☆ 4.7 Article

Discovery of a first-in-class ANXA3 degrader for the treatment of triple-negative breast cancer

ACTA PHARMACEUTICA SINICA B (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Pharmacology & Pharmacy

Sacituzumab Govitecan-hziy: An Antibody-Drug Conjugate for the Treatment of Refractory, Metastatic, Triple-Negative Breast Cancer

John M. Seligson et al.

Summary: This review examines the pharmacology, efficacy, and safety of sacituzumab govitecan for patients with metastatic triple-negative breast cancer who have received at least 2 prior therapies. Sacituzumab govitecan is an antibody-drug conjugate with promising activity in mTNBC, evidenced by accelerated FDA approval based on a phase I/II study. Common adverse reactions include nausea, neutropenia, and diarrhea, with ongoing confirmatory clinical trials.

ANNALS OF PHARMACOTHERAPY (2021)

添加到收藏夹

Article Chemistry, Medicinal

Small-Molecule Drug Discovery in Triple Negative Breast Cancer: Current Situation and Future Directions

Minru Liao et al.

Summary: TNBC, the most aggressive subtype of breast cancer, lacks effective targeted therapy. Novel small-molecule drugs targeting specific molecular characteristics of TNBC may be a promising intervention, but face challenges. Emerging strategies such as dual-target drugs, drug repurposing, and combination strategies offer new insights for improving TNBC therapeutics.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

添加到收藏夹

Review Oncology

Triple-negative breast cancer: A run-through of features, classification and current therapies

Meghana Manjunath et al.

Summary: TNBC is the most aggressive subtype of breast cancer, with challenging treatment due to its heterogeneity. Recent research and new therapies have brought hope for the treatment of TNBC.

ONCOLOGY LETTERS (2021)

添加到收藏夹

Article Chemistry, Medicinal

Discovery of 5,6-Bis(4-methoxy-3-methylphenyl)pyridin-2-amine as a WSB1 Degrader to Inhibit Cancer Cell Metastasis

Jinxin Che et al.

Summary: The compound 4 was identified as a WSB1 degrader, inhibiting the migration capacity of WSB1-overexpressing cells and showing promising anticancer metastatic effects in vivo.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

添加到收藏夹

Article Cell Biology

Exosomal annexin A6 induces gemcitabine resistance by inhibiting ubiquitination and degradation of EGFR in triple-negative breast cancer

Ting Li et al.

Summary: Exosomes derived from resistant cancer cells induce gemcitabine resistance in triple-negative breast cancer cells through upregulating ANXA6 expression, which is associated with the inhibition of EGFR ubiquitination and degradation. Exosomal ANXA6 levels in the serum of patients with TNBC may serve as a predictive factor for response to gemcitabine-based chemotherapy.

CELL DEATH & DISEASE (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Annexin A3, a Calcium-Dependent Phospholipid-Binding Protein: Implication in Cancer

Liu Yang et al.

Summary: ANXA3 is dysregulated in various malignancies and contributes to tumor development as well as resistance to chemotherapy. Genetic alterations on the ANXA3 gene are associated with certain familial tumors. Thus, ANXA3 may serve as an important target for anticancer therapies and early tumor detection.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

添加到收藏夹

Review Oncology

Advancing targeted protein degradation for cancer therapy

Brandon Dale et al.

Summary: The development of small-molecule degraders such as proteolysis-targeting chimeras (PROTACs) has enabled the targeting of previously considered undruggable oncoproteins. This review discusses recent advances in the field, with a focus on opportunities and challenges for future development.

NATURE REVIEWS CANCER (2021)

添加到收藏夹

Article Oncology

Downregulation of beta-catenin in chemo-tolerant TNBC through changes in receptor and antagonist profiles of the WNT pathway: Clinical and prognostic implications

Saimul Islam et al.

CELLULAR ONCOLOGY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

ANXA4 Activates JAK-STAT3 Signaling by Interacting with ANXA1 in Basal-Like Breast Cancer

Lei Li et al.

DNA AND CELL BIOLOGY (2020)

添加到收藏夹

Review Pharmacology & Pharmacy

Pharmacotherapeutic options for patients with refractory breast cancer

Palma Fedele et al.

EXPERT OPINION ON PHARMACOTHERAPY (2019)

添加到收藏夹

Article Medicine, Research & Experimental

Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast cancer stem-like cells

Bai Cui et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

添加到收藏夹

Review Oncology

Insights into Molecular Classifications of Triple-Negative Breast Cancer: Improving Patient Selection for Treatment

Ana C. Garrido-Castro et al.

CANCER DISCOVERY (2019)

添加到收藏夹

Meeting Abstract Oncology

Triple-negative (TNBC) metastatic breast cancer (MBC) patients (pts): Is chemotherapy (CHT) choice influenced by adjuvant (adj) treatments? Results from the GIM-13 AMBRA study.

Giorgio Mustacchi et al.

JOURNAL OF CLINICAL ONCOLOGY (2019)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Targeted protein degradation: expanding the toolbox

Matthieu Schapira et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

添加到收藏夹

Review Cell Biology

Ubiquitylation at the crossroads of development and disease

Michael Rape

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

添加到收藏夹

Article Oncology

Tumor-Suppressing Effect of Silencing of Annexin A3 Expression in Breast Cancer

Ju-Yeon Kim et al.

CLINICAL BREAST CANCER (2018)

添加到收藏夹

Article Cell Biology

Downregulation of annexin A3 inhibits tumor metastasis and decreases drug resistance in breast cancer

Ruikai Du et al.

CELL DEATH & DISEASE (2018)

添加到收藏夹

Article Medicine, General & Internal

Talazoparib in Patients with Advanced Breast Cancer and a Germline BRCA Mutation

Jennifer K. Litton et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

添加到收藏夹

Article Pathology

The regulatory role of Annexin 3 in a nude mouse bearing a subcutaneous xenograft of MDA-MB-231 human breast carcinoma

Jie Li et al.

PATHOLOGY RESEARCH AND PRACTICE (2018)

添加到收藏夹

Article Medicine, General & Internal

Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer

P. Schmid et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

添加到收藏夹

Article Cell Biology

miR-221/222 activate the Wnt/beta-catenin signaling to promote triple-negative breast cancer

Sanhong Liu et al.

JOURNAL OF MOLECULAR CELL BIOLOGY (2018)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Induced protein degradation: an emerging drug discovery paradigm

Ashton C. Lai et al.

NATURE REVIEWS DRUG DISCOVERY (2017)

添加到收藏夹

Article Oncology

Silencing of ANXA3 expression by RNA interference inhibits the proliferation and invasion of breast cancer cells

Tao Zhou et al.

ONCOLOGY REPORTS (2017)

添加到收藏夹

Article Chemistry, Organic

Dimericbiscognienyne A: A Meroterpenoid Dimer from Biscogniauxia sp with New Skeleton and Its Activity

Huan Zhao et al.

ORGANIC LETTERS (2017)

添加到收藏夹

Article Medicine, General & Internal

Olaparib for Metastatic Breast Cancer in Patients with a Germline BRCA Mutation

Mark Robson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

添加到收藏夹

Article Oncology

Weekly Paclitaxel, Capecitabine, and Bevacizumab With Maintenance Capecitabine and Bevacizumab as First-Line Therapy for Triple-Negative, Metastatic, or Locally Advanced Breast Cancer: Results From the GINECO A-TaXel Phase 2 Study

Jean-Marc Ferrero et al.

CANCER (2016)

添加到收藏夹

Review Oncology

Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease

Giampaolo Bianchini et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2016)

添加到收藏夹

Article Chemistry, Organic

Polycycloiridals A-D, Four Iridal-Type Triterpenoids with an α-Terpineol Moiety from Iris tectorum

Chun-Lei Zhang et al.

ORGANIC LETTERS (2015)

添加到收藏夹

Review Oncology

Role of annexin A6 in cancer (Review)

Houbao Qi et al.

ONCOLOGY LETTERS (2015)

添加到收藏夹

Review Oncology

The role of annexin A3 playing in cancers

Na Wu et al.

CLINICAL & TRANSLATIONAL ONCOLOGY (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

The wnt/beta-catenin signaling pathway: A potential therapeutic target in the treatment of triple negative breast cancer

Taj D. King et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2012)

添加到收藏夹

Article Biotechnology & Applied Microbiology

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

Guangchuang Yu et al.

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2012)

添加到收藏夹

Article Medicine, Research & Experimental

Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

Brian D. Lehmann et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

添加到收藏夹

Article Oncology

Triple-Negative Breast Cancer: An Unmet Medical Need

Clifford A. Hudis et al.

ONCOLOGIST (2011)

添加到收藏夹

Article Pathology

Wnt/β-Catenin Pathway Activation Is Enriched in Basal-Like Breast Cancers and Predicts Poor Outcome

Andrey I. Khramtsov et al.

AMERICAN JOURNAL OF PATHOLOGY (2010)

添加到收藏夹

Editorial Material Biochemistry & Molecular Biology

Probing the Probes: Fitness Factors For Small Molecule Tools

Paul Workman et al.

CHEMISTRY & BIOLOGY (2010)

添加到收藏夹

Article Chemistry, Medicinal

New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

Jonathan B. Baell et al.

JOURNAL OF MEDICINAL CHEMISTRY (2010)

添加到收藏夹

Review Oncology

The role of annexins in tumour development and progression

S. Mussunoor et al.

JOURNAL OF PATHOLOGY (2008)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Drug discovery in the ubiquitin-proteasome system

Grzegorz Nalepa et al.

NATURE REVIEWS DRUG DISCOVERY (2006)

添加到收藏夹

Article Multidisciplinary Sciences

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

A Subramanian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

添加到收藏夹

Review Cell Biology

Annexins:: Linking Ca2+ signalling to membrane dynamics

V Gerke et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)

添加到收藏夹

Review Chemistry, Multidisciplinary

Protein-reactive natural products

C Drahl et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2005)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.