☆ 4.6 Review

Nanoparticles and Nanomaterials-Based Recent Approaches in Upgraded Targeting and Management of Cancer: A Review

CANCERS (2023)

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Article Engineering, Biomedical

Macrophage membrane-biomimetic adhesive polycaprolactone nanocamptothecin for improving cancer-targeting efficiency and impairing metastasis

Kangkang Ying et al.

Summary: This study describes a novel therapeutic strategy that utilizes polymeric prodrug design and cell membrane cloaking to create a highly effective and low-toxicity treatment. In animal model experiments, this biomimetic therapy exhibited a higher level of tumor accumulation and effectively suppressed tumor growth and metastasis.

BIOACTIVE MATERIALS (2023)

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Article Engineering, Biomedical

Synergistic interventional photothermal therapy and immunotherapy using an iron oxide nanoplatform for the treatment of pancreatic cancer

Meng Wang et al.

Summary: In this study, a tumor microenvironment-responsive nanoplatform was developed for the local treatment of pancreatic cancer. The nanoplatform improved drug penetration in the tumor and induced immunogenic cell death through photothermal therapy, leading to a strong antitumor immune response. The results demonstrate the effectiveness of this strategy in treating pancreatic cancer and prolonging patient survival.

ACTA BIOMATERIALIA (2022)

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Article Chemistry, Physical

DNAzyme-Based nanoflowers for reversing P-glycoprotein-mediated multidrug resistance in breast cancer

Linna Liang et al.

Summary: Tumor multidrug resistance is a major cause of chemotherapy failure, and reversing tumor multidrug resistance is crucial for increasing the sensitivity of tumor cells to chemodrugs. The self-assembled DNAzyme nanoflowers can efficiently reverse multidrug resistance, enhance drug loading capacity, and suppress P-glycoprotein expression.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2022)

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Review Chemistry, Multidisciplinary

RNA cancer nanomedicine: nanotechnology-mediated RNA therapy

Bijan Emiliano Ferdows et al.

Summary: This article discusses the research progress in using nanoparticles to deliver therapeutic RNAs for cancer therapy. By selectively regulating cancer-specific genes, researchers have successfully suppressed tumor progression and metastasis, overcoming the degradation of exogenous RNAs by the human immune system. Various types of nanoparticles have been developed for delivering therapeutic RNAs and eliciting tumor suppressing responses.

NANOSCALE (2022)

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Review Chemistry, Multidisciplinary

Chemodynamic Therapy via Fenton and Fenton-Like Nanomaterials: Strategies and Recent Advances

Chenyang Jia et al.

Summary: Chemodynamic therapy (CDT) is a novel cancer treatment strategy that generates hydroxyl radicals in the tumor region using Fenton or Fenton-like reactions. It has advantages such as low side effects, independence from external stimulation, modulation of the tumor microenvironment, and low treatment cost. CDT can also be combined with other therapies to enhance anticancer effects.

SMALL (2022)

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Article Multidisciplinary Sciences

Combining p53 mRNA nanotherapy with immune checkpoint blockade reprograms the immune microenvironment for effective cancer therapy

Yuling Xiao et al.

Summary: In this study, the authors demonstrate that combining CXCR4-targeted p53 mRNA nanoparticles with anti-PD-1 therapy effectively reverses immunosuppression and improves anti-tumor effects in hepatocellular carcinoma models.

NATURE COMMUNICATIONS (2022)

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Article Engineering, Biomedical

Photosynthetic Oxygenation-Augmented Sonodynamic Nanotherapy of Hypoxic Tumors

Shuting Lu et al.

Summary: A hybrid sonosensitizer, M@C, integrating cyanobacteria and ultrasmall oxygen-deficient bimetallic oxide nanosonosensitizers, is designed to overcome hypoxia-induced tumor resistance and enhance sonodynamic therapy (SDT) efficiency. The sustained oxygen production by cyanobacteria under light illumination promotes nanosonosensitizers to generate more ROS against cancer cells, ultimately improving SDT effectiveness. This work demonstrates the potential of rationally engineered biohybrid microorganism-based sonosensitizers for enhancing SDT in the treatment of hypoxic tumors.

ADVANCED HEALTHCARE MATERIALS (2022)

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Article Materials Science, Biomaterials

Ultrathin Nanosheet-Supported Ag@Ag2O Core-Shell Nanoparticles with Vastly Enhanced Photothermal Conversion Efficiency for NIR-II-Triggered Photothermal Therapy

Kunle Li et al.

Summary: This study develops a new and highly efficient NIR-II photothermal nanotheranostic agent, greatly improving the photothermal performance. The nanotheranostic agent shows impressive photothermal conversion efficiency and stability, and demonstrates good biocompatibility and outstanding therapeutic efficacy in in vitro and in vivo studies.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2022)

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Article Biophysics

Biocompatible BSA-Ag2S nanoparticles for photothermal therapy of cancer

Junwei Zhao et al.

Summary: This study successfully synthesized biocompatible BSA-coated Ag2S nanoparticles as photothermal agents for cancer therapy. The nanoparticles exhibited high photothermal conversion efficiency and strong absorption, effectively inducing apoptosis in tumor cells with excellent killing effect. The research provided a simple and reproducible method to fabricate water-soluble and biocompatible Ag2S nanoparticles, offering new insights for designing functional nanoparticles for photothermal therapy of tumors.

COLLOIDS AND SURFACES B-BIOINTERFACES (2022)

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Article Biochemistry & Molecular Biology

CRPC Membrane-Camouflaged, Biomimetic Nanosystem for Overcoming Castration-Resistant Prostate Cancer by Cellular Vehicle-Aided Tumor Targeting

Kai Lu et al.

Summary: In this work, a CRPC-targeting nanocomposite with fine biocompatibility was developed using CRPC cell membranes as biomimetic vectors. The encapsulated chemotherapy drug DTX was successfully delivered to the targeting site, improving therapeutic efficiency. The use of CRPC cell membrane coating enabled homotypic targeting and significantly improved therapeutic efficacy in a mice model bearing CRPC tumors.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Pharmacology & Pharmacy

Biomineralized synthesis of palladium nanoflowers for photothermal treatment of cancer and wound healing

Jinfeng He et al.

Summary: This study presents the preparation and characterization of daptomycin micelles-stabilized palladium nanoflowers, which exhibit high photothermal conversion efficiency and good biocompatibility. These nanoflowers have the potential for application in tumor treatment and wound healing.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

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Article Chemistry, Physical

Magnetic Resonance/Infrared Dual-Modal Imaging-Guided Synergistic Photothermal/Photodynamic Therapy Nanoplatform Based on Cu1.96S-Gd@FA for Precision Cancer Theranostics

Lixin Cheng et al.

Summary: This study developed Gd-surface functionalized copper sulfide nanoparticles modified with folic acid for efficient synergistic photothermal/photodynamic therapy. The nanoparticles showed high longitudinal relaxivity, strong photothermal conversion efficiency, and enhanced reactive oxygen species production. The targeted Cu1.96S-Gd@FA nanoparticles exhibited higher signal enhancement for magnetic resonance and could be visualized in infrared imaging. Additionally, the nanoparticles showed biodegradation behavior and good drug elimination performance.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2022)

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Article Engineering, Chemical

Suppressed XIAP and cIAP expressions in human brain cancer stem cells using BV6-and GDC0152-encapsulated nanoparticles

Yung-Chih Kuo et al.

Summary: By encapsulating BV6 and GDC0152 in solid lipid nanoparticles with surface transferrin and folic acid modifications, the efficacy of these two Smac mimetics in glioblastoma multiforme treatment can be enhanced, allowing for targeted drug delivery and release in GBM cells.

JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS (2022)

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Review Oncology

How Did Conventional Nanoparticle-Mediated Photothermal Therapy Become Hot in Combination with Cancer Immunotherapy?

Wan Su Yun et al.

Summary: Photothermal therapy (PTT) using nanoparticle-based photoabsorbers has shown good therapeutic efficiency. It induces photothermal damage in tumor tissues with minimal side effects and activates immune cells for systemic anti-cancer effect. This review investigates various nanoparticle-based PTT agents and their transition from thermotherapy to immunotherapy.

CANCERS (2022)

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Article Biophysics

Laser-responsive multi-functional nanoparticles for efficient combinational chemo-photodynamic therapy against breast cancer

Qingran Guan et al.

Summary: Novel laser-responsive multi-functional nanoparticles (NPs-Lip@PTX/CyA/Ce6) were developed using bovine serum albumins (BSA) as the base material, simultaneously carrying chemotherapeutic drug paclitaxel (PTX) and P-gp inhibitor cyclosporin A (CyA) as the core, and Tf-modified liposomal bilayer loaded with photosensitizer Chlorin e6 (Ce6) as the shell. The NPs-Lip@PTX/CyA/Ce6 exhibited a core-shell structure with good stability in aqueous solution. Upon laser irradiation, the NPs-Lip@PTX/CyA/Ce6 showed laser-responsive release profiles, enabling efficient combinatorial chemophotodynamic therapy and reversal of drug resistance. The NPs-Lip@PTX/CyA/Ce6 demonstrated excellent intracellular ROS productivity and anti-cancer therapy effect without systemic toxicity. In conclusion, this nano-drug delivery system holds promise for clinical applications in compositional chemophotodynamic therapy synergistically.

COLLOIDS AND SURFACES B-BIOINTERFACES (2022)

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Article Pharmacology & Pharmacy

Biomimetic nanotherapeutics: Employing nanoghosts to fight melanoma

Deepkumar Bagasariya et al.

Summary: Nanomedicine provides a promising platform for the treatment of melanoma and other cancers. Cell membrane camouflaged nanocarriers, by utilizing natural cell membranes, overcome some challenges and offer various advantages in therapy. This article discusses different biomimetic systems, their processing and coating approaches, and explores the potential breakthroughs achieved through their combination with smart nanoparticulate systems.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2022)

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Article Pharmacology & Pharmacy

Bufalin exacerbates Photodynamic therapy of colorectal cancer by targeting SRC-3/HIF-1? pathway

Zeting Yuan et al.

Summary: This study designed iRGD-modified nanoparticles to co-deliver mTHPC and BU, aiming to enhance the efficacy of photodynamic therapy (PDT) in colorectal cancer (CRC). The nanoparticles passively accumulated in tumor cells, with mTHPC inducing apoptosis and death under laser irradiation, while the sustained release of BU inhibited hypoxia and angiogenesis by targeting the SRC-3/HIF-1α pathway.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

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Review Oncology

miRacle of microRNA-Driven Cancer Nanotherapeutics

Goknur Kara et al.

Summary: The discovery of microRNAs has revolutionized cancer treatment and their effective and safe delivery remains a challenge. New nanoparticle-based carriers have enabled successful tumor-targeted delivery of miRNA therapeutics, accelerating the transition of miRNAs from the lab to the bedside.

CANCERS (2022)

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Article Chemistry, Multidisciplinary

Reshaping hypoxia and silencing CD73 via biomimetic gelatin nanotherapeutics to boost immunotherapy

Cong-Shan Yuan et al.

Summary: In this study, cancer cell membrane-camouflaged gelatin nanoparticles were used to co-deliver oxygen-generating agent and siRNA to improve tumor hypoxic microenvironment and enhance immune cell activity. The results demonstrated that this approach significantly suppressed tumor growth and enhanced cytotoxic T cell activity.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Chemistry, Multidisciplinary

Biomimetic nanotherapeutics based on oxygen supply and ultrasmall Cu-Se-Au alloy nanoparticles for boosting radio-photothermal ablation of breast cancer

Zhaoyang Guo et al.

Summary: In this study, a biomimetic nanoplatform was developed using dendritic large pore mesoporous silica nanoparticles (DLMSNs) for efficient co-loading and precise co-delivery of oxygen and nanoradiosensitizer, aiming to address the limitations of radiotherapy. The results showed that this biomimetic nanotherapeutic system had potent suppression effects against breast cancer.

NANO TODAY (2022)

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Article Engineering, Biomedical

Disulfiram loaded calcium phosphate nanoparticles for enhanced cancer immunotherapy

Qiaofeng Li et al.

Summary: This study developed pH-responsive lipid-coated calcium phosphate nanoparticles (LCP NPs) that co-loaded with disulfiram (DSF) and copper ions (Cu2+). The nanoparticles selectively accumulated in tumors and released DSF and Cu2+ in the acidic tumor microenvironment, inducing cytotoxicity and immunogenic cell death (ICD) of cancer cells. These findings demonstrate the potential of repurposing DSF as a new ICD inducer for improved tumor-responsive therapy and enhanced immune checkpoint blockade (ICB) therapy.

BIOMATERIALS (2022)

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Review Chemistry, Multidisciplinary

Bioengineered nanogels for cancer immunotherapy

Xianbin Ma et al.

Summary: Nanogels, as a versatile drug delivery system, play a crucial role in cancer immunotherapy, offering advantages such as enhanced drug bioavailability and reduced immune-related adverse events.

CHEMICAL SOCIETY REVIEWS (2022)

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Review Oncology

Targeting cancer cells with nanotherapeutics and nanodiagnostics: Current status and future perspectives

Eunus S. Ali et al.

Summary: Nanotechnology is reshaping healthcare strategies with a tremendous impact, especially in the fields of medical diagnostics and drug delivery, offering potential for improved effectiveness and sustainability in treating diseases like cancer. The application of nano-level elements can reduce drug toxicities and enhance drug delivery efficiency.

SEMINARS IN CANCER BIOLOGY (2021)

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Article Clinical Neurology

Comparison of Freshly Isolated Adipose Tissue-derived Stromal Vascular Fraction and Bone Marrow Cells in a Posterolateral Lumbar Spinal Fusion Model

Alexander Perdomo-Pantoja et al.

Summary: This study compared the efficacy of freshly isolated adipose tissue-derived stromal vascular fraction (A-SVF) cells and bone marrow cells (BMCs) in achieving spinal fusion in a rat model. The results showed that A-SVF cells performed comparably to BMCs in terms of fusion volume and radiographic fusion rate.

SPINE (2021)

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Article Chemistry, Physical

Biodegradable iron-doped ZIF-8 based nanotherapeutic system with synergistic chemodynamic/photothermal/chemo-therapy

Huiyuan Chu et al.

Summary: A biodegradable iron-doped ZIF-8 based nanoconstruct was developed, integrating chemodynamic therapy, photothermal therapy, and chemotherapy into one platform, which showed smart tumor microenvironment-responsive release of Fe2+, DOX, and ICG with high therapeutic efficacy. The nanoconstruct exhibited a fatality rate as high as 93.7% for cancer cells, making it a promising approach for efficient cancer eradication.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2021)

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Review Pharmacology & Pharmacy

Venom peptides in cancer therapy: An updated review on cellular and molecular aspects

Sepideh Mirzaei et al.

Summary: Venom peptides are an important source of bioactive compounds with anti-tumor activities. They can induce cancer cell death, enhance chemotherapy and radiotherapy efficacy, and mitigate cancer cell migration through suppression of angiogenesis and epithelial-to-mesenchymal transition. Moreover, nanoparticles have been used to enhance the bioavailability and targeted delivery of venom peptides, leading to elevated anti-tumor activity and potential application in cancer therapy.

PHARMACOLOGICAL RESEARCH (2021)

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Review Chemistry, Multidisciplinary

Current trends in smart mesoporous silica-based nanovehicles for photoactivated cancer therapy

Kaili Wang et al.

Summary: Photoactivated therapeutic strategies such as photothermal therapy and photodynamic therapy have become prevalent for fighting tumors, with mesoporous silica nanoparticles showing promise for multimodal cancer therapy. However, challenges remain in the application of these therapies for deep-seated tumors.

JOURNAL OF CONTROLLED RELEASE (2021)

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Review Chemistry, Multidisciplinary

Versatile Nanoscale Metal-Organic Frameworks (nMOFs): An Emerging 3D Nanoplatform for Drug Delivery and Therapeutic Applications

Ting Wen et al.

Summary: Nanoscale metal-organic frameworks (nMOFs) have garnered extensive interest in biomedicine for their porous structure and adjustable biocompatibility. This review outlines the classification, synthesis, drug loading strategies, and stimulation-responsive drug release mechanisms of nMOFs, as well as the smart designs of nMOFs-based platforms for anticancer and antibacterial treatment.

SMALL (2021)

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Article Pharmacology & Pharmacy

Nanoparticles Dual Targeting Both Myeloma Cells and Cancer-Associated Fibroblasts Simultaneously to Improve Multiple Myeloma Treatment

Honglan Wang et al.

Summary: A dual-targeting drug delivery system was developed to simultaneously target CAFs and myeloma cells, showing better therapeutic effects than targeting each cell type alone. In vitro cellular uptake and cytotoxicity tests demonstrated the system's advantages, while in vivo experiments confirmed its stronger anti-tumor efficacy compared to conventional methods.

PHARMACEUTICS (2021)

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Review Medicine, Research & Experimental

Nanotechnology shaping stem cell therapy: Recent advances, application, challenges, and future outlook

Yongqiang Dong et al.

Summary: Stem cell nanotechnology, an emerging field, has made significant progress in experimental studies, confirming the importance of nanotechnology in stem cell therapies. The structure and properties of nanomaterials impact the proliferation and differentiation of stem cells, leading to a new interdisciplinary frontier in material science and regenerative medicine.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Review Biotechnology & Applied Microbiology

Recent advances in selective photothermal therapy of tumor

Liping Zhao et al.

Summary: Photothermal therapy (PTT) is a promising approach in cancer treatment, but challenges such as accurate laser exposure and potential side effects need to be addressed. Enhancing the selectivity of PTT involves increasing the accumulation of photothermal agents at tumor sites and giving them self-regulating photothermal conversion functions.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Review Chemistry, Multidisciplinary

Novel Perspectives towards RNA-Based Nano-Theranostic Approaches for Cancer Management

Rabia Arshad et al.

Summary: The development of multi-functional nanoparticles and nano-biosensors has revolutionized cancer diagnosis and treatment by attaching biocompatible ligands to over-expressed cancer tissues, allowing for targeted action. Advancements in modifying molecular genetics for personalized and targeted treatments using RNA interference have become a key breakthrough in cancer therapy.

NANOMATERIALS (2021)

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Review Biochemistry & Molecular Biology

mRNA therapeutics in cancer immunotherapy

Jan D. Beck et al.

Summary: Synthetic mRNA serves as a versatile template for protein synthesis and has a wide range of pharmaceutical applications, including cancer immunotherapy. Strategies such as stimulating pattern recognition receptors and nucleoside modification enhance the effectiveness and safety of mRNA vaccines.

MOLECULAR CANCER (2021)

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Article Pharmacology & Pharmacy

Self-propelled nanomotor reconstructs tumor microenvironment through synergistic hypoxia alleviation and glycolysis inhibition for promoted anti-metastasis

Wenqi Yu et al.

Summary: The study introduces a novel cascade enzyme-powered nanomotor that provides sufficient oxygen and inhibits aerobic glycolysis in deep tumors, effectively alleviating hypoxia and inhibiting tumor metastasis. The nanomotor autonomously moves towards deep tumors, facilitating efficient gene knockdown to inhibit tumor metabolism and metastasis.

ACTA PHARMACEUTICA SINICA B (2021)

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Review Biochemistry & Molecular Biology

Advances in Nanomaterial-Mediated Photothermal Cancer Therapies: Toward Clinical Applications

Hwa Seung Han et al.

Summary: Photothermal therapy (PTT) is a promising noninvasive cancer treatment strategy, although current limitations include low photothermal conversion efficiency, low accumulation of agents in tumor tissue, and heat resistance in specific cancer types. Innovative nanomaterial-based approaches show potential for improving therapeutic outcomes and reducing side effects in PTT applications.

BIOMEDICINES (2021)

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Article Chemistry, Multidisciplinary

Acidity-Activatable Dynamic Nanoparticles Boosting Ferroptotic Cell Death for Immunotherapy of Cancer

Rundi Song et al.

Summary: Researchers have developed a immunotherapy method that enhances the immunogenicity of tumor cells by inducing ferroptosis, thereby improving the efficacy of cancer immunotherapy.

ADVANCED MATERIALS (2021)

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Article Pharmacology & Pharmacy

Hypoxia-targeted cupric-tirapazamine liposomes potentiate radiotherapy in prostate cancer spheroids

Vera L. Silva et al.

Summary: Novel cupric-tirapazamine [Cu(TPZ)2]-liposomes were developed as an effective hypoxia-targeted therapeutic, which potentiated radiotherapy in a three dimensional (3D) prostate cancer (PCa) model. The highest loading efficiency was obtained at neutral pH, and enhanced drug loading was achieved upon decreasing the lipid:complex molar ratio.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Review Chemistry, Multidisciplinary

Photodynamic cancer therapy using liposomes as an advanced vesicular photosensitizer delivery system

Saeid Moghassemi et al.

Summary: Photodynamic therapy (PDT) combines photochemistry and photophysics sciences for cancer therapy, showing significant potential. Despite advantages and progress, common photosensitizing agents have limitations, which can be addressed by using liposomes as carriers for PS.

JOURNAL OF CONTROLLED RELEASE (2021)

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Review Oncology

Nanomaterials for cancer therapy: current progress and perspectives

Zhe Cheng et al.

Summary: Nanomaterials play an important role in cancer therapy by targeting cancer cells, tumor microenvironment, and the immune system. However, despite an increasing number of studies, the approval of nano-drugs has not significantly increased, requiring further research to improve clinical translation efficiency.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

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Article Biotechnology & Applied Microbiology

Pluronic F127-micelles improve the stability and enhance the anticancer stem cell efficacy of citral in breast cancer

Marwa M. Abu-Serie et al.

Summary: The citral-loaded micelles (CLM) improved the stability and growth inhibitory effects of citral, fully blocking the stemness traits of breast cancer stem cells (CSCs). Additionally, in combination with paclitaxel, CLM sensitized breast cancer cells to chemotherapy, suggesting a potential strategy for treating advanced breast cancer.

NANOMEDICINE (2021)

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Article Environmental Sciences

Assessment of the Toxicity of Quantum Dots through Biliometric Analysis

Lishi Zhong et al.

Summary: With the rapid development of nanotechnology, researchers have paid attention to the biosafety of quantum dots (QDs). By analyzing scientific publications and constructing a bibliometric model, the toxicity of QDs was qualitatively and quantitatively evaluated, presenting the current status and future trends in toxicological studies of QDs.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

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Article Biotechnology & Applied Microbiology

Extracellular vesicles-based pre-targeting strategy enables multi-modal imaging of orthotopic colon cancer and image-guided surgery

Boping Jing et al.

Summary: In this study, an extracellular vesicles-based nanoprobe was synthesized for visualizing colon cancer with PET/CT and NIRF imaging, showing promising results in preoperative evaluation and image-guided surgery in animal models. The nanoprobe showed a strong binding ability to tumor cells and achieved clear imaging results using PET/CT and NIRF imaging techniques. This study suggests the potential clinical application of extracellular vesicles as nanocarriers for multi-modal imaging and image-guided surgery of colon cancer.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Pharmacology & Pharmacy

siRNA-Loaded Hydroxyapatite Nanoparticles for KRAS Gene Silencing in Anti-Pancreatic Cancer Therapy

Dandan Luo et al.

Summary: A novel nanoparticle HAp-PEI/siKras was successfully fabricated for efficient targeted delivery of siRNA to pancreatic cancer cells, achieving successful gene silencing and tumor-targeted therapy. Experimental results confirmed its effectiveness in inhibiting pancreatic cancer cell proliferation in vitro, while exhibiting no cytotoxicity towards normal pancreatic cells.

PHARMACEUTICS (2021)

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Review Pharmacology & Pharmacy

Clinical Advances of siRNA-Based Nanotherapeutics for Cancer Treatment

Dima Hattab et al.

Summary: RNA interference (RNAi) offers a genetic approach for cancer treatment by inhibiting specific messenger RNA signaling uncontrollable cell growth and proliferation. Challenges such as low tumor localization, stability and rapid clearance from circulation hinder the success of gene therapy applications.

PHARMACEUTICS (2021)

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Review Engineering, Biomedical

The application of nanoparticles in cancer immunotherapy: Targeting tumor microenvironment

Muyue Yang et al.

Summary: The development and metastasis of tumors are closely linked to the tumor microenvironment (TME). Nanoparticles, with their unique physical properties and design, show potential in efficiently penetrating TME and delivering therapeutic agents to specific components. However, the heterogeneity of tumors and individuals may limit the effectiveness of nanoparticle delivery systems in all types of tumors, calling for further understanding of TME changes at different stages of tumor development for the design of more personalized nanoplatforms.

BIOACTIVE MATERIALS (2021)

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Review Nanoscience & Nanotechnology

Nanoparticles for Cancer Therapy: Current Progress and Challenges

Shreelaxmi Gavas et al.

Summary: Nanotechnology has revolutionized cancer diagnosis and treatment by overcoming limitations of traditional therapies and multidrug resistance. Nanoparticles, with their unique advantages, offer new perspectives for cancer treatment. However, challenges still exist in research and clinical translation of nanotherapeutics.

NANOSCALE RESEARCH LETTERS (2021)

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Article Medicine, Research & Experimental

Extracellular-vesicles delivered tumor-specific sequential nanocatalysts can be used for MRI-informed nanocatalytic Therapy of hepatocellular carcinoma

Han Wu et al.

Summary: This study utilized HCC-derived extracellular vesicles (EVs) as surface nanocarriers, applying sequential nanocatalysts GOD-ESIONs@EVs (GE@EVs) for tumor-specific and cascade nanocatalytic therapy against HCC. By enhancing intracellular endocytosis and generating highly toxic hydroxyl radicals in the mildly acidic tumor microenvironment, efficient apoptosis and necrosis of HCC cells were achieved.

THERANOSTICS (2021)

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Article Pharmacology & Pharmacy

Cell-derived biomimetic nanocarriers for targeted cancer therapy: cell membranes and extracellular vesicles

Aixue Li et al.

Summary: Nanotechnology provides synthetic carriers for cancer drug delivery, while cell-derived biomimetic vehicles based on the concept of 'mimicking nature' offer low immunogenicity, long circulation time, and targeting ability. Cell membrane-coated carriers and extracellular vesicles are two widely used cell-based biomimetic materials in targeted cancer therapy, but they also face future challenges and development prospects.

DRUG DELIVERY (2021)

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Review Engineering, Biomedical

Tumor microenvironment targeted nanotherapeutics for cancer therapy and diagnosis: A review

Shreya Thakkar et al.

ACTA BIOMATERIALIA (2020)

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Article Nanoscience & Nanotechnology

Platinum(II) Drug-Loaded Gold Nanoshells for Chemo-Photothermal Therapy in Colorectal Cancer

Shin-Yu Lee et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Biochemistry & Molecular Biology

Drug-Loaded Photosensitizer-Chitosan Nanoparticles for Combinatorial Chemo- and Photodynamic-Therapy of Cancer

Abhilash D. Pandya et al.

BIOMACROMOLECULES (2020)

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Article Materials Science, Biomaterials

Phthalocyanine-loaded nanostructured lipid carriers functionalized with folic acid for photodynamic therapy

Joao A. Oshiro-Junior et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

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Article Nanoscience & Nanotechnology

Green synthesis of near-infrared absorbing eugenate capped iron oxide nanoparticles for photothermal application

Prashant Kharey et al.

NANOTECHNOLOGY (2020)

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Review Oncology

Malignant Pleural Mesothelioma: State-of-the-Art on Current Therapies and Promises for the Future

Fabio Nicolini et al.

FRONTIERS IN ONCOLOGY (2020)

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Article Chemistry, Multidisciplinary

Targeting cancer-associated fibroblasts by dual-responsive lipid-albumin nanoparticles to enhance drug perfusion for pancreatic tumor therapy

Qianwen Yu et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Cell Biology

Cuprous oxide nanoparticles trigger reactive oxygen species-induced apoptosis through activation of erk-dependent autophagy in bladder cancer

Qiao Xiong et al.

CELL DEATH & DISEASE (2020)

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Review Medicine, Research & Experimental

Emerging Nano Drug Delivery Systems Targeting Cancer-Associated Fibroblasts for Improved Antitumor Effect and Tumor Drug Penetration

Jian Guo et al.

MOLECULAR PHARMACEUTICS (2020)

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Review Cell Biology

RNA delivery by extracellular vesicles in mammalian cells and its applications

Killian O'Brien et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

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Review Chemistry, Multidisciplinary

Engineered Nanoparticles for Cancer Vaccination and Immunotherapy

Marisa E. Aikins et al.

ACCOUNTS OF CHEMICAL RESEARCH (2020)

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Article Chemistry, Multidisciplinary

Activating Macrophage-Mediated Cancer Immunotherapy by Genetically Edited Nanoparticles

Lang Rao et al.

ADVANCED MATERIALS (2020)

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Review Biochemistry & Molecular Biology

Functionalized Graphene Oxide for Chemotherapeutic Drug Delivery and Cancer Treatment: A Promising Material in Nanomedicine

Horrick Sharma et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Editorial Material Medicine, General & Internal

Chemotherapy Drugs Based on Solid Lipid Nanoparticles for Breast Cancer Treatment

Atefeh Ashtari et al.

MEDICINA-LITHUANIA (2020)

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Review Nanoscience & Nanotechnology

Nanomaterial-Based Tumor Photothermal Immunotherapy

Peng Xu et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Review Biochemistry & Molecular Biology

Exosome-based immunotherapy: a promising approach for cancer treatment

Zhijie Xu et al.

MOLECULAR CANCER (2020)

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Article Pharmacology & Pharmacy

Chitosan nanoparticles for oral photothermally enhanced photodynamic therapy of colon cancer

Gang Chen et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

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Review Medicine, Research & Experimental

RNA Nanotechnology-Mediated Cancer Immunotherapy

Yao-Xin Lin et al.

THERANOSTICS (2020)

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Review Biochemistry & Molecular Biology

Cancer Nanotechnology: A New Revolution for Cancer Diagnosis and Therapy

Vivek K. Chaturvedi et al.

CURRENT DRUG METABOLISM (2019)

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Article Engineering, Biomedical

A biodegradable MnSiO3@Fe3O4 nanoplatform for dual-mode magnetic resonance imaging guided combinatorial cancer therapy

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BIOMATERIALS (2019)

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Article Engineering, Biomedical

Systematic evaluation of graphene quantum dot toxicity to male mouse sexual behaviors, reproductive and offspring health

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BIOMATERIALS (2019)

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Photoresponsive Self-Assembled DNA Nanomaterials: Design, Working Principles, and Applications

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SMALL (2019)

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Zinc-Doped Copper Oxide Nanocomposites Inhibit the Growth of Pancreatic Cancer by Inducing Autophagy Through AMPK/mTOR Pathway

Xiao Li et al.

FRONTIERS IN PHARMACOLOGY (2019)

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Article Engineering, Biomedical

A pH-sensitive nanotherapeutic system based on a marine sulfated polysaccharide for the treatment of metastatic breast cancer through combining chemotherapy and COX-2 inhibition

Tao Zhang et al.

ACTA BIOMATERIALIA (2019)

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Article Engineering, Biomedical

A pH-responsive platform combining chemodynamic therapy with limotherapy for simultaneous bioimaging and synergistic cancer therapy

Jianmin Xiao et al.

BIOMATERIALS (2019)

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Use of nanoparticles as radiosensitizing agents in radiotherapy: State of play

C. Verry et al.

CANCER RADIOTHERAPIE (2019)

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Nanoparticle-Enhanced Radiotherapy to Trigger Robust Cancer Immunotherapy

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Enhancement of Radiosensitization by Silver Nanoparticles Functionalized with Polyethylene Glycol and Aptamer As1411 for Glioma Irradiation Therapy

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INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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Gold nanorod enhanced conjugated polymer/photosensitizer composite nanoparticles for simultaneous two-photon excitation fluorescence imaging and photodynamic therapy

Shuang Li et al.

NANOSCALE (2019)

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Review Cell & Tissue Engineering

Application of Nanotechnology in Targeting of Cancer Stem Cells: A Review

Fatemeh Asghari et al.

INTERNATIONAL JOURNAL OF STEM CELLS (2019)

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Smart NIR-Light-Mediated Nanotherapeutic Agents for Enhancing Tumor Accumulation and Overcoming Hypoxia in Synergistic Cancer Therapy

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ACS APPLIED BIO MATERIALS (2019)

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The acidic tumor microenvironment: a target for smart cancer nano-theranostics

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NATIONAL SCIENCE REVIEW (2018)

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Rattle-Structured Rough Nanocapsules with in-Situ-Formed reil Gold Nanorod Cores for Complementary Gene/Chemo/Photothermal Therapy

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Engineering Multifunctional RNAi Nanomedicine To Concurrently Target Cancer Hallmarks for Combinatorial Therapy

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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

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Tumor-selective catalytic nanosystem for activatable theranostics

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NATURE COMMUNICATIONS (2018)

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Gold Nanoparticles in Radiotherapy and Recent Progress in Nanobrachytherapy

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ADVANCED HEALTHCARE MATERIALS (2018)

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Chemotherapeutic Drug Based Metal-Organic Particles for Microvesicle-Mediated Deep Penetration and Programmable pH/NIR/Hypoxia Activated Cancer Photochemotherapy

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Review Medicine, Research & Experimental

TLR4-Based Immunotherapeutics in Cancer: A Review of the Achievements and Shortcomings

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MOLECULAR PHARMACEUTICS (2018)

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Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA

Mohammad Ariful Islam et al.

NATURE BIOMEDICAL ENGINEERING (2018)

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Synthesis of Chiral Carbo-Nanotweezers for Enantiospecific Recognition and DNA Duplex Winding in Cancer Cells

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Nanomedicine in cancer stem cell therapy: from fringe to forefront

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CELL AND TISSUE RESEARCH (2018)

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3D Biomimetic Chips for Cancer Cell Migration in Nanometer-Sized Spaces Using Ship-in-a-Bottle Femtosecond Laser Processing

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Reprogramming Cells for Synergistic Combination Therapy with Nanotherapeutics against Uveal Melanoma

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BIOMIMETICS (2018)

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Gambogic acid-loaded biomimetic nanoparticles in colorectal cancer treatment

Zhen Zhang et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

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Dual functions of silver nanoparticles in F9 teratocarcinoma stem cells, a suitable model for evaluating cytotoxicity- and differentiation-mediated cancer therapy

Jae Woong Han et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

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Review Public, Environmental & Occupational Health

Review of toxicity studies of carbon nanotubes

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JOURNAL OF OCCUPATIONAL HEALTH (2017)

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Nanoemulsion: A Novel Eon in Cancer Chemotherapy

Prashant Sahu et al.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2017)

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Green synthesis: In-vitro anticancer activity of copper oxide nanoparticles against human cervical carcinoma cells

P. C. Nagajyothi et al.

ARABIAN JOURNAL OF CHEMISTRY (2017)

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Dual-drug loaded nanoneedles with targeting property for efficient cancer therapy

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JOURNAL OF NANOBIOTECHNOLOGY (2017)

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Review Oncology

Recent Advances in Cancer Therapy Based on Dual Mode Gold Nanoparticles

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CANCERS (2017)

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Toxicology of silica nanoparticles: an update

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ARCHIVES OF TOXICOLOGY (2017)

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Inflammation-Triggered Cancer Immunotherapy by Programmed Delivery of CpG and Anti-PD1 Antibody

Chao Wang et al.

ADVANCED MATERIALS (2016)

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New photosensitizers for photodynamic therapy

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BIOCHEMICAL JOURNAL (2016)

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Review Biochemistry & Molecular Biology

Dendrimers as Innovative Radiopharmaceuticals in Cancer Radionanotherapy

Flonja Liko et al.

BIOMACROMOLECULES (2016)

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P-selectin is a nanotherapeutic delivery target in the tumor microenvironment

Yosi Shamay et al.

SCIENCE TRANSLATIONAL MEDICINE (2016)

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Solid Matrix Based Lipidic Nanoparticles in Oral Cancer Chemotherapy: Applications and Pharmacokinetics

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CURRENT DRUG METABOLISM (2015)

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Polysilsesquioxane nanoparticles for triggered release of cisplatin and effective cancer chemoradiotherapy

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NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2015)

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Review Materials Science, Biomaterials

Nanotherapy for Cancer: Targeting and Multifunctionality in the Future of Cancer Therapies

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ACS BIOMATERIALS SCIENCE & ENGINEERING (2015)

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Review Materials Science, Biomaterials

Nanotherapy for Cancer: Targeting and Multifunctionality in the Future of Cancer Therapies

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ACS BIOMATERIALS SCIENCE & ENGINEERING (2015)

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Biodegradable Polymeric Nanoparticles Show High Efficacy and Specificity at DNA Delivery to Human Glioblastoma in Vitro and in Vivo

Hugo Guerrero-Cazares et al.

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Review Pharmacology & Pharmacy

Liposomal siRNA nanocarriers for cancer therapy

Bulent Ozpolat et al.

ADVANCED DRUG DELIVERY REVIEWS (2014)

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Review Radiology, Nuclear Medicine & Medical Imaging

The use of theranostic gadolinium-based nanoprobes to improve radiotherapy efficacy

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BRITISH JOURNAL OF RADIOLOGY (2014)

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A Comparison of TiO2 and ZnO Nanoparticles as Photosensitizers in Photodynamic Therapy for Cancer

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JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2014)

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Synergistic anti-tumor effects of combined gemcitabine and cisplatin nanoparticles in a stroma-rich bladder carcinoma model

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A general mechanism for intracellular toxicity of metal-containing nanoparticles

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NANOSCALE (2014)

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Graphene-based magnetic plasmonic nanocomposite for dual bioimaging and photothermal therapy

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BIOMATERIALS (2013)

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INDIAN JOURNAL OF SURGERY (2013)

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Nanotechnology in cancer therapy

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JOURNAL OF DRUG TARGETING (2013)

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Dendrimers in Photodynamic Therapy

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CURRENT MEDICINAL CHEMISTRY (2012)

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Review Immunology

Cancer-associated fibroblasts as targets for immunotherapy

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IMMUNOTHERAPY (2012)

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Review Biotechnology & Applied Microbiology

Toxicological studies on silver nanoparticles: challenges and opportunities in assessment, monitoring and imaging

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NANOMEDICINE (2011)

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Immunosuppressive effects of triclosan, nonylphenol, and DDT on human natural killer cells in vitro

Felicia Udoji et al.

JOURNAL OF IMMUNOTOXICOLOGY (2010)

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Article Engineering, Biomedical

Radiosensitizer-eluting nanocoatings on gold fiducials for biological in-situ image-guided radio therapy (BIS-IGRT)

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PHYSICS IN MEDICINE AND BIOLOGY (2010)

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Review Oncology

Mechanisms in photodynamic therapy: part two-cellular signaling, cell metabolism and modes of cell death

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PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY (2005)

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