Cathepsin B, D and S as Potential Biomarkers of Brain Glioma Malignancy

Article Medicine, General & Internal

UCHL1 and Proteasome in Blood Serum in Relation to Dietary Habits, Concentration of Selected Antioxidant Minerals and Total Antioxidant Status among Patients with Alzheimer's Disease

Sylwia Bogdan et al.

Summary: Alzheimer's disease (AD) is a common form of dementia with no cure. The concentration of serum markers UCHL1 and the proteasome may be important for early diagnosis. Additionally, diet habits may play a protective role against AD.

JOURNAL OF CLINICAL MEDICINE (2022)

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Article Chemistry, Analytical

A Comparison of Various Chips Used for the Manufacture of Biosensors Applied in Non-Fluidic Array SPRi, Based on the Example of Determination of Cathepsin D

Pawel Falkowski et al.

Summary: The study compared different material solutions for the determination of a specific biomarker in the blood serum of patients with glioblastoma and control samples, showing good linearity, LOQ, precision, and recovery rates. This effectively resolved the issue of accurately determining the levels of a specific biomarker in the serum of healthy individuals.

BIOSENSORS-BASEL (2022)

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Review Oncology

Machine Learning Tools for Image-Based Glioma Grading and the Quality of Their Reporting: Challenges and Opportunities

Sara Merkaj et al.

Summary: Despite their prevalence in research, ML tools that can predict glioma grade from medical images have not been incorporated clinically. The reporting quality of ML glioma grade prediction studies is low, but current efforts to create reporting guidelines and risk of bias tools may help address this. There are also other deficiencies in ML model data and glioma classification, but promising efforts are being made to overcome these challenges and encourage implementation in clinical settings.

CANCERS (2022)

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Article Chemistry, Analytical

An Immunosensor for the Determination of Cathepsin S in Blood Plasma by Array SPRi-A Comparison of Analytical Properties of Silver-Gold and Pure Gold Chips

Pawel Falkowski et al.

Summary: The study investigated the analytical characteristics of a biosensor formed on an Ag/Au chip compared to a biosensor formed on a gold chip, showing better performance for the biosensor on the Ag/Au chip in low concentration Cath S determination.

BIOSENSORS-BASEL (2021)

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Article Oncology

EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood

Michael Weller et al.

Summary: The European Association of Neuro-Oncology (EANO) has released guidelines for the diagnosis, treatment, and follow-up of adult patients with diffuse gliomas, incorporating major changes in diagnostic algorithms based on the 2016 update of the WHO Classification of Tumors of the Central Nervous System, as well as evidence from recent large clinical trials.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

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Article Chemistry, Analytical

Two SPRi biosensors for the determination of cathepsin S in blood plasma

Lukasz Oldak et al.

Summary: Two 'analytically specific' SPRi biosensors have been developed for the determination of cathepsin S in blood plasma samples of ovarian cancer patients and healthy individuals, showing good precision and recoveries. Plasma cathepsin S concentration can serve as a marker for ovarian cancer, given the highly elevated concentrations detected.

TALANTA (2021)

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Article Chemistry, Analytical

An SPRi Biosensor for Determination of the Ovarian Cancer Marker HE4 in Human Plasma

Beata Szymanska et al.

Summary: An alternative biosensor for the determination of ovarian cancer marker HE4 in blood plasma has been developed, showing acceptable precision and recovery rates. The biosensor's results were in good agreement with commercial tests, validating its diagnostic application, such as studying the influence of ovarian tumor resection on the level of HE4 in blood serum.

SENSORS (2021)

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Article Biochemistry & Molecular Biology