☆ 4.6 Article

Volatile Compounds in Actinomycete Communities: A New Tool for Biosynthetic Gene Cluster Activation, Cooperative Growth Promotion, and Drug Discovery

CELLS (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Biotechnology & Applied Microbiology

Colibrimycins, Novel Halogenated Hybrid Polyketide Synthase-Nonribosomal Peptide Synthetase (PKS-NRPS) Compounds Produced by Streptomyces sp. Strain CS147

Laura Prado-Alonso et al.

Summary: Genome mining has revealed the biosynthetic potential of actinomycetes and led to the discovery of novel halogenated bioactive compounds. In this study, a screening for halogenase coding genes in Streptomyces strains isolated from fungus-growing ants identified six genes. Mutants were constructed to study the biosynthetic gene clusters and a novel family of halogenated compounds, named colibrimycins, were identified in Streptomyces sp. strain CS147.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Capturing the microbial volatilome: an oft overlooked 'ome'

Laura K. Meredith et al.

Summary: Microbial metabolomic studies have focused mainly on nonvolatile metabolites, neglecting the volatile organic compounds (VOCs) that play important roles in microbial systems. Advances in VOC detection allow real-time observation and overcome sampling limitations, leading to a more comprehensive understanding of microbial processes when integrating VOC and other 'omics approaches.

TRENDS IN MICROBIOLOGY (2022)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Strategies to access biosynthetic novelty in bacterial genomes for drug discovery

Franziska Hemmerling et al.

Summary: Bacteria are a rich source of natural products with potential therapeutic applications. Advances in sequencing technology and computational tools have revealed diverse and chemically distinct natural products in previously unstudied bacteria, which have important implications for drug discovery.

NATURE REVIEWS DRUG DISCOVERY (2022)

添加到收藏夹

Article Microbiology

Analysis of Streptomyces Volatilomes Using Global Molecular Networking Reveals the Presence of Metabolites with Diverse Biological Activities

Jingyu Liu et al.

Summary: This study is the first to analyze Streptomyces volatilomes using the MSHub/GNPS workflow. By combining the MSHub/GNPS method with conventional approaches, more volatile organic compounds (VOCs) were annotated, many of which have antimicrobial, anticancer, and insect behavior-modulating activities. The discovery of plant-associated VOCs suggests that members of the genus have the potential for large-scale production of these compounds by Streptomyces. Plant-associated VOCs with antimicrobial activities, such as 1-octen-3-ol, octanol, and phenylethyl alcohol, may have applications as fumigants. The annotated VOCs that influence insect behavior provide insights into the functions of Streptomyces VOCs in dispersal and nutrient acquisition.

MICROBIOLOGY SPECTRUM (2022)

添加到收藏夹

Review Biochemical Research Methods

Natural products in antibiotic development: is the success story over?

Freddy A. Bernal et al.

Summary: Natural product-based antibiotics have been saving countless lives for more than 80 years. However, there is a lack of research and development in antimicrobial drugs to counteract antimicrobial resistance. Most antibiotics on the market today were inspired by natural product classes discovered over 50 years ago. With advanced genomic approaches and cultivation methods, there is potential for the discovery of even more powerful antibiotics. However, the current antibiotic research and development pipeline is moving away from natural product-based programs, and innovative compounds are rare in early stages.

CURRENT OPINION IN BIOTECHNOLOGY (2022)

添加到收藏夹

Review Chemistry, Multidisciplinary

Prospects for Antibacterial Discovery and Development

Thomas M. Privalsky et al.

Summary: The increasing prevalence of multidrug-resistant bacteria has become an urgent health crisis, requiring renewed investment in the discovery and development of antibiotics. A multifaceted approach is necessary to address the antibacterial resistance crisis, with a focus on exploring validated antibacterial targets and lead molecules. Creative techniques, such as studying underexplored ecological niches or utilizing available data from genome mining efforts, can help in the search for new antibiotic leads.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

添加到收藏夹

Article Microbiology

A Multidisciplinary Approach to Unraveling the Natural Product Biosynthetic Potential of a Streptomyces Strain Collection Isolated from Leaf-Cutting Ants

Ana Ceniceros et al.

Summary: By analyzing the genomes of 12 Streptomyces sp. strains isolated from leaf-cutting ants of the Attini tribe, it was revealed that over half of the predicted biosynthetic gene clusters were strain-specific, indicating the potential for novel compound discovery in this strain collection.

MICROORGANISMS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

antiSMASH 6.0: improving cluster detection and comparison capabilities

Kai Blin et al.

Summary: antiSMASH, a tool for detecting biosynthetic gene clusters in microorganisms, has been updated to version 6, which increases the supported cluster types, displays the structure of multi-modular BGCs, adds a new comparison algorithm, allows integration of results from other prediction tools, and improves detection of tailoring enzymes in RiPP clusters.

NUCLEIC ACIDS RESEARCH (2021)

添加到收藏夹

Article Microbiology

Volatile Organic Compound Chamber: A Novel Technology for Microbiological Volatile Interaction Assays

Samuel Alvarez-Garcia et al.

Summary: The VOC chambers are a new tool designed for studying microbial interactions mediated by VOCs. Through testing with Trichoderma strains against Fusarium oxysporum and Rhizoctonia solani, it has been demonstrated that VOC chambers provide higher sensitivity and selectivity, as well as more uniform results.

JOURNAL OF FUNGI (2021)

添加到收藏夹

Article Microbiology

Ammonia Production by Streptomyces Symbionts of Acromyrmex Leaf-Cutting Ants Strongly Inhibits the Fungal Pathogen Escovopsis

Basanta Dhodary et al.

Summary: Leaf-cutting ants have a mutualistic symbiosis with their garden fungus, which can be attacked by a specialized pathogenic fungus. Actinomyces symbionts from the ants contribute to protecting the garden fungus by producing ammonia, which inhibits the growth of the pathogenic fungus Escovopsis. This demonstrates that simple ammonia released by symbionts can play a role in controlling pathogen growth in ant colonies.

MICROORGANISMS (2021)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Auto-deconvolution and molecular networking of gas chromatography-mass spectrometry data

Alexander A. Aksenov et al.

Summary: This study developed a machine learning approach that enables auto-deconvolution of gas chromatography-mass spectrometry data for the analysis and comparison of chemical compounds.

NATURE BIOTECHNOLOGY (2021)

添加到收藏夹

Review Microbiology

Chemical Mediators at the Bacterial-Fungal Interface

Kirstin Scherlach et al.

ANNUAL REVIEW OF MICROBIOLOGY, VOL 74, 2020 (2020)

添加到收藏夹

Article Chemistry, Medicinal

Antibacterial Activity of Chromomycins from a Marine-Derived Streptomyces microflavus

Eunji Cho et al.

MARINE DRUGS (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Chemical warfare between fungus-growing ants and their pathogens

Sibyl F. D. Batey et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

The antimicrobial potential of Streptomyces from insect microbiomes

Marc G. Chevrette et al.

NATURE COMMUNICATIONS (2019)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Regulatory and evolutionary roles of pseudo γ-butyrolactone receptors in antibiotic biosynthesis and resistance

Gangming Xu et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2019)

添加到收藏夹

Review Microbiology

Unlocking the trove of metabolic treasures: activating silent biosynthetic gene clusters in bacteria and fungi

Xiafei Zhang et al.

CURRENT OPINION IN MICROBIOLOGY (2019)

添加到收藏夹

Review Microbiology

Antibiotics: past, present and future

Matthew I. Hutchings et al.

CURRENT OPINION IN MICROBIOLOGY (2019)

添加到收藏夹

Review Microbiology

Healthy scents: microbial volatiles as new frontier in antibiotic research?

Mariana Avalos et al.

CURRENT OPINION IN MICROBIOLOGY (2018)

添加到收藏夹

Article Microbiology

Searching for Glycosylated Natural Products in Actinomycetes and Identification of Novel Macrolactams and Angucyclines

Monica G. Malmierca et al.

FRONTIERS IN MICROBIOLOGY (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Streptomyces Exploration: Competition, Volatile Communication and New Bacterial Behaviours

Stephanie E. Jones et al.

TRENDS IN MICROBIOLOGY (2017)

添加到收藏夹

Article Biology

Streptomyces exploration is triggered by fungal interactions and volatile signals

Stephanie E. Jones et al.

ELIFE (2017)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Exploring bacterial interspecific interactions for discovery of novel antimicrobial compounds

Olaf Tyc et al.

MICROBIAL BIOTECHNOLOGY (2017)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Improved antibiotic production and silent gene activation in Streptomyces diastatochromogenes by ribosome engineering

Xuping Shentu et al.

JOURNAL OF ANTIBIOTICS (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Alteramide B is a microtubule antagonist of inhibiting Candida albicans

Yanjiao Ding et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2016)

添加到收藏夹

Review Plant Sciences

Combined LC/UV/MS and NMR Strategies for the Dereplication of Marine Natural Products

Ignacio Perez-Victoria et al.

PLANTA MEDICA (2016)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Metabolite induction via microorganism co-culture: A potential way to enhance chemical diversity for drug discovery

Samuel Bertrand et al.

BIOTECHNOLOGY ADVANCES (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Symbiotic adaptations in the fungal cultivar of leaf-cutting ants

Henrik H. De Fine Licht et al.

NATURE COMMUNICATIONS (2014)

添加到收藏夹

Article Biology

Microbial secondary metabolites and their impacts on insect symbioses

Jonathan L. Klassen

CURRENT OPINION IN INSECT SCIENCE (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

Engineering the Biosynthesis of the Polyketide-Nonribosomal Peptide Collismycin A for Generation of Analogs with Neuroprotective Activity

Ignacio Garcia et al.

CHEMISTRY & BIOLOGY (2013)

添加到收藏夹

Article Microbiology

Production of fungal and bacterial growth modulating secondary metabolites is widespread among mycorrhiza-associated streptomycetes

Silvia D. Schrey et al.

BMC MICROBIOLOGY (2012)

添加到收藏夹

Review Biochemistry & Molecular Biology

Volatile Metabolites

Daryl D. Rowan

METABOLITES (2011)

添加到收藏夹

Review Microbiology

Interspecies Chemical Communication in Bacterial Development

Paul D. Straight et al.

ANNUAL REVIEW OF MICROBIOLOGY (2009)

添加到收藏夹

Article Chemistry, Organic

The marinopyrroles, antibiotics of an unprecedented structure class from a marine Streptomyces sp.

Chambers C. Hughes et al.

ORGANIC LETTERS (2008)

添加到收藏夹

Article Multidisciplinary Sciences

Biosynthesis of γ-butyrolactone autoregulators that switch on secondary metabolism and morphological development in Streptomyces

Jun-ya Kato et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

添加到收藏夹

Article Microbiology

Desferrioxamine E produced by Streptomyces griseus stimulates growth and development of Streptomyces tanashiensis

K Yamanaka et al.

MICROBIOLOGY-SGM (2005)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Bioactive microbial metabolites - A personal view

J Berdy

JOURNAL OF ANTIBIOTICS (2005)

添加到收藏夹

Article Chemistry, Multidisciplinary

Abyssomicin C - A polycyclic antibiotic from a marine Verrucosispora strain as an inhibitor of the p-aminobenzoic acid/tetrahydrofolate biosynthesis pathway

B Bister et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2004)

添加到收藏夹

Review Microbiology

Prokaryotic diversity and its limits: microbial community structure in nature and implications for microbial ecology

TP Curtis et al.

CURRENT OPINION IN MICROBIOLOGY (2004)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Goadsporin, a chemical substance which promotes secondary metabolism and morphogenesis in streptomycetes - I. Purification and characterization

H Onaka et al.

JOURNAL OF ANTIBIOTICS (2001)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.