiemstra et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

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Article Biochemistry & Molecular Biology

Structure of a covalently stabilized complex of a human αβ T-cell receptor, influenza HA peptide and MHC class II molecule, HLA-DR1

J Hennecke et al.

EMBO JOURNAL (2000)

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Review Rheumatology

Association of MHC and rheumatoid arthritis HLA-DR4 and rheumatoid arthritis: studies in mice and men

L Fugger et al.

ARTHRITIS RESEARCH (2000)

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