Multiple Cutaneous Manifestations in ANCA-Positive Eosinophilic Granulomatosis with Polyangiitis before and after Biologic Therapy: Clinical and Histopathologic Characterization of a Paradigmatic Case

Article Rheumatology

2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Eosinophilic Granulomatosis with Polyangiitis

Peter C. Grayson et al.

Summary: The revised classification criteria for EGPA demonstrate strong performance characteristics and are validated for use in research.

ANNALS OF THE RHEUMATIC DISEASES (2022)

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Review Clinical Neurology

ANCA-Associated Vasculitic Neuropathies: A Review

Haruki Koike et al.

Summary: ANCA-associated vasculitis is a systemic disorder that commonly affects the peripheral nervous system, and its neuropathic features typically include mononeuritis multiplex. Multidisciplinary approaches are required for the diagnosis and management of this condition.

NEUROLOGY AND THERAPY (2022)

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Review Allergy

Antineutrophil Cytoplasmic Antibodies and Organ-Specific Manifestations in Eosinophilic Granulomatosis with Polyangiitis: A Systematic Review and Meta-Analysis

Hua-Ching Chang et al.

Summary: The study investigated the association of ANCA status with organ-specific manifestations in EGPA, revealing that compared with ANCA-negative patients, ANCA-positive patients had higher risks of peripheral neuropathy, renal involvement, and cutaneous purpura, and lower risks of pulmonary infiltrates and cardiac involvement. The study also found no significant association of ANCA status with asthma and involvements of the central nervous system, gastrointestinal tract, or skin.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2021)

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Review Immunology

The value of anti-neutrophil cytoplasmic antibodies (ANCA) testing for the diagnosis of ANCA-associated vasculitis, a systematic review and meta-analysis

Niels A. D. Guchelaar et al.

Summary: Testing for ANCA is crucial in diagnosing AAV, with immunoassays showing high sensitivity for PR3 and MPO antibodies. Furthermore, the specificity for c-ANCA tested by IIF is also high. This supports the recommendation to prioritize immunoassays for primary anti-PR3 and anti-MPO screening in the diagnostic workup of AAV, without the need for IIF ANCA testing.

AUTOIMMUNITY REVIEWS (2021)

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Review Immunology

Rituximab for the treatment of eosinophilic granulomatosis with polyangiitis: A systematic literature review

Mitsuhiro Akiyama et al.

Summary: Rituximab was found effective in inducing and sustaining remission, reducing glucocorticoid dose, and potentially providing greater benefit in ANCA-positive patients with EGPA. Scheduled maintenance treatment with rituximab significantly decreased relapse rates compared to on-demand administration, with no new safety concerns reported.

AUTOIMMUNITY REVIEWS (2021)

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Article Rheumatology

2021 American College of Rheumatology/Vasculitis Foundation Guideline for the Management of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

Sharon A. Chung et al.

Summary: This article provides evidence-based recommendations and expert guidance for the management of AAV, including 26 recommendations and 5 ungraded position statements for GPA/MPA and 15 recommendations and 5 ungraded position statements for EGPA. The guidance aims to assist healthcare professionals in treating these diseases.

ARTHRITIS & RHEUMATOLOGY (2021)

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Article Clinical Neurology