☆ 4.6 Review

Long Non-Coding RNAs as Epigenetic Regulators of Immune Checkpoints in Cancer Immunity

CANCERS (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Pathology

Gene of the month: T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT)

Louisa Bolm et al.

Summary: TIGIT, an immune modulator expressed in immune cells, plays a role in cancer progression by regulating T-cell function and cancer cell recognition. Multiple studies have found an association between TIGIT expression and poor survival. Blocking TIGIT can prevent tumor progression, distant metastasis, and tumor recurrence.

JOURNAL OF CLINICAL PATHOLOGY (2022)

添加到收藏夹

Review Immunology

mTOR-Mediated Regulation of Immune Responses in Cancer and Tumor Microenvironment

Sahar Mafi et al.

Summary: mTOR serves as a downstream mediator in the PI3K/Akt signaling pathways and plays a vital role in regulating cellular functions. Dysregulation of mTOR pathway is frequently observed in human tumors and targeting this pathway has been considered as a potential therapeutic option. It has been discovered that mTOR has a crucial regulatory role in immune responses, affecting the phenotypic and functional reprogramming of tumor-associated immune cells in the tumor microenvironment.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹

Article Oncology

Interleukin-6 blockade abrogates immunotherapy toxicity and promotes tumor immunity

Yared Hailemichael et al.

Summary: Immune checkpoint blockade therapy can cause immune-related adverse events. IL-6 expression is higher in colitis and Th17 cells are more prevalent in immune-related enterocolitis. Anti-CTLA-4 induces stronger Th17 memory in colitis than anti-PD-1. In mouse models, IL-6 blockade enhances tumor control and increases CD4(+)/CD8(+) effector T cell density, while reducing Th17, macrophages, and myeloid cells. Combined IL-6 blockade and ICB enhances tumor rejection and mitigates EAE symptoms. IL-6 blockade with ICB can decouple autoimmunity from antitumor immunity.

CANCER CELL (2022)

添加到收藏夹

Article Ecology

Transcriptional and post-transcriptional regulation of checkpoint genes on the tumour side of the immunological synapse

Paula Dobosz et al.

Summary: Cancer is a disease of the genome, and its development is influenced by multiple factors including genetic variations, acquired somatic mutations, and epigenetic effects. The importance of the immune system has been highlighted in recent years, with the discovery of immune checkpoint genes offering new possibilities for cancer treatment.

HEREDITY (2022)

添加到收藏夹

Article Pathology

lncRNA MIAT targets miR-411-5p/STAT3/PD-L1 axis mediating hepatocellular carcinoma immune response

Xiaoxia Zhang et al.

Summary: The long noncoding RNA MIAT plays a crucial role in the immune escape of hepatocellular carcinoma (HCC) by regulating the miR-411-5p/STAT3/PD-L1 pathway. MIAT suppresses miR-411-5p expression, upregulates STAT3, and ultimately enhances PD-L1 expression, facilitating immune evasion of HCC cells.

INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (2022)

添加到收藏夹

Article Immunology

Long Noncoding RNA Hotair Promotes the Progression and Immune Escape in Laryngeal Squamous Cell Carcinoma through MicroRNA-30a/GRP78/PD-L1 Axis

Xiaowei Yuan et al.

Summary: The oncogenic role of Hotair in human laryngeal squamous cell carcinoma (LSCC) was investigated in this study. High expression levels of Hotair were observed in LSCC cell lines compared to normal cells. Knockdown of Hotair inhibited cell proliferation and enhanced apoptosis. Overexpression of hsa-miR-30a-5p inhibited the expression of GRP78 and PD-L1, but Hotair overexpression rescued both proteins. Combined treatment with si-Hotair and a VEGF inhibitor showed significant inhibition of LSCC growth. These findings suggest that Hotair may be a potential target for treating LSCC.

JOURNAL OF IMMUNOLOGY RESEARCH (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Next RNA Therapeutics: The Mine of Non-Coding

Sabrina Garbo et al.

Summary: The increasing understanding of non-coding RNAs (ncRNAs) and their functional roles has sparked great interest in the scientific community. This review summarizes the therapeutic potential of ncRNA in disease treatment and discusses the advantages and limitations of RNA therapeutics, as well as the development of targeted delivery strategies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Article Oncology

miR-150 expression in breast cancer attracts and activates immune cells, and is associated with better patient outcome.

Masanori Oshi et al.

JOURNAL OF CLINICAL ONCOLOGY (2022)

添加到收藏夹

Review Cell Biology

Use of Circular RNAs in Diagnosis, Prognosis and Therapeutics of Renal Cell Carcinoma

Rebeca Osca-Verdegal et al.

Summary: Renal cell carcinoma is the most common and deadliest type of kidney cancer. The clinical characteristics are unspecific, hindering the diagnostic process. Surgical resection remains the main treatment strategy, but most metastatic renal cell carcinomas are resistant to traditional treatment methods. Therefore, finding new biomarkers for early detection and treatment of renal cell carcinoma is essential.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

添加到收藏夹

Review Medicine, Research & Experimental

ZEB1: Catalyst of immune escape during tumor metastasis

Jiahui Lu et al.

Summary: ZEB1, a critical transcription factor in tumor metastasis, is regulated by various pathways and molecules and influences tumor cell movement, stemness, and immune environment, providing new insights for targeted therapy of malignant tumors.

BIOMEDICINE & PHARMACOTHERAPY (2022)

添加到收藏夹

Article Oncology

miR-5590-3p inhibits the proliferation and metastasis of renal cancer cells by targeting ROCK2 to inhibit proliferation, migration and invasion

Queling Liu et al.

Summary: The study demonstrated that miR-5590-3p inhibits the proliferation, migration, and invasion of RCC cells by targeting ROCK2. Overexpression of ROCK2 effectively reverses these regulatory effects.

ONCOLOGY LETTERS (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

NEAT1 polyA-modulating antisense oligonucleotides reveal opposing functions for both long non-coding RNA isoforms in neuroblastoma

Alina Naveed et al.

Summary: Numerous lncRNAs, including NEAT1, are dysregulated in cancer and are considered therapeutic targets. Researchers have developed ASOs targeting NEAT1_1 to increase NEAT1_2 expression and paraspeckle abundance in neuroblastoma cells, leading to a decrease in cell viability in high-risk neuroblastoma. Furthermore, altering lncRNA polyadenylation events using ASOs shows potential as an anti-cancer strategy.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

添加到收藏夹

Article Biology

Transmembrane adaptor protein PAG is a mediator of PD-1 inhibitory signaling in human T cells

Marianne Strazza et al.

Summary: Strazza et al. demonstrate that PAG is phosphorylated following PD-1 ligation, and its deletion sensitizes tumors to PD-1 blockade. This study suggests that PAG is a critical mediator of PD-1 signaling and a promising target to enhance T cell activation in tumors.

COMMUNICATIONS BIOLOGY (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

The roles of non-coding RNAs in vascular calcification and opportunities as therapeutic targets

Juhee Ryu et al.

Summary: This article reviews the role and therapeutic implications of non-coding RNAs (ncRNAs) in vascular calcification (VC). Studies suggest that ncRNAs, including miRNAs, lncRNAs, and circRNAs, play important roles in regulating VC and may be useful in clinical diagnosis and treatment.

PHARMACOLOGY & THERAPEUTICS (2021)

添加到收藏夹

Review Medicine, Research & Experimental

Exosomal Long Non-coding RNAs: Emerging Players in the Tumor Microenvironment

Anup S. Pathania et al.

Summary: Recent advances in exosome biology have highlighted the crucial role of exosomal lncRNAs in cancer, regulating intercellular communication and impacting cancer growth and progression. Dysregulated expression of lncRNAs is commonly found in cancers and can serve as diagnostic biomarkers.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Thalidomide suppresses angiogenesis and immune evasion via lncRNA FGD5-AS1/miR-454-3p/ZEB1 axis-mediated VEGFA expression and PD-1/PD-L1 checkpoint in NSCLC

Yang Xia et al.

Summary: This study demonstrated that thalidomide inhibits NSCLC angiogenesis and immune evasion by targeting FGD5-AS1. FGD5-AS1 regulates the expression of PD-L1 and VEGFA through the miR-454-3p/ZEB1 axis, affecting the PD-1/PD-L1 checkpoint and exerting anti-tumor effects.

CHEMICO-BIOLOGICAL INTERACTIONS (2021)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Long non-coding RNA C5orf64 is a potential indicator for tumor microenvironment and mutation pattern remodeling in lung adenocarcinoma

Zhaofei Pang et al.

Summary: This study explored the synergistic and antagonistic effects of tumor microenvironment and tumor mutation pattern on lung adenocarcinoma. A 14-lncRNA immune-related signature, with C5orf64 identified as a potential indicator for TME modulation and tumor mutation pattern remodeling, was developed through analysis of immune-related genes and construction of a ceRNA network. High expression of PD-1, PD-L1 and CTLA-4 was demonstrated in high-level C5orf64 groups, while a negative correlation was observed between C5orf64 and TP53 mutation frequency. A novel model based on age, tumor stage and immune-related lncRNA signature was proposed.

GENOMICS (2021)

添加到收藏夹

Article Gastroenterology & Hepatology

Dual targeting of PD-L1 and PD-L2 by PCED1B-AS1 via sponging hsa-miR-194-5p induces immunosuppression in hepatocellular carcinoma

Fei Fan et al.

Summary: In HCC, PD-L1 and PD-L2 expression are highly correlated, while PCED1B-AS1 and hsa-miR-194-5p expression are up-regulated. PCED1B-AS1 interacts with hsa-miR-194-5p to inhibit PD-Ls expression, promoting immunosuppression in HCC cells. This study suggests a potential role of PCED1B-AS1 in regulating immune response and tumor behavior in HCC.

HEPATOLOGY INTERNATIONAL (2021)

添加到收藏夹

Article Medical Laboratory Technology

Genetic signature of CTLA-4, BTLA, TIM-3 and LAG-3 molecular expression in colorectal cancer patients: Implications in diagnosis and survival outcomes

Amany M. Kamal et al.

Summary: Accumulating evidences suggest that immune checkpoints inhibit immune response against cancer and promote tumor cell survival. The study found that gene expression of CTLA-4, BTLA, TIM-3, and LAG-3 in the blood of CRC patients was significantly up-regulated and associated with cancer stage and patients' survival. CTLA-4, BTLA, TIM-3, and LAG-3 were independent prognostic factors for survival in CRC patients after adjustment for age and gender.

CLINICAL BIOCHEMISTRY (2021)

添加到收藏夹

Article Medicine, Research & Experimental

FGD5-AS1 promotes cisplatin resistance of human lung adenocarcinoma cell via the miR-142-5p/PD-L1 axis

Feng Zhu et al.

Summary: The study revealed that FGD5-AS1 increases resistance of LAD to DDP via the miR-142/PD-L1 axis, suggesting a novel treatment approach for patients with DDP-resistant LAD.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2021)

添加到收藏夹

Review Oncology

Regulation of PD-L1 expression in the tumor microenvironment

Ming Yi et al.

Summary: PD-L1 expression is regulated by various factors, impacting the treatment effect and patient selection. Understanding the mechanisms of PD-L1 regulation helps enhance the efficacy of immunotherapy.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

添加到收藏夹

Review Cell Biology

Gene regulation by long non-coding RNAs and its biological functions

Luisa Statello et al.

Summary: Recent studies have shed new light on the biogenesis and functions of long non-coding RNAs (lncRNAs), showcasing their diverse roles in gene regulation and signaling pathways, particularly in the contexts of neuronal disorders, immune responses, and cancer. The discovery of unique biogenesis pathways and subcellular localizations of lncRNAs has opened up potential therapeutic avenues for targeting lncRNAs in various biological and pathophysiological conditions.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

添加到收藏夹

Article Oncology

Low microRNA150 expression is associated with activated carcinogenic pathways and a poor prognosis in patients with breast cancer

San-Qi An et al.

Summary: This study identified that low miR150 expression in breast cancer may be associated with unfavorable clinical features, upregulation of carcinogenic signaling pathways, and poor patient survival. Additionally, a proposed miR150-BTLA axis was suggested to regulate cell viability and migration in breast cancer.

ONCOLOGY REPORTS (2021)

添加到收藏夹

Article Nanoscience & Nanotechnology

Nano-Coated si-SNHG14 Regulated PD-L1 Expression and Decreased Epithelial-Mesenchymal Transition in Nasopharyngeal Carcinoma Cells

Haoran Yu et al.

Summary: This study found that SNHG14 was upregulated in NPC tissues, and silencing SNHG14 could significantly inhibit the EMT process in NPC. Additionally, ZEB1 could promote EMT by upregulating PD-L1 transcription, while SNHG14 could accelerate EMT in NPC by regulating PD-1 and PD-L1.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2021)

添加到收藏夹

Article Cell Biology

CircKRT1 drives tumor progression and immune evasion in oral squamous cell carcinoma by sponging miR-495-3p to regulate PDL1 expression

Zhongheng Yang et al.

Summary: The study reveals that circKRT1 regulates cancer progression and immune evasion in oral squamous cell carcinoma (OSCC) by affecting the miR-495-3p/PDL1 axis.

CELL BIOLOGY INTERNATIONAL (2021)

添加到收藏夹

Review Immunology

The Potential Regulatory Roles of Circular RNAs in Tumor Immunology and Immunotherapy

Zhixiao Fang et al.

Summary: CircRNAs are covalently closed RNA molecules in eukaryotes with high stability and tissue-specific expression, playing important regulatory roles in various human cancers through multiple mechanisms. They are also closely associated with immune cells in the tumor immune microenvironment and have implications for immune checkpoint blockade immunotherapy in tumor treatment.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Oncology

PD-L2 Is Constitutively Expressed in Normal and Malignant Urothelium

Alexander C. Dowell et al.

Summary: The study found widespread expression of PD-L2 in urothelial bladder cancer and normal urothelium, with significantly increased expression in advanced disease, contrary to decreased expression in muscle-invasive bladder cancer.

FRONTIERS IN ONCOLOGY (2021)

添加到收藏夹

Article Oncology

Circular RNA CHST15 Sponges miR-155-5p and miR-194-5p to Promote the Immune Escape of Lung Cancer Cells Mediated by PD-L1

Jianru Yang et al.

Summary: The up-regulated CircCHST15 in lung cancer promotes PD-L1-mediated immune escape of cancer cells by sponging miR-155-5p and miR-194-5p, which may affect tumor growth and proliferation.

FRONTIERS IN ONCOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Antisense RNAs during early vertebrate development are divided in groups with distinct features

Sanjana Pillay et al.

Summary: During early vertebrate development, zebrafish NATs can be divided into two major classes based on their coexpression patterns with overlapping protein-coding genes. Group 1 NATs show characteristics similar to maternally deposited RNAs with levels decreasing as development progresses and negative correlation with overlapping sense-strand protein-coding genes, while Group 2 NATs are coexpressed with overlapping protein-coding genes and enriched in housekeeping functions.

GENOME RESEARCH (2021)

添加到收藏夹

Review Oncology

Next generation of immune checkpoint inhibitors and beyond

Julian A. Marin-Acevedo et al.

Summary: The immune system plays a crucial role in defending against cancer, but tumor cells can evade immune recognition. Immunotherapy enhances host immune response to combat tumors.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

A Pan-Cancer Landscape of HOX-Related lncRNAs and Their Association With Prognosis and Tumor Microenvironment

Wei Shao et al.

Summary: This study systematically analyzed the expression levels of HOXATs in different cancer tissues and found their associations with cancer prognosis, immune regulation, and stemness scores. Gene set enrichment analysis revealed the participation of HOXATs in cancer- and immune-related pathways. Additionally, HOXB-AS1 showed potential oncogenic roles and immune regulation across various cancer types.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

circ-Keratin 6c Promotes Malignant Progression and Immune Evasion of Colorectal Cancer through microRNA-485-3p/Programmed Cell Death Receptor Ligand 1 Axis

Zhipeng Jiang et al.

Summary: This study reveals that circ-KRT6C is overexpressed in colorectal cancer cells and tissues, and its inhibition can suppress proliferation, migration, invasion, and immune escape of colorectal cancer cells while promoting apoptosis. Additionally, miR-485-3p can repress malignant progression and immune evasion of colorectal cancer by targeting PDL1. The findings suggest that circ-KRT6C and miR-485-3p play crucial roles in the development and progression of colorectal cancer.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Clinical Insights Into Novel Immune Checkpoint Inhibitors

Jii Bum Lee et al.

Summary: The success of immune checkpoint inhibitors has revolutionized solid tumor treatment, but challenges remain with lack of response and immune related adverse events. Targeting other immune checkpoints associated with tumor microenvironment offers promising options to overcome limitations of ICIs.

FRONTIERS IN PHARMACOLOGY (2021)

添加到收藏夹

Article Immunology

TIGIT and PD-1 Immune Checkpoint Pathways Are Associated With Patient Outcome and Anti-Tumor Immunity in Glioblastoma

Itay Raphael et al.

Summary: Glioblastoma (GBM) remains a highly aggressive brain tumor with limited success in immune checkpoint (IC) inhibitors therapy. PD1 and TIGIT have been identified as top targets for GBM immunotherapy, and dual blockade of these molecules has shown improved survival in a murine GBM model. Additionally, this combination immunotherapy affects specific myeloid cells and restores T cell proliferation inhibited by immunosuppressive myeloid cells in human GBM tissue.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Review Oncology

Inhibitors of immune checkpoints-PD-1, PD-L1, CTLA-4-new opportunities for cancer patients and a new challenge for internists and general practitioners

Marek Z. Wojtukiewicz et al.

Summary: Immune checkpoint inhibitors (ICI) have made a significant breakthrough in cancer treatment, improving outcomes and prognosis for patients with different types of malignancy. However, the expansion of their use presents new challenges, highlighting the need for multidisciplinary teamwork to address adverse reactions.

CANCER AND METASTASIS REVIEWS (2021)

添加到收藏夹

Article Immunology

miR-194-5p down-regulates tumor cell PD-L1 expression and promotes anti-tumor immunity in pancreatic cancer

Chengzhi Wang et al.

Summary: High expression of miR-194-5p in pancreatic cancer patients is associated with a better survival rate and inhibits the expression of PD-L1. Overexpression of miR-194-5p suppresses the progression of pancreatic cancer, promotes the infiltration of CD8+ T cells in tumor immune microenvironments, and enhances IFN-gamma production of CD8+ T cells.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

添加到收藏夹

Review Immunology

TIGIT, the Next Step Towards Successful Combination Immune Checkpoint Therapy in Cancer

Zhouhong Ge et al.

Summary: TIGIT is an inhibitory receptor expressed on multiple types of lymphocytes, and the efficacy of TIGIT blockade in cancer immunotherapy is currently under investigation. While single TIGIT blockade has limited anti-tumor efficacy, co-blockade with the PD-1/PD-L1 pathway leads to tumor rejection.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Cell Biology

LncRNA KCNQ1OT1 Secreted by Tumor Cell-Derived Exosomes Mediates Immune Escape in Colorectal Cancer by Regulating PD-L1 Ubiquitination via MiR-30a-5p/USP22

Di Xian et al.

Summary: The study revealed that lncRNA KCNQ1OT1 expression was significantly increased in tumor tissues and tumor cell-derived exosomes, mediating the ubiquitination of PD-L1 through the miR-30a-5p/USP22 pathway to inhibit CD8+ T cell response and promote colorectal cancer development.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

添加到收藏夹

Article Genetics & Heredity

The prospective prognostic value of the immune checkpoint BTLA expression in adult acute myeloid leukemia patients

Sara M. Radwan et al.

Summary: The study found significantly elevated BTLA expression in AML patients, with over-expression associated with poorer overall survival times. These observations suggest that BTLA over-expression may be associated with reduced immunity against tumors and could be recommended as a promising biomarker for unfavorable prognosis in AML.

EGYPTIAN JOURNAL OF MEDICAL HUMAN GENETICS (2021)

添加到收藏夹

Review Immunology

Soluble B7-CD28 Family Inhibitory Immune Checkpoint Proteins and Anti-Cancer Immunotherapy

Muhammad Khan et al.

Summary: Soluble checkpoint molecules play important roles in immune regulation and anti-cancer immunotherapy, with correlations to tumor progression, metastasis, and prognosis. Understanding their production mechanisms and biological activities may pave the way for their use as therapeutic targets.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Long Non-Coding RNA (lncRNA) Roles in Cell Biology, Neurodevelopment and Neurological Disorders

Vincenza Aliperti et al.

Summary: Understanding the functions and altered expression of lncRNAs in neurodevelopmental and mental health diseases is essential to comprehend the complex transcriptional processes in brain function. Exploiting lncRNAs as novel targets for treating neurological disorders shows promising potential.

NON-CODING RNA (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Immunosurveillance and Immunoediting of Lung Cancer: Current Perspectives and Challenges

Kei Kunimasa et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Review Oncology

Long non-coding RNAs in development and disease: conservation to mechanisms

Ioannis Tsagakis et al.

JOURNAL OF PATHOLOGY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

A novel IFNα-induced long noncoding RNA negatively regulates immunosuppression by interrupting H3K27 acetylation in head and neck squamous cell carcinoma

Hailong Ma et al.

MOLECULAR CANCER (2020)

添加到收藏夹

Article Cell Biology

circRNA-002178 act as a ceRNA to promote PDL1/PD1 expression in lung adenocarcinoma

JunFeng Wang et al.

CELL DEATH & DISEASE (2020)

添加到收藏夹

Article Oncology

LncSpA: LncRNA Spatial Atlas of Expression across Normal and Cancer Tissues

Dezhong Lv et al.

CANCER RESEARCH (2020)

添加到收藏夹

Review Oncology

Dissecting the transcriptional regulatory networks of promoter-associated noncoding RNAs in development and cancer

Lidia Chellini et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

A long noncoding RNA sensitizes genotoxic treatment by attenuating ATM activation and homologous recombination repair in cancers

Kunming Zhao et al.

PLOS BIOLOGY (2020)

添加到收藏夹

Article Cell Biology

LncRNA GATA3-AS1 facilitates tumour progression and immune escape in triple-negative breast cancer through destabilization of GATA3 but stabilization of PD-L1

Ming Zhang et al.

CELL PROLIFERATION (2020)

添加到收藏夹

Article Cell Biology

Paper Long non-coding RNA SNHG12 promotes immune escape of ovarian cancer cells through their crosstalk with M2 macrophages

Min Qian et al.

AGING-US (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Cancer cell-derived exosomal circUHRF1 induces natural killer cell exhaustion and may cause resistance to anti-PD1 therapy in hepatocellular carcinoma

Peng-Fei Zhang et al.

MOLECULAR CANCER (2020)

添加到收藏夹

Article Oncology

LncRNA KCNQ1OT1 sponges miR-15a to promote immune evasion and malignant progression of prostate cancer via up-regulating PD-L1

Qi-Hua Chen et al.

CANCER CELL INTERNATIONAL (2020)

添加到收藏夹

Article Multidisciplinary Sciences

A decade of immune-checkpoint inhibitors in cancer therapy

Caroline Robert

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Spatial and Temporal Changes in PD-L1 Expression in Cancer: The Role of Genetic Drivers, Tumor Microenvironment and Resistance to Therapy

Elena Shklovskaya et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Article Oncology

Circular RNA circ-CPA4/let-7 miRNA/PD-L1 axis regulates cell growth, stemness, drug resistance and immune evasion in non-small cell lung cancer (NSCLC)

Weijun Hong et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

添加到收藏夹

Review Oncology

Progress of immune checkpoint LAG-3 in immunotherapy

Chanchan Shan et al.

ONCOLOGY LETTERS (2020)

添加到收藏夹

Article Oncology

Long non-coding RNA HOXA-AS2 promotes the expression levels of hypoxia-inducible factor-1α and programmed death-ligand 1, and regulates nasopharyngeal carcinoma progression via miR-519

Shuyong Wang et al.

ONCOLOGY LETTERS (2020)

添加到收藏夹

Article Oncology

LncRNA NUTM2A-AS1 positively modulates TET1 and HIF-1A to enhance gastric cancer tumorigenesis and drug resistance by sponging miR-376a

Ji Wang et al.

CANCER MEDICINE (2020)

添加到收藏夹

Review Immunology

IDO Expression in Cancer: Different Compartment, Different Functionality?

Annabel Meireson et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹

Review Oncology

TIGIT in cancer immunotherapy

Joe-Marc Chauvin et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

添加到收藏夹

Editorial Material Medicine, General & Internal

Epigenetics modulates the complexity of the response to Immune Checkpoint Blockade

Isabel Barragan

EBIOMEDICINE (2020)

添加到收藏夹

Review Cell & Tissue Engineering

Epidrugs: novel epigenetic regulators that open a new window for targeting osteoblast differentiation

Mahsa Ghorbaninejad et al.

STEM CELL RESEARCH & THERAPY (2020)

添加到收藏夹

Article Oncology

Long noncoding RNA CASC11 promotes hepatocarcinogenesis and HCC progression through EIF4A3-mediated E2F1 activation

Hang Song et al.

CLINICAL AND TRANSLATIONAL MEDICINE (2020)

添加到收藏夹

Review Medicine, Research & Experimental

The emerging role of super enhancer-derived noncoding RNAs in human cancer

Yutong Wang et al.

THERANOSTICS (2020)

添加到收藏夹

Review Immunology

A guide to cancer immunotherapy: from T cell basic science to clinical practice

Alex D. Waldman et al.

NATURE REVIEWS IMMUNOLOGY (2020)

添加到收藏夹

Article Medicine, General & Internal

A Robust 6-lncRNA Prognostic Signature for Predicting the Prognosis of Patients With Colorectal Cancer Metastasis

Shuyuan Li et al.

FRONTIERS IN MEDICINE (2020)

添加到收藏夹

Article Oncology

MicroRNA-411 Inhibits Cervical Cancer Progression by Directly Targeting STAT3

Dan Shan et al.

ONCOLOGY RESEARCH (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Upregulation of long noncoding RNA SNHG20 promotes cell growth and metastasis in esophageal squamous cell carcinoma via modulating ATM-JAK-PD-L1 pathway

Chunrong Zhang et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Repression of lncRNA NEAT1 enhances the antitumor activity of CD8+T cells against hepatocellular carcinoma via regulating miR-155/Tim-3

Kai Yan et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2019)

添加到收藏夹

Review Oncology

The Function of Non-Coding RNAs in Lung Cancer Tumorigenesis

Cornelia Braicu et al.

CANCERS (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

How are circRNAs translated by non-canonical initiation mechanisms?

Leila Halidou Diallo et al.

BIOCHIMIE (2019)

添加到收藏夹

Article Immunology

Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression

Qingsong Hu et al.

NATURE IMMUNOLOGY (2019)

添加到收藏夹

Review Pharmacology & Pharmacy

Drugs Targeting Epigenetic Modifications and Plausible Therapeutic Strategies Against Colorectal Cancer

Srinivas Patnaik et al.

FRONTIERS IN PHARMACOLOGY (2019)

添加到收藏夹

Article Cell Biology

A disparate role of RP11-424C20.2/UHRF1 axis through control of tumor immune escape in liver hepatocellular carcinoma and thymoma

Jue Yang et al.

AGING-US (2019)

添加到收藏夹

Article Oncology

Long non-coding RNA HOTTIP enhances IL-6 expression to potentiate immune escape of ovarian cancer cells by upregulating the expression of PD-L1 in neutrophils

Anquan Shang et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Long non-coding RNA: Classification, biogenesis and functions in blood cells

Swati Dahariya et al.

MOLECULAR IMMUNOLOGY (2019)

添加到收藏夹

Article Cell Biology

LncRNA SNHG14/miR-5590-3p/ZEB1 positive feedback loop promoted diffuse large B cell lymphoma progression and immune evasion through regulating PD-1/PD-L1 checkpoint

Lina Zhao et al.

CELL DEATH & DISEASE (2019)

添加到收藏夹

Review Cell Biology

Insights into Biological Role of LncRNAs in Epithelial-Mesenchymal Transition

Jun-Ting Cheng et al.

CELLS (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Novel immune checkpoint targets: moving beyond PD-1 and CTLA-4

Shuang Qin et al.

MOLECULAR CANCER (2019)

添加到收藏夹

Article Oncology

BTLA blockade enhances Cancer therapy by inhibiting IL-6/IL-10-induced CD19high B lymphocytes

Yu-Li Chen et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

添加到收藏夹

Review Oncology

The Role of Long Non-coding RNAs in Immunotherapy Resistance

Yuwen Zhou et al.

FRONTIERS IN ONCOLOGY (2019)

添加到收藏夹

Review Oncology

From Super-Enhancer Non-coding RNA to Immune Checkpoint: Frameworks to Functions

Manqing Wu et al.

FRONTIERS IN ONCOLOGY (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape

Xianjie Jiang et al.

MOLECULAR CANCER (2019)

添加到收藏夹

Review Oncology

Cancer immunoediting and resistance to T cell-based immunotherapy

Jake S. O'Donnell et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2019)

添加到收藏夹

Review Medicine, General & Internal

Treating Disease at the RNA Level with Oligonucleotides

Arthur A. Levin

NEW ENGLAND JOURNAL OF MEDICINE (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Circular RNA circFGFR1 promotes progression and anti-PD-1 resistance by sponging miR-381-3p in non-small cell lung cancer cells

Peng-Fei Zhang et al.

MOLECULAR CANCER (2019)

添加到收藏夹

Article Immunology

Immune Checkpoints in Circulating and Tumor-Infiltrating CD4+ T Cell Subsets in Colorectal Cancer Patients

Salman M. Toor et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹

Article Immunology

LncRNA MALAT1 contributes to non-small cell lung cancer progression via modulating miR-200a-3p/programmed death-ligand 1 axis

Shuquan Wei et al.

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY (2019)

添加到收藏夹

Article Computer Science, Artificial Intelligence

Evaluation of deep learning in non-coding RNA classification

Noorul Amin et al.

NATURE MACHINE INTELLIGENCE (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

miR-5590-3p inhibited tumor growth in gastric cancer by targeting DDX5/AKT/m-TOR pathway

Nan Wu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

添加到收藏夹

Review Oncology

Regulation of cancer immune escape: The roles of miRNAs in immune checkpoint proteins

Qin Yang et al.

CANCER LETTERS (2018)

添加到收藏夹

Review Immunology

Oxygen-dependent regulation of immune checkpoint mechanisms

Akio Ohta

INTERNATIONAL IMMUNOLOGY (2018)

添加到收藏夹

Article Oncology

Lymphocyte-Activation Gene-3 Expression and Prognostic Value in Neoadjuvant-Treated Triple-Negative Breast Cancer

Yunxuan Wang et al.

JOURNAL OF BREAST CANCER (2018)

添加到收藏夹

Article Oncology

Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline

Julie R. Brahmer et al.

JOURNAL OF CLINICAL ONCOLOGY (2018)

添加到收藏夹

Review Medicine, Research & Experimental

Tim-3-Biomarker and therapeutic target in oncology

Clemence Granier et al.

M S-MEDECINE SCIENCES (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Control of PD-L1 expression by miR-140/142/340/383 and oncogenic activation of the OCT4-miR-18a pathway in cervical cancer

Peixin Dong et al.

ONCOGENE (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Genetic, transcriptional and post-translational regulation of the programmed death protein ligand 1 in cancer: biology and clinical correlations

Ioannis Zerdes et al.

ONCOGENE (2018)

添加到收藏夹

Editorial Material Oncology

AGC kinases in cancer metastasis, immune checkpoint regulation and drug resistance

Gongda Xue et al.

SEMINARS IN CANCER BIOLOGY (2018)

添加到收藏夹

Article Cell Biology

Long non-coding RNA Lnc-Tim3 exacerbates CD8 T cell exhaustion via binding to Tim-3 and inducing nuclear translocation of Bat3 in HCC

Jie Ji et al.

CELL DEATH & DISEASE (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression

Yuan Jiang et al.

NATURE COMMUNICATIONS (2018)

添加到收藏夹

Article Multidisciplinary Sciences

NKX2-1-AS1 negatively regulates CD274/PD-L1, cell-cell interaction genes, and limits human lung carcinoma cell migration

Hasmeena Kathuria et al.

SCIENTIFIC REPORTS (2018)

添加到收藏夹

Article Oncology

A novel feedback loop between high MALAT-1 and low miR-200c-3p promotes cell migration and invasion in pancreatic ductal adenocarcinoma and is predictive of poor prognosis

Meng Zhuo et al.

BMC CANCER (2018)

添加到收藏夹

Review Oncology

Soluble immune checkpoints in cancer: production, function and biological significance

Daqian Gu et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2018)

添加到收藏夹

Article Hematology

Soluble PD-1 ligands regulate T-cell function in Waldenstrom macroglobulinemia

Shahrzad Jalali et al.

BLOOD ADVANCES (2018)

添加到收藏夹

Review Immunology

The diverse functions of the PD1 inhibitory pathway

Arlene H. Sharpe et al.

NATURE REVIEWS IMMUNOLOGY (2018)

添加到收藏夹

Article Oncology

Differential Expression and Significance of PD-L1, IDO-1, and B7-H4 in Human Lung Cancer

Kurt A. Schalper et al.

CLINICAL CANCER RESEARCH (2017)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Non-coding RNAs as drug targets

Masayuki Matsui et al.

NATURE REVIEWS DRUG DISCOVERY (2017)

添加到收藏夹

Article Oncology

A competing endogenous RNA network identifies novel mRNA, miRNA and lncRNA markers for the prognosis of diabetic pancreatic cancer

Kanyu Yao et al.

TUMOR BIOLOGY (2017)

添加到收藏夹

Article Oncology

Co-expression of AFAP1-AS1 and PD-1 predicts poor prognosis in nasopharyngeal carcinoma

Yanyan Tang et al.

ONCOTARGET (2017)

添加到收藏夹

Article Cell Biology

BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1

Simon J. Hogg et al.

CELL REPORTS (2017)

添加到收藏夹

Article Cell Biology

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

Angel Garcia-Diaz et al.

CELL REPORTS (2017)

添加到收藏夹

Article Cell Biology

Hsa_circ_0020397 regulates colorectal cancer cell viability, apoptosis and invasion by promoting the expression of the miR-138 targets TERT and PD-L1

Xiu-li Zhang et al.

CELL BIOLOGY INTERNATIONAL (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

miR-142-5p regulates tumor cell PD-Ll expression and enhances anti-tumor immunity

Long Jia et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

添加到收藏夹

Article Medicine, Research & Experimental

Role of soluble programmed death-1 (sPD-1) and sPD- ligand 1 in patients with cystic echinococcosis

Yanhua Li et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2016)

添加到收藏夹

Review Oncology

CTLA-4 and PD-1 Pathways Similarities, Differences, and Implications of Their Inhibition

Elizabeth I. Buchbinder et al.

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS (2016)

添加到收藏夹

Article Oncology

Long non-coding RNA CASC11 interacts with hnRNP-K and activates the WNT/β-catenin pathway to promote growth and metastasis in colorectal cancer

Zheying Zhang et al.

CANCER LETTERS (2016)

添加到收藏夹

Article Medicine, General & Internal

Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial

Roy S. Herbst et al.

LANCET (2016)

添加到收藏夹

Review Medicine, General & Internal

Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway

Vassiliki A. Boussiotis

NEW ENGLAND JOURNAL OF MEDICINE (2016)

添加到收藏夹

Editorial Material Genetics & Heredity

Epigenetic epidemiology as a tool to understand the role of immunity in chronic disease

Heather H. Nelson et al.

EPIGENOMICS (2016)

添加到收藏夹

Review Immunology

The PD1:PD-L1/2 Pathway from Discovery to Clinical implementation

Kankana Bardhan et al.

FRONTIERS IN IMMUNOLOGY (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Soluble B7-H3 promotes the invasion and metastasis of pancreatic carcinoma cells through the TLR4/NF-κB pathway

Chao Xie et al.

SCIENTIFIC REPORTS (2016)

添加到收藏夹

Article Gastroenterology & Hepatology

Tim-3 fosters HCC development by enhancing TGF-β-mediated alternative activation of macrophages

Wenjiang Yan et al.

GUT (2015)

添加到收藏夹

Editorial Material Biochemistry & Molecular Biology

Discovery and annotation of long noncoding RNAs

John S. Mattick et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)

添加到收藏夹

Article Medicine, General & Internal

Pembrolizumab versus Ipilimumab in Advanced Melanoma

Caroline Robert et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

添加到收藏夹

Review Multidisciplinary Sciences

The future of immune checkpoint therapy

Padmanee Sharma et al.

SCIENCE (2015)

添加到收藏夹

Article Cell Biology

Enhancer RNAs: A Class of Long Noncoding RNAs Synthesized at Enhancers

Tae-Kyung Kim et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2015)

添加到收藏夹

Editorial Material Biochemistry & Molecular Biology

Discovery and annotation of long noncoding RNAs

John S. Mattick et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)

添加到收藏夹

Review Oncology

4-1 BB agonists: multi-potent potentiators of tumor immunity

Todd Bartkowiak et al.

FRONTIERS IN ONCOLOGY (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Cancer Specific Long Noncoding RNAs Show Differential Expression Patterns and Competing Endogenous RNA Potential in Hepatocellular Carcinoma

Jian Zhang et al.

PLOS ONE (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

Efficient backsplicing produces translatable circular mRNAs

Yang Wang et al.

RNA (2015)

添加到收藏夹

Article Cell Biology

Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus

Jian-Feng Xiang et al.

CELL RESEARCH (2014)

添加到收藏夹

Review Biochemistry & Molecular Biology

Non-coding RNAs as direct and indirect modulators of epigenetic regulation

Veronica J. Peschansky et al.

EPIGENETICS (2014)

添加到收藏夹

Review Biochemistry & Molecular Biology

Cancer Epigenetics: Tumor Heterogeneity, Plasticity of Stem-like States, and Drug Resistance

Hariharan Easwaran et al.

MOLECULAR CELL (2014)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Detecting and characterizing circular RNAs

William R. Jeck et al.

NATURE BIOTECHNOLOGY (2014)

添加到收藏夹

Article Immunology

The soluble isoform of CTLA-4 as a regulator of T-cell responses

Frank J. Ward et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2013)

添加到收藏夹

Review Genetics & Heredity

Long Noncoding RNAs: Past, Present, and Future

Johnny T. Y. Kung et al.

GENETICS (2013)

添加到收藏夹

Review Immunology

Oncology Meets Immunology: The Cancer-Immunity Cycle

Daniel S. Chen et al.

IMMUNITY (2013)

添加到收藏夹

Article Oncology

Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors

Esra A. Akbay et al.

CANCER DISCOVERY (2013)

添加到收藏夹

Article Oncology

Reconstructed Adeno-Associated Virus with the Extracellular Domain of Murine PD-1 Induces Antitumor Immunity

Osama A. O. Elhag et al.

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION (2012)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Detecting transcription of ribosomal protein pseudogenes in diverse human tissues from RNA-seq data

Peter Tonner et al.

BMC GENOMICS (2012)

添加到收藏夹

Review Biochemistry & Molecular Biology

Cancer Epigenetics: From Mechanism to Therapy

Mark A. Dawson et al.

CELL (2012)

添加到收藏夹

Article Gastroenterology & Hepatology

Tim-3/galectin-9 signaling pathway mediates T-cell dysfunction and predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma

Hang Li et al.

HEPATOLOGY (2012)

添加到收藏夹

Article Multidisciplinary Sciences

An integrated encyclopedia of DNA elements in the human genome

Ian Dunham et al.

NATURE (2012)

添加到收藏夹

Review Biochemistry & Molecular Biology

The hallmarks of cancer A long non-coding RNA point of view

Tony Gutschner et al.

RNA BIOLOGY (2012)

添加到收藏夹

Review Oncology

The blockade of immune checkpoints in cancer immunotherapy

Drew M. Pardoll

NATURE REVIEWS CANCER (2012)

添加到收藏夹

Article Immunology

The role of the PD-1 pathway in autoimmunity and peripheral tolerance

Brian T. Fife et al.

YEAR IN IMMUNOLOGY (2011)

添加到收藏夹

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

CELL (2011)

添加到收藏夹

Review Biochemistry & Molecular Biology

Molecular Mechanisms of Long Noncoding RNAs

Kevin C. Wang et al.

MOLECULAR CELL (2011)

添加到收藏夹

Article Multidisciplinary Sciences

A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression

Kevin C. Wang et al.

NATURE (2011)

添加到收藏夹

Review Oncology

The Emergence of lncRNAs in Cancer Biology

John R. Prensner et al.

CANCER DISCOVERY (2011)

添加到收藏夹

Review Oncology

Epigenetics in cancer

Shikhar Sharma et al.

CARCINOGENESIS (2010)

添加到收藏夹

Article Multidisciplinary Sciences

Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals

Mitchell Guttman et al.

NATURE (2009)

添加到收藏夹

Article Immunology

Soluble CD276 (B7-H3) is released from monocytes, dendritic cells and activated T cells and is detectable in normal human serum

Guangbo Zhang et al.

IMMUNOLOGY (2008)

添加到收藏夹

Article Oncology

Targeting cytotoxic T-lymphocyte antigen-4 (CTLA-4) - A novel strategy for the treatment of melanoma and other malignancies

Steven J. O'Day et al.

CANCER (2007)

添加到收藏夹

Article Oncology

Ultraconserved regions encoding ncRNAs are, altered in human leukemias and carcinomas

George A. Calin et al.

CANCER CELL (2007)

添加到收藏夹

Article Biochemistry & Molecular Biology

Functional demarcation of active and silent chromatin domains in human HOX loci by Noncoding RNAs

John L. Rinn et al.

CELL (2007)

添加到收藏夹

Review Biochemistry & Molecular Biology

Non-coding RNA

JS Mattick et al.

HUMAN MOLECULAR GENETICS (2006)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.