Tumor Recurrence and Follow-Up Intervals in Oral Squamous Cell Carcinoma

Tumor recurrence in oral squamous cell carcinoma (OSCC) is frequent. However, no consensus about follow-up interval is available. The aim of this study was to analyze the recurrence pattern, detection method and associated parameters for possible risk stratification. Histopathological and epidemiological features were obtained retrospectively and correlated with tumor recurrence and overall survival, distant and lymph node metastases. A total of 760 patients were included, of which 216 patients showed tumor recurrence (mean after 24 +/- 26 months). Within the first 12 months, 24% of the recurrences were detected. The primary detection method was clinical examination (n = 123, 57%). Tumor recurrence significantly correlated with advanced histopathological grading (G2/3 vs. G1, p < 0.000) and lymph node metastasis (p = 0.004). Tumor recurrence was frequent. Clinical examination was the primary detection method and manifestation within the first 6-12 months was high. The degree of histopathological grading may be useful for risk stratification.

Automated summary

Tumor recurrence is common in oral squamous cell carcinoma (OSCC), with clinical examination being the primary detection method. 24% of recurrences were detected within the first 12 months. Lymph node metastasis and histopathological grading are significantly correlated with tumor recurrence.