Association between Serum Uric Acid and Liver Enzymes in Adults Aged 20 Years and Older in the United States: NHANES 2005-2012

Although the relationship between serum uric acid (SUA) and nonalcoholic fatty liver disease has been widely reported, the relationship between SUA and liver enzymes has rarely been reported. The purpose of this study was to evaluate the association of SUA levels with alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in populations aged 20 years and older in the United States. We analyzed 7165 individuals aged 20 years and older from the National Health and Nutrition Examination Survey (NHANES) in the United States. Weighted multiple linear regression models were used to analyze the relationship between SUA and ALT and AST. A generalized additive model and a smooth curve fitting were used to observe the linear relationship. SUA was positively correlated with ALT and AST. In addition, the overall increasing trend of ALT and SUA was observed across the SUA quartile groups. In the stratified analysis by sex and race, the SUA levels in male, female, Mexican American, and Non-Hispanic White individuals, and those of another race, were positively correlated with ALT and AST. However, the SUA levels in Non-Hispanic Black individuals had a nonlinear relationship with ALT and AST. In individuals aged 20 years and older in the United States (excluding Non-Hispanic Black individuals), SUA levels were positively associated with ALT and AST. Therefore, with a rise in SUA levels, liver function should be monitored or intervened with in people aged 20 years and older in the United States.

Automated summary

This study evaluated the association between serum uric acid (SUA) levels and alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the US population aged 20 years and older. The results showed a positive correlation between SUA and ALT/AST. Stratified analysis by sex and race also supported this association. Therefore, liver function should be monitored or intervened with as SUA levels rise in individuals aged 20 years and older in the United States (excluding Non-Hispanic Black individuals).