Human Vδ2 T Cells and Their Versatility for Immunotherapeutic Approaches

Gamma/delta (gamma delta) T cells are innate-like immune effectors that are a critical component linking innate and adaptive immune responses. They are recognized for their contribution to tumor surveillance and fight against infectious diseases. gamma delta T cells are excellent candidates for cellular immunotherapy due to their unique properties to recognize and destroy tumors or infected cells. They do not depend on the recognition of a single antigen but rather a broad-spectrum of diverse ligands through expression of various cytotoxic receptors. In this manuscript, we review major characteristics of the most abundant circulating gamma delta subpopulation, V delta 2 T cells, their immunotherapeutic potential, recent advances in expansion protocols, their preclinical and clinical applications for several infectious diseases and malignancies, and how additional modulation could enhance their therapeutic potential.

Automated summary

This manuscript reviews the major characteristics of gamma/delta T cells, the most abundant circulating subpopulation being V delta 2 T cells. It discusses their potential in cellular immunotherapy, recent advances in expansion protocols, their applications in preclinical and clinical settings for infectious diseases and malignancies, and the potential to enhance their therapeutic effects through additional modulation.