First-Phase Left Ventricular Ejection Fraction as an Early Sign of Left Ventricular Dysfunction in Patients with Stable Coronary Artery Disease

Left ventricular (LV) systolic function is often measured with echocardiography using LV ejection fraction (LVEF) or global longitudinal peak systolic strain (GLPSS). Global wasted work (GWW), global work efficiency (GWE), and first-phase ejection fraction (LVEF-1) are newer LV systolic function indices. We examined these parameters in 45 healthy individuals and 50 patients with stable coronary artery disease (CAD), normal LV contractility, and LVEF > 50%. Compared to healthy individuals, CAD patients had similar LVEF but increased GLPSS and GWW and reduced GWE and LVEF-1. The highest area under the receiver operating characteristic for detecting CAD was found for LVEF-1 (0.84; 95% CI 0.75-0.91; p < 0.0001), and it was significantly larger than for GLPSS (+0.166, p = 0.0082) and LVEF (+0.283, p = 00001). For LVEF-1 < 30%, the odds ratio for the presence of CAD was 22.67 (95% CI 6.47-79.44, p < 0.0001) in the logistic regression adjusted for age, sex, and body mass index. Finding LVEF-1 < 30% in an individual with normal LV myocardial contraction and preserved LVEF strongly suggests the presence of CAD.

Automated summary

Left ventricular systolic function can be assessed using echocardiography with parameters such as LV ejection fraction (LVEF) or global longitudinal peak systolic strain (GLPSS). Newer indices, including global wasted work (GWW), global work efficiency (GWE), and first-phase ejection fraction (LVEF-1), were examined in healthy individuals and patients with stable coronary artery disease (CAD). The results showed that CAD patients had similar LVEF but higher GLPSS and GWW, and lower GWE and LVEF-1 compared to healthy individuals. LVEF-1 was found to have the highest diagnostic accuracy for detecting CAD.