Adoptive Cell Therapy for T-Cell Malignancies

Article Hematology

Systemic IL-15 promotes allogeneic cell rejection in patients treated with natural killer cell adoptive therapy

Melissa M. Berrien-Elliott et al.

Summary: Using IL-15 for allogeneic cellular therapy may paradoxically limit therapeutic efficacy as it accelerates CD8 T-cell activation, leading to rejection of donor NK cells.

BLOOD (2022)

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Review Immunology

Double-negative T cells: Setting the stage for disease control or progression

Teresiama Velikkakam et al.

Summary: Double-negative (DN) T cells, characterized by their low frequency and potent cytokine production, play pivotal roles in human immune responses and disease development. Understanding the phenotypic and functional characteristics of DN T cells can provide valuable insights into human diseases and offer potential therapeutic targets.

IMMUNOLOGY (2022)

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Article Biotechnology & Applied Microbiology

A new immunotherapy strategy targeted CD30 in peripheral T-cell lymphomas: CAR-modified T-cell therapy based on CD30 mAb

Yang Wu et al.

Summary: The study demonstrated an effective CAR-T cell treatment for CD30-positive PTCL tumors by using CD30 CAR T cells to suppress tumor growth.

CANCER GENE THERAPY (2022)

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Article Multidisciplinary Sciences

Decade-long leukaemia remissions with persistence of CD4(+) CAR T cells

J. Joseph Melenhorst et al.

Summary: CAR T cells redirected to target CD19 demonstrated long-lasting potential and clonal stability in two patients with chronic lymphocytic leukaemia. Highly activated CD4(+) cells emerged and dominated the CAR T cell population at later time points. These unexpected CAR T cell populations provide novel insights into anti-cancer response and long-term remission in leukaemia.

NATURE (2022)

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Review Immunology

iPSC-Derived Natural Killer Cell Therapies-Expansion and Targeting

Benjamin H. Goldenson et al.

Summary: The use of iPSC-derived NK cells in cancer treatment, particularly hematologic malignancies, has rapidly advanced. Genetic modifications have been employed to enhance tumor targeting, expansion, and persistence of NK cells. This review highlights recent important developments in iPSC-derived NK cell therapies, with a focus on improved cancer targeting. The potential combination of these advances may lead to effective NK cell-based therapies for both hematologic malignancies and solid tumors in the future.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Immunology

Allogeneic CD20-targeted γδ T cells exhibit innate and adaptive antitumor activities in preclinical B-cell lymphoma models

Kevin P. Nishimoto et al.

Summary: This study evaluated the feasibility and functionality of CD20 CAR T-cell therapy using γδT cells derived from peripheral blood. The results showed that these CAR T-cells exhibited innate and adaptive antitumor activities and inhibited tumor growth in vivo.

CLINICAL & TRANSLATIONAL IMMUNOLOGY (2022)

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Review Biotechnology & Applied Microbiology

Combination therapy with CAR T cells and oncolytic viruses: a new era in cancer immunotherapy

Ramazan Rezaei et al.

Summary: CAR T-cell therapy has shown success in hematologic malignancies but faces obstacles in solid tumors, which oncolytic virotherapy can help overcome by synergizing with CAR T-cell application and enhancing therapeutic effects. Researchers can use oncolytic virotherapy to engineer viruses that selectively deliver specific therapeutic agents to the tumor environment.

CANCER GENE THERAPY (2022)

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Article Oncology

Autologous Nanobody-Derived Fratricide-Resistant CD7-CAR T-cell Therapy for Patients with Relapsed and Refractory T-cell Acute Lymphoblastic Leukemia/Lymphoma

Mingzhi Zhang et al.

Summary: This study investigated the safety and efficacy of autologous CD7-chimeric antigen receptor (CAR) T cells in patients with relapsed and refractory T-ALL/LBL and found promising and durable antitumor response in these patients.

CLINICAL CANCER RESEARCH (2022)

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Letter Oncology

Chimeric antigen receptor T cells for gamma-delta T cell malignancies

P. A. Wawrzyniecka et al.

LEUKEMIA (2022)

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Article Urology & Nephrology

TCRαβ+ CD4−/CD8– “double negative” T cells in health and disease—implications for the kidney

Andrea M. Newman-Rivera et al.

KIDNEY INTERNATIONAL (2022)

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Article Immunology

A Simple and Robust Single-Step Method for CAR-Vδ1 γδT Cell Expansion and Transduction for Cancer Immunotherapy

Gabrielle M. Ferry et al.

Summary: The V delta 1 subset of peripheral gamma delta T cells has shown potent cancer antigen recognition and has the potential for allogeneic cancer adoptive immunotherapy. However, the lack of robust expansion protocols has hindered the clinical progress of V delta 1 cells. In this study, a reproducible and clinically translatable protocol for V delta 1-gamma delta T cell expansion was developed, which can be further used for high-efficiency gene engineering for immunotherapy purposes.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Oncology

Chimeric Antigen Receptor Based Cellular Therapy for Treatment Of T-Cell Malignancies

Kamila Polgarova et al.

Summary: T-cell malignancies can be divided into precursor and mature types, with aggressive behavior and poor prognosis. Targeted therapies are only effective in subsets of patients. CAR-T cell therapy shows potential for T-cell malignancies, but specific obstacles need to be addressed. Further research is needed to optimize CAR-based products and evaluate long-term outcomes.

FRONTIERS IN ONCOLOGY (2022)

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Article Immunology

Allogeneic double-negative CAR-T cells inhibit tumor growth without off-tumor toxicities

Daniel Vasic et al.

Summary: This study evaluated the feasibility, safety, and efficacy of using healthy donor-derived allogeneic DNTs as a CAR-T cell therapy platform. CAR19-DNTs showed comparable efficacy with CAR19-T-convs, but without the risk of alloreactivity or xenogeneic GvHD-related mortality.

SCIENCE IMMUNOLOGY (2022)

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Article Oncology

Phase I study of donor-derived CD5 CAR T cells in patients with relapsed or refractory T-cell acute lymphoblastic leukemia.

Jing Pan et al.

JOURNAL OF CLINICAL ONCOLOGY (2022)

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Article Immunology

Treatment of aggressive T-cell lymphoma/leukemia with anti-CD4 CAR T cells

Jia Feng et al.

Summary: Researchers have modified CD4 CAR cells to secrete an IL-15/IL-15sushi complex, which has shown improved efficacy in targeting T-cell malignancies in preclinical and in vivo models. In a Phase I clinical trial, infusion of these modified cells was well-tolerated by patients with T-cell lymphomas and led to remission of the disease.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Hematology

UCART19, a first-in-class allogeneic anti-CD19 chimeric antigen receptor T-cell therapy for adults with relapsed or refractory B-cell acute lymphoblastic leukaemia (CALM): a phase 1, dose-escalation trial

Reuben Benjamin et al.

Summary: This study evaluated the safety and efficacy of UCART19 in adult patients with relapsed or refractory B-cell acute lymphoblastic leukaemia, showing that UCART19 has a manageable safety profile and demonstrated anti-leukaemic activity in treating such patients.

LANCET HAEMATOLOGY (2022)

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Meeting Abstract Hematology

First in Human Study of AUTO4, a TRBC1-Targeting CAR T-Cell Therapy in Relapsed/Refractory TRBC1-Positive Peripheral T-Cell Lymphoma

Kate Cwynarski et al.

BLOOD (2022)

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Article Immunology

Allogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer

Yan Xu et al.

Summary: The study focused on utilizing allogeneic V gamma 9V delta 2 T cells for tumor immunotherapy, developing a novel formula for expanding gamma delta T cells from healthy donors, and conducting clinical trials to prove the safety and efficacy of allogeneic V gamma 9V delta 2 T cells, showing promising results in late-stage cancer patients.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

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Article Biotechnology & Applied Microbiology

Engineered off-the-shelf therapeutic T cells resist host immune rejection

Feiyan Mo et al.

Summary: Engineered T cells targeting allogeneic lymphocytes through the alloimmune defense receptor (ADR) demonstrated effective tumor eradication in mouse models of hematopoietic and solid cancers, offering a potential 'off-the-shelf' therapy for immunocompetent recipients. The ADR selectively recognizes the 4-1BB receptor transiently expressed on activated lymphocytes, allowing for prolonged persistence and therapeutic benefit of rejection-resistant allogeneic T cells. This approach may provide a promising solution to the challenges of manufacturing autologous T cells for cancer therapy.

NATURE BIOTECHNOLOGY (2021)

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Review Oncology

Exploring the NK cell platform for cancer immunotherapy

Jacob A. Myers et al.

Summary: NK cells have innate potential to kill cancer cells, leading to the development of various NK cell-based therapies for cancer treatment. The main focus of NK cell therapy research is on optimizing sources of therapeutic NK cells and enhancing their cytotoxicity and persistence in the body.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

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Meeting Abstract Hematology

Safety and Efficacy of Off-the-Shelf CD30.CAR-Modified Epstein-Barr Virus-Specific T Cells in Patients with CD30-Positive Lymphoma

David H. Quach et al.

BLOOD (2021)

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Meeting Abstract Hematology

A Novel and Successful Patient or Donor-Derived CD7-Targeted CAR T-Cell Therapy for Relapsed or Refractory T-Cell Lymphoblastic Lymphoma (R/R T-LBL)

Junfnag Yang et al.

BLOOD (2021)

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Meeting Abstract Hematology

CD30-Directed CAR-T Cells Co-Expressing CCR4 in Relapsed/Refractory Hodgkin Lymphoma and CD30+Cutaneous T Cell Lymphoma

Natalie S. Grover et al.

BLOOD (2021)

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Meeting Abstract Hematology

Development of Multi- Engineered iPSCDerived CAR-NK Cells for the Treatment of B-Cell Malignancies

Luis Borges et al.

BLOOD (2021)

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Meeting Abstract Hematology

Safety and Efficacy of FT596, a First-in-Class, Multi-Antigen Targeted, Off-the-Shelf, iPSC-Derived CD19 CAR NK Cell Therapy in Relapsed/Refractory B-Cell Lymphoma

Veronika Bachanova et al.

BLOOD (2021)

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Review Oncology

NK cell-based cancer immunotherapy: from basic biology to clinical development

Sizhe Liu et al.

Summary: NK cells, as a specialized immune effector cell type, play a critical role in immune activation against abnormal cells. Unlike T cell activation, NK cell activation is governed by interactions between NK receptors and target cells, leading to significant attention in cancer immunotherapy. Many efforts are focused on developing and engineering NK cell-based cancer immunotherapy.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

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Article Immunology

HLA Class I Knockout Converts Allogeneic Primary NK Cells Into Suitable Effectors for Off-the-Shelf Immunotherapy

Keven Hoerster et al.

Summary: The study demonstrates the feasibility of genome editing in primary allogeneic NK cells to reduce their recognition and killing by mismatched T cells, making them potential off-the-shelf immune effectors for immunotherapy in cancer. Genetically engineered NK cells are functionally indistinguishable from unmodified cells with natural cytotoxicity towards AML cell lines.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Immunology

The Dual Roles of Human γδ T Cells: Anti-Tumor or Tumor-Promoting

Yang Li et al.

Summary: Gamma delta T cells, a unique subgroup of T cells, can promote anti-tumor immune response but also potentially contribute to tumor progression. Studies have summarized and discussed their functions and effects in cancer, as well as reviewed recent anti-tumor immunotherapy based on gamma delta T cells, and identified existing problems and future prospects of this immunotherapy.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Cell & Tissue Engineering

CAR-T cell therapy in T-cell malignancies: Is success a low-hanging fruit?

Pouya Safarzadeh Kozani et al.

Summary: CAR-T therapy has been successful in treating various types of relapsed/refractory B-cell malignancies, but faces challenges when combating T-cell malignancies, including fratricide, T-cell aplasia, and product contamination. Further research and improvements are needed to address these obstacles and enhance CAR-T therapy in T-cell malignancies.

STEM CELL RESEARCH & THERAPY (2021)

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Review Biochemistry & Molecular Biology

Current status and perspective of CAR-T and CAR-NK cell therapy trials in Germany

Nawid Albinger et al.

Summary: CAR-T cell therapies and CAR-NK cell therapies are powerful immunotherapeutic tools for hematological diseases, with the latter emerging as a novel therapeutic option with advantages over the former. There are currently numerous CAR-T and CAR-NK cell trials being conducted worldwide, offering potential additional choices for clinical applications.

GENE THERAPY (2021)

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Review Oncology

The emerging role of off-the-shelf engineered natural killer cells in targeted cancer immunotherapy

Kellsye P. Fabian et al.

Summary: This review outlines the importance of NK cells in cancer treatment and the development of NK-92 cell line in CAR-engineering, demonstrating robust antitumor activity and potential as a next-generation off-the-shelf cell therapy platform.

MOLECULAR THERAPY-ONCOLYTICS (2021)

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Article Oncology

Off-the-shelf Vδ1 gamma delta T cells engineered with glypican-3 (GPC-3)-specific chimeric antigen receptor (CAR) and soluble IL-15 display robust antitumor efficacy against hepatocellular carcinoma

Amani Makkouk et al.

Summary: The use of engineered V delta 1 CAR T cells targeting GPC-3 in HCC shows promising efficacy and can overcome challenges faced by traditional T cell therapies in solid tumors.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

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Article Hematology

Activated natural killer cells predict poor clinical prognosis in high-risk B- and T-cell acute lymphoblastic leukemia

Caroline Duault et al.

Summary: NK cells from B/T-ALL patients exhibit reduced cytotoxicity but increased activation, preventing efficient lysis of NK cell-sensitive targets and leading to exhaustion, possibly contributing to disease severity and poor clinical outcomes. Developing NK cell profiling as a diagnostic tool and utilizing allogeneic NK cell infusions may hold clinical potential in preventing ALL recurrence.

BLOOD (2021)

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Review Medicine, General & Internal

Perspectives of tumor-infiltrating lymphocyte treatment in solid tumors

Shuhang Wang et al.

Summary: TIL therapy involves harvesting, culturing, and infusing infiltrated lymphocytes from tumors, offering unique advantages in treating solid tumors, yet facing limitations in its current applications.

BMC MEDICINE (2021)

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Review Biochemistry & Molecular Biology

CAR T-Cell Therapy in Hematological Malignancies

Theresa Haslauer et al.

Summary: CAR T-cells are a promising therapeutic approach for hematological malignancies, particularly in lymphoma and acute lymphocytic leukemia. Despite encouraging clinical results, challenges remain in treating other hematological malignancies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Oncology

Donor-Derived CD7 Chimeric Antigen Receptor T Cells for T-Cell Acute Lymphoblastic Leukemia: First-in-Human, Phase I Trial

Jing Pan et al.

Summary: Donor-derived anti-CD7 CAR T cells showed efficient expansion and high complete remission rate in patients with r/r T-ALL, with manageable adverse events.

JOURNAL OF CLINICAL ONCOLOGY (2021)

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Article Cell Biology

Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy

Yan-Ruid Li et al.

Summary: Through hematopoietic stem cell gene engineering and in vitro differentiation, human allogeneic iNKT cells can be produced at high yield and purity, effectively targeting tumor cells with low immunogenicity. These cells can be further engineered to enhance tumor targeting or reduce immunogenicity for potential cancer therapy.

CELL REPORTS MEDICINE (2021)

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Article Cell & Tissue Engineering

Treatment of Aggressive T Cell Lymphoblastic Lymphoma/leukemia Using Anti-CD5 CAR T Cells

Jia Feng et al.

Summary: In this study, the modification of CD5 CAR to secrete an IL-15/IL-15sushi complex successfully targeted CNS-invading T-LBL, leading to the rapid ablation of lymphoblasts and remission of lymphoma in the patient. Despite the presence of CD5 on normal T cells, the treatment only caused brief, transient T-cell aplasia. These results suggest that CD5-IL15/IL15sushi CAR T cells may offer a safe and effective treatment option for T-cell malignancies, particularly for those with CNS involvement.

STEM CELL REVIEWS AND REPORTS (2021)

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Review Oncology

T-cell Acute Lymphoblastic Leukemia: A Roadmap to Targeted Therapies

Valentina Cordo et al.

Summary: T-cell acute lymphoblastic leukemia (T-ALL) is a hematologic malignancy characterized by abnormal proliferation of immature thymocytes. Despite a high overall survival rate in pediatric patients, a significant number of T-ALL patients still die from relapsed or refractory disease. Novel therapies targeting recurrent genetic drivers of T-ALL are being investigated in clinical trials to improve outcomes for these patients.

BLOOD CANCER DISCOVERY (2021)

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Review Biotechnology & Applied Microbiology

Translating gammadelta (gamma delta) T cells and their receptors into cancer cell therapies

Zsolt Sebestyen et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

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Article

CD5 CAR T-Cells for Treatment of Patients with Relapsed/Refractory CD5 Expressing T-Cell Lymphoma Demonstrates Safety and Anti-Tumor Activity

LaQuisa Hill et al.

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2020)

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Article

Potent Synergy between Combination of Chimeric Antigen Receptor (CAR) Therapy Targeting CD19 in Conjunction with Dendritic Cell (DC)/Tumor Fusion Vaccine in Hematological Malignancies.

Marzia Capelletti et al.

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2020)

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Article Medicine, General & Internal

Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors

Enli Liu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Biotechnology & Applied Microbiology

Human chimeric antigen receptor macrophages for cancer immunotherapy

Michael Klichinsky et al.

NATURE BIOTECHNOLOGY (2020)

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Article Hematology

Endogenous TCR promotes in vivo persistence of CD19-CAR-T cells compared to a CRISPR/Cas9-mediated TCR knockout CAR

Dana Stenger et al.

BLOOD (2020)

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Article Oncology

Tumor infiltrating lymphocytes (TIL) therapy in metastatic melanoma: boosting of neoantigen-specific T cell reactivity and long-term follow-up

Joost H. van den Berg et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

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Review Cell & Tissue Engineering

Genome engineering of induced pluripotent stem cells to manufacture natural killer cell therapies

Keerthana Shankar et al.

STEM CELL RESEARCH & THERAPY (2020)

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Review Immunology

Leveraging Endogenous Dendritic Cells to Enhance the Therapeutic Efficacy of Adoptive T-Cell Therapy and Checkpoint Blockade

Mie Linder Hubbe et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Immunology

Cord-Blood Natural Killer Cell-Based Immunotherapy for Cancer

Xiaoyan Zhao et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Oncology

Non-signaling Chimeric Antigen Receptors Enhance Antigen-Directed Killing by γδ T Cells in Contrast to αβ T Cells

Lauren C. Fleischer et al.

MOLECULAR THERAPY-ONCOLYTICS (2020)

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Review Medicine, General & Internal

CAR-NK cells: A promising cellular immunotherapy for cancer

Guozhu Xie et al.

EBIOMEDICINE (2020)

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Meeting Abstract Hematology

Phase I Study of Adoptive Immunotherapy with HA-1-Specific CD8+ and CD4+ Memory T Cells for Children and Adults with Relapsed Acute Leukemia after Allogeneic Hematopoietic Stem Cell Transplantation (HCT): Trial in Progress

Elizabeth F. Krakow et al.

BLOOD (2020)

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Meeting Abstract Hematology

Safety and Efficacy of Ex Vivo Expanded Healthy Donor-Derived Double Negative T Cells for the Treatment of AML Relapsed after Allogeneic Stem Cell Transplantation: A First in-Human Phase I/IIa Clinical Trial

Tang Baolin et al.

BLOOD (2020)

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Article Medicine, General & Internal

Characterization of Donor Variability for γδ T Cell ex vivo Expansion and Development of an Allogeneic γδ T Cell Immunotherapy

Rebecca E. Burnham et al.

FRONTIERS IN MEDICINE (2020)

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Article Biochemistry & Molecular Biology

Irreversible electroporation plus allogenic Vγ9Vδ2 T cells enhances antitumor effect for locally advanced pancreatic cancer patients

Mao Lin et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Article Gastroenterology & Hepatology

Unique T-Cell Populations Define Immune-Inflamed Hepatocellular Carcinoma

Daniela Di Blasi et al.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2020)

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Article Hematology

Fratricide-resistant CD1a-specific CAR T cells for the treatment of cortical T-cell acute lymphoblastic leukemia

Diego Sanchez-Martinez et al.

BLOOD (2019)

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Review Immunology

T lymphocytes in the intestinal mucosa: defense and tolerance

Hongdi Ma et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2019)

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Article Oncology

Targeting late-stage non-small cell lung cancer with a combination of DNT cellular therapy and PD-1 checkpoint blockade

Linan Fang et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

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Article Cell & Tissue Engineering

Targeting T Cell Malignancies Using CD4CAR T-Cells and Implementing a Natural Safety Switch

Gina Ma et al.

STEM CELL REVIEWS AND REPORTS (2019)

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Review Oncology

The Emerging World of TCR-T Cell Trials Against Cancer: A Systematic Review

Jianxiang Zhang et al.

TECHNOLOGY IN CANCER RESEARCH & TREATMENT (2019)

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Article Oncology

Broad Cytotoxic Targeting of Acute Myeloid Leukemia by Polyclonal Delta One T Cells

Biagio Di Lorenzo et al.

CANCER IMMUNOLOGY RESEARCH (2019)

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Review Oncology

Chimeric Antigen Receptors for T-Cell Malignancies

Lauren D. Scherer et al.

FRONTIERS IN ONCOLOGY (2019)

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Article Oncology

2B4 costimulatory domain enhancing cytotoxic ability of anti-CD5 chimeric antigen receptor engineered natural killer cells against T cell malignancies

Yingxi Xu et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

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Letter Oncology

Unique CDR3 epitope targeting by CAR-T cells is a viable approach for treating T-cell malignancies

Jinqi Huang et al.

LEUKEMIA (2019)

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Article Immunology

A Distinct Subset of Highly Proliferative and Lentiviral Vector (LV)-Transducible NK Cells Define a Readily Engineered Subset for Adoptive Cellular Therapy

Rafijul Bari et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Oncology

Developing Allogeneic Double-Negative T Cells as a Novel Off-the-Shelf Adoptive Cellular Therapy for Cancer

Jong Bok Lee et al.

CLINICAL CANCER RESEARCH (2019)

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Review Oncology

Targeting cancers through TCR-peptide/MHC interactions

Qinghua He et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

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Review Oncology

Targeting T cell malignancies using CAR-based immunotherapy: challenges and potential solutions

Lauren C. Fleischer et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

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Review Oncology

γδ T cells: pleiotropic immune effectors with therapeutic potential in cancer

Bruno Silva-Santos et al.

NATURE REVIEWS CANCER (2019)

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Review Oncology

T-Cell Receptor-Based Immunotherapy for Hematologic Malignancies

Melinda A. Biernacki et al.

CANCER JOURNAL (2019)

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Article Oncology

Reversible Transgene Expression Reduces Fratricide and Permits 4-1BB Costimulation of CAR T Cells Directed to T-cell Malignancies

Maksim Mamonkin et al.

CANCER IMMUNOLOGY RESEARCH (2018)

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Article Oncology

Development of chimeric antigen receptors targeting T-cell malignancies using two structurally different anti-CD5 antigen binding domains in NK and CRISPR-edited T cell lines

Sunil S. Raikar et al.

ONCOIMMUNOLOGY (2018)

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Article Cell & Tissue Engineering

Human iPSC-Derived Natural Killer Cells Engineered with Chimeric Antigen Receptors Enhance Anti-tumor Activity

Ye Li et al.

CELL STEM CELL (2018)

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Article Hematology

The outcome of peripheral T-cell lymphoma patients failing first-line therapy: a report from the prospective, International T-Cell Project

Monica Bellei et al.

HAEMATOLOGICA (2018)

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Article Oncology

Targeting chemotherapy-resistant leukemia by combining DNT cellular therapy with conventional chemotherapy

Branson Chen et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2018)

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Article Oncology

An off-the-shelf fratricide-resistant CAR-T for the treatment of T cell hematologic malignancies

Matthew L. Cooper et al.

LEUKEMIA (2018)

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Article Biotechnology & Applied Microbiology

Chimeric Antigen Receptor-Engineered Human Gamma Delta T Cells: Enhanced Cytotoxicity with Retention of Cross Presentation

Anna Capsomidis et al.

MOLECULAR THERAPY (2018)

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Article Hematology

The outcome of peripheral T-cell lymphoma patients failing first-line therapy: a report from the prospective, International T-Cell Project

Monica Bellei et al.

HAEMATOLOGICA (2018)

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Review Immunology

Improving the Efficiency of Vγ9Vδ2 T Cell Immunotherapy in Cancer

Timm Hoeres et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Immunology

Molecular Determinants of Target Cell Recognition by Human γδ T Cells

Andre E. Simoes et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Oncology

Progress and Innovations in the Management of Adult Acute Lymphoblastic Leukemia

Elias Jabbour et al.

JAMA ONCOLOGY (2018)

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Article Immunology

Infusion of ex-vivo expanded human TCR-+ double-negative regulatory T cells delays onset of xenogeneic graft-versus-host disease

P. Achita et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2018)

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Article Biochemistry & Molecular Biology

Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell

Marco Ruella et al.

NATURE MEDICINE (2018)

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Review Oncology

CAR T-cells for T-cell malignancies: challenges in distinguishing between therapeutic, normal, and neoplastic T-cells

Marion Alcantara et al.

LEUKEMIA (2018)

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Article Hematology

Anti-CD37 chimeric antigen receptor T cells are active against B- and T-cell lymphomas

Irene Scarfo et al.

BLOOD (2018)

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Article Oncology

Allogeneic Human Double Negative T Cells as a Novel Immunotherapy for Acute Myeloid Leukemia and Its Underlying Mechanisms

JongBok Lee et al.

CLINICAL CANCER RESEARCH (2018)

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Review Biophysics

Viral-specific T-cell transfer from HSCT donor for the treatment of viral infections or diseases after HSCT

C. Qian et al.

BONE MARROW TRANSPLANTATION (2018)

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Letter Cell Biology

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Multiplex Genome Editing to Generate Universal CAR T Cells Resistant to PD1 Inhibition

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HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells

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Virus-Specific T Cells for the Immunocompromised Patient

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Blockade of CD7 expression in T cells for effective chimeric antigen receptor targeting of T-cell malignancies

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RNA-transfection of γ/δ T cells with a chimeric antigen receptor or an α/β T-cell receptor: a safer alternative to genetically engineered α/β T cells for the immunotherapy of melanoma

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CD7-edited T cells expressing a CD7-specific CAR for the therapy of T-cell malignancies

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Delta One T Cells for Immunotherapy of Chronic Lymphocytic Leukemia: Clinical-Grade Expansion/Differentiation and Preclinical Proof of Concept

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Harnessing NK Cell Memory for Cancer Immunotherapy

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Novel anti-CD3 chimeric antigen receptor targeting of aggressive T cell malignancies

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Expansion of tumor-infiltrating lymphocytes (TIL) from human pancreatic tumors

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Multiplex Genome-Edited T-cell Manufacturing Platform for Off-the-Shelf Adoptive T-cell Immunotherapies

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Programmed Cell Death 1 and Helios Distinguish TCR-αβ+ Double-Negative (CD4-CD8-) T Cells That Derive from Self-Reactive CD8 T Cells

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Human Cytokine-Induced Memory-Like Natural Killer Cells

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Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia

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Expanded human blood-derived γδT cells display potent antigen-presentation functions

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Donor haplotype B of NK KIR receptor reduces the relapse risk in HLA-icentical sibling hematopoetic stem cell transplantation of AML patients

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Infusion of donor-derived CD19-redirected virus-specific T cells for B-cell malignancies relapsed after allogeneic stem cell transplant: a phase 1 study

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CELLULAR & MOLECULAR IMMUNOLOGY (2010)

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Bromohydrin Pyrophosphate-stimulated Vγ9δ2 T Cells Expanded Ex Vivo From Patients With Poor-Prognosis Neuroblastoma Lyse Autologous Primary Tumor Cells

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Human TCR-αβ+ CD4- CD8- T Cells Can Derive from CD8+ T Cells and Display an Inflammatory Effector Phenotype

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Double-negative regulatory T cells induce allotolerance when expanded after allogeneic haematopoietic stem cell transplantation

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V gamma 9V delta 2 T cell cytotoxicity against tumor cells is enhanced by monoclonal antibody drugs - Rituximab and trastuzumab

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Both infiltrating regulatory T cells and insufficient antigen presentation are involved in long-term cardiac xenograft survival

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New differentiation pathway for double-negative regulatory T cells that regulates the magnitude of immune responses

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Double-negative T regulatory cells can develop outside the thymus and do not mature from CD8+ T cell precursors

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Marker expression in peripheral T-cell lymphoma: A proposed clinical-pathologic prognostic score

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Donor lymphocyte infusion induces long-term donor-specific cardiac xenograft survival through activation of recipient double-negative regulatory T cells

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Professional antigen-presentation function by human γδ T cells

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Isolation and characterization of human antigen-specific TCRαβ+ CD4-CD8- double-negative regulatory T cells

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Determinants of antileukemia effects of allogeneic NK cells

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Inhibition of graft-versus-host disease by double-negative regulatory T cells

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Role of double-negative regulatory T cells in long-term cardiac xenograft survival

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Ex vivo expansion of the highly cytotoxic human natural killer cell line NK-92 under current good manufacturing practice conditions for clinical adoptive cellular immunotherapy

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Recognition mechanism of non-peptide antigens by human gamma delta T cells

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Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants

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Synthetic phosphoantigens enhance human Vγ9Vδ2 T lymphocytes killing of non-Hodgkin's B lymphoma

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Immunotherapy through TCR gene transfer

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Transfer of specificity for human immunodeficiency virus type 1 into primary human T lymphocytes by introduction of T-cell receptor genes

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