期刊
CANCERS
卷 14, 期 22, 页码 -出版社
MDPI
DOI: 10.3390/cancers14225591
关键词
hyperspectral imaging; image-guided surgery; hepatectomy; major hepatectomy; post-hepatectomy liver failure (PHLF)
类别
资金
- European Research Council (ERC) under the European Union [715737]
- Agence Nationale de la Recherche [ANR-18CE19-0026]
- European Union's Horizon 2020 Research and Innovation Program under the Marie Sklodowska-Curie Grant [857894-CAST]
- European Research Council (ERC) [715737] Funding Source: European Research Council (ERC)
Hyperspectral imaging (HSI) has been used to predict short-term post-operative outcomes in major hepatectomy. This non-invasive technology allows for the detection of liver dysfunction and is associated with post-operative complications and liver failure.
Simple Summary Major hepatic resections are associated with higher risk of post-operative complications and post-hepatectomy liver failure. After hepatic pedicle clamping, ischemia-reperfusion injury may sometimes lead to post-hepatectomy liver failure. Early detection or, ideally, intra-operative prediction of liver dysfunction or failure would be essential for timely treatment. Hyperspectral imaging (HSI) is a non-invasive technology that detects the relative reflectance of light at a wavelength between 500 and 1000 nm, allowing the quantification of relevant organic compounds. This is the first clinical application of HSI in a monocentric major hepatectomy series, and the reported results suggest that HSI values could be associated with short-term post-operative outcomes. Ischemia-reperfusion injury during major hepatic resections is associated with high rates of post-operative complications and liver failure. Real-time intra-operative detection of liver dysfunction could provide great insight into clinical outcomes. In the present study, we demonstrate the intra-operative application of a novel optical technology, hyperspectral imaging (HSI), to predict short-term post-operative outcomes after major hepatectomy. We considered fifteen consecutive patients undergoing major hepatic resection for malignant liver lesions from January 2020 to June 2021. HSI measures included tissue water index (TWI), organ hemoglobin index (OHI), tissue oxygenation (StO(2)%), and near infrared (NIR). Pre-operative, intra-operative, and post-operative serum and clinical outcomes were collected. NIR values were higher in unhealthy liver tissue (p = 0.003). StO(2)% negatively correlated with post-operative serum ALT values (r = -0.602), while Delta StO(2)% positively correlated with ALP (r = 0.594). TWI significantly correlated with post-operative reintervention and OHI with post-operative sepsis and liver failure. In conclusion, the HSI imaging system is accurate and precise in translating from pre-clinical to human studies in this first clinical trial. HSI indices are related to serum and outcome metrics. Further experimental and clinical studies are necessary to determine clinical value of this technology.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据