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Multi-Omics Approaches in Colorectal Cancer Screening and Diagnosis, Recent Updates and Future Perspectives

CANCERS (2022)

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Review Genetics & Heredity

Gut Microbiome in Colorectal Cancer: Clinical Diagnosis and Treatment

Yali Liu et al.

Summary: Colorectal cancer (CRC) is a common and deadly form of cancer, with both genetic and environmental factors playing a role in its development. Dysbiosis in the gut microbiome has been identified as a risk factor for CRC. Recent data has shown that the gut microbiome is directly involved in DNA damage, inflammation, and drug resistance in CRC, suggesting that modulating the gut microbiome could be a powerful tool in prevention and therapy. This article provides an overview of the relationship between the gut microbiome and CRC, explores the mechanisms of colorectal tumorigenesis, and discusses the potential of bacterial species as clinical biomarkers.

GENOMICS PROTEOMICS & BIOINFORMATICS (2023)

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Article Biochemistry & Molecular Biology

Identification of a Novel Five-Gene Signature as a Prognostic and Diagnostic Biomarker in Colorectal Cancers

Souvik Ghatak et al.

Summary: A novel five-gene signature has been identified as an independent predictor of overall survival in CRC patients, showing promising predictive value in combination with TNM stage and gender status. This signature also serves as a potential easily applicable tool for personalized risk assessment in clinical settings.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Multidisciplinary Sciences

Tissue miR-200c-3p and circulating miR-1290 as potential prognostic biomarkers for colorectal cancer

Enoch Kang et al.

Summary: This study evaluated the prognostic potential of EMT-related miRNAs as biomarkers in colorectal cancer (CRC). The results showed that the tissue expression of miR-200c-3p and the plasma levels of miR-1290 were associated with poor prognosis.

SCIENTIFIC REPORTS (2022)

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Article Microbiology

Altered gut metabolites and microbiota interactions are implicated in colorectal carcinogenesis and can be non-invasive diagnostic biomarkers

Olabisi Oluwabukola Coker et al.

Summary: This study identifies gut microbiota-associated metabolites and their role in colorectal carcinogenesis. Additionally, the integrated analysis of metabolomics and metagenomics profiles reveals the perturbation of gut metabolites and their association with gut microbiota along colorectal carcinogenesis. Fecal metabolites show potential for non-invasive diagnosis of colorectal neoplasia.

MICROBIOME (2022)

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Article Medicine, General & Internal

Changing Metabolic Patterns along the Colorectal Adenoma-Carcinoma Sequence

Julia Tevini et al.

Summary: This study uses serum metabolomics to identify the metabolic differences between colorectal cancer patients, adenoma patients, and healthy controls. The perturbations in lipid metabolism and amino acid metabolism provide a foundation for further mechanistic studies and highlight the importance of lipid metabolites. Biomarkers related to these pathways could improve the sensitivity and specificity of diagnosis, as well as the monitoring of therapies.

JOURNAL OF CLINICAL MEDICINE (2022)

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Article Oncology

A Novel Urinary miRNA Biomarker for Early Detection of Colorectal Cancer

Hiroyasu Iwasaki et al.

Summary: This study identified a non-invasive urinary biomarker panel that can be used for early detection of colorectal cancer.

CANCERS (2022)

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Review Oncology

Alterations in the Gut Microbiota and Their Metabolites in Colorectal Cancer: Recent Progress and Future Prospects

Jing Li et al.

Summary: Dysbiosis of gut bacteria is associated with colorectal cancer (CRC), and the association analysis of metabolomics and gut microbiome will provide novel strategies for the prevention, diagnosis, and therapy of CRC.

FRONTIERS IN ONCOLOGY (2022)

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Article Health Care Sciences & Services

Multi-Omic Approaches in Colorectal Cancer beyond Genomic Data

Emilia Sardo et al.

Summary: Colorectal cancer is one of the most common and deadly tumors globally. Its increasing incidence may be related to unhealthy dietary habits, environmental factors, and genetics. Recent advances in omics sciences have led to a better understanding of the development and heterogeneity of this type of cancer.

JOURNAL OF PERSONALIZED MEDICINE (2022)

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Review Pharmacology & Pharmacy

Lipidomics as Tools for Finding Biomarkers of Intestinal Pathology: From Irritable Bowel Syndrome to Colorectal Cancer

Lorena Ortega Moreno et al.

Summary: Lipidomics is a promising method for analyzing lipid molecules in biological samples. It is considered as a branch of metabolomics and has potential applications in disease prognosis and diagnosis, as well as in the study of intestinal diseases and tumor progression.

CURRENT DRUG TARGETS (2022)

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Article Gastroenterology & Hepatology

Increased expression of NOP14 is associated with improved prognosis due to immune regulation in colorectal cancer

Caijie Lu et al.

Summary: In this study, high NOP14 expression was found to lead to improved prognosis in colorectal cancer patients by inhibiting signaling pathways involved in tumor growth and promoting immune responses.

BMC GASTROENTEROLOGY (2022)

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Article Gastroenterology & Hepatology

Integrated analysis of the faecal metagenome and serum metabolome reveals the role of gut microbiome-associated metabolites in the detection of colorectal cancer and adenoma

Feng Chen et al.

Summary: By integrating untargeted serum metabolomics and metagenome sequencing, this study identified 8 gut microbiome-associated serum metabolites that accurately distinguished CRC and adenoma. The model based on these metabolites showed high diagnostic accuracy for CRC and adenoma, outperforming traditional clinical markers like carcinoembryonic antigen. This suggests that gut microbiome-associated metabolites have potential applications in detecting CRC and adenoma.

GUT (2022)

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Review Pathology

Advances in tests for colorectal cancer screening and diagnosis

Sarah Cheuk Hei Chan et al.

Summary: Colorectal cancer is the second leading cause of cancer-related deaths globally, but mortality can be reduced with early detection. This review summarizes advances in different methods for CRC screening, including noninvasive and minimally invasive methods, and discusses the cost-effectiveness of these methods.

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS (2022)

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Article Biochemistry & Molecular Biology

Prognostic Significance of GPR55 mRNA Expression in Colon Cancer

Hager Tarek H. Ismail et al.

Summary: This study investigated the prognostic value of GPR55 in colon cancer. Combining GPR55 with CEA, CXCL16, or CXCL17 improved the discrimination between high and low expression groups. The GPR55/CEA ratio showed the best result, with a significant increase in mean survival time.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Biochemistry & Molecular Biology

Granzymes-Their Role in Colorectal Cancer

Sara Paczek et al.

Summary: Colorectal cancer is a common malignancy with heterogeneous characteristics. Despite increased awareness and expanded screening programs, there is still a need for new diagnostic tools for early detection. Classical tumor markers have limited effectiveness in CRC diagnosis, thus the search for new proteins involved in CRC is ongoing. Recent studies suggest the potential significance of granzymes, particularly Granzyme A, in CRC pathogenesis through their involvement in inflammation processes.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Genetics & Heredity

Promoter hypermethylation of GALR1 acts as an early epigenetic susceptibility event in colorectal carcinogenesis

Simeng Gu et al.

Summary: Epigenetic alterations of the GALR1 promoter gradually accumulate during colorectal neoplastic progression, and loss of gene expression is common in adenomas and carcinomas.

JOURNAL OF HUMAN GENETICS (2022)

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Review Genetics & Heredity

A new era in functional genomics screens

Laralynne Przybyla et al.

Summary: The latest approaches in CRISPR-based functional genomics screens provide a scalable and multiplexable way to characterize genes and gene regulatory elements encoded by the human genome. These tools promise to reveal mechanisms of gene function and regulation, as well as enable exploration of how genes work together to modulate complex phenotypes.

NATURE REVIEWS GENETICS (2022)

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Article Biochemical Research Methods

The potential of PIK3CA, KRAS, BRAF, and APC hotspot mutations as a non-invasive detection method for colorectal cancer

Maryam Alizadeh-Sedigh et al.

Summary: This study investigated several gene mutations in colorectal cancer tumor tissue and evaluated their diagnostic performance in plasma cfDNA. The results showed that a panel of PIK3CA, KRAS, and BRAF mutations had good diagnostic performance for detecting colorectal cancer in plasma cfDNA.

MOLECULAR AND CELLULAR PROBES (2022)

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Article Medicine, General & Internal

The Significance of Selected C-C Motif Chemokine Ligands in Colorectal Cancer Patients

Monika Zajkowska et al.

Summary: This study assessed the usefulness of selected CC chemokines in the diagnosis of colorectal cancer. The concentrations of these chemokines were found to be higher in CRC patients compared to healthy individuals. The diagnostic sensitivity, specificity, and predictive values of the chemokines were higher than that of the classical tumor marker CA 19-9.

JOURNAL OF CLINICAL MEDICINE (2022)

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Article Medicine, General & Internal

CDK3, CDK5 and CDK8 Proteins as Prognostic and Potential Biomarkers in Colorectal Cancer Patients

Dan Wang et al.

Summary: In this study, the expression pattern and prognostic significance of the CDK family in colorectal cancer (CRC) were systematically investigated. CDK3, CDK5, and CDK8 were identified as potential diagnostic and prognostic markers, and their association with tumor immune infiltration was also explored.

INTERNATIONAL JOURNAL OF GENERAL MEDICINE (2022)

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Article Plant Sciences

Prediction of the mechanism of Dachengqi Decoction treating colorectal cancer based on the analysis method of into serum components -action target-key pathway

Feng-ting Yin et al.

Summary: This study explored the main constituents and potential targets of Dachengqi Decoction (DCQ) in the treatment of colorectal cancer (CRC) using serum pharmacochemistry and network pharmacology. The results showed that flavonoids and anthraquinones were the main active substances of DCQ, which may exert anti-tumor effects by regulating targets such as MAPK, IL-6, and VEGF, as well as pathways including PI3K-AKT signaling pathway, AGE-RAGE signaling pathway, and IL-17 signaling pathway.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Oncology

MTUS1 is a promising diagnostic and prognostic biomarker for colorectal cancer

Lin-Yao Cheng et al.

Summary: This study suggests that MTUS1 is a promising biomarker for predicting the diagnosis and prognosis of colorectal cancer (CRC) patients and may become a new molecular target for tumor immunotherapy.

WORLD JOURNAL OF SURGICAL ONCOLOGY (2022)

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Review Genetics & Heredity

Epigenetic Alteration in Colorectal Cancer: A Biomarker for Diagnostic and Therapeutic Application

Hafsa Yousif Solayman Essa et al.

Summary: Colorectal cancer (CRC) is the leading cause of cancer death worldwide. The initiation and progression of CRC are closely associated with various epigenetic and genetic changes in colon epithelial cells. Recent advances in understanding cancer epigenetics, particularly DNA methylation changes, histone modifications, dysregulation of miRNAs and noncoding RNAs, have provided significant insights. Abnormal methylation of genes causing gene alterations or miRNA expression has been reported in almost all CRC cases, indicating the important role of epigenetic changes in CRC. Furthermore, epigenetic changes are being established as clinical biomarkers for therapeutic and diagnostic purposes, showing promise for the prevention and treatment of CRC in the future.

GLOBAL MEDICAL GENETICS (2022)

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Article Cell Biology

Spastic Paraplegia 20 and Serine/Threonine Protein Kinase 31 Expression for the Detection of Colorectal Cancer

Nivin A. Hassan et al.

Summary: This study found that circulating mRNA levels of SPG20 and STK31 could be used as noninvasive biomarkers for early diagnosis of CRC, and the expression levels of these two potential tumor biomarkers were upregulated in patients with CRC. In addition, the expression level of STK31 was correlated with patient disease-free survival and overall survival.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2022)

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Article Oncology

Assessing Oncologists' Adoption of Biomarker Testing in Metastatic Colorectal Cancer Using Real-World Data

Pritish Iyer et al.

Summary: Despite national guideline recommendations, adherence to universal biomarker testing in routine practice for patients with metastatic colorectal cancer is low. However, there has been an increase in testing rates for NRAS, BRAF, and MMR/MSI between 2013 and 2018.

JNCI CANCER SPECTRUM (2022)

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Review Gastroenterology & Hepatology

The role of gut microbiota in the development of colorectal cancer: a review

Navami Koyande et al.

Summary: This review explores the impact of gut microbiota dysbiosis on colorectal cancer progression and the development of chemoresistance. Altered abundance of numerous microbiota in CRC patients can serve as biomarkers for diagnosis and treatment. Microbes play a role in chemoresistance development through mechanisms such as immune system activation, drug modification, and autophagy modulation.

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE (2022)

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Article Oncology

FJX1 as a candidate diagnostic and prognostic serum biomarker for colorectal cancer

Lei Liu et al.

Summary: This study aimed to screen candidate biomarkers for the diagnosis and prognosis of colorectal cancer (CRC) using a novel strategy. The researchers identified 18 candidate biomarkers with efficient diagnostic value in CRC. FJX1 was identified as a prognostic biomarker that showed good performance in predicting overall survival in CRC patients. Furthermore, the concentration of FJX1 in serum was associated with distant metastasis in CRC. The study also found that FJX1 was significantly decreased in the serum after surgery in CRC patients. Compared to traditional CRC biomarkers, FJX1 still showed good efficiency in diagnosis and prognosis. Additionally, inhibition of FJX1 expression or neutralization of secreted FJX1 could suppress cell proliferation and migration in vitro. These findings provide a novel strategy for identifying diagnostic biomarkers and suggest that FJX1 is a candidate diagnostic and prognostic biomarker in CRC patients.

CLINICAL & TRANSLATIONAL ONCOLOGY (2022)

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Review Genetics & Heredity

Integrating genetic and non-genetic determinants of cancer evolution by single-cell multi-omics

Anna S. Nam et al.

Summary: Cancer is an evolutionary process involving genetic and non-genetic factors, with intratumoural heterogeneity playing a key role in cancer evolution. Single-cell multi-omics technologies are essential for capturing and integrating the different layers of heritable information to study cancer evolution effectively.

NATURE REVIEWS GENETICS (2021)

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Article Oncology

Cancer Statistics, 2021

Rebecca L. Siegel et al.

Summary: Every year, the American Cancer Society projects the numbers of new cancer cases and deaths in the United States, with the latest data showing a significant decline in lung cancer mortality, while prostate cancer mortality has plateaued and breast and colorectal cancer mortality have slowed. Improvements in treatment have accelerated progress against lung cancer, leading to a record drop in overall cancer mortality.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Review Oncology

Gut microbiome and its role in colorectal cancer

Martina Rebersek

Summary: Colorectal cancer is still common worldwide, and the gut microbiome plays a key role in its development. Understanding the composition of bacterial strains influenced by various factors is crucial for screening, early detection, and predicting treatment outcomes. Microbiome modulation is a promising strategy in medicine to improve health outcomes.

BMC CANCER (2021)

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Editorial Material Oncology

Lipid Metabolism as a Targetable Metabolic Vulnerability in Colorectal Cancer

Yekaterina Zaytseva

CANCERS (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Oncology

Alterations of circulating bacterial DNA in colorectal cancer and adenoma: A proof-of-concept study

Qian Xiao et al.

Summary: This study demonstrated alterations of circulating bacterial DNA in colorectal neoplasia patients, indicating its potential as non-invasive biomarkers for colorectal neoplasia screening and early diagnosis, which could play a significant role in disease diagnosis and treatment.

CANCER LETTERS (2021)

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Review Oncology

Colorectal cancer screening and diagnosis: omics-based technologies for development of a non-invasive blood-based method

Maria Gallardo-Gomez et al.

Summary: CRC is a significant health issue in the Western world, with screening and early detection in symptomatic patients being key strategies to reduce its burden. Blood-based biomarkers have been explored recently through omics technologies such as genomics and epigenomics, showing promise for early diagnosis and prevention. Collaboration between researchers, technology experts, and clinicians is crucial for successful translation of these biomarkers into clinical practice.

EXPERT REVIEW OF ANTICANCER THERAPY (2021)

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Review Biochemistry & Molecular Biology

Current Achievements and Applications of Transcriptomics in Personalized Cancer Medicine

Stanislaw Supplitt et al.

Summary: Transcriptome profiling has emerged as a powerful approach in oncology, providing prognostic and predictive utility for cancer management. It enables the identification of cancer biomarkers, gene signatures, and molecular targets for anticancer therapies, contributing to a change in the holistic understanding of cancer from histopathological to molecular classifications. Further advancements in transcriptome profiling may lead to standardization and cost reduction of its analysis, making it a canon of contemporary cancer medicine.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Colon Cancer, Version 2.2021

Al B. Benson et al.

Summary: This section of the NCCN Clinical Practice Guidelines in Oncology focuses on systemic therapy options for metastatic colorectal cancer, with important updates including first-line use of checkpoint inhibitors and expanded recommendations for biomarker testing.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2021)

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Review Biochemistry & Molecular Biology

Microbial Metabolites in Colorectal Cancer: Basic and Clinical Implications

Yao Peng et al.

Summary: Colorectal cancer is a leading cause of cancer-related deaths worldwide, and its pathogenesis is closely related to microbial metabolites from the gut microbiota. Some of these metabolites can act as oncogenic factors for CRC by influencing host physiology. Through metabolomics technology, the study of microbiota-derived metabolites has accelerated our understanding of host-microbiota interactions in CRC.

METABOLITES (2021)

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Article Gastroenterology & Hepatology

The Colorectal Cancer Lipidome: Identification of a Robust Tumor-Specific Lipid Species Signature

Josef Ecker et al.

Summary: Analysis of the CRC lipidome revealed a robust TG-species signature with prognostic potential, shedding light on the importance of lipid metabolism abnormalities in CRC.

GASTROENTEROLOGY (2021)

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Article Oncology

SDC2 and TFPI2 Methylation in Stool Samples as an Integrated Biomarker for Early Detection of Colorectal Cancer

Weisong Zhang et al.

Summary: The study found that SDC2 and TFPI2 were highly methylated in CRC, and integrated detection of them in stool samples has the potential to be an effective and noninvasive tool for early screening of CRC.

CANCER MANAGEMENT AND RESEARCH (2021)

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Article Medicine, General & Internal

Comparing Metabolomics Profiles in Various Types of Liquid Biopsies among Screening Participants with and without Advanced Colorectal Neoplasms

Vanessa Erben et al.

Summary: Analysis of metabolomics has shown significant differences in metabolite concentrations in blood, stool, and urine samples, which can aid in early detection of colorectal cancer and adenomas. There are correlations between metabolite concentrations in different bio-samples, with mostly positive correlations between blood and urine or stool samples, and significant differences found in metabolite concentrations between subjects with and without advanced colorectal neoplasms.

DIAGNOSTICS (2021)

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Article Oncology

Metabolic profiling analysis for clinical urine of colorectal cancer

Wu Ning et al.

Summary: This study aimed to demonstrate the metabolic changes and pathways in patients with colorectal cancer through urine metabolic profiling using GC-TOF/MS. The results showed clear discriminations in metabolic profiles between CRC patients and healthy controls, with significant upregulation of glycolysis and amino acid metabolism and downregulation of lipid metabolism in CRC patients. GC-TOF/MS-based metabolomics has the potential to be a novel, non-invasive tool for CRC diagnosis and understanding disease mechanisms.

ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2021)

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Spatially organized multicellular immune hubs in human colorectal cancer

Karin Pelka et al.

Summary: By analyzing the transcriptional profiles of cells in tumors, differences in immune responses between mismatch repair-deficient (MMRd) and mismatch repair-proficient (MMRp) tumors were identified, as well as the logic behind the interaction of malignant and immune cells discovered within tumors.

CELL (2021)

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Identification of microbial markers across populations in early detection of colorectal cancer

Yuanqi Wu et al.

Summary: The study identifies microbial markers associated with adenoma, aiding in early detection of colorectal cancer (CRC) through integrated analysis of public fecal samples. Classification models constructed based on the markers show promising results in discriminating adenoma from control and CRC, with potential clinical implications in multi-population settings.

NATURE COMMUNICATIONS (2021)

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CRISPR/Cas13-Based Platforms for a Potential Next-Generation Diagnosis of Colorectal Cancer through Exosomes Micro-RNA Detection: A Review

Benjamin Duran-Vinet et al.

Summary: Colorectal cancer is a prevalent cancer with high mortality rates, often diagnosed late with low survival rates. CRISPR/Cas-based molecular platforms show promise in detecting cancer-derived exosome micro-RNAs for early CRC diagnosis, presenting a cost-effective and efficient approach to improve patient outcomes.

CANCERS (2021)

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A novel faecal Lachnoclostridium marker for the non-invasive diagnosis of colorectal adenoma and cancer

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Untargeted multi-omic analysis of colorectal cancer-specific exosomes reveals joint pathways of colorectal cancer in both clinical samples and cell culture

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Transcriptional diversity and bioenergetic shift in human breast cancer metastasis revealed by single-cell RNA sequencing

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Microbiome in Colorectal Cancer: How to Get from Meta-omics to Mechanism?

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Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families

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CXCL-8 in Preoperative Colorectal Cancer Patients: Significance for Diagnosis and Cancer Progression

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Metabolomics profile in gastrointestinal cancers: Update and future perspectives

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Microbiome analyses of blood and tissues suggest cancer diagnostic approach

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Localised colon cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

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Single-cell multiomics: technologies and data analysis methods

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Association of tumour mutational burden with outcomes in patients with advanced solid tumours treated with pembrolizumab: prospective biomarker analysis of the multicohort, open-label, phase 2 KEYNOTE-158 study

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Blood-derived molecular signatures as biomarker panels for the early detection of colorectal cancer

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MOLECULAR BIOLOGY REPORTS (2020)

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The Significance of CXCL1 and CXCL8 as Well as Their Specific Receptors in Colorectal Cancer

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Urinary charged metabolite profiling of colorectal cancer using capillary electrophoresis-mass spectrometry

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SCIENTIFIC REPORTS (2020)

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Glycoproteomic Analysis Reveals Aberrant Expression of Complement C9 and Fibronectin in the Plasma of Patients with Colorectal Cancer

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NFATC3-PLA2G15 Fusion Transcript Identified by RNA Sequencing Promotes Tumor Invasion and Proliferation in Colorectal Cancer Cell Lines

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Review Biochemistry & Molecular Biology

From Samples to Insights into Metabolism: Uncovering Biologically Relevant Information in LC-HRMS Metabolomics Data

Julijana Ivanisevic et al.

METABOLITES (2019)

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Article Oncology

Circulating miR-1290 and miR-320d as Novel Diagnostic Biomarkers of Human Colorectal Cancer

Xiangxiang Liu et al.

JOURNAL OF CANCER (2019)

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Article Multidisciplinary Sciences

Urine-NMR metabolomics for screening of advanced colorectal adenoma and early stage colorectal cancer

Run Ran Kim et al.

SCIENTIFIC REPORTS (2019)

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Article Medicine, Research & Experimental

Integrated microbiome and metabolome analysis reveals a novel interplay between commensal bacteria and metabolites in colorectal cancer

Yongzhi Yang et al.

THERANOSTICS (2019)

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Review Biotechnology & Applied Microbiology

Epigenetic biomarkers in colorectal cancer: premises and prospects

Mozhdeh Zamani et al.

BIOMARKERS (2018)

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Review Spectroscopy

Mass spectrometry-driven drug discovery for development of herbal medicine

Aihua Zhang et al.

MASS SPECTROMETRY REVIEWS (2018)

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Review Biochemical Research Methods

Proteomics for early detection of colorectal cancer: recent updates

Abdo Alnabulsi et al.

EXPERT REVIEW OF PROTEOMICS (2018)

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Article Gastroenterology & Hepatology

Leveraging sequence-based faecal microbial community survey data to identify a composite biomarker for colorectal cancer

Manasi S. Shah et al.

GUT (2018)

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Article Biochemistry & Molecular Biology

LinkedOmics: analyzing multi-omics data within and across 32 cancer types

Suhas V. Vasaikar et al.

NUCLEIC ACIDS RESEARCH (2018)

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Article Medicine, Research & Experimental

MiR-32 promotes tumorigenesis of colorectal cancer by targeting BMP5

Erfei Chen et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Article Oncology

The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy

Vancheswaran Gopalakrishnan et al.

CANCER CELL (2018)

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Article Medical Laboratory Technology

Serum FBLN1 and STK31 as biomarkers of colorectal cancer and their ability to noninvasively differentiate colorectal cancer from benign polyps

Mona Mohamed Watany et al.

CLINICA CHIMICA ACTA (2018)

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Article Medical Laboratory Technology

A Simple and Novel Fecal Biomarker for Colorectal Cancer: Ratio of Fusobacterium Nucleatum to Probiotics Populations, Based on Their Antagonistic Effect

Songhe Guo et al.

CLINICAL CHEMISTRY (2018)

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Article Gastroenterology & Hepatology

Fecal Fatty Acid Profiling as a Potential New Screening Biomarker in Patients with Colorectal Cancer

Eun Mi Song et al.

DIGESTIVE DISEASES AND SCIENCES (2018)

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Article Medical Laboratory Technology

Circular RNA hsa_circ_0000567 can be used as a promising diagnostic biomarker for human colorectal cancer

Jianjun Wang et al.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2018)

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Article Multidisciplinary Sciences

A RNA-Sequencing approach for the identification of novel long non-coding RNA biomarkers in colorectal cancer

Atsushi Yamada et al.

SCIENTIFIC REPORTS (2018)

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Article Oncology

Integrated analyses of multi-omics reveal global patterns of methylation and hydroxymethylation and screen the tumor suppressive roles of HADHB in colorectal cancer

Yimin Zhu et al.

CLINICAL EPIGENETICS (2018)

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Review Oncology

Colorectal Cancers: An Update on Their Molecular Pathology

Kentaro Inamura

CANCERS (2018)

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Article Medicine, Research & Experimental

MiR-92a promotes tumorigenesis of colorectal cancer, a transcriptomic and functional based study

Erfei Chen et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Article Biology

Decreased expression of chromodomain helicase DNA-binding protein 9 is a novel independent prognostic biomarker for colorectal cancer

Li Xu et al.

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH (2018)

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Article Biochemistry & Molecular Biology

RNA sequencing and bioinformatics analysis of the long noncoding RNA-mRNA network in colorectal cancer

Zheying Zhang et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2018)

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Review Biochemistry & Molecular Biology

Molecular and Immunohistochemical Markers with Prognostic and Predictive Significance in Liver Metastases from Colorectal Carcinoma

Gianluca Lopez et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Medicine, Research & Experimental

CBX8 and CD96 Are Important Prognostic Biomarkers of Colorectal Cancer

Xin Song et al.

MEDICAL SCIENCE MONITOR (2018)

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Article Oncology

Pan-Asian adapted ESMO consensus guidelines for the management of patients with metastatic colorectal cancer: a JSMO-ESMO initiative endorsed by CSCO, KACO, MOS, SSO and TOS

T. Yoshino et al.

ANNALS OF ONCOLOGY (2018)

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Article Gastroenterology & Hepatology

Quantitation of faecal Fusobacterium improves faecal immunochemical test in detecting advanced colorectal neoplasia

Sunny H. Wong et al.

GUT (2017)

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Review Oncology

Imaging biomarker roadmap for cancer studies

James P. B. O'Connor et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2017)

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Article Biochemistry & Molecular Biology

Single-cell RNA-sequencing: The future of genome biology is now

Simone Picelli

RNA BIOLOGY (2017)

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Review Pathology

Genetic and epigenetic markers in colorectal cancer screening: recent advances

Manish Pratap Singh et al.

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS (2017)

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Article Biochemistry & Molecular Biology

Altered hydroxymethylation is seen at regulatory regions in pancreatic cancer and regulates oncogenic pathways

Sanchari Bhattacharyya et al.

GENOME RESEARCH (2017)

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Article Oncology

Cancer-associated fecal microbial markers in colorectal cancer detection

Vincy Eklof et al.

INTERNATIONAL JOURNAL OF CANCER (2017)

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Review Biochemistry & Molecular Biology

Transcriptome Profiling in Human Diseases: New Advances and Perspectives

Amelia Casamassimi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Article Biochemical Research Methods

Identification of actin beta-like 2 (ACTBL2) as novel, upregulated protein in colorectal cancer

Saba Ghazanfar et al.

JOURNAL OF PROTEOMICS (2017)

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Article Biochemical Research Methods

Quantitative proteomic profiling of paired cancerous and normal colon epithelial cells isolated freshly from colorectal cancer patients

Chengjian Tu et al.

PROTEOMICS CLINICAL APPLICATIONS (2017)

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Article Genetics & Heredity

Methylation of SLFN11 is a marker of poor prognosis and cisplatin resistance in colorectal cancer

Tao He et al.

EPIGENOMICS (2017)

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Article Oncology

Investigations in the possibility of early detection of colorectal cancer by gas chromatography/triple-quadrupole mass spectrometry

Shin Nishiumi et al.

ONCOTARGET (2017)

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Review Genetics & Heredity

A practical guide to single-cell RNA-sequencing for biomedical research and clinical applications

Ashraful Haque et al.

GENOME MEDICINE (2017)

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Review Biochemical Research Methods

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PLOS COMPUTATIONAL BIOLOGY (2017)

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Article Oncology

Methylation of DIRAS1 promotes colorectal cancer progression and may serve as a marker for poor prognosis

Ruipan Zheng et al.

CLINICAL EPIGENETICS (2017)

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Article Oncology

LINE-1 is preferentially hypomethylated within adenomatous polyps in the presence of synchronous colorectal cancer

Alice Chu Jiang et al.

CLINICAL EPIGENETICS (2017)

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Article Oncology

Methylation of ZNF331 is an independent prognostic marker of colorectal cancer and promotes colorectal cancer growth

Yuzhu Wang et al.

CLINICAL EPIGENETICS (2017)

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Article Biochemical Research Methods

OLFM4, KNG1 and Sec24C identified by proteomics and immunohistochemistry as potential markers of early colorectal cancer stages

Florence Quesada-Calvo et al.

CLINICAL PROTEOMICS (2017)

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Review Medicine, General & Internal

Liquid Biopsies for Cancer: Coming to a Patient near You

Nithya Krishnamurthy et al.

JOURNAL OF CLINICAL MEDICINE (2017)

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Review Oncology

Abnormal DNA methylation as a cell-free circulating DNA biomarker for colorectal cancer detection: A review of literature

Michail Galanopoulos et al.

WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY (2017)

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Editorial Material Cell Biology

Single-cell analyses to tailor treatments

Alex K. Shalek et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

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Article Multidisciplinary Sciences

Comprehensive Proteomic Characterization of the Human Colorectal Carcinoma Reveals Signature Proteins and Perturbed Pathways

Jian-Jiang Hao et al.

SCIENTIFIC REPORTS (2017)

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Article Multidisciplinary Sciences

Identification of MST1 as a potential early detection biomarker for colorectal cancer through a proteomic approach

Jiekai Yu et al.

SCIENTIFIC REPORTS (2017)

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Article Oncology

Macrophage mannose receptor 1 and S100A9 were identified as serum diagnostic biomarkers for colorectal cancer through a label-free quantitative proteomic analysis

Nai-Jun Fan et al.

CANCER BIOMARKERS (2016)

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Article Oncology

Loss of Tet1-Associated 5-Hydroxymethylcytosine Is Concomitant with Aberrant Promoter Hypermethylation in Liver Cancer

John P. Thomson et al.

CANCER RESEARCH (2016)

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Article Biochemical Research Methods

Quantitative proteomic analysis exploring progression of colorectal cancer: Modulation of the serpin family

Julien Peltier et al.

JOURNAL OF PROTEOMICS (2016)

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Review Cell Biology

Metabolomics: beyond biomarkers and towards mechanisms

Caroline H. Johnson et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)

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Article Oncology

Identification of aldolase A as a potential diagnostic biomarker for colorectal cancer based on proteomic analysis using formalin-fixed paraffin-embedded tissue

Tetsushi Yamamoto et al.

TUMOR BIOLOGY (2016)

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Article Oncology

Metabolomics and metabolic pathway networks from human colorectal cancers, adjacent mucosa, and stool

Dustin G. Brown et al.

CANCER & METABOLISM (2016)

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Article Oncology

Aberrant TET1 Methylation Closely Associated with CpG Island Methylator Phenotype in Colorectal Cancer

Norihisa Ichimura et al.

CANCER PREVENTION RESEARCH (2015)

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Article Oncology

5-hydroxymethylcytosine in cancer: significance in diagnosis and therapy

Aparna Vasanthakumar et al.

CANCER GENETICS (2015)

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Article Oncology

The Human Gut Microbiome as a Screening Tool for Colorectal Cancer

Joseph P. Zackular et al.

CANCER PREVENTION RESEARCH (2014)

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Article Gastroenterology & Hepatology

Biomarkers of Coordinate Metabolic Reprogramming in Colorectal Tumors in Mice and Humans

Soumen K. Manna et al.

GASTROENTEROLOGY (2014)

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Article Gastroenterology & Hepatology

Hypomethylation of long interspersed nuclear element-1 (LINE-1) leads to activation of proto-oncogenes in human colorectal cancer metastasis

Keun Hur et al.

GUT (2014)

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Editorial Material Gastroenterology & Hepatology

5-Methylcytosine hydroxylation-mediated LINE-1 hypomethylation: a novel mechanism of proto-oncogenes activation in colorectal cancer?

Abbes Belkhiri et al.

GUT (2014)

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Article Biochemistry & Molecular Biology

Potential of fecal microbiota for early-stage detection of colorectal cancer

Georg Zeller et al.

MOLECULAR SYSTEMS BIOLOGY (2014)

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Article Biotechnology & Applied Microbiology

miR-429 Identified by Dynamic Transcriptome Analysis Is a New Candidate Biomarker for Colorectal Cancer Prognosis

Yingnan Sun et al.

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2014)

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Article Oncology

Use of blood-based biomarkers for early diagnosis and surveillance of colorectal cancer

Ganepola A. P. Ganepola et al.

WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY (2014)

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Article Medicine, Research & Experimental

Comparing Bioinformatic Gene Expression Profiling Methods: Microarray and RNA-Seq

Kirk J. Mantione et al.

MEDICAL SCIENCE MONITOR BASIC RESEARCH (2014)

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Article Oncology

Proteome Profiling of Cancer-Associated Fibroblasts Identifies Novel Proinflammatory Signatures and Prognostic Markers for Colorectal Cancer

Sofia Torres et al.

CLINICAL CANCER RESEARCH (2013)

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Article Biochemistry & Molecular Biology

From human genome to cancer genome: The first decade

David A. Wheeler et al.

GENOME RESEARCH (2013)

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Review Biochemistry & Molecular Biology

Lipidomics as a Principal Tool for Advancing Biomedical Research

Sin Man Lam et al.

JOURNAL OF GENETICS AND GENOMICS (2013)

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Article Multidisciplinary Sciences

Deep Sequencing the MicroRNA Transcriptome in Colorectal Cancer

Kristina Schee et al.

PLOS ONE (2013)

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Article Multidisciplinary Sciences

Stool Microbiome and Metabolome Differences between Colorectal Cancer Patients and Healthy Adults

Tiffany L. Weir et al.

PLOS ONE (2013)

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Article Oncology

Serum miR-21 and miR-92a as biomarkers in the diagnosis and prognosis of colorectal cancer

Guang-Hui Liu et al.

TUMOR BIOLOGY (2013)

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Article Dermatology

An Introduction to Functional Genomics and Systems Biology

Evelien M. Bunnik et al.

ADVANCES IN WOUND CARE (2013)

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Review Biochemistry & Molecular Biology

Untargeted metabolomics: an emerging approach to determine the composition of herbal products

Mauro Commisso et al.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2013)

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Editorial Material Biochemistry & Molecular Biology

Modeling Transcriptome Dynamics in a Complex World

Philipp A. Jaeger et al.

CELL (2012)

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Review Cell Biology

Gut Microbiota Composition and Activity in Relation to Host Metabolic Phenotype and Disease Risk

Elaine Holmes et al.

CELL METABOLISM (2012)

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Article Multidisciplinary Sciences

Transcriptome Profiling of the Cancer, Adjacent Non-Tumor and Distant Normal Tissues from a Colorectal Cancer Patient by Deep Sequencing

Yan'an Wu et al.

PLOS ONE (2012)

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Article Medicine, Research & Experimental

Serum fatty acid profiling of colorectal cancer by gas chromatography/mass spectrometry

Yasuyuki Kondo et al.

BIOMARKERS IN MEDICINE (2011)

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Review Oncology

Molecular Tests for Colorectal Cancer Screening

Linda J. W. Bosch et al.

CLINICAL COLORECTAL CANCER (2011)

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Article Peripheral Vascular Disease

Lipidomics as a Tool for the Study of Lipoprotein Metabolism

Anatol Kontush et al.

CURRENT ATHEROSCLEROSIS REPORTS (2010)

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Review Oncology

Metabolomics and detection of colorectal cancer in humans: a systematic review

Haili Wang et al.

FUTURE ONCOLOGY (2010)

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Review Biochemistry & Molecular Biology

A New View of Carcinogenesis and an Alternative Approach to Cancer Therapy

Miguel Lopez-Lazaro

MOLECULAR MEDICINE (2010)

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Review Biochemistry & Molecular Biology

MicroRNAs in colorectal cancer: translation of molecular biology into clinical application

Ondrej Slaby et al.

MOLECULAR CANCER (2009)

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Review Plant Sciences

Assessing the impact of transcriptomics, proteomics and metabolomics on fungal phytopathology

Kar-Chun Tan et al.

MOLECULAR PLANT PATHOLOGY (2009)

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Review Genetics & Heredity

The complex eukaryotic transcriptome: unexpected pervasive transcription and novel small RNAs

Alain Jacquier

NATURE REVIEWS GENETICS (2009)

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Review Genetics & Heredity

RNA-Seq: a revolutionary tool for transcriptomics

Zhong Wang et al.

NATURE REVIEWS GENETICS (2009)

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Review Oncology

Non-protein coding RNA biomarkers and differential expression in cancers: a review

Massimo Mallardo et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2008)

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Review Genetics & Heredity

Cancer epigenomics: DNA methylomes and histone-modification maps

Manel Esteller

NATURE REVIEWS GENETICS (2007)

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