4.6 Article

Bevacizumab versus Ramucirumab in EGFR-Mutated Metastatic Non-Small-Cell Lung Cancer Patients: A Real-World Observational Study

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

The validity of progression-free survival 2 as a surrogate trial end point for overall survival

Rachel G. Woodford et al.

Summary: Overall survival (OS) is the gold standard endpoint for oncology trials, but progression-free survival 2 (PFS-2) has been proposed as a surrogate endpoint due to delays in OS data maturation. A meta-analysis found that PFS-2 had a moderate correlation with OS across diverse tumors and therapies, performing consistently better than PFS-1 and objective response rate (ORR). PFS-2 should be included as a key endpoint in future randomized trials of solid tumors.

CANCER (2022)

Article Oncology

IMpower150 Final Exploratory Analyses for Atezolizumab Plus Bevacizumab and Chemotherapy in Key NSCLC Patient Subgroups With EGFR Mutations or Metastases in the Liver or Brain

Naoyuki Nogami et al.

Summary: This study presents the final overall survival (OS) analyses for EGFR mutations and liver or brain metastases subgroups in the IMpower150 study. The results show that ABCP has sustained OS improvements compared to BCP in sensitizing EGFR mutations and baseline liver metastases subgroups. However, ACP does not provide a survival benefit in these subgroups compared to BCP. The study also suggests further investigation into the impact of ABCP on delaying the development of new brain lesions.

JOURNAL OF THORACIC ONCOLOGY (2022)

Article Oncology

When to add anti-angiogenesis drugs to EGFR-mutated metastatic non-small cell lung cancer patients: a real-world study from Taiwan

Chieh-Lung Chen et al.

Summary: In patients with EGFR-mutant NSCLC, first-line combination therapy with EGFR-TKI and anti-angiogenesis treatment improves progression-free survival. Adding an anti-angiogenesis drug to patients with L858R mutation and pleural, liver, or bone metastases provides survival benefits.

BMC CANCER (2022)

Article Oncology

The Clinical Outcomes of Different First-Line EGFR-TKIs Plus Bevacizumab in Advanced EGFR-Mutant Lung Adenocarcinoma

Yen-Hsiang Huang et al.

Summary: This study aimed to investigate the efficacy of different EGFR-TKIs plus bevacizumab in advanced EGFR-mutant lung adenocarcinoma patients. The results showed that both erlotinib plus bevacizumab and afatinib plus bevacizumab as first-line treatment provided solid clinical efficacy in advanced EGFR-mutant lung adenocarcinoma patients.

CANCER RESEARCH AND TREATMENT (2022)

Article Critical Care Medicine

Bevacizumab plus erlotinib versus erlotinib alone in Japanese patients with advanced, metastatic, EGFR-mutant non-small-cell lung cancer (NEJ026): overall survival analysis of an open-label, randomised, multicentre, phase 3 trial

Yosuke Kawashima et al.

Summary: The combination treatment of bevacizumab and erlotinib did not prolong overall survival in patients with metastatic EGFR-mutant NSCLC, but both treatment groups showed relatively long survival durations.

LANCET RESPIRATORY MEDICINE (2022)

Article Oncology

RELAY, ramucirumab plus erlotinib versus placebo plus erlotinib in untreated EGFR-mutated metastatic non-small cell lung cancer: exposure-response relationship

Kazuhiko Nakagawa et al.

Summary: In the RELAY study, the combination of ramucirumab and erlotinib (RAM + ERL) showed improved progression-free survival in patients with untreated, metastatic, EGFR-mutated NSCLC. The exposure-response relationship of RAM was evaluated and no association was observed between RAM exposure and response, indicating that RAM 10 mg/kg Q2W with ERL is an effective and safe first-line treatment for this patient population.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2022)

Article Health Care Sciences & Services

Impact of time-varying cumulative bevacizumab exposures on survival: re-analysis of data from randomized clinical trial in patients with metastatic colo-rectal cancer

Adrien Guilloteau et al.

Summary: This study re-analyzed the data from the PRODIGE9 trial to assess the effects of maintaining bevacizumab during CFI on all-cause mortality of mCRC patients using alternative time-varying exposure metrics. The results consistently suggested protective effects of higher cumulative bevacizumab doses, but caution is needed in interpreting the findings due to potential confusion bias and lack of randomization in the analysis.

BMC MEDICAL RESEARCH METHODOLOGY (2021)

Article Oncology

Erlotinib plus bevacizumab vs erlotinib monotherapy as first-line treatment for advanced EGFR mutation-positive non-squamous non-small-cell lung cancer: Survival follow-up results of the randomized JO25567 study

N. Yamamoto et al.

Summary: The addition of bevacizumab to first-line erlotinib did not significantly improve overall survival in Japanese patients with EGFR+ NSCLC. Both treatment arms showed a similar median OS benefit (up to 4 years), regardless of individual patient characteristics. Results from ongoing studies evaluating the combination of EGFR and VEGF signaling inhibitors are eagerly awaited.

LUNG CANCER (2021)

Article Medicine, General & Internal

EGFR-TKI plus bevacizumab versus EGFR-TKI monotherapy for patients with EGFR mutation-positive advanced non-small cell lung cancer-A propensity score matching analysis

Jeng-Shiuan Tsai et al.

Summary: Real-world data analysis demonstrates that the combination of EGFR-TKI and bevacizumab improves progression-free survival (PFS) in patients with EGFR-mutant non-small cell lung cancer, with better overall survival (OS) observed in patients harboring the L858R mutation.

JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION (2021)

Article Medicine, Research & Experimental

Assessment of exposure-response relationship for bevacizumab in patients with metastatic colorectal cancer

Silvia Pena-Cabia et al.

Summary: Limited literature is available on the exposure-response relationship of bevacizumab, and no concentration threshold is associated with optimal disease control. This real-life observational study aimed to evaluate the relationship between bevacizumab concentrations at steady state and disease control in patients with metastatic colorectal cancer. While no positive association was found with clinical benefit, a higher median Ctrough, SS was associated with better overall survival. More controlled randomized studies are needed to confirm these findings.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Medicine, General & Internal

Osimertinib in Untreated EGFR-Mutated Advanced Non-Small-Cell Lung Cancer

J. -C. Soria et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Gastroenterology & Hepatology

Measurement of circulating levels of VEGF-A, -C, and -D and their receptors, VEGFR-1 and -2 in gastric adenocarcinoma

Mansour S. Al-Moundhri et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2008)