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Perineural Invasion in Pancreatic Ductal Adenocarcinoma: From Molecules towards Drugs of Clinical Relevance

CANCERS (2022)

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Article Anesthesiology

Capsaicin 8% Patch for Spinal Cord Injury Focal Neuropathic Pain, a Randomized Controlled Trial

Adedeji Olusanya et al.

Summary: This study investigates the use of capsaicin 8% patch (C8P) in the treatment of neuropathic pain (NP) in patients with spinal cord injury (SCI). The results show that C8P can effectively reduce pain and improve mobility in SCI patients, but does not improve quality of life (QOL).

PAIN MEDICINE (2023)

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Review Biochemistry & Molecular Biology

Targeting the Endocannabinoidome in Pancreatic Cancer

Valerio Falasca et al.

Summary: Pancreatic Ductal adenocarcinoma (PDAC) is a common and aggressive malignancy of the pancreas with high mortality rate. Current therapeutic approaches for PDAC have limited efficacy, leading researchers to explore the potential of cannabinoids as anti-cancer agents.

BIOMOLECULES (2022)

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Article Chemistry, Medicinal

GPR55 and GPR119 Receptors Contribute to the Processing of Neuropathic Pain in Rats

Angel Zuniga-Romero et al.

Summary: This study explored the participation of GPR55 and GPR119 in the processing of neuropathic pain and found that they could be useful targets to manage neuropathic pain disorders.

PHARMACEUTICALS (2022)

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Review Oncology

Emerging experimental models for assessing perineural invasion in human cancers

Shu-Heng Jiang et al.

Summary: Cancer neuroscience is a growing field that focuses on the interactions between cancer and the nervous system. Perineural invasion (PNI), in which cancer cells invade and surround nerves in the tumor microenvironment, is associated with increased tumor recurrence and decreased survival. Various in vitro, ex vivo, and in vivo models have been developed to study PNI, revealing the role of factors such as neurotrophins, chemokines, exosomes, and inflammatory cells in the reciprocal crosstalk between nerves and cancer cells. These models allow the study of isolated factors, neuroaffinity, and the complex pathophysiological processes of PNI.

CANCER LETTERS (2022)

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Article Medicine, General & Internal

Perineural Invasion in Pancreatic Ductal Adenocarcinoma (PDAC): A Saboteur of Curative Intended Therapies?

Matthaus Felsenstein et al.

Summary: This study confirms the improvement in long-term survival of PDAC-resected cancer patients with Pn0, and highlights the significant impact of perineural invasion on the long-term survival of formally curative patients. These findings provide new insights into risk stratification and multimodal treatment strategies for pancreatic cancer patients.

JOURNAL OF CLINICAL MEDICINE (2022)

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Review Cell Biology

The Role of Extracellular Vesicles in Cancer-Nerve Crosstalk of the Peripheral Nervous System

Yuanning Guo et al.

Summary: The pathogenic operations of cancer-nerve crosstalk and the roles of extracellular vesicles (EVs) in this process have gained significant attention in recent years. By promoting interdisciplinary research and collaboration, important advancements in the diagnosis and treatment of cancer-nerve interaction can be achieved.

CELLS (2022)

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Article Nutrition & Dietetics

The Efficacy of Camelina sativa Defatted Seed Meal against Colitis-Induced Persistent Visceral Hypersensitivity: The Relevance of PPAR α Receptor Activation in Pain Relief

Elena Lucarini et al.

Summary: Camelina sativa seed meal has therapeutic effects on colon damage and persistent visceral hypersensitivity associated with colitis in rats, reducing pain and promoting gut healing.

NUTRIENTS (2022)

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Article Oncology

Serum Extracellular Vesicle Stratifin Is a Biomarker of Perineural Invasion in Patients With Colorectal Cancer and Predicts Worse Prognosis

Wenyun Hou et al.

Summary: In this study, quantitative proteomics was used to analyze serum-derived extracellular vesicles (EV) in colorectal cancer patients, revealing differences in proteomic profiles between PNI and NPNI groups. Stratifin (SFN) expression levels in EV were identified as a potential biomarker for distinguishing PNI from NPNI patients and as an independent predictor of CRC prognosis.

FRONTIERS IN ONCOLOGY (2022)

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Article Biochemistry & Molecular Biology

Postsynaptic glutamate response downregulates within presynaptic exaggerated glutamate release by activating TRPV1 in the spinal dorsal horn

Ming-Ming Zhang et al.

Summary: The study found that postsynaptic glutamate responses are attenuated when activating TRPV1(+) fibers, possibly through postsynaptic glutamate receptor occupancy and/or downmodulation.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022)

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Article Pharmacology & Pharmacy

Anti-neuropathic pain activity of Ajugarin-I via activation of Nrf2 signaling and inhibition of TRPV1/TRPM8 nociceptors in STZ-induced diabetic neuropathy

Adnan Khan et al.

Summary: This study investigated the anti-neuropathic pain activity of Ajugarin-I in a rat model of diabetic neuropathic pain. The results showed that Ajugarin-I reduced pain hypersensitivity, restored pathological changes, suppressed oxidative stress and inflammation, and modulated Nrf2/Keap-1/HO-1 signaling and TRPV1/TRPM8 nociceptors.

PHARMACOLOGICAL RESEARCH (2022)

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Review Oncology

Neural Component of the Tumor Microenvironment in Pancreatic Ductal Adenocarcinoma

Michal Gola et al.

Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with limited treatment options and poor prognosis. The tumor microenvironment in PDAC is characterized by a dense stroma and intricate cross-talk between various elements. Despite the presence of neural components, their role in PDAC remains poorly understood. Recent studies have explored the targeting of autonomic nerves as a novel treatment approach for PDAC. Perineural invasion is a common feature in PDAC and its severity is associated with a worse prognosis. Quantification methods that distinguish between perineural and endoneural invasion could potentially improve risk assessment for PDAC patients. The concepts of cancer-related neurogenesis and axonogenesis in PDAC are understudied and warrant further research. Understanding the interplay between nerves and cancer cells in the PDAC microenvironment could lead to new nerve-oriented treatment strategies and improved outcomes. This review aims to summarize the current knowledge and future challenges in the field of nerve-cancer interactions in PDAC.

CANCERS (2022)

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Article Biochemistry & Molecular Biology

N-Palmitoyl-D-Glucosamine Inhibits TLR-4/NLRP3 and Improves DNBS-Induced Colon Inflammation through a PPAR-α-Dependent Mechanism

Irene Palenca et al.

Summary: Micronized PGA can effectively reduce the severity of colitis and improve intestinal mucosa integrity in DNBS-treated mice. It achieves this by downregulating the TLR-4/NLRP3/iNOS pathway and shows potential as a new strategy for the treatment and prevention of inflammation-related changes in IBD.

BIOMOLECULES (2022)

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Article Biochemistry & Molecular Biology

The Beneficial Effects of Ultramicronized Palmitoylethanolamide in the Management of Neuropathic Pain and Associated Mood Disorders Induced by Paclitaxel in Mice

Claudia Cristiano et al.

Summary: This study aims to investigate whether palmitoylethanolamide (PEA) can reduce chemotherapy-induced peripheral neuropathy (CIPN) and associated mood disorders caused by paclitaxel (PTX). The results showed that ultramicronized PEA (um-PEA) reduced the development of hypersensitivity, reduced pro-inflammatory cytokines in the spinal and hippocampal regions, and had antidepressive and anxiolytic effects. Additionally, the effects of um-PEA were blocked by PPAR-alpha and CB1 receptor antagonists.

BIOMOLECULES (2022)

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Article Chemistry, Medicinal

Discovery of Potent and Selective Transient Receptor Potential Vanilloid 1 (TRPV1) Agonists with Analgesic Effects In Vivo Based on the Functional Conversion Induced by Altering the Orientation of the Indazole Core

Qianqian Liang et al.

Summary: This study reports the synthesis of N-indazole-4-aryl piperazine carboxamide analogues as TRPV1 modulators. Compound 28 is identified as a potent and selective TRPV1 agonist, relieving inflammatory and thermal pain by desensitizing the native TRPV1 current in mice. The study also reveals an important hydrogen interaction between Arg557 and the indazole of compound 28.

JOURNAL OF MEDICINAL CHEMISTRY (2022)

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Article Pharmacology & Pharmacy

Contribution of G Protein-Coupled Receptor 55 to Periaqueductal Gray-Mediated Antinociception in the Inflammatory Pain

Henry Blanton et al.

Summary: This study found that blockade of GPR55 action in the periaqueductal gray can alleviate inflammatory pain, suggesting an important role of GPR55 in the descending pain modulatory system.

CANNABIS AND CANNABINOID RESEARCH (2022)

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Review Gastroenterology & Hepatology

Pharmacology, Clinical Effects, and Therapeutic Potential of Cannabinoids for Gastrointestinal and Liver Diseases

Daniel B. Maselli et al.

Summary: Cannabinoids have both beneficial and adverse effects on gastrointestinal symptoms, and further research is needed to fully understand their effects in patients. Gastroenterologists and hepatologists should be aware of the mechanisms, effects, and risks associated with cannabinoid-based therapies.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2021)

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Article Multidisciplinary Sciences

Beta-blockers have no impact on survival in pancreatic ductal adenocarcinoma prior to cancer diagnosis

Anthony Yang et al.

Summary: The study found that incidental use of beta-blockers before diagnosis did not confer a survival advantage for PDAC patients, but continuous use before and after diagnosis did improve survival. Differences in survival between users and non-users were not significant based on underlying conditions like hypertension, coronary artery disease, and cardiac arrhythmia.

SCIENTIFIC REPORTS (2021)

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Article Behavioral Sciences

GPR55 in the brain and chronic neuropathic pain

Sabiha Armin et al.

Summary: The study suggests that blocking the GPR55 receptor in the periaqueductal gray (PAG) can alleviate neuropathic pain by restoring and driving the descending control system. The data demonstrate the significant role of GPR55 in the descending pain control system and identify it as a brain mechanism of neuropathic pain at the supraspinal level.

BEHAVIOURAL BRAIN RESEARCH (2021)

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Article Multidisciplinary Sciences

Targeting neurons in the tumor microenvironment with bupivacaine nanoparticles reduces breast cancer progression and metastases

Maya Kaduri et al.

Summary: Neurons within the tumor microenvironment play a role in promoting cancer progression, making local targeting of neurons potentially beneficial in clinical applications. Utilizing PEGylated lipid nanoparticles loaded with bupivacaine, researchers were able to suppress nerve-to-cancer cross-talk and inhibit cancer cell viability by curbing neurite growth and signaling in breast cancer tumors. The findings suggest that reducing nerve involvement in tumors is crucial for effective cancer treatment.

SCIENCE ADVANCES (2021)

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Review Biochemistry & Molecular Biology

Functional Fine-Tuning of Metabolic Pathways by the Endocannabinoid System-Implications for Health and Disease

Estefania Moreno et al.

Summary: The endocannabinoid system plays a crucial role in maintaining cellular and tissue homeostasis by controlling multiple metabolic pathways, and is implicated in regulating various physiological and pathological states. It is an important pharmacological target with potential for diverse biochemical outcomes.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Oncology

Honokiol Suppresses Perineural Invasion of Pancreatic Cancer by Inhibiting SMAD2/3 Signaling

Tao Qin et al.

Summary: The study showed that HNK can inhibit the invasion and migration of pancreatic cancer cells, as well as the PNI of pancreatic cancer, partially through inhibition of SMAD2/3 phosphorylation. In vivo, HNK was found to suppress EMT in pancreatic cancer, inhibit cancer cell migration along the nerve, reduce damage to the sciatic nerve caused by tumor cells, and protect the function of the sciatic nerve.

FRONTIERS IN ONCOLOGY (2021)

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Article Oncology

Pancreas Cancer-Associated Pain Management

Andrew L. Coveler et al.

Summary: Pain is prevalent in patients with pancreatic cancer, and its management is crucial to improve quality of life. The multifactorial nature of pain in pancreatic cancer requires a multifaceted approach to alleviate pain and improve patient outcomes. Tumor response to treatment does not eliminate the risk of ongoing cancer-related pain, making pain management in pancreatic cancer challenging.

ONCOLOGIST (2021)

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Article Multidisciplinary Sciences

Tumor innervation and clinical outcome in pancreatic cancer

Aysha Ferdoushi et al.

Summary: This study revealed that the presence and size of nerves in the pancreatic cancer microenvironment are associated with tumor aggressiveness, with larger nerves correlated with poorer patient survival.

SCIENTIFIC REPORTS (2021)

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Article Oncology

Exosomal integrins and their influence on pancreatic cancer progression and metastasis

Ilaria Casari et al.

Summary: Pancreatic cancer, as one of the most lethal types of cancer, is difficult to diagnose and treat in time. The appearance of metastasis is dreaded by every cancer patient.

CANCER LETTERS (2021)

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Article Multidisciplinary Sciences

Perineural invasion as a risk factor for locoregional recurrence of invasive breast cancer

Priyanka Narayan et al.

Summary: This study explored the association between perineural invasion (PNI) and locoregional recurrence (LRR) in breast cancer patients, finding that PNI significantly increases the risk of LRR. Multivariable Fine-Gray regression modeling confirmed the potentiated association between PNI and LRR. Propensity score matching analysis further supported the significant link between PNI and LRR.

SCIENTIFIC REPORTS (2021)

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Review Biochemistry & Molecular Biology

MicroRNAs: emerging driver of cancer perineural invasion

Mei Zhang et al.

Summary: Perineural invasion (PNI) is a common clinical feature in malignant tumors that can lead to postoperative recurrence and metastasis. Recent studies have shown that miRNA plays a crucial role in regulating PNI, offering potential new biomarkers and therapeutic targets for cancer treatment.

CELL AND BIOSCIENCE (2021)

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Review Oncology

Cellular and molecular mechanisms of perineural invasion of pancreatic ductal adenocarcinoma

Jingbo Li et al.

Summary: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignant disease characterized by a unique tumor microenvironment surrounded by an interlaced network of cancer and noncancerous cells. Recent studies have shown that the dynamic interaction between cancer cells and neuronal cells leads to perineural invasion (PNI), which is closely related to tumor development, growth, invasion, metastasis, and poor disease prognosis. The formation and function of PNI are regulated by various mechanisms involving molecular, metabolic, and cellular factors, providing opportunities for further exploration to benefit PDAC patients.

CANCER COMMUNICATIONS (2021)

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Review Biochemistry & Molecular Biology

The nervous system: Orchestra conductor in cancer, regeneration, inflammation and immunity

Hubert Hondermarck et al.

Summary: Recent studies have shown that nerves play a crucial role in cancer growth, dissemination, immunity, and inflammation. This orchestrator role of nerves offers new possibilities for targeting or enhancing neurosignaling in human health and diseases.

FASEB BIOADVANCES (2021)

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Article Oncology

The Appropriate First-Line Chemotherapy Regimen for Incurable Pancreatic Cancer in Clinical Practice: A Consideration of Patients' Overall Survival and Quality of Life

Yasuko Murakawa et al.

Summary: The study investigated the impact of different chemotherapy regimens on the survival, hospital-free survival (HFS), and quality of life of patients with advanced pancreatic cancer. While no significant differences were found among the first-line therapies, S-1 monotherapy showed good HFS in some cases.

JOURNAL OF PANCREATIC CANCER (2021)

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Article Multidisciplinary Sciences

Loss of p53 drives neuron reprogramming in head and neck cancer

Moran Amit et al.

NATURE (2020)

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Article Gastroenterology & Hepatology

CXCL10 and CCL21 Promote Migration of Pancreatic Cancer Cells Toward Sensory Neurons and Neural Remodeling in Tumors in Mice, Associated With Pain in Patients

Michael Hirth et al.

GASTROENTEROLOGY (2020)

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Article Biochemistry & Molecular Biology

Genetic variants of the peroxisome proliferator-activated receptor (PPAR) signaling pathway genes and risk of pancreatic cancer

Xiaowen Liu et al.

MOLECULAR CARCINOGENESIS (2020)

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Review Oncology

The tumour microenvironment in pancreatic cancer - clinical challenges and opportunities

Won Jin Ho et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

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Article Oncology

US Phase I First-in-human Study of Taletrectinib (DS-6051b/AB-106), a ROS1/TRK Inhibitor, in Patients with Advanced Solid Tumors

Kyriakos P. Papadopoulos et al.

CLINICAL CANCER RESEARCH (2020)

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Article Oncology

Oncolytic Virus-Mediated Targeting of the ERK Signaling Pathway Inhibits Invasive Propensity in Human Pancreatic Cancer

Takeshi Koujima et al.

MOLECULAR THERAPY-ONCOLYTICS (2020)

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Review Surgery

Neoadjuvant therapy in pancreatic cancer: what is the true oncological benefit?

Lei Ren et al.

LANGENBECKS ARCHIVES OF SURGERY (2020)

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Article Neurosciences

Antinociceptive Effects of the GPR55 Antagonist CID16020046 Injected into the Rat Anterior Cingulate Cortex

Bright N. Okine et al.

NEUROSCIENCE (2020)

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Article Oncology

Cannabidiol and Oxygen-Ozone Combination Induce Cytotoxicity in Human Pancreatic Ductal Adenocarcinoma Cell Lines

Margherita Luongo et al.

CANCERS (2020)

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Review Biochemistry & Molecular Biology

Nerve input to tumours: Pathophysiological consequences of a dynamic relationship

Charlotte Hutchings et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2020)

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Review Anesthesiology

Update on cannabis and cannabinoids for cancer pain

Matthew Chung et al.

CURRENT OPINION IN ANESTHESIOLOGY (2020)

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Review Cell Biology

Nerves in the Tumor Microenvironment: Origin and Effects

Wenjun Wang et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Article Biochemistry & Molecular Biology

Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer

Robert S. Banh et al.

CELL (2020)

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Meeting Abstract Oncology

First-time in-human study of VMD-928, an allosteric and irreversible TrkA selective inhibitor, in patients with solid tumors or lymphoma.

Vincent Chung et al.

JOURNAL OF CLINICAL ONCOLOGY (2019)

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Review Pharmacology & Pharmacy

Signaling in the microenvironment of pancreatic cancer: Transmitting along the nerve

Noelle Jurcak et al.

PHARMACOLOGY & THERAPEUTICS (2019)

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Article Medicine, Research & Experimental

Suppression of TRPV1 and P2Y nociceptors by honokiol isolated from Magnolia officinalis in 3rd degree burn mice by inhibiting inflammatory mediators

Sidra Khalid et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Article Oncology

A phase 1, open-label, dose-escalation trial of oral TSR-011 in patients with advanced solid tumours and lymphomas

Chia-Chi Lin et al.

BRITISH JOURNAL OF CANCER (2019)

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Review Oncology

Nerves and Pancreatic Cancer: New Insights into A Dangerous Relationship

Giulia Gasparini et al.

CANCERS (2019)

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Review Oncology

Glucose Metabolism in Pancreatic Cancer

Liang Yan et al.

CANCERS (2019)

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Article Neurosciences

Possible involvement of peripheral TRP channels in the hydrogen sulfide-induced hyperalgesia in diabetic rats

Jose Eduardo Roa-Coria et al.

BMC NEUROSCIENCE (2019)

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Article Oncology

Relationship between cachexia and perineural invasion in pancreatic adenocarcinoma

Livia Petrusel et al.

WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY (2019)

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Review Chemistry, Multidisciplinary

New Technologies for Analysis of Extracellular Vesicles

Huilin Shao et al.

CHEMICAL REVIEWS (2018)

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Review Dentistry, Oral Surgery & Medicine

Perineural Invasion in Head and Neck Cancer

L. B. Schmitd et al.

JOURNAL OF DENTAL RESEARCH (2018)

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Review Medicine, Research & Experimental

Exosome Theranostics: Biology and Translational Medicine

Chuanjiang He et al.

THERANOSTICS (2018)

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Article Biochemistry & Molecular Biology

GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine

R. Ferro et al.

ONCOGENE (2018)

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Letter Oncology

Molecular Profiling of Pancreatic Cancer Patients-Response

Michael J. Pishvaian et al.

CLINICAL CANCER RESEARCH (2018)

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Article Multidisciplinary Sciences

Cancer exosomes induce tumor innervation

Marianna Madeo et al.

NATURE COMMUNICATIONS (2018)

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Article

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Ines Lohse et al.

Oncotarget (2018)

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Article Oncology

LIF Drives Neural Remodeling in Pancreatic Cancer and Offers a New Candidate Biomarker

Christian Bressy et al.

CANCER RESEARCH (2018)

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Review Biochemistry & Molecular Biology

Pancreatic Ductal Adenocarcinoma: Current and Evolving Therapies

Aleksandra Adamska et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Review Oncology

The influence of neural invasion on survival and tumor recurrence in pancreatic ductal adenocarcinoma - A systematic review and meta-analysis

Stephan Schorn et al.

SURGICAL ONCOLOGY-OXFORD (2017)

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Article Oncology

The significance of Trk receptors in pancreatic cancer

Matthew D. Johnson et al.

TUMOR BIOLOGY (2017)

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Article Multidisciplinary Sciences

Gold nanoclusters-assisted delivery of NGF siRNA for effective treatment of pancreatic cancer

Yifeng Lei et al.

NATURE COMMUNICATIONS (2017)

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Article Oncology

Impact of perineural invasion on survival in node negative colon cancer

Katelin A. Mirkin et al.

CANCER BIOLOGY & THERAPY (2017)

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Review Oncology

The role of pancreatic cancer-derived exosomes in cancer progress and their potential application as biomarkers

H. Jin et al.

CLINICAL & TRANSLATIONAL ONCOLOGY (2017)

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Article Neurosciences

Peripheral interactions between cannabinoid and opioid receptor agonists in a model of inflammatory mechanical hyperalgesia

Q-Schick Auh et al.

BRAIN RESEARCH BULLETIN (2016)

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Article Pathology

Biologic effect of neurogenesis in pancreatic cancer

Dandan He et al.

HUMAN PATHOLOGY (2016)

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Article Multidisciplinary Sciences

Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer

Jami L. Saloman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Article Oncology

Pancreatic stellate cells contribute pancreatic cancer pain via activation of sHH signaling pathway

Liang Han et al.

ONCOTARGET (2016)

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Review Oncology

The concept and controversy of retroperitoneal nerve dissection in pancreatic head carcinoma (Review)

Xuan Wang et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2015)

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Article Cell Biology

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

Bruno Costa-Silva et al.

NATURE CELL BIOLOGY (2015)

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Article Pathology

Biological correlates of prostate cancer perineural invasion diameter

Adriana Olar et al.

HUMAN PATHOLOGY (2014)

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Article Surgery

Outcome of superior mesenteric-portal vein resection during pancreatectomy for borderline ductal adenocarcinoma: results of a prospective comparative study

Federico Selvaggi et al.

LANGENBECKS ARCHIVES OF SURGERY (2014)

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Article Gastroenterology & Hepatology

Midkine promotes perineural invasion in human pancreatic cancer

Jun Yao et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2014)

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Review Oncology

A review on CXCR4/CXCL12 axis in oncology: No place to hide

Urszula M. Domanska et al.

EUROPEAN JOURNAL OF CANCER (2013)

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Article Oncology

Impact of FOLFIRINOX Compared With Gemcitabine on Quality of Life in Patients With Metastatic Pancreatic Cancer: Results From the PRODIGE 4/ACCORD 11 Randomized Trial

Sophie Gourgou-Bourgade et al.

JOURNAL OF CLINICAL ONCOLOGY (2013)

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Article Pathology

Perineural and Intraneural Invasion in Posttherapy Pancreaticoduodenectomy Specimens Predicts Poor Prognosis in Patients With Pancreatic Ductal Adenocarcinoma

Deyali Chatterjee et al.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2012)

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Therapeutic Potential of Perineural Invasion, Hypoxia and Desmoplasia in Pancreatic Cancer

Han Liu et al.

CURRENT PHARMACEUTICAL DESIGN (2012)

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Substance P and Neprilysin in Chronic Pancreatitis

G. Mascetta et al.

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Jonathan M. Street et al.

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Sustained blockade of neurotrophin receptors TrkA, TrkB and TrkC reduces non-malignant skeletal pain but not the maintenance of sensory and sympathetic nerve fibers

Joseph R. Ghilardi et al.

BONE (2011)

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Neural Invasion in Pancreatic Cancer: The Past, Present and Future

Ihsan Ekin Demir et al.

Cancers (2010)

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Exosomes: proteomic insights and diagnostic potential

Richard J. Simpson et al.

EXPERT REVIEW OF PROTEOMICS (2009)

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Identification of N,1,4,4-Tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide (PHA-848125), a Potent, Orally Available Cyclin Dependent Kinase Inhibitor

Maria Gabriella Brasca et al.

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Review Oncology

Targeting Nerve Growth Factor in Pain What is the Therapeutic Potential

Judy J. Watson et al.

BIODRUGS (2008)

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A phase I trial of CEP-701+gemcitabine in patients with advanced adenocarcinoma of the pancreas

Emily Chan et al.

INVESTIGATIONAL NEW DRUGS (2008)

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Hsp70 translocates into the plasma membrane after stress and is released into the extracellular environment in a membrane-associated form that activates macrophages

Virginia L. Vega et al.

JOURNAL OF IMMUNOLOGY (2008)

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Article Biochemistry & Molecular Biology

Exosomes released from infected macrophages contain mycobacterium avium glycopeptidolipids and are proinflammatory

Sanchita Bhatnagar et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

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Article Surgery

Increase in substance P precursor mRNA in noninflamed small-bowel sections in patients with Crohn's disease

Christoph W. Michalski et al.

AMERICAN JOURNAL OF SURGERY (2007)

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Article Multidisciplinary Sciences

The function neutralizing anti-TrkA antibody MNAC13 reduces inflammatory and neuropathic pain

Gabriele Ugolini et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

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Article Gastroenterology & Hepatology

Vanilloids in pancreatic cancer:: potential for chemotherapy and pain management

M Hartel et al.

GUT (2006)

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Article Oncology

Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells

R Gastpar et al.

CANCER RESEARCH (2005)

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Article Neurosciences

Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer pain

JR Ghilardi et al.

JOURNAL OF NEUROSCIENCE (2005)

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Article Immunology

Mast cell-derived exosomes induce phenotypic and functional maturation of dendritic cells and elicit specific immune responses in vivo

D Skokos et al.

JOURNAL OF IMMUNOLOGY (2003)

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