☆ 4.6 Review

Merkel Cell Polyomavirus: Infection, Genome, Transcripts and Its Role in Development of Merkel Cell Carcinoma

CANCERS (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Oncology

Inhibition of T-antigen expression promoting glycogen synthase kinase 3 impairs merkel cell carcinoma cell growth

Roland Houben et al.

Summary: GSK3 inhibitors, such as CHIR99021, have been identified as potential therapeutics for Merkel cell carcinoma (MCC) by repressing TA expression in MCC cells, demonstrating in vivo antitumor activity in a MCC xenograft mouse model. This study provides a promising approach for future treatment of MCC by targeting virus-encoded T antigens.

CANCER LETTERS (2022)

添加到收藏夹

Article Pathology

Genomic evidence suggests that cutaneous neuroendocrine carcinomas can arise from squamous dysplastic precursors

Paul W. Harms et al.

Summary: MCC and SCCIS show significant overlap in gene mutations, with no unique gene mutations found in all cases of MCC. Transcriptome analysis reveals large differences in gene expression between MCC and SCCIS, including epidermal markers and immune genes. Immunohistochemistry studies show increased expression of SOX2 in the MCC component.

MODERN PATHOLOGY (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Induction of APOBEC3-mediated genomic damage in urothelium implicates BK polyomavirus (BKPyV) as a hit-and-run driver for bladder cancer

Simon C. Baker et al.

Summary: Limited understanding of bladder cancer aetiopathology hampers progress in reducing incidence. This study provides missing mechanistic evidence linking reactivated BKPyV-infection to bladder cancer risk.

ONCOGENE (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

DNA-methylation patterns imply a common cellular origin of virus- and UV-associated Merkel cell carcinoma

Jan Gravemeyer et al.

Summary: Analysis of DNA methylation suggests a common epithelial origin of UV- and VP-MCC cell lines.

ONCOGENE (2022)

添加到收藏夹

Review Virology

Merkel Cell Polyomavirus: Oncogenesis in a Stable Genome

Mona M. Ahmed et al.

Summary: This review summarizes the current understanding of the oncogenic mechanisms driven by Merkel cell polyomavirus (MCV) in Merkel cell carcinoma (MCC). The study focuses on the roles of large T (LT) and small T (ST) antigens in promoting MCC oncogenesis and evading growth suppression. The paper also highlights unresolved research questions regarding the origin of MCC and viral integration mechanisms.

VIRUSES-BASEL (2022)

添加到收藏夹

Review Microbiology

Functional Domains of the Early Proteins and Experimental and Epidemiological Studies Suggest a Role for the Novel Human Polyomaviruses in Cancer

Ugo Moens et al.

Summary: Polyomaviruses can induce tumors, with some strains classified as carcinogenic to humans and others possibly carcinogenic. Whether novel HPyVs play a role in cancer is still under question, as they share common features with known PyVs but their role in oncogenic processes is not fully understood. Studies have examined the functional domains of early proteins in novel HPyVs and presented experimental evidence of their potential oncogenic properties. Detection of novel HPyV in human tumors has also been reviewed in the literature.

FRONTIERS IN MICROBIOLOGY (2022)

添加到收藏夹

Article Dermatology

Merkel Cell Polyomavirus-Negative Merkel Cell Carcinoma Originating from In Situ Squamous Cell Carcinoma: A Keratinocytic Tumor with Neuroendocrine Differentiation

Thibault Kervarrec et al.

Summary: The study reveals the association between virus-negative Merkel cell carcinoma (MCC) and squamous cell carcinoma (SCC), suggesting a common origin. RB1 inactivation in SCC facilitates MCC development and epigenetic changes contribute to the transition from SCC to MCC.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2022)

添加到收藏夹

Article Microbiology

Merkel cell polyomavirus large T antigen binding to pRb promotes skin hyperplasia and tumor development

Megan E. Spurgeon et al.

Summary: This study provides clear evidence supporting a causal link between MCPyV and Merkel cell carcinoma, and highlights the importance of the interaction between MCPyV LT and the host protein pRb in tumorigenesis.

PLOS PATHOGENS (2022)

添加到收藏夹

Review Oncology

Prevalence of Merkel Cell Polyomavirus in Normal and Lesional Skin: A Systematic Review and Meta-Analysis

Wilson A. Wijaya et al.

Summary: The prevalence of Merkel cell polyomavirus (MCPyV) in Merkel cell carcinoma (MCC) and its role in the etiology of other skin diseases are still controversial. This study conducted a systematic review and meta-analysis to assess the association between MCPyV infection and MCC, non-MCC skin lesions, and normal skin. The results showed that MCPyV infection was significantly associated with an increased risk of MCC, but the prevalence rate of MCPyV+ in non-MCC skin lesions was low, indicating a possible pathogenic association with the development of non-MCC skin lesions.

FRONTIERS IN ONCOLOGY (2022)

添加到收藏夹

Article Virology

Merkel cell polyomavirus and associated Merkel cell carcinoma

June F. Yang et al.

Summary: Merkel cell polyomavirus is a common skin infection that can cause a highly lethal form of skin cancer. Our current understanding of the virus's infection and oncogenic mechanisms is incomplete, necessitating further research to develop more effective treatments.

TUMOUR VIRUS RESEARCH (2022)

添加到收藏夹

Article Pathology

RB1-deficient squamous cell carcinoma: the proposed source of combined Merkel cell carcinoma

Ryan C. DeCoste et al.

Summary: Merkel cell carcinoma (MCC) is an aggressive skin cancer with different subtypes based on the origin of Merkel cell polyomavirus and genetic damage. This study used genomic profiling and immunohistochemistry to investigate the mutational profiles and pathogenesis of MCC. The results showed that MCPyV+ and MCPyV- MCCs are distinct entities in terms of pathogenesis and the NE and SCC components of combined MCCs are linked through shared genetic profiles.

MODERN PATHOLOGY (2022)

添加到收藏夹

Article Medicine, Research & Experimental

Reversal of viral and epigenetic HLA class I repression in Merkel cell carcinoma

Patrick C. Lee et al.

Summary: This study reveals transcriptional suppression of HLA-I antigen presentation in Merkel cell carcinoma and identifies MYCL, PRC1.1, and USP7 as regulators in this process.

JOURNAL OF CLINICAL INVESTIGATION (2022)

添加到收藏夹

Article Medicine, Research & Experimental

Direct cellular reprogramming enables development of viral T antigen-driven Merkel cell carcinoma in mice

Monique E. Verhaegen et al.

Summary: Merkel cell carcinoma (MCC) is an aggressive skin cancer that expresses specific genes similar to skin-resident Merkel cells. Researchers have used ATOH1 to induce MCC development in mice by cellular reprogramming. By conditionally expressing MCPyV TAgs and ATOH1 in mouse epidermal cells, they were able to generate MCC-like tumor cells from hair follicles. The study confirmed the similarity between mouse and human MCCs and revealed that loss of p53 is necessary for the progression of MCC in this mouse model.

JOURNAL OF CLINICAL INVESTIGATION (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Genome-wide profiling of BK polyomavirus integration in bladder cancer of kidney transplant recipients reveals mechanisms of the integration at the nucleotide level

Yu Jin et al.

Summary: Chronic BK polyomavirus (BKPyV) infection is considered a potential oncogenic factor for urothelial carcinoma (UC) in renal transplant recipients. Integration sites between human and BKPyV genomes were enriched with microhomologies, and viral insertional integration led to fusion sequences of 75 human genes, with 15 genes showing statistical association with UC based on expression analysis. These findings suggest a potential mechanism of viral-driven carcinogenesis in BKPyV-related UC.

ONCOGENE (2021)

添加到收藏夹

Review Medicine, Research & Experimental

Molecular Pathogenesis of Merkel Cell Carcinoma

James A. DeCaprio

Summary: Merkel cell carcinoma (MCC) has two distinct etiologies, with one caused by viral DNA integration and the other by UV damage. Despite different causes, both forms of MCC have similar presentation, prognosis, and response to therapy. Oncogenic transcriptional programs, cell proliferation rates, and neuroendocrine differentiation programs play important roles in both types of MCC.

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 16, 2021 (2021)

添加到收藏夹

Article Oncology

The Merkel Cell Polyomavirus T Antigens Function as Tumor Promoters in Murine Skin

Megan E. Spurgeon et al.

Summary: Merkel cell polyomavirus (MCPyV) is associated with the development of Merkel cell carcinoma, with its T antigens acting primarily as tumor promoters in skin cancer development. The viral T antigens synergize with tumor initiator DMBA but not with tumor promoter TPA, suggesting a complex interaction between viral oncogenes and other carcinogenic factors in tumor formation. These findings provide valuable insights into the pathogenic mechanisms of MCPyV in human skin cancer.

CANCERS (2021)

添加到收藏夹

Article Microbiology

Natural History of Cutaneous Human Polyomavirus Infection in Healthy Individuals

Luisa Bopp et al.

Summary: This study evaluated the cutaneous prevalence, persistence, and viral load of HPyVs in healthy individuals, finding several risk factors associated with HPyV prevalence and persistence. TSPyV, HPyV9, and HPyV10 do not appear to be long-term constituents of the human skin virome in healthy individuals. Higher viral loads were found to be associated with both short- and long-term persistence of HPyVs on the skin. Multiplicity of HPyVs was identified as a risk factor for prevalence and persistence for several types of HPyVs.

FRONTIERS IN MICROBIOLOGY (2021)

添加到收藏夹

Article Microbiology

Characterization of ALTO-encoding circular RNAs expressed by Merkel cell polyomavirus and trichodysplasia spinulosa polyomavirus

Rong Yang et al.

Summary: The study reveals that human polyomavirus (HPyV) generate circular RNAs (circRNAs) in human tumors and infected tissues which can express proteins that have the potential to modulate the infectious and tumorigenic properties of these viruses. In particular, MCPyV and TSPyV generate circRNAs encompassing part of the early region that can be translated to ALTO protein in cultured cells, and MCPyV ALTO has the ability to regulate transcription.

PLOS PATHOGENS (2021)

添加到收藏夹

Review Microbiology

Biology of Polyomavirus miRNA

Wei Zou et al.

Summary: Polyomaviruses are a family of non-enveloped DNA viruses with wide host ranges that can cause asymptomatic infection and severe diseases upon reactivation. Research has shown that most well-studied polyomaviruses encode viral miRNA to regulate viral replication and pathogenesis by controlling both host and viral gene expression. The potential application of polyomavirus miRNA as a marker for disease progression and reactivation is also discussed.

FRONTIERS IN MICROBIOLOGY (2021)

添加到收藏夹

Article Oncology

Expression of Mismatch Repair Proteins in Merkel Cell Carcinoma

Thilo Gambichler et al.

Summary: This study found a significant association between low expression of mismatch repair proteins and a negative MCPyV status in Merkel cell carcinoma. Microsatellite instability was detected in only one case, suggesting a potential impact on immune checkpoint inhibitor therapy outcome. Further research is needed to determine if this subset of MCC patients respond better to ICI therapy.

CANCERS (2021)

添加到收藏夹

Article Oncology

Merkel cell polyomavirus oncoproteins induce microRNAs that suppress multiple autophagy genes

Satendra Kumar et al.

INTERNATIONAL JOURNAL OF CANCER (2020)

添加到收藏夹

Article Dermatology

Polyomavirus-Positive Merkel Cell Carcinoma Derived from a Trichoblastoma Suggests an Epithelial Origin of this Merkel Cell Carcinoma

Thibault Kervarrec et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2020)

添加到收藏夹

Review Dermatology

Merkel cell carcinoma update: the case for two tumours

A. Nirenberg et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

添加到收藏夹

Article Virology

The Ubiquitin-Specific Protease Usp7, a Novel Merkel Cell Polyomavirus Large T-Antigen Interaction Partner, Modulates Viral DNA Replication

Manja Czech-Sioli et al.

JOURNAL OF VIROLOGY (2020)

添加到收藏夹

Review Virology

Evidence of the Mechanism by Which Polyomaviruses Exploit the Extracellular Vesicle Delivery System during Infection

Simone Giannecchini

VIRUSES-BASEL (2020)

添加到收藏夹

Article Microbiology

Merkel Cell Polyomavirus DNA Replication Induces Senescence in Human Dermal Fibroblasts in a Kap1/Trim28-Dependent Manner

Svenja Siebels et al.

MBIO (2020)

添加到收藏夹

Article Genetics & Heredity

Clinical and molecular characterization of virus-positive and virus-negative Merkel cell carcinoma

Gabriel J. Starrett et al.

GENOME MEDICINE (2020)

添加到收藏夹

Article Oncology

Surface charge of Merkel cell polyomavirus small T antigen determines cell transformation through allosteric FBW7 WD40 domain targeting

Nnenna Nwogu et al.

ONCOGENESIS (2020)

添加到收藏夹

Article Cell Biology

Merkel cell polyomavirus activates LSD1-mediated blockade of non-canonical BAF to regulate transformation and tumorigenesis

Donglim Esther Park et al.

NATURE CELL BIOLOGY (2020)

添加到收藏夹

Review Oncology

Merkel Cell Polyomavirus and Merkel Cell Carcinoma

Valeria Pietropaolo et al.

CANCERS (2020)

添加到收藏夹

Article Dermatology

Morphologic Diversity of Merkel Cell Carcinoma

Toru Ogawa et al.

AMERICAN JOURNAL OF DERMATOPATHOLOGY (2020)

添加到收藏夹

Article Virology

Merkel Cell Polyomavirus Small Tumor Antigen Activates Matrix Metallopeptidase-9 Gene Expression for Cell Migration and Invasion

Nnenna Nwogu et al.

JOURNAL OF VIROLOGY (2020)

添加到收藏夹

Article Oncology

Merkel Cell Polyomavirus Small T Antigen Activates Noncanonical NF-κB Signaling to Promote Tumorigenesis

Jiawei Zhao et al.

MOLECULAR CANCER RESEARCH (2020)

添加到收藏夹

Article Virology

Merkel Cell Polyomavirus Large T Antigen Unique Domain Regulates Its Own Protein Stability and Cell Growth

Nnenna Nwogu et al.

VIRUSES-BASEL (2020)

添加到收藏夹

Review Virology

Genetic Diversity of the Noncoding Control Region of the Novel Human Polyomaviruses

Ugo Moens et al.

VIRUSES-BASEL (2020)

添加到收藏夹

Article Microbiology

Merkel Cell Polyomavirus Encodes Circular RNAs (circRNAs) Enabling a Dynamic circRNA/microRNA/mRNA Regulatory Network

Bizunesh Abere et al.

MBIO (2020)

添加到收藏夹

Article Oncology

Characterization of six Merkel cell polyomavirus-positive Merkel cell carcinoma cell lines: Integration pattern suggest that large T antigen truncating events occur before or during integration

David Schrama et al.

INTERNATIONAL JOURNAL OF CANCER (2019)

添加到收藏夹

Article Microbiology

Merkel cell polyomavirus Tumor antigens expressed in Merkel cell carcinoma function independently of the ubiquitin ligases Fbw7 and -TrCP

Kristine N. Dye et al.

PLOS PATHOGENS (2019)

添加到收藏夹

Review Oncology

Histogenesis of Merkel Cell Carcinoma: A Comprehensive Review

Thibault Kervarrec et al.

FRONTIERS IN ONCOLOGY (2019)

添加到收藏夹

Article Virology

Infectious Entry of Merkel Cell Polyomavirus

Miriam Becker et al.

JOURNAL OF VIROLOGY (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Dual inhibition of MDM2 and MDM4 in virus-positive Merkel cell carcinoma enhances the p53 response

Donglim Esther Park et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

添加到收藏夹

Article Virology

Merkel Cell Polyomavirus Small T Antigen Drives Cell Motility via Rho-GTPase-Induced Filopodium Formation

Gabriele Stakaityte et al.

JOURNAL OF VIROLOGY (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

The cellular chloride channels CLIC1 and CLIC4 contribute to virus-mediated cell motility

Gabriele Stakaityte et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

添加到收藏夹

Article Dermatology

MCV-miR-M1 Targets the Host-Cell Immune Response Resulting in the Attenuation of Neutrophil Chemotaxis

Pouria Akhbari et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2018)

添加到收藏夹

Article Virology

Novel Human Polyomavirus Noncoding Control Regions Differ in Bidirectional Gene Expression according to Host Cell, Large T-Antigen Expression, and Clinically Occurring Rearrangements

Elvis T. Ajuh et al.

JOURNAL OF VIROLOGY (2018)

添加到收藏夹

Article Pathology

Polyoma virus-associated carcinomas of the urologic tract: a clinicopathologic and molecular study

Deepika Sirohi et al.

MODERN PATHOLOGY (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Are there multiple cells of origin of Merkel cell carcinoma?

J. C. Sunshine et al.

ONCOGENE (2018)

添加到收藏夹

Review Microbiology

The Human Polyomavirus Middle and Alternative T-Antigens; Thoughts on Roles and Relevance to Cancer

Els van der Meijden et al.

FRONTIERS IN MICROBIOLOGY (2018)

添加到收藏夹

Review Endocrinology & Metabolism

Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation

Jacob O'Brien et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

添加到收藏夹

Review Infectious Diseases

Biology, evolution, and medical importance of polyomaviruses: An update

Ugo Moens et al.

INFECTION GENETICS AND EVOLUTION (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Protein-mediated viral latency is a novel mechanism for Merkel cell polyomavirus persistence

Hyun Jin Kwun et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

添加到收藏夹

Article Microbiology

Merkel Cell Polyomavirus Exhibits Dominant Control of the Tumor Genome and Transcriptome in Virus-Associated Merkel Cell Carcinoma

Gabriel J. Starrett et al.

MBIO (2017)

添加到收藏夹

Article Microbiology

Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis

Jingwei Cheng et al.

PLOS PATHOGENS (2017)

添加到收藏夹

Review Oncology

Reviewing the current evidence supporting early B-cells as the cellular origin of Merkel cell carcinoma

C. M. Sauer et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2017)

添加到收藏夹

Article Oncology

Merkel Cell Polyomavirus Small T Antigen Initiates Merkel Cell Carcinoma-like Tumor Development in Mice

Monique E. Verhaegen et al.

CANCER RESEARCH (2017)

添加到收藏夹

Article Oncology

Serine 220 phosphorylation of the Merkel cell polyomavirus large T antigen crucially supports growth of Merkel cell carcinoma cells

David Schrama et al.

INTERNATIONAL JOURNAL OF CANCER (2016)

添加到收藏夹

Article Oncology

Mutational landscape of MCPyV-positive and MCPyV-negative Merkel cell carcinomas with implications for immunotherapy

Gerald Goh et al.

ONCOTARGET (2016)

添加到收藏夹

Article Oncology

Analysis of Prognostic Factors from 9387 Merkel Cell Carcinoma Cases Forms the Basis for the New 8th Edition AJCC Staging System

Kelly L. Harms et al.

ANNALS OF SURGICAL ONCOLOGY (2016)

添加到收藏夹

Article Dermatology

Survival with nonmelanoma skin cancer in Germany

N. Eisemann et al.

BRITISH JOURNAL OF DERMATOLOGY (2016)

添加到收藏夹

Article Microbiology

Identifying the Target Cells and Mechanisms of Merkel Cell Polyomavirus Infection

Wei Liu et al.

CELL HOST & MICROBE (2016)

添加到收藏夹

Article Immunology

Ecology of Merkel Cell Polyomavirus in Healthy Skin Among Individuals in an Asian Cohort

Yumiko Hashida et al.

JOURNAL OF INFECTIOUS DISEASES (2016)

添加到收藏夹

Article Oncology

RB1 is the crucial target of the Merkel cell polyomavirus Large T antigen in Merkel cell carcinoma cells

Sonja Hesbacher et al.

ONCOTARGET (2016)

添加到收藏夹

Article Microbiology

Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation

Christian Berrios et al.

PLOS PATHOGENS (2016)

添加到收藏夹

Article Oncology

Tumorigenic Activity of Merkel Cell Polyomavirus T Antigens Expressed in the Stratified Epithelium of Mice

Megan E. Spurgeon et al.

CANCER RESEARCH (2015)

添加到收藏夹

Article Oncology

The Distinctive Mutational Spectra of Polyomavirus-Negative Merkel Cell Carcinoma

Paul William Harms et al.

CANCER RESEARCH (2015)

添加到收藏夹

Article Cell & Tissue Engineering

Basal Cell Carcinoma Preferentially Arises from Stem Cells within Hair Follicle and Mechanosensory Niches

Shelby C. Peterson et al.

CELL STEM CELL (2015)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Early and late promoters of BK polyomavirus, Merkel cell polyomavirus, Trichodysplasia spinulosa-associated polyomavirus and human polyomavirus 12 are among the strongest of all known human polyomaviruses in 10 different cell lines

Ugo Moens et al.

JOURNAL OF GENERAL VIROLOGY (2015)

添加到收藏夹

Article Dermatology

Merkel Cell Polyomavirus Small T Antigen Is Oncogenic in Transgenic Mice

Monique E. Verhaegen et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2015)

添加到收藏夹

Article Multidisciplinary Sciences

CDK1 substitutes for mTOR kinase to activate mitotic cap-dependent protein translation

Masahiro Shuda et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

添加到收藏夹

Article Microbiology

A Comprehensive Analysis of Replicating Merkel Cell Polyomavirus Genomes Delineates the Viral Transcription Program and Suggests a Role for mcv-miR-M1 in Episomal Persistence

Juliane Marie Theiss et al.

PLOS PATHOGENS (2015)

添加到收藏夹

Article Oncology

Characterization of functional domains in the Merkel cell polyoma virus Large T antigen

Roland Houben et al.

INTERNATIONAL JOURNAL OF CANCER (2015)

添加到收藏夹

Article Immunology

Natural History of Polyomaviruses in Men: The HPV Infection in Men (HIM) Study

Shalaka S. Hampras et al.

JOURNAL OF INFECTIOUS DISEASES (2015)

添加到收藏夹

Article Virology

Merkel Cell Polyomavirus Small T Antigen Mediates Microtubule Destabilization To Promote Cell Motility and Migration

Laura M. Knight et al.

JOURNAL OF VIROLOGY (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Merkel Cell Polyomavirus Small T Antigen Induces Cancer and Embryonic Merkel Cell Proliferation in a Transgenic Mouse Model

Masahiro Shuda et al.

PLOS ONE (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

Merkel Cells Transduce and Encode Tactile Stimuli to Drive Aβ-Afferent Impulses

Ryo Ikeda et al.

CELL (2014)

添加到收藏夹

Article Dermatology

Merkel cells and touch domes: more than mechanosensory functions?

Ying Xiao et al.

EXPERIMENTAL DERMATOLOGY (2014)

添加到收藏夹

Article Virology

High-Affinity Rb Binding, p53 Inhibition, Subcellular Localization, and Transformation by Wild-Type or Tumor-Derived Shortened Merkel Cell Polyomavirus Large T Antigens

Sophie Borchert et al.

JOURNAL OF VIROLOGY (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Piezo2 is the major transducer of mechanical forces for touch sensation in mice

Sanjeev S. Ranade et al.

NATURE (2014)

添加到收藏夹

Article Oncology

Early B-Cell Differentiation in Merkel Cell Carcinomas: Clues to Cellular Ancestry

Axel zur Hausen et al.

CANCER RESEARCH (2013)

添加到收藏夹

Article Microbiology

Merkel Cell Polyomavirus Small T Antigen Controls Viral Replication and Oncoprotein Expression by Targeting the Cellular Ubiquitin Ligase SCFFbw7

Hyun Jin Kwun et al.

CELL HOST & MICROBE (2013)

添加到收藏夹

Article Immunology

Age-Specific Seroprevalences of Merkel Cell Polyomavirus, Human Polyomaviruses 6, 7, and 9, and Trichodysplasia Spinulosa-Associated Polyomavirus

Jerome T. J. Nicol et al.

CLINICAL AND VACCINE IMMUNOLOGY (2013)

添加到收藏夹

Article Dermatology

Mechanisms of p53 Restriction in Merkel Cell Carcinoma Cells Are Independent of the Merkel Cell Polyoma Virus T Antigens

Roland Houben et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2013)

添加到收藏夹

Article Virology

Merkel Cell Polyomavirus Large T Antigen Disrupts Host Genomic Integrity and Inhibits Cellular Proliferation

Jing Li et al.

JOURNAL OF VIROLOGY (2013)

添加到收藏夹

Article Virology

Merkel Cell Polyomavirus Large T Antigen Has Growth-Promoting and Inhibitory Activities

Jingwei Cheng et al.

JOURNAL OF VIROLOGY (2013)

添加到收藏夹

Article Virology

Merkel Cell Polyomavirus Small T Antigen Targets the NEMO Adaptor Protein To Disrupt Inflammatory Signaling

David A. Griffiths et al.

JOURNAL OF VIROLOGY (2013)

添加到收藏夹

Review Microbiology

A cornucopia of human polyomaviruses

James A. DeCaprio et al.

NATURE REVIEWS MICROBIOLOGY (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Identification of an overprinting gene in Merkel cell polyomavirus provides evolutionary insight into the birth of viral genes

Joseph J. Carter et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

添加到收藏夹

Article Microbiology

The Merkel Cell Polyomavirus Minor Capsid Protein

Rachel M. Schowalter et al.

PLOS PATHOGENS (2013)

添加到收藏夹

Article Immunology

Positive correlation between Merkel cell polyomavirus viral load and capsid-specific antibody titer

Diana V. Pastrana et al.

MEDICAL MICROBIOLOGY AND IMMUNOLOGY (2012)

添加到收藏夹

Article Multidisciplinary Sciences

Entry Tropism of BK and Merkel Cell Polyomaviruses in Cell Culture

Rachel M. Schowalter et al.

PLOS ONE (2012)

添加到收藏夹

Article Microbiology

Structures of Merkel Cell Polyomavirus VP1 Complexes Define a Sialic Acid Binding Site Required for Infection

Ursula Neu et al.

PLOS PATHOGENS (2012)

添加到收藏夹

Review Dermatology

Which Are the Cells of Origin in Merkel Cell Carcinoma?

Thomas Tilling et al.

JOURNAL OF SKIN CANCER (2012)

添加到收藏夹

Article Virology

Taxonomical developments in the family Polyomaviridae

Reimar Johne et al.

ARCHIVES OF VIROLOGY (2011)

添加到收藏夹

Article Hematology

Merkel cell polyomavirus DNA sequences in the buffy coats of healthy blood donors

Cecilia Pancaldi et al.

BLOOD (2011)

添加到收藏夹

Article Immunology

Age-Specific Seroprevalence of Merkel Cell Polyomavirus, BK Virus, and JC Virus

Raphael P. Viscidi et al.

CLINICAL AND VACCINE IMMUNOLOGY (2011)

添加到收藏夹

Article Biochemistry & Molecular Biology

Merkel Cell Polyomavirus Large T Antigen Disrupts Lysosome Clustering by Translocating Human Vam6p from the Cytoplasm to the Nucleus

Xi Liu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

添加到收藏夹

Article Medicine, Research & Experimental

Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator

Masahiro Shuda et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

添加到收藏夹

Article Virology

Identification and validation of a novel mature microRNA encoded by the Merkel cell polyomavirus in human Merkel cell carcinomas

Sherry Lee et al.

JOURNAL OF CLINICAL VIROLOGY (2011)

添加到收藏夹

Article Virology

Detection of Merkel Cell Polyomavirus on Environmental Surfaces

Vincent Foulongne et al.

JOURNAL OF MEDICAL VIROLOGY (2011)

添加到收藏夹

Article Microbiology

Glycosaminoglycans and Sialylated Glycans Sequentially Facilitate Merkel Cell Polyomavirus Infectious Entry

Rachel M. Schowalter et al.

PLOS PATHOGENS (2011)

添加到收藏夹

Article Immunology

Asymptomatic Primary Merkel Cell Polyomavirus Infection among Adults

Yanis L. Tolstov et al.

EMERGING INFECTIOUS DISEASES (2011)

添加到收藏夹

Article Virology

A comparative study of Merkel cell, BK and JC polyomavirus infections in renal transplant recipients and healthy subjects

Mohamed I. Husseiny et al.

JOURNAL OF CLINICAL VIROLOGY (2010)

添加到收藏夹

Article Dermatology

Inflammatory Monocytes Are a Reservoir for Merkel Cell Polyomavirus

Kirsten D. Mertz et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2010)

添加到收藏夹

Article Virology

Merkel Cell Polyomavirus-Infected Merkel Cell Carcinoma Cells Require Expression of Viral T Antigens

Roland Houben et al.

JOURNAL OF VIROLOGY (2010)

添加到收藏夹

Article Virology

Nuclear localization of Merkel cell polyomavirus large T antigen in Merkel cell carcinoma

Tomoyuki Nakamura et al.

VIROLOGY (2010)

添加到收藏夹

Article Immunology

Merkel Cell Polyomavirus in Cutaneous Swabs

Vincent Foulongne et al.

EMERGING INFECTIOUS DISEASES (2010)

添加到收藏夹

Article Developmental Biology

Mammalian Merkel cells are descended from the epidermal lineage

Kristin M. Morrison et al.

DEVELOPMENTAL BIOLOGY (2009)

添加到收藏夹

Article Biochemistry & Molecular Biology

Most mammalian mRNAs are conserved targets of microRNAs

Robin C. Friedman et al.

GENOME RESEARCH (2009)

添加到收藏夹

Article Oncology

Merkel cell carcinoma of the skin: pathological and molecular evidence for a causative role of MCV in oncogenesis

Xavier Sastre-Garau et al.

JOURNAL OF PATHOLOGY (2009)

添加到收藏夹

Article Virology

Ganglioside GT1b Is a Putative Host Cell Receptor for the Merkel Cell Polyomavirus

Kimberly D. Erickson et al.

JOURNAL OF VIROLOGY (2009)

添加到收藏夹

Article Multidisciplinary Sciences

Merkel Cells Are Essential for Light-Touch Responses

Stephen M. Maricich et al.

SCIENCE (2009)

添加到收藏夹

Review Oncology

Cellular transformation by Simian Virus 40 and Murine Polyoma Virus T antigens

Jingwei Cheng et al.

SEMINARS IN CANCER BIOLOGY (2009)

添加到收藏夹

Review Virology

How the Rb tumor suppressor structure and function was revealed by the study of Adenovirus and SV40

James A. DeCaprio

VIROLOGY (2009)

添加到收藏夹

Article Virology

Merkel cell polyomavirus encodes a microRNA with the ability to autoregulate viral gene expression

Gil Ju Seo et al.

VIROLOGY (2009)

添加到收藏夹

Article Immunology

Merkel Cell Polyomavirus DNA in Respiratory Specimens from Children and Adults

Seweryn Bialasiewicz et al.

EMERGING INFECTIOUS DISEASES (2009)

添加到收藏夹

Review Oncology

SV40 small T antigen and PP2A phosphatase in cell transformation

Anna A. Sablina et al.

CANCER AND METASTASIS REVIEWS (2008)

添加到收藏夹

Article Multidisciplinary Sciences

T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus

Masahiro Shuda et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

添加到收藏夹

Article Multidisciplinary Sciences

Clonal integration of a polyomavirus in human Merkel cell carcinoma

Huichen Feng et al.

SCIENCE (2008)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Avian polyomavirus mutants with deletions in the VP4-encoding region show deficiencies in capsid assembly and virus release, and have reduced infectivity in chicken

Reimar Johne et al.

JOURNAL OF GENERAL VIROLOGY (2007)

添加到收藏夹

Article Multidisciplinary Sciences

A transgenic mouse model of metastatic carcinoma. involving transdifferentiation of a gastric epithelial lineage progenitor to a neuroendocrine phenotype

AJ Syder et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

添加到收藏夹

Review Anatomy & Morphology

Friedrich Sigmund Merkel and his Merkel cell, morphology, development, and physiology: Review and new results

Z Halata et al.

ANATOMICAL RECORD PART A-DISCOVERIES IN MOLECULAR CELLULAR AND EVOLUTIONARY BIOLOGY (2003)

添加到收藏夹

Article Cell Biology

Human Vam6p promotes lysosome clustering and fusion in vivo

S Caplan et al.

JOURNAL OF CELL BIOLOGY (2001)

添加到收藏夹

Article Pathology

Primary neuroendocrine (Merkel cell) carcinoma of the skin: Morphologic diversity and implications thereof

NMG Walsh

HUMAN PATHOLOGY (2001)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.