4.6 Article

Identification of Factors Driving Doxorubicin-Resistant Ewing Tumor Cells to Survival

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Niclosamide Suppresses Migration and Invasion of Human Osteosarcoma Cells by Repressing TGFBI Expression via the ERK Signaling Pathway

Liang-Tsai Yeh et al.

Summary: Niclosamide inhibits migration and invasion of osteosarcoma cells by suppressing TGFBI expression and phosphorylation of the ERK pathway. This study suggests that niclosamide may be a promising preventive and therapeutic agent for osteosarcoma.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Biochemistry & Molecular Biology

Selective histone methyltransferase G9a inhibition reduces metastatic development of Ewing sarcoma through the epigenetic regulation of NEU1

Daniel J. Garcia-Dominguez et al.

Summary: The study evaluated the effects of a selective G9a histone methyltransferase inhibitor (BIX01294) on the metastatic process of Ewing sarcoma (EWS). The results showed that overexpression of G9a in EWS tumors is associated with poor prognosis. Furthermore, the inhibition of G9a with BIX01294 disrupted several steps of metastasis in vitro and reduced tumor growth and metastases in mouse models. The study also identified the sialidase NEU1 as a direct target and effector of G9a in the metastatic process of EWS.

ONCOGENE (2022)

Article Medicine, General & Internal

Development of a Machine Learning-Based Predictive Model for Lung Metastasis in Patients With Ewing Sarcoma

Wenle Li et al.

Summary: This study developed and validated machine learning-based prediction models for lung metastasis in patients with Ewing sarcoma. The best-performing model, Random Forest, was used to create an online tool for clinicians to optimize individual treatment. Machine learning proved to be useful in predicting lung metastasis and the RF model had the best performance.

FRONTIERS IN MEDICINE (2022)

Review Oncology

An international working group consensus report for the prioritization of molecular biomarkers for Ewing sarcoma

David S. Shulman et al.

Summary: The introduction of dose intensified interval compressed therapy has improved event-free survival for localized Ewing sarcoma patients. However, a significant number of patients still experience relapse and die of the disease, with surviving patients often facing debilitating late effects. Traditional clinical features are inadequate for risk stratification, highlighting the need to develop approaches based on molecular features. New technology has allowed the study of multiple molecular biomarkers in Ewing sarcoma, which may enable risk-adapted treatment in the future.

NPJ PRECISION ONCOLOGY (2022)

Article Biochemistry & Molecular Biology

A novel HDGF-ALCAM axis promotes the metastasis of Ewing sarcoma via regulating the GTPases signaling pathway

Yang Yang et al.

Summary: Research has shown that HDGF promotes metastasis in Ewing sarcoma (ES) and leads to poor patient outcomes by regulating multiple metastasis-associated genes, particularly ALCAM. The study further reveals associations among HDGF, ALCAM, and GTPases, suggesting that the HDGF/ALCAM/GTPases axis may serve as a promising therapeutic target for limiting ES metastasis.

ONCOGENE (2021)

Article Oncology

MYCT1 Inhibits the Adhesion and Migration of Laryngeal Cancer Cells Potentially Through Repressing Collagen VI

Peng-Peng Wang et al.

Summary: The study identified that MYCT1 inhibits laryngeal cancer cell migration by targeting COL6, providing an important clue for further research on the role of MYCT1 in laryngeal cancer progression.

FRONTIERS IN ONCOLOGY (2021)

Article Biotechnology & Applied Microbiology

COL3A1 and Its Related Molecules as Potential Biomarkers in the Development of Human Ewing's Sarcoma

Min Tang et al.

Summary: Bioinformatics analysis identified a significant correlation between COL1A2, COL3A1, and TGFBI with the overall survival of ES patients. Specifically, high COL3A1 mRNA expression was associated with poor overall survival, distant metastasis, and margin status in ES patients.

BIOMED RESEARCH INTERNATIONAL (2021)

Article Oncology

Prognosis and Immune Infiltration of Chromobox Family Genes in Sarcoma

Jian Zhou et al.

Summary: This study identified that CBXs are significantly overexpressed in human sarcomas and are associated with survival rate and immune cell infiltration in sarcoma patients. These findings suggest that CBXs could serve as potential biomarkers for prognosis and immune infiltration in sarcoma.

FRONTIERS IN ONCOLOGY (2021)

Article Multidisciplinary Sciences

Diffusion of a disordered protein on its folded ligand

Felix Wiggers et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Medicine, Research & Experimental

Establishment and Characterisation of Metastatic Extraskeletal Ewing Sarcoma Mouse Models

Carmelo Cerra et al.

Summary: The study demonstrated that animal models of extraskeletal Ewing sarcoma can metastasize to multiple organs, with a more significant infiltration of immune cells in metastatic tumors.

IN VIVO (2021)

Article Oncology

DNA methylation profiling distinguishes Ewing-like sarcoma with EWSR1-NFATc2 fusion from Ewing sarcoma

Christian Koelsche et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2019)

Article Biochemistry & Molecular Biology

g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update)

Uku Raudvere et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Oncology

Reactivation of TWIST1 contributes to Ewing sarcoma metastasis

Sun Choo et al.

PEDIATRIC BLOOD & CANCER (2018)

Article Oncology

SerpinE2 promotes multiple cell proliferation and drug resistance in osteosarcoma

Minzhi Mao et al.

MOLECULAR MEDICINE REPORTS (2016)

Article Oncology

Cadherin-11 regulates the metastasis of Ewing sarcoma cells to bone

Mihoko Hatano et al.

CLINICAL & EXPERIMENTAL METASTASIS (2015)

Article Pharmacology & Pharmacy

Carbonic anhydrase IX inhibition is an effective strategy for osteosarcoma treatment

Francesca Perut et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2015)

Article Biotechnology & Applied Microbiology

Extracellular Matrix Modulates Angiogenesis in Physiological and Pathological Conditions

Anna Neve et al.

BIOMED RESEARCH INTERNATIONAL (2014)

Article Oncology

Ewing sarcoma cells express RANKL and support osteoclastogenesis

Richard Taylor et al.

JOURNAL OF PATHOLOGY (2011)

Review Oncology

Promiscuous partnerships in Ewing's sarcoma

Savita Sankar et al.

CANCER GENETICS (2011)

Article Genetics & Heredity

Over-Expression of DSCAM and COL6A2 Cooperatively Generates Congenital Heart Defects

Tamar R. Grossman et al.

PLOS GENETICS (2011)

Article Oncology

Caveolin-1 Modulates the Ability of Ewing's Sarcoma to Metastasize

Miguel Sainz-Jaspeado et al.

MOLECULAR CANCER RESEARCH (2010)

Article Multidisciplinary Sciences

Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy

Danielle B. Ulanet et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Pathology

Prognostic significance of drug-regulated genes in high-grade osteosarcoma

Joerg Fellenberg et al.

MODERN PATHOLOGY (2007)

Review Biochemistry & Molecular Biology

Glutathione S-transferase polymorphisms:: cancer incidence and therapy

CC McIlwain et al.

ONCOGENE (2006)

Article Biotechnology & Applied Microbiology

Cathepsin L antisense oligonucleotides in a human osteosarcoma cell line: Effects on the invasive phenotype

S Krueger et al.

CANCER GENE THERAPY (2001)