期刊
CANCERS
卷 15, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/cancers15030630
关键词
prostate cancer; prostate inflammation; prostate biopsy
类别
This study investigated the association between inflammation, proliferative inflammatory atrophy, and Prostate Cancer (PCa) in frustules from prostate biopsies. The results showed a significant association between prostate inflammation (PI) and PCa, suggesting that anti-inflammatory therapies may be a potential preventive approach for PCa.
Simple Summary The association between inflammation and cancer is well demonstrated. The aim of our study was to investigate the topographic and quantitative association between inflammation, proliferative inflammatory atrophy and Prostate Cancer (PCa) in frustules from prostate biopsies. We demonstrated an association between prostate inflammation (PI) and PCa in tissue from prostate biopsies, confirming the basis of future research aimed at evaluating anti-inflammatory therapies as a way to prevent PCa. Background: Extensive research effort has been devoted to investigating the link between inflammation and PCa. However, this relationship remains unclear and controversial. The aim of our multi-center study was to investigate this association by histologically evaluating the distribution of PI and PCA in prostate biopsy cores from patients of eight referral centers in Italy. Results: We evaluated 2220 cores from 197 patients; all the frustules were re-evaluated by dedicated pathologists retrospectively. Pathologists assigned IRANI scores and determined the positions of PIs; pathologists also re-evaluated the presence of PCa and relative ISUP grade. PCa was recorded in 749/2220 (33.7%). We divided this sample into a PCa PI group (634/749 cores [84.7%]) and a non-PCa + PI group (1157/1471 cores [78.7%]). We observed a statistically significant difference in the presence of inflammation among cores with cancer (p < 0.01). Moreover, periglandular inflammation was higher in the cores with neoplasia, while stromal inflammation was higher in cores without neoplasia (38.5% vs. 31.1% and 55.4% vs. 63.5% p < 0.01). Conclusions: In our experience, there is evidence of an association between PI and PCa at a tissue level. Further studies are needed to confirm our findings and to identify patients who might benefit from target therapies to prevent PCa occurrence and/or progression.
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