Implantable intracortical microelectrodes: reviewing the present with a focus on the future

Implantable intracortical microelectrodes can record a neuron's rapidly changing action potentials (spikes). In vivo neural activity recording methods often have either high temporal or spatial resolution, but not both. There is an increasing need to record more neurons over a longer duration in vivo. However, there remain many challenges to overcome before achieving long-term, stable, high-quality recordings and realizing comprehensive, accurate brain activity analysis. Based on the vision of an idealized implantable microelectrode device, the performance requirements for microelectrodes are divided into four aspects, including recording quality, recording stability, recording throughput, and multifunctionality, which are presented in order of importance. The challenges and current possible solutions for implantable microelectrodes are given from the perspective of each aspect. The current developments in microelectrode technology are analyzed and summarized.

Automated summary

Implantable intracortical microelectrodes are capable of recording fast-changing action potentials in neurons. Current methods for in vivo neural activity recording have limitations in either temporal or spatial resolution. The need to record more neurons over longer durations in vivo is increasing, but there are still challenges to overcome in achieving stable, high-quality recordings and comprehensive brain activity analysis.