☆ 4.7 Article

Chronic Fatigue, Depression and Anxiety Symptoms in Long COVID Are Strongly Predicted by Neuroimmune and Neuro-Oxidative Pathways Which Are Caused by the Inflammation during Acute Infection

JOURNAL OF CLINICAL MEDICINE (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Biochemistry & Molecular Biology

Long-COVID post-viral chronic fatigue and affective symptoms are associated with oxidative damage, lowered antioxidant defenses and inflammation: a proof of concept and mechanism study

Hussein Kadhem Al-Hakeim et al.

Summary: The immune-inflammatory response during the acute phase of COVID-19 predicts the severity of chronic fatigue, depression, and anxiety symptoms in Long COVID. SpO2 and PBT during acute infection affect immune and oxidative stress pathways in Long COVID.

MOLECULAR PSYCHIATRY (2023)

添加到收藏夹

Article Clinical Neurology

Intersections between pneumonia, lowered oxygen saturation percentage and immune activation mediate depression, anxiety, and chronic fatigue syndrome-like symptoms due to COVID-19: A nomothetic network approach

Hawraa Kadhem Al-Jassas et al.

Summary: This study aims to investigate the associations between affective and chronic fatigue syndrome-like symptoms and chest CT scan anomalies, oxygen saturation, inflammatory biomarkers, etc. in COVID-19 patients. The results showed that the immune response core was associated with lung lesions and affective and physiosomatic symptoms. The infection-immune-inflammatory core plays a significant role in pneumonia-associated CT scan anomalies, decreased oxygen saturation, and immune activation, and it affects the affective and neuropsychiatric symptoms of patients.

JOURNAL OF AFFECTIVE DISORDERS (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

In COVID-19, NLRP3 inflammasome genetic variants are associated with critical disease and these effects are partly mediated by the sickness symptom complex: a nomothetic network approach

Michael Maes et al.

Summary: The NLRP3 inflammasome is activated in response to SARS-CoV-2 infection in COVID-19 patients. Acute infections are accompanied by a sickness symptom complex (SSC) that plays a protective role against COVID-19. Increased SSC can protect against severe COVID-19, while factors such as age, gender, and specific gene variants can attenuate this protection.

MOLECULAR PSYCHIATRY (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Inflammation and nitro-oxidative stress in current suicidal attempts and current suicidal ideation: a systematic review and meta-analysis

Asara Vasupanrajit et al.

Summary: Recent studies have shown a significant association between activated immune-inflammatory and nitro-oxidative pathways and suicide attempts. Inflammation, immune activation, nitro-oxidative stress, lowered neuroprotection, and increased neurotoxicity may explain why psychiatric patients exhibit increased suicidal behaviors.

MOLECULAR PSYCHIATRY (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Effectiveness of COVID-19 booster vaccines against COVID-19-related symptoms, hospitalization and death in England

Nick Andrews et al.

Summary: This study examined the relative and absolute effectiveness of mRNA booster vaccination against COVID-19. The results showed that the booster dose of BNT162b2 or mRNA-1273 had a relative effectiveness ranging from 85% to 95% against symptomatic disease, and an absolute effectiveness ranging from 94% to 97%. For hospitalization or death, the absolute effectiveness of the BNT162b2 booster ranged from 97% to 99% in all age groups. The study provides real-world evidence of significantly increased protection from the booster vaccine dose against mild and severe disease.

NATURE MEDICINE (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Vaccines may cause rare, Long Covid–like symptoms

Jennifer Couzin-Frankel et al.

SCIENCE (2022)

添加到收藏夹

Review Pharmacology & Pharmacy

Immunopathogenesis and Immunogenetic Variants in COVID-19

Pakorn Sagulkoo et al.

Summary: This study reviews the immunopathogenesis and immunogenetic variants of COVID-19, proposing potential therapeutic targets and preventive strategies, providing important insights for predicting and treating severe COVID-19.

CURRENT PHARMACEUTICAL DESIGN (2022)

添加到收藏夹

Editorial Material Chemistry, Medicinal

The Tryptophan Catabolite or Kynurenine Pathway's Role in Major Depression

Abbas F. Almulla et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2022)

添加到收藏夹

Article Food Science & Technology

Innate immune suppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs

Stephanie Seneff et al.

Summary: This study provides evidence that mRNA vaccines may have adverse effects on human health, including impairment of interferon signaling system and potential links to other diseases. The study calls for a comprehensive risk/benefit assessment of mRNA vaccines.

FOOD AND CHEMICAL TOXICOLOGY (2022)

添加到收藏夹

Article Multidisciplinary Sciences

High prevalence of an alpha variant lineage with a premature stop codon in ORF7a in Iraq, winter 2020-2021

Nihad A. M. Al-Rashedi et al.

Summary: Since the first reported case of COVID-19 in China, SARS-CoV-2 has been spreading globally. Genomic surveillance plays a crucial role in tracking the emergence, introduction, and spread of new variants. The rapid increase in COVID-19 infections in Iraq during the second wave is attributed to the introduction of concern variants, likely imported from Europe. Molecular epidemiological analysis revealed the dominance of the B.1.1.7 lineage in Iraq, with multiple strains closely related to those from European countries. A notable frequency of stop codon mutation was observed among the B.1.1.7 lineage sequences, but it didn't significantly affect the function of NS7a protein.

PLOS ONE (2022)

添加到收藏夹

Review Psychiatry

Aberrations in the Cross-Talks Among Redox, Nuclear Factor-κB, and Wnt/β-Catenin Pathway Signaling Underpin Myalgic Encephalomyelitis and Chronic Fatigue Syndrome

Michael Maes et al.

Summary: There is evidence that chronic fatigue spectrum disorders (CFAS-Ds), including myalgic encephalomyelitis (ME), chronic fatigue syndrome (CFS), and chronic fatigue with physiosomatic symptoms, are characterized by neuroimmune and neuro-oxidative biomarkers. This study aimed to analyze the protein-protein interaction (PPI) network of CFAS-D and discover the enriched pathways, molecular patterns, and domains. The results revealed a highly connected network involving immune-oxidative-nitrosative and Wnt/beta-catenin subnetworks. The CFAS-D network was found to be associated with detoxification, inflammatory signaling, and dysfunctions in multicellular organismal homeostatic processes.

FRONTIERS IN PSYCHIATRY (2022)

添加到收藏夹

Article Health Care Sciences & Services

Precision Nomothetic Medicine in Depression Research: A New Depression Model, and New Endophenotype Classes and Pathway Phenotypes, and A Digital Self

Michael Maes

Summary: This paper discusses the use of machine learning in depression research and the development of precision psychiatry. Precision psychiatry aims to customize the best medical treatments based on individual's genomics, environmental, and lifestyle data. The paper outlines three steps in the development of precision medicine and highlights the challenges in developing precision psychiatry.

JOURNAL OF PERSONALIZED MEDICINE (2022)

添加到收藏夹

Review Psychiatry

False dogmas in mood disorders research: Towards a nomothetic network approach

Michael H. J. Maes et al.

Summary: The current understanding of major depressive disorder (MDD) and bipolar disorder (BD) is riddled with controversies, but a new, data-driven machine learning method called nomothetic network psychiatry (NNP) provides a new direction for research.

WORLD JOURNAL OF PSYCHIATRY (2022)

添加到收藏夹

Article Neurosciences

Lowered oxygen saturation and increased body temperature in acute COVID-19 largely predict chronic fatigue syndrome and affective symptoms due to Long COVID: A precision nomothetic approach

Dhurgham Shihab Al-Hadrawi et al.

Summary: This study aims to explore the physio-affective phenome of long coronavirus disease 2019 (LC) and investigate the effects of oxygen saturation (SpO2) and body temperature during the acute phase on LC. The results indicate that lowered SpO2 and increased body temperature during the acute phase, as well as female sex, can predict the physio-affective phenome of LC. Additionally, a new endophenotype class, characterized by very low SpO2 and very high body temperature, and associated with depression, anxiety, chronic fatigue, and autonomic and gastro-intestinal symptoms, was identified.

ACTA NEUROPSYCHIATRICA (2022)

添加到收藏夹

Review Immunology

The tryptophan catabolite or kynurenine pathway in major depressive and bipolar disorder: A systematic review and meta-analysis

Abbas F. Almulla et al.

Summary: This study systematically reviewed and meta-analyzed TRP levels, CAAs ratios, and TRYCATs in MDD and BD patients. The study found that MDD and BD are accompanied by TRP depletion without activation of the IDO and TRYCAT pathways.

BRAIN, BEHAVIOR, & IMMUNITY - HEALTH (2022)

添加到收藏夹

Article Multidisciplinary Sciences

The prevalence of depression, anxiety, and sleep disturbances in COVID-19 patients: a meta-analysis

Jiawen Deng et al.

Summary: Evidence from previous coronavirus outbreaks indicates that COVID-19 patients are at risk of developing psychiatric disorders such as depression, anxiety, and sleep disturbances. A systematic review and meta-analysis found high prevalence rates of depression (45%), anxiety (47%), and sleep disturbances (34%) in COVID-19 patients. Prevalence estimates varied based on screening tools used, highlighting the need for more studies on mental well-being in COVID-19 patients.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2021)

添加到收藏夹

Article Immunology

Comprehensive Health Assessment 3 Months After Recovery From Acute Coronavirus Disease 2019 (COVID-19)

Bram van den Borst et al.

Summary: This study conducted a comprehensive health assessment on recovered COVID-19 patients from Radboud University Medical Center, Nijmegen, the Netherlands, and found severe problems in multiple health domains. The research revealed that a significant number of discharged patients experienced lung function abnormalities, residual pulmonary parenchymal abnormalities, low exercise capacity, mental and cognitive issues, as well as fatigue. Longer follow-up studies are needed to understand natural trajectories and predictors of complicated long-term recovery paths.

CLINICAL INFECTIOUS DISEASES (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

The NLRP3 inflammasome and COVID-19: Activation, pathogenesis and therapeutic strategies

Ni Zhao et al.

Summary: This review discusses the role of NLRP3 inflammasome activation in inducing cytokine storms in severe cases of COVID-19. By introducing the canonical NLRP3 inflammasome activation pathway and the cellular/molecular mechanisms of NLRP3 activation by SARSCoV-2 infection, the study highlights the involvement of NLRP3 inflammasome in the pathogenesis of COVID-19. Several promising inhibitors targeting NLRP3 inflammasome, cytokine products, and neutrophils are proposed as novel therapeutic strategies for COVID-19.

CYTOKINE & GROWTH FACTOR REVIEWS (2021)

添加到收藏夹

Article Immunology

Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients

Tamara S. Rodrigues et al.

Summary: The active NLRP3 inflammasome in response to SARS-CoV-2 infection is associated with disease severity in COVID-19 patients, with higher levels of IL-18 and Casp1p20 correlating with poor clinical outcomes. These findings suggest that inflammasomes may serve as markers of disease severity and potential therapeutic targets for COVID-19.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

添加到收藏夹

Article Medicine, General & Internal

6-month consequences of COVID-19 in patients discharged from hospital: a cohort study (Publication with Expression of Concern. See vol. 401, pg. 90, 2023)

Chaolin Huang et al.

Summary: This study aimed to investigate the long-term health consequences of discharged COVID-19 patients and associated risk factors, particularly disease severity. Patients with more severe illness during hospitalization showed more severe impaired pulmonary diffusion capacities and abnormal chest imaging manifestations, highlighting the need for targeted interventions for long-term recovery.

LANCET (2021)

添加到收藏夹

Article Respiratory System

Patient outcomes after hospitalisation with COVID-19 and implications for follow-up: results from a prospective UK cohort

David T. Arnold et al.

Summary: The study found that most COVID-19 patients still experienced persistent symptoms and limitations in physical ability during the recovery period, but clinically significant abnormalities in chest radiograph, exercise tests, blood tests, and spirometry were less frequent, especially in patients who did not require supplementary oxygen during their acute infection.

THORAX (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Characterizing the NLRP3 Inflammasome in Mood Disorders: Overview, Technical Development, and Measures of Peripheral Activation in Adolescent Patients

Xinyang Zhou et al.

Summary: The NLRP3 inflammasome plays a role in numerous diseases but lacks reliable measurement techniques. Researchers have proposed a method to measure ASC levels and have achieved success in inhibiting NLRP3 activation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Editorial Material Medicine, General & Internal

Managing the long term effects of covid-19: summary of NICE, SIGN, and RCGP rapid guideline

Waqaar Shah et al.

BMJ-BRITISH MEDICAL JOURNAL (2021)

添加到收藏夹

Article Psychiatry

Anxiolytic effects of NLRP3 inflammasome inhibition in a model of chronic sleep deprivation

Chad Smith et al.

Summary: Research on the impact of sleep deprivation on anxiety and anxiolytic properties reveals that a flavanol-rich dietary preparation can alleviate neuroimmune activation and reduce anxiety. Additionally, the study found that sleep deprivation alters the expression of circadian genes, leading to changes in NLRP3 expression and IL-1 beta production.

TRANSLATIONAL PSYCHIATRY (2021)

添加到收藏夹

Article Medicine, General & Internal

Respiratory and Psychophysical Sequelae Among Patients With COVID-19 Four Months After Hospital Discharge

Mattia Bellan et al.

Summary: The study examined the prevalence of lung function, exercise function, and psychological sequelae among survivors of severe COVID-19 four months after discharge. Over half of patients experienced reduced lung capacity, one-fifth had functional impairment, and about one-fifth showed symptoms of posttraumatic stress. These findings suggest that a significant proportion of COVID-19 survivors may continue to experience respiratory, functional, or psychological issues months after hospital discharge.

JAMA NETWORK OPEN (2021)

添加到收藏夹

Review Psychiatry

Onset and frequency of depression in post-COVID-19 syndrome: A systematic review

Olivier Renaud-Charest et al.

Summary: The frequency of depressive symptoms after recovery from COVID-19 ranges from 11% to 28%, while clinically significant depression and severe depressive symptoms range from 3% to 12%. Studies show a lack of consistency in methods and locations.

JOURNAL OF PSYCHIATRIC RESEARCH (2021)

添加到收藏夹

Article Immunology

The Impact of Vaccination on Coronavirus Disease 2019 (COVID-19) Outbreaks in the United States

Seyed M. Moghadas et al.

Summary: The study evaluated the impact of a 2-dose COVID-19 vaccination campaign in the United States on reducing the incidence, hospitalizations, and deaths. Results showed that vaccination significantly reduced the overall attack rate, with the greatest reduction observed in individuals aged 65 and older. Additionally, vaccination markedly decreased the risk of non-ICU hospitalizations, ICU hospitalizations, and deaths.

CLINICAL INFECTIOUS DISEASES (2021)

添加到收藏夹

Article Neurosciences

Prevalence and correlates of chronic fatigue syndrome and post-traumatic stress disorder after the outbreak of the COVID-19

Leila Simani et al.

Summary: The prevalence of CFS among patients with COVID-19 is similar to that in the general population, and PTSD in patients with COVID-19 is not associated with an increased risk of CFS. Medical institutions should pay attention to the psychological consequences of the COVID-19 outbreak.

JOURNAL OF NEUROVIROLOGY (2021)

添加到收藏夹

Article Environmental Sciences

Defining Post-COVID Symptoms (Post-Acute COVID, Long COVID, Persistent Post-COVID): An Integrative Classification

Cesar Fernandez-de-las-Penas et al.

Summary: The symptoms of long-haulers of COVID-19 can be classified into potentially infection-related, acute post-COVID, long post-COVID, and persistent post-COVID stages. Establishing time reference points is crucial, while the plethora of symptoms affecting multiple systems suggests the presence of different underlying mechanisms.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Modulation of the NLRP3 inflammasome by Sars-CoV-2 Envelope protein

Mustafa Yalcinkaya et al.

Summary: Although some drugs and vaccines targeting COVID-19 have shown initial success, understanding the underlying disease pathogenesis of SARS-CoV-2 is crucial for further treatment development. Research indicates that the SARS-CoV-2 envelope protein may initially suppress the host NLRP3 inflammasome response to viral RNA, but potentially increase inflammasome responses in later stages of infection. Targeting the SARS-CoV-2 E protein, especially in early infection stages, could be a novel approach to COVID-19 therapy.

SCIENTIFIC REPORTS (2021)

添加到收藏夹

Editorial Material Medicine, General & Internal

Toward Understanding COVID-19 Recovery: National Institutes of Health Workshop on Postacute COVID-19

Andrea M. Lerner et al.

Summary: The SARS-CoV-2 pandemic has caused a massive global burden of infection and mortality over the past year, with additional tolls from long-term consequences yet to be quantified. A virtual workshop was held in December 2020 to discuss postacute COVID-19 and identify key knowledge gaps in understanding this condition, which includes heterogeneous disease manifestations among some individuals even after their initial recovery from acute SARS-CoV-2 infection.

ANNALS OF INTERNAL MEDICINE (2021)

添加到收藏夹

Article Immunology

Elevated Levels of Neutrophil Activated Proteins, Alpha-Defensins (DEFA1), Calprotectin (S100A8/A9) and Myeloperoxidase (MPO) Are Associated With Disease Severity in COVID-19 Patients

Shubham Shrivastava et al.

Summary: The study found that DEFA1 protein levels were significantly elevated in COVID-19 patients at the onset of the disease, regardless of severity, while S100A8/A9 protein levels were significantly elevated in all patients. Levels of DEFA1, S100A8/A9, and MPO returned to normal in recovering patients, and DEFA1 levels were higher in severe patients than in mild patients at the onset of the disease.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Rapamycin attenuates depression and anxiety-like behaviors through modulation of the NLRP3 pathway in pentylenetetrazole-kindled male Wistar rats

Fatemeh Aghaie et al.

Summary: This study evaluated the effects of rapamycin on anxiety and depression in rats induced by pentylenetetrazole, showing that rapamycin delayed kindling development and seizure onset time, exerted antidepressant and anxiolytic effects, and affected oxidative stress and gene expression parameters to bring about behavioral alterations in anxiety and depression through inhibition of mTOR inhibitor on reactive oxygen species production during NLRP3 inflammasome activation.

FUNDAMENTAL & CLINICAL PHARMACOLOGY (2021)

添加到收藏夹

Article Neurosciences

A Novel Inhibitor Targeting NLRP3 Inflammasome Reduces Neuropathology and Improves Cognitive Function in Alzheimer's Disease Transgenic Mice

Ram Kuwar et al.

Summary: The study demonstrated that the novel compound JC124 successfully inhibited the NLRP3 inflammasome, reducing various pathological processes in transgenic AD mice such as Aβ load, neuroinflammation, and neuronal cell cycle re-entry, while also improving cognitive function.

JOURNAL OF ALZHEIMERS DISEASE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

More than 50 long-term effects of COVID-19: a systematic review and meta-analysis

Sandra Lopez-Leon et al.

Summary: This study aimed to identify studies assessing the long-term effects of COVID-19, estimating that 80% of infected patients will develop one or more long-term symptoms, with the most common being fatigue, headache, attention disorder, hair loss, and dyspnea.

SCIENTIFIC REPORTS (2021)

添加到收藏夹

Review Immunology

Long COVID and Post-infective Fatigue Syndrome: A Review

Carolina X. Sandler et al.

Summary: Fatigue is a prominent feature in both acute and convalescent stages of COVID-19, with lasting effects on long-term recovery. Studying post-COVID fatigue and fatigue after other infections can provide valuable insights into clinical and research approaches to assess and address this issue.

OPEN FORUM INFECTIOUS DISEASES (2021)

添加到收藏夹

Article Gastroenterology & Hepatology

Long-term clinical and biochemical residue after COVID-19 recovery

Mohammed Ali Gameil et al.

Summary: Research found that COVID-19 survivors showed abnormal clinical and biochemical changes in blood pressure, blood inflammatory response, liver function, and other biochemical indicators, which require comprehensive medical care and long-term follow-up.

EGYPTIAN LIVER JOURNAL (2021)

添加到收藏夹

Article Medicine, General & Internal

Characterizing long COVID in an international cohort: 7 months of symptoms and their impact

Hannah E. Davis et al.

Summary: Patients with Long COVID report prolonged, multisystem involvement and significant disability. By seven months, many patients have not yet recovered (mainly from systemic and neurological/cognitive symptoms), have not returned to previous levels of work, and continue to experience significant symptom burden.

ECLINICALMEDICINE (2021)

添加到收藏夹

Article Immunology

Inflammasome activation at the crux of severe COVID-19

Setu M. Vora et al.

Summary: This article provides an update on the role of inflammasomes in SARS-CoV-2 infection and COVID-19, discussing their activation and contribution to the overactive inflammatory response in severe cases. Efforts are being made to target inflammasomes therapeutically. Severe COVID-19 is characterized by dysregulated cytokine release, pneumonia, and acute respiratory distress syndrome, with ongoing clinical efforts to suppress inflammation for prevention and treatment.

NATURE REVIEWS IMMUNOLOGY (2021)

添加到收藏夹

Article Respiratory System

'Long-COVID': a cross-sectional study of persisting symptoms, biomarker and imaging abnormalities following hospitalisation for COVID-19

Swapna Mandal et al.

Summary: Following discharge from hospital, a significant number of COVID-19 patients continue to experience persistent symptoms such as breathlessness, cough, fatigue, and depression. Some patients also show elevated levels of biomarkers indicating ongoing health issues. Chest radiographs reveal abnormalities in a considerable portion of patients, with a small percentage showing deterioration.

THORAX (2021)

添加到收藏夹

Letter Medicine, General & Internal

Persistent Symptoms in Patients After Acute COVID-19

Angelo Carfi et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

添加到收藏夹

Review Microbiology

Surviving Reactive Chlorine Stress: Responses of Gram-Negative Bacteria to Hypochlorous Acid

Waleska Stephanie da Cruz Nizer et al.

MICROORGANISMS (2020)

添加到收藏夹

Letter Infectious Diseases

Post-discharge persistent symptoms and health-related quality of life after hospitalization for COVID-19

Eve Garrigues et al.

JOURNAL OF INFECTION (2020)

添加到收藏夹

Article Multidisciplinary Sciences

C-reactive protein and risk of cognitive decline: The REGARDS study

Miguel Arce Renteria et al.

PLOS ONE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Description of neurotoxicity in a series of patients treated with CAR T-cell therapy

Catherine Belin et al.

SCIENTIFIC REPORTS (2020)

添加到收藏夹

Letter Critical Care Medicine

Body temperature correlates with mortality in COVID-19 patients

Serena Tharakan et al.

CRITICAL CARE (2020)

添加到收藏夹

Article Neurosciences

Major Differences in Neurooxidative and Neuronitrosative Stress Pathways Between Major Depressive Disorder and Types I and II Bipolar Disorder

Michael Maes et al.

MOLECULAR NEUROBIOLOGY (2019)

添加到收藏夹

Article Endocrinology & Metabolism

Total and ionized calcium and magnesium are significantly lowered in drug-naive depressed patients: effects of antidepressants and associations with immune activation

Arafat Hussein Al-Dujaili et al.

METABOLIC BRAIN DISEASE (2019)

添加到收藏夹

Review Medicine, General & Internal

Systematic review and meta-analysis of the association between peripheral inflammatory cytokines and generalised anxiety disorder

Harry Costello et al.

BMJ OPEN (2019)

添加到收藏夹

Article Microbiology

An NLRP3 inflammasome-triggered cytokine storm contributes to Streptococcal toxic shock-like syndrome (STSLS)

Lan Lin et al.

PLOS PATHOGENS (2019)

添加到收藏夹

Review Behavioral Sciences

Inflammatory proteins are altered in chronic fatigue syndrome-A systematic review and meta-analysis

Rebecca Strawbridge et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2019)

添加到收藏夹

Review Clinical Neurology

Neuroinflammation and Cytokines in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Critical Review of Research Methods

Michael B. VanElzakker et al.

FRONTIERS IN NEUROLOGY (2019)

添加到收藏夹

Review Immunology

The NLRP3 inflammasome: molecular activation and regulation to therapeutics

Karen V. Swanson et al.

NATURE REVIEWS IMMUNOLOGY (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Gene deficiency and pharmacological inhibition of caspase-1 confers resilience to chronic social defeat stress via regulating the stability of surface AMPARs

M-X Li et al.

MOLECULAR PSYCHIATRY (2018)

添加到收藏夹

Article Psychiatry

Alterations of serum macro-minerals and trace elements are associated with major depressive disorder: a case-control study

Md Rabiul Islam et al.

BMC PSYCHIATRY (2018)

添加到收藏夹

Review Neurosciences

The Compensatory Immune-Regulatory Reflex System (CIRS) in Depression and Bipolar Disorder

Michael Maes et al.

MOLECULAR NEUROBIOLOGY (2018)

添加到收藏夹

Article Neurosciences

Generalized Anxiety Disorder (GAD) and Comorbid Major Depression with GAD Are Characterized by Enhanced Nitro-oxidative Stress, Increased Lipid Peroxidation, and Lowered Lipid-Associated Antioxidant Defenses

Michael Maes et al.

NEUROTOXICITY RESEARCH (2018)

添加到收藏夹

Article Endocrinology & Metabolism

Serum calcium levels and neuropsychological performance in depression and matched healthy controls: Reversal of correlation a marker of the aging cognitive clock?

Thea Marianne Gruetzner et al.

PSYCHONEUROENDOCRINOLOGY (2018)

添加到收藏夹

Article Neurosciences

Lower Serum Zinc and Higher CRP Strongly Predict Prenatal Depression and Physio-somatic Symptoms, Which All Together Predict Postnatal Depressive Symptoms

Chutima Roomruangwong et al.

MOLECULAR NEUROBIOLOGY (2017)

添加到收藏夹

Article Neurosciences

A Functional Interleukin-18 Haplotype Predicts Depression and Anxiety through Increased Threat-Related Amygdala Reactivity in Women but Not Men

Johnna R. Swartz et al.

NEUROPSYCHOPHARMACOLOGY (2017)

添加到收藏夹

Article Endocrinology & Metabolism

Acute fasting inhibits central caspase-1 activity reducing anxiety-like behavior and increasing novel object and object location recognition

Albert E. Towers et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2017)

添加到收藏夹

Article Neurosciences

NLRP3 INFLAMMASOME ACTIVATION MEDIATES FATIGUE-LIKE BEHAVIORS IN MICE VIA NEUROINFLAMMATION

Ziteng Zhang et al.

NEUROSCIENCE (2017)

添加到收藏夹

Review Neurosciences

NLRP3 Inflammasome in Neurological Diseases, from Functions to Therapies

Limin Song et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2017)

添加到收藏夹

Review Immunology

NLRP3 inflammasome-driven pathways in depression: Clinical and preclinical findings

Fernanda N. Kaufmann et al.

BRAIN BEHAVIOR AND IMMUNITY (2017)

添加到收藏夹

Article Immunology

Activation of the NLRP3 inflammasome in lipopolysaccharide-induced mouse fatigue and its relevance to chronic fatigue syndrome

Zi-Teng Zhang et al.

JOURNAL OF NEUROINFLAMMATION (2016)

添加到收藏夹

Article Medicine, Research & Experimental

Myeloperoxidase gene expression and cognitive functions in depression

Monika Talarowska et al.

ADVANCES IN MEDICAL SCIENCES (2015)

添加到收藏夹

Article Medicine, General & Internal

Serum Immune Proteins in Moderate and Severe Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients

Sharni Lee Hardcastle et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2015)

添加到收藏夹

Article Medicine, General & Internal

Myalgic encephalomyelitis/chronic fatigue syndrome and encephalomyelitis disseminata/multiple sclerosis show remarkable levels of similarity in phenomenology and neuroimmune characteristics

Gerwyn Morris et al.

BMC MEDICINE (2013)

添加到收藏夹

Article Clinical Neurology

Relationships among serum C-reactive protein, receptor for advanced glycation products, metabolic dysfunction, and cognitive impairments

Xia Ge et al.

BMC NEUROLOGY (2013)

添加到收藏夹

Article Cell Biology

C-Reactive Protein Increases BBB Permeability: Implications for Obesity and Neuroinflammation

Hung Hsuchou et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2012)

添加到收藏夹

Review Microbiology

Into the Eye of the Cytokine Storm

Jennifer R. Tisoncik et al.

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2012)

添加到收藏夹

Article Medicine, General & Internal

C-Reactive Protein and High-Sensitivity C-Reactive Protein: An Update for Clinicians

Elizabeth B. Windgassen et al.

POSTGRADUATE MEDICINE (2011)

添加到收藏夹

Review Clinical Neurology

The new '5-HT' hypothesis of depression: Cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression

M. Maes et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2011)

添加到收藏夹

Article Multidisciplinary Sciences

The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence

Jorge Ivan Alvarez et al.

SCIENCE (2011)

添加到收藏夹

Article Biochemistry & Molecular Biology

Associations of Serum Ca and Mg Levels with Mental Health in Adult Women Without Psychiatric Disorders

Kyu In Jung et al.

BIOLOGICAL TRACE ELEMENT RESEARCH (2010)

添加到收藏夹

Review Pharmacology & Pharmacy

Interleukin-18, From Neuroinflammation to Alzheimer's Disease

Paola Bossu et al.

CURRENT PHARMACEUTICAL DESIGN (2010)

添加到收藏夹

Article Primary Health Care

Primary Hyperparathyroidism as a Secondary Cause of Depression

Katherine Hurst

JOURNAL OF THE AMERICAN BOARD OF FAMILY MEDICINE (2010)

添加到收藏夹

Article Clinical Neurology

Is There an Association between the Level of High-Sensitivity C-Reactive Protein and Idiopathic Parkinson's Disease? A Comparison of Parkinson's Disease Patients, Disease Controls and Healthy Individuals

In-Uk Song et al.

EUROPEAN NEUROLOGY (2009)

添加到收藏夹

Review Psychiatry

Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis

M. Bryant Howren et al.

PSYCHOSOMATIC MEDICINE (2009)

添加到收藏夹

Article Neurosciences

Association of major depressive disorder with serum myeloperoxidase and other markers of inflammation: A twin study

Viola Vaccarino et al.

BIOLOGICAL PSYCHIATRY (2008)

添加到收藏夹

Article Clinical Neurology

Elevated activity and microglial expression of myeloperoxidase in demyelinated cerebral cortex in multiple sclerosis

Elizabeth Gray et al.

BRAIN PATHOLOGY (2008)

添加到收藏夹

Review Cell Biology

The importance of being subtle: small changes in calcium homeostasis control cognitive decline in normal aging

Emil C. Toescu et al.

AGING CELL (2007)

添加到收藏夹

Article Medicine, General & Internal

High-sensitivity C-reactive protein, lipoprotein-associated phospholipase A2, and outcome after ischemic stroke

Mitchell S. V. Elkind et al.

ARCHIVES OF INTERNAL MEDICINE (2006)

添加到收藏夹

Article Clinical Neurology

Poststroke C-reactive protein is a powerful prognostic tool among candidates for thrombolysis

J Montaner et al.

STROKE (2006)

添加到收藏夹

Article Medicine, General & Internal

Prognostic role of C-reactive protein in very old patients with acute ischaemic stroke

L Masotti et al.

JOURNAL OF INTERNAL MEDICINE (2005)

添加到收藏夹

Review Neurosciences

IL-18: a key player in neuroinflammation and neurodegeneration?

U Felderhoff-Mueser et al.

TRENDS IN NEUROSCIENCES (2005)

添加到收藏夹

Article Biochemistry & Molecular Biology

Neuronal expression of myeloperoxidase is increased in Alzheimer's disease

PS Green et al.

JOURNAL OF NEUROCHEMISTRY (2004)

添加到收藏夹

Article Pathology

Reversible demyelination, blood-brain barrier breakdown, and pronounced neutrophil recruitment induced by chronic IL-1 expression in the brain

CC Ferrari et al.

AMERICAN JOURNAL OF PATHOLOGY (2004)

添加到收藏夹

Article Clinical Neurology

Increased expression of caspase-1 and interleukin-18 in peripheral blood mononuclear cells in patients with multiple sclerosis

WX Huang et al.

MULTIPLE SCLEROSIS JOURNAL (2004)

添加到收藏夹

Article Psychiatry

A rating scale for fibromyalgia and chronic fatigue syndrome (the FibroFatigue scale)

O Zachrisson et al.

JOURNAL OF PSYCHOSOMATIC RESEARCH (2002)

添加到收藏夹

Article Immunology

Production of IL-1β and IL-1Ra as risk factors for susceptibility and progression of relapse-onset multiple sclerosis

BA de Jong et al.

JOURNAL OF NEUROIMMUNOLOGY (2002)

添加到收藏夹

Article Immunology

Synergy of IL-12 and IL-18 for IFN-γ gene expression:: IL-12-induced STAT4 contributes to IFN-γ promoter activation by up-regulating the binding activity of IL-18-induced activator protein 1

M Nakahira et al.

JOURNAL OF IMMUNOLOGY (2002)

添加到收藏夹

Article Clinical Neurology

C-reactive protein in ischemic stroke - An independent prognostic factor

M Di Napoli et al.

STROKE (2001)

添加到收藏夹

Article Clinical Neurology

Antidepressant activity and calcium signaling cascades

IA Paul

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL (2001)

添加到收藏夹

Article Immunology

Increased plasma levels of interleukin-1, interleukin-6 and α-1-antichymotrypsin in patients with Alzheimer's disease:: peripheral inflammation or signals from the brain?

F Licastro et al.

JOURNAL OF NEUROIMMUNOLOGY (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.