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Chendi Zhan et al.
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Vu N. Ngo et al.
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Animal models of rheumatoid arthritis
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Yingqiu Xie et al.
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Shaival H. Dave et al.
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Nicholas P. Shinners et al.
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Wataru Shibata et al.
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Sandra M. Sacre et al.
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Tom Luedde et al.
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P. De Paepe et al.
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