☆ 4.7 Article

Longitudinal Assessment of Plasma Syndecan-1 Predicts 60-Day Mortality in Patients with COVID-19

JOURNAL OF CLINICAL MEDICINE (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Chemistry, Multidisciplinary

Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies

Suo-wen Xu et al.

Summary: This review examines the impact of COVID-19 on endothelial cell function and provides a comprehensive summary of biomarkers associated with endothelial cell activation in COVID-19. COVID-19 is considered a vascular and endothelial disease, and several drugs have shown potential in improving clinical manifestations of patients. Further research using cellular and animal models can accelerate the discovery of new drugs targeting endothelial dysfunction in COVID-19 patients.

ACTA PHARMACOLOGICA SINICA (2023)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Current and novel biomarkers of thrombotic risk in COVID-19: a Consensus Statement from the International COVID-19 Thrombosis Biomarkers Colloquium

Diana A. Gorog et al.

Summary: COVID-19 predisposes patients to thrombotic and thromboembolic events. Numerous biomarkers have emerged to assess the thrombotic risk in these patients, informing prognosis and predicting thrombosis.

NATURE REVIEWS CARDIOLOGY (2022)

添加到收藏夹

Article Immunology

Heparanase Is a Putative Mediator of Endothelial Glycocalyx Damage in COVID-19-A Proof-of-Concept Study

Carolin Christina Drost et al.

Summary: COVID-19 is associated with eGC damage, and excess activity of HPSE in COVID-19 patients is correlated with eGC damage. In translational experiments, changes in eGC thickness of cells exposed to COVID-19 serum are closely correlated with HPSE activity in corresponding plasma samples. Inhibition of HPSE by a nonanticoagulant heparin fragment prevents eGC injury, suggesting a potential protective effect of heparin in COVID-19 due to its effect on eGC.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹

Article Medicine, General & Internal

Plasma Endothelial and Oxidative Stress Biomarkers Associated with Late Mortality in Hospitalized COVID-19 Patients

Arturo Orea-Tejada et al.

Summary: Endothelial dysfunction and oxidative stress are independent indicators of a worse prognosis in hospitalized COVID-19 patients.

JOURNAL OF CLINICAL MEDICINE (2022)

添加到收藏夹

Review Cell Biology

Regulation and Dysregulation of Endothelial Permeability during Systemic Inflammation

Katharina E. M. Hellenthal et al.

Summary: The loss of endothelial barrier function during systemic inflammation is a key contributor to organ dysfunction and mortality. Endothelial cells play a critical role in maintaining organ integrity and regulating tissue perfusion. Inflammatory stimuli can activate endothelial cells, leading to a loss of endothelial barrier function and the development of tissue edema and hypotension, which are lethal outcomes.

CELLS (2022)

添加到收藏夹

Article Medicine, General & Internal

Mild-to-Moderate COVID-19 Convalescents May Present Pro-Longed Endothelium Injury

Pawel Kozlowski et al.

Summary: This study found that COVID-19 convalescents without other comorbidities related to endothelial impairment only showed slight evidence of endothelial dysfunction at least 6 months after infection.

JOURNAL OF CLINICAL MEDICINE (2022)

添加到收藏夹

Article Respiratory System

Heparan sulfate mimetic fucoidan restores the endothelial glycocalyx and protects against dysfunction induced by serum of COVID-19 patients in the intensive care unit

Lushun Yuan et al.

Summary: Accumulating evidence suggests that endothelial dysfunction is involved in the progression of COVID-19. This study found that serum factors of severe COVID-19 patients may affect the glycocalyx and lead to endothelial dysfunction. The study also demonstrated that certain substances circulating in the plasma of COVID-19 patients in intensive care units are associated with endothelial glycocalyx degradation, barrier disruption, inflammation, and increased coagulation.

ERJ OPEN RESEARCH (2022)

添加到收藏夹

Article Hematology

Temporal change in Syndecan-1 as a therapeutic target and a biomarker for the severity classification of COVID-19

Fumihiro Ogawa et al.

Summary: The study suggests that SDC-1, a component of the endothelial glycocalyx, may serve as a biomarker for reflecting the severity of COVID-19 related to endothelial injury.

THROMBOSIS JOURNAL (2021)

添加到收藏夹

Review Peripheral Vascular Disease

Biomarkers of endothelial dysfunction and outcomes in coronavirus disease 2019 (COVID-19) patients: A systematic review and meta-analysis

Andrianto et al.

Summary: Biomarkers of endothelial dysfunction, including VWF antigen, t-PA, PAI-1, and sTM, are significantly associated with increased composite poor outcomes in patients with COVID-19, indicating the importance of endothelial dysfunction in COVID-19 patients.

MICROVASCULAR RESEARCH (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Syndecan-1, an indicator of endothelial glycocalyx degradation, predicts outcome of patients admitted to an ICU with COVID-19

Dong Zhang et al.

Summary: The study found that COVID-19 patients with high Syndecan-1 levels develop more serious endothelial damage and inflammatory reactions, leading to increased mortality. Syndecan-1 has potential as a marker for disease progression or severity in COVID-19, and protecting the glycocalyx may be a potential treatment for the disease.

MOLECULAR MEDICINE (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Endothelial Glycocalyx as a Regulator of Fibrotic Processes

Valentina Masola et al.

Summary: The endothelial glycocalyx, composed of glycosaminoglycans, proteoglycans, and adsorbed plasma proteins, plays a crucial role in regulating mechanotransduction, vascular permeability, and leukocyte adhesion in blood vessels. Disruption of glycocalyx stability by reactive oxygen species, matrix metalloproteinases, and heparanase can lead to profibrotic events, highlighting the importance of pharmacological strategies to preserve this delicate structure.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Biology

Convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activation

Florence W. J. Chioh et al.

Summary: The impact of COVID-19 on vascular health of recovered patients is significant, with elevated levels of circulating endothelial cells indicating vascular injury. The presence of proinflammatory and activated T lymphocyte-associated cytokines suggests cytokine-driven endothelial dysfunction. Effector T cells were more frequent in COVID-19 convalescents, pointing to a possible cytotoxic effector cell targeting of activated endothelial cells.

ELIFE (2021)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Association of COVID-19 with impaired endothelial glycocalyx, vascular function and myocardial deformation 4 months after infection

Vaia Lambadiari et al.

Summary: Findings from the study suggest that COVID-19 infection may result in endothelial and vascular dysfunction four months after infection, manifesting in altered arterial stiffness, coronary and myocardial function, and changes in markers related to endothelial health.

EUROPEAN JOURNAL OF HEART FAILURE (2021)

添加到收藏夹

Article Immunology

A possible pathogenic role of Syndecan-1 in the pathogenesis of coronavirus disease 2019 (COVID-19)

Sajad Karampoor et al.

Summary: The study investigated the dynamic changes in Syndecan-1 levels in COVID-19 patients. Results showed that COVID-19 patients had significantly higher levels of SDC-1, CRP, IL-6, IL-10, and IL-18 compared to healthy subjects, with lower levels of Vitamin D. ICU patients exhibited higher levels of these markers compared to non-ICU patients. Tracking the markers indicated an initial increase followed by a decrease by day 10, suggesting that SDC-1, IL-6, and IL-18 could be valuable indicators in evaluating COVID-19 activity.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

添加到收藏夹

Article Virology

Direct Activation of Endothelial Cells by SARS-CoV-2 Nucleocapsid Protein Is Blocked by Simvastatin

Yisong Qian et al.

Summary: Evidence suggests that SARS-CoV-2's NP significantly activates human endothelial cells through TLR2/NF-κB and MAPK signaling pathways, with simvastatin identified as a potential inhibitor. This study provides insights on COVID-19-induced vasculopathy and coagulopathy, emphasizing the importance of understanding the mechanistic role of vasculature in these patients.

JOURNAL OF VIROLOGY (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Heparin prevents in vitro glycocalyx shedding induced by plasma from COVID-19 patients

Simone R. Potje et al.

Summary: Plasma from COVID-19 patients promotes glycocalyx shedding and redox imbalance in endothelial cells, and heparin treatment potentially inhibits glycocalyx disruption.

LIFE SCIENCES (2021)

添加到收藏夹

Article Hematology

Severe COVID-19 is associated with endothelial activation and abnormal glycosylation of von Willebrand factor in patients undergoing hemodialysis

Golzar Mobayen et al.

Summary: Severe COVID-19 in hemodialysis patients is associated with elevated VWF and decreased ADAMTS-13 levels. High soluble Syndecan-1 levels in severely ill patients are related to risk of death. Elevated VWF levels in severely ill patients are correlated with lower VWF sialic acid content, indicating altered VWF processing.

RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Endothelial cell infection and dysfunction, immune activation in severe COVID-19

Zhongnan Qin et al.

Summary: The study found that SARS-CoV-2 infection in K18 mice results in severe COVID-19 symptoms, including body weight loss, lung inflammation, perivascular inflammation, and endothelial dysfunction. The infection also leads to immune activation and vascular abnormalities in the lungs, suggesting a possible link between endotheliitis and severe COVID-19 pathogenesis.

THERANOSTICS (2021)

添加到收藏夹

Article Hematology

Hypercoagulability of COVID-19 patients in intensive care unit: A report of thromboelastography findings and other parameters of hemostasis

Mauro Panigada et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

添加到收藏夹

Letter Medicine, General & Internal

Endothelial cell infection and endotheliitis in COVID-19

Zsuzsanna Varga et al.

LANCET (2020)

添加到收藏夹

Article Anesthesiology

Decreased endothelial glycocalyx thickness is an early predictor of mortality in sepsis

Danielle M. H. Beurskens et al.

ANAESTHESIA AND INTENSIVE CARE (2020)

添加到收藏夹

Letter Critical Care Medicine

Injury to the Endothelial Glycocalyx in Critically Ill Patients with COVID-19

Klaus Stahl et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

添加到收藏夹

Article Hematology

Elevated plasma levels of syndecan-1 and soluble thrombomodulin predict adverse outcomes in thrombotic thrombocytopenic purpura

Ruinan Lu et al.

BLOOD ADVANCES (2020)

添加到收藏夹

Article Urology & Nephrology

Aldosterone induces albuminuria via matrix metalloproteinase-dependent damage of the endothelial glycocalyx

Matthew J. Butler et al.

KIDNEY INTERNATIONAL (2019)

添加到收藏夹

Article Critical Care Medicine

Glycocalyx biomarker syndecan-1 is a stronger predictor of respiratory failure in patients with sepsis due to pneumonia, compared to endocan

Lisa Smart et al.

JOURNAL OF CRITICAL CARE (2018)

添加到收藏夹

Article Hematology

Low Plasma ADAMTS13 Activity Is Associated with Coagulopathy, Endothelial Cell Damage and Mortality after Severe Paediatric Trauma

Robert T. Russell et al.

THROMBOSIS AND HAEMOSTASIS (2018)

添加到收藏夹

Article Neurosciences

Sialic acids regulate microvessel permeability, revealed by novel in vivo studies of endothelial glycocalyx structure and function

Kai B. Betteridge et al.

JOURNAL OF PHYSIOLOGY-LONDON (2017)

添加到收藏夹

Article Surgery

Syndecan-1: A Quantitative Marker for the Endotheliopathy of Trauma

Erika Gonzalez Rodriguez et al.

JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS (2017)

添加到收藏夹

Article Neurosciences

Endothelial Dysfunction in Acute Brain Injury and the Development of Cerebral Ischemia

Sabrina H. van Ierssel et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2015)

添加到收藏夹

Review Immunology

New insights into Shiga toxin-mediated endothelial dysfunction in hemolytic uremic syndrome

Tania N. Petruzziello-Pellegrini et al.

VIRULENCE (2013)

添加到收藏夹

Review Biochemistry & Molecular Biology

Molecular functions of syndecan-1 in disease

Yvonne Hui-Fang Teng et al.

MATRIX BIOLOGY (2012)

添加到收藏夹

Article Immunology

Platelets, inflammatory cells, von Willebrand factor, syndecan-1, fibrin, fibronectin, and bacteria co-localize in the liver thrombi of Bacillus anthracis-infected mice

Taissia G. Popova et al.

MICROBIAL PATHOGENESIS (2012)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Relative roles of doxycycline and cation chelation in endothelial glycan shedding and adhesion of leukocytes

Herbert H. Lipowsky et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2011)

添加到收藏夹

Review Multidisciplinary Sciences

Heparan sulfate proteoglycans: structure, protein interactions and cell signaling

Juliana L. Dreyfuss et al.

ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS (2009)

添加到收藏夹

Article Multidisciplinary Sciences

Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice

F Paris et al.

SCIENCE (2001)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.