Labyrinthin Expression Is Associated with Poor Prognosis in Patients with Non-Small-Cell Lung Cancer

Review Oncology

Molecular Mechanisms of Sanguinarine in Cancer Prevention and Treatment

Asmat Ullah et al.

Summary: In this critical study, the utilization of Sanguinarine (SANG) mimics and nano-technologies to improve its support in cancer treatment is reviewed, with a focus on recently disclosed studies on the anti-cancer properties of SANG.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2023)

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Review Oncology

Molecular Mechanisms of Sanguinarine in Cancer Prevention and Treatment

Asmat Ullah et al.

Summary: Historically, natural plant-derived drugs have played an important role in treating human-related diseases. Sanguinarine (SANG), a naturally isolated plant alkaloidal agent, has been found to impede tumor metastasis and development by disrupting various cell signaling pathways. However, its low chemical stability and poor oral bioavailability need to be addressed. The utilization of nano-technologies provides an exciting approach to improve the efficacy of SANG in cancer treatment. SANG has also shown the ability to regulate cancer-specific miRNA expression, but the mechanism remains unclear.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2023)

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Review Biochemical Research Methods

Two Promising Anti-Cancer Compounds, 2-Hydroxycinnaldehyde and 2-Benzoyloxycinnamaldehyde: Where do we stand?

Haroon Iqbal et al.

Summary: Natural bioactive compounds from cinnamon, such as 2-hydroxycinnaldehyde and 2benzoyloxycinnamaldehyde, show significant anti-carcinogenic activity and have immunomodulatory, anti-platelet, and anti-inflammatory effects. However, understanding their exact molecular mechanisms remains challenging.

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2022)

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Article Multidisciplinary Sciences

Labyrinthin: A distinct pan-adenocarcinoma diagnostic and immunotherapeutic tumor specific antigen

Michael Babich et al.

Summary: In this study, the structural analysis and optimal cell surface localization of labyrinthin, a pan-adenocarcinoma target, were investigated. The results confirmed the specificity of labyrinthin for adenocarcinoma cells and raised a controversial issue regarding the role of intracellular ASPH as an adenocarcinoma tumor-associated antigen.

HELIYON (2022)

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Article Oncology

A first-in-human, phase I, open-label study of a novel cancer vaccine labvax 3(22)-23 and adjuvant GM-CSF in patients with advanced stage adenocarcinomas.

Weijie Ma et al.

JOURNAL OF CLINICAL ONCOLOGY (2022)

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Review Oncology

Advances in the development of personalized neoantigen-based therapeutic cancer vaccines

Eryn Blass et al.

Summary: Immunotherapy has revolutionized cancer treatment with the development of immune-checkpoint inhibitors and personalized neoantigen vaccines. These vaccines trigger specific T cell responses against individual patient's tumors, showing promising tumor-specific immunogenicity and antitumor activity.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

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Article Cell Biology

Cephalomannine inhibits hypoxia-induced cellular function via the suppression of APEX1/HIF-1α interaction in lung cancer

Asmat Ullah et al.

Summary: This study investigated the cellular responses to hypoxia and the modulation of APEX1, which regulates HIF-1α and downstream pathways. Hypoxia-induced APEX1/HIF-1α pathways were found to regulate key cellular functions including ROS production, intracellular pH, migration, and angiogenesis. The natural compound Cephalomannine (CPM) exerted inhibitory effects on hypoxic LC cells by inhibiting APEX1/HIF-1α interaction, suggesting it could be a promising compound for lung cancer treatment.

CELL DEATH & DISEASE (2021)

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Review Oncology