相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。
Article
Infectious Diseases
Cesar Fernandez-de-las-Penas et al.
Summary: By using cluster analysis on clinical data of COVID-19 survivors, three different subgroups were identified with distinct post-COVID symptoms and clinical characteristics. The study found that some patients experienced more long-term symptoms post-recovery, with greater limitations in daily activities, higher levels of anxiety and depression, and poorer sleep quality.
Review
Infectious Diseases
Joan B. Soriano et al.
Summary: People with COVID-19 might experience long-term symptoms known as long COVID or long-haul COVID. The lack of a standardized definition hinders the understanding and treatment of this condition. In a WHO-led Delphi process, a consensus definition was developed, stating that post-COVID-19 condition occurs in individuals with a history of SARS-CoV-2 infection, with symptoms lasting for at least 2 months and impacting everyday functioning. This common framework provides a foundation for future studies and therapy.
LANCET INFECTIOUS DISEASES
(2022)
Article
Biology
Thomas Sonnweber et al.
Summary: This study observed the respiratory and symptom recovery in COVID-19 patients during the follow-up period. The results showed that 49% of patients reported persistent symptoms at the 6-month follow-up. Structural lung abnormalities and impaired lung function were more common in severe cases. The study also found that early clinical indicators could predict the risk of incomplete pulmonary recovery.
Article
Public, Environmental & Occupational Health
Laerke Storgaard Duerlund et al.
Summary: The study examined the positive predictive value (PPV) of International Classification version 10 (ICD-10) diagnosis codes for long COVID-19 in a Danish Health registry. The overall PPV of diagnosis codes for long COVID-19 was high in the North Denmark Region and suitable for future registry-based studies. Caution is advised at the extremes of age and with secondary diagnosis codes.
CLINICAL EPIDEMIOLOGY
(2022)
Article
Multidisciplinary Sciences
Nida Ziauddeen et al.
Summary: Long Covid is a significant health concern with a wide range of symptoms, including fatigue, chest tightness, shortness of breath, headache, and cognitive dysfunction. It can lead to decreased work and daily life abilities.
Article
Immunology
Grace Kenny et al.
Summary: The study identified three clusters of symptoms in long COVID patients, including predominantly pain symptoms, cardiovascular symptoms, and a cluster with fewer symptoms. Clusters 1 and 2 showed greater functional impairment, suggesting potential distinct underlying pathophysiologic mechanisms.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Letter
Biotechnology & Applied Microbiology
Julius O. B. Jacobsen et al.
NATURE BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sebastian Koehler et al.
Summary: The Human Phenotype Ontology (HPO) serves as a global standard for phenotype exchange, with recent major extensions in neurology, nephrology, immunology, pulmonology, and other fields. Efforts have been made to improve computational definitions of phenotypic abnormalities across HPO and multiple phenotype ontologies for animal disease models, benefiting software accuracy and cross-species phenotype matching. Recent initiatives include translating HPO into indigenous languages and advancing its use in electronic health record systems.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Respiratory System
Knut Stavem et al.
Summary: The study assessed symptoms and their determinants 1.5-6 months after symptom onset in non-hospitalised subjects with confirmed COVID-19 until 1 June 2020. Findings showed that individuals reported fewer symptoms after 1.5-6 months compared to during the acute COVID-19 phase, with persistent symptoms being associated with the number of comorbidities and symptoms experienced during the acute phase.
Article
Medicine, General & Internal
Damian Smedley et al.
Summary: The pilot study, involving 4660 participants with rare diseases, provided actionable diagnoses and identified three newly implicated disease genes, offering a road map for the larger implementation of genome sequencing in the setting of a national health service.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Carole H. Sudre et al.
Summary: Reports on long-lasting COVID-19 symptoms, known as 'long COVID', are increasing. Analysis of data from over 4,000 COVID-19 cases revealed that long COVID is more common in older individuals, those with higher body mass index, and females. Experiencing more than five symptoms in the first week of illness was associated with long COVID. A simple model showed promise in distinguishing between short and long COVID cases early in the disease.
Article
Mathematical & Computational Biology
Rebecca Jackson et al.
Summary: Biological ontologies are used to organize and interpret data from experiments, but integrating multiple ontologies can lead to compatibility issues. The OBO Foundry aims to promote the development and sharing of ontologies through a set of principles. Researchers have improved ontology quality and interoperability by encoding principles as operational rules and implementing automated validation checks.
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
(2021)
Article
Medicine, General & Internal
Maxime Taquet et al.
Summary: This study investigated the incidence and co-occurrence of long-COVID features in COVID-19 survivors, with comparisons to influenza patients, using electronic health records data. The findings showed that long-COVID clinical features were more commonly reported after COVID-19 infection, and differences were associated with sex, age, and illness severity.
Article
Genetics & Heredity
Katherine Crawford et al.
Summary: Pathogenic variants in SCN2A lead to a range of neurodevelopmental phenotypes. By extracting and analyzing phenotypic data from literature using Human Phenotype Ontology terms, this study identified key associations between genetic variants, clinical features, and protein structure in SCN2A-related disorders. The findings highlight the importance of standardized language in enabling quantitative phenotype analysis and mapping the phenotypic landscape in detail to reveal genotype-phenotype correlations.
GENETICS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Rachel R. Deer et al.
Article
Multidisciplinary Sciences
Ziyad Al-Aly et al.
Summary: This study comprehensively describes the post-acute sequelae of COVID-19 using national healthcare databases, finding increased risk of death and use of health resources beyond the first 30 days of illness, as well as incident sequelae in various organ systems, increased use of therapeutic agents, and evidence of laboratory abnormalities. The findings show a risk gradient according to the severity of acute COVID-19 infection and highlight the burden of health loss experienced by patients who survive the acute phase.
Review
Biochemistry & Molecular Biology
Ani Nalbandian et al.
Summary: SARS-CoV-2 is responsible for the COVID-19 pandemic, causing global healthcare crises. Recovery from COVID-19 may lead to persistent symptoms and long-term complications, prompting the need for multidisciplinary care and follow-up for survivors.
Article
Physiology
Qinyi Gan et al.
Summary: Liver function test abnormality is common in COVID-19 patients and more prevalent in severe cases. A significant percentage of patients still had abnormal liver functions at the time of discharge. Younger age, hypertension, and low lymphocyte counts were identified as independent risk factors for persistent abnormal liver functions during hospitalization.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Virology
Bircan Kayaaslan et al.
Summary: This study investigated the prevalence and characteristics of post-COVID syndrome among COVID-19 survivors, finding that 47.5% of patients had persistent symptoms, with fatigue, myalgia, and weight loss being the most common. Factors such as severe acute COVID-19, hospitalization, and comorbidities were identified as independent factors for the development of persistent symptoms.
JOURNAL OF MEDICAL VIROLOGY
(2021)
News Item
Multidisciplinary Sciences
Michael Marshall
Summary: Scientists are gaining insights into the long-term effects of SARS-CoV-2 on some infected individuals, but many mysteries surrounding this issue remain unsolved.
Article
Multidisciplinary Sciences
Rustem I. Litvinov et al.
Summary: In COVID-19 patients, coagulopathies mainly present as hypercoagulability, directly correlating with systemic inflammation and disease severity. Hindered clot contraction may increase the risk of bleeding, with associations found between elevated levels of C-reactive protein and antiphospholipid antibodies in most cases.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Nicolas Barizien et al.
Summary: Heart rate variability assessment in long COVID-19 patients revealed signs of autonomic dysregulation, suggesting a potential explanation for persistent symptoms in these individuals.
SCIENTIFIC REPORTS
(2021)
Review
Infectious Diseases
Shin Jie Yong
Summary: Long COVID or post-COVID-19 syndrome is a poorly understood condition that affects survivors with symptoms like fatigue, dyspnoea, cognitive impairments, and more. The pathophysiology, risk factors, and treatments are still lacking in literature, but potential treatments may include rehabilitation training and repurposed drugs from similar conditions. Further research is needed to substantiate risk factors and treatment options.
INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Henrique Pott-Junior et al.
Summary: Liver transaminase abnormalities in COVID-19 patients are directly related to disease severity and inflammatory parameters. The study suggests that liver transaminases can serve as a complementary marker for disease severity in COVID-19 patients.
FRONTIERS IN MEDICINE
(2021)
Review
Public, Environmental & Occupational Health
Melina Michelen et al.
Summary: Long COVID is a complex condition with prolonged and heterogeneous symptoms, including weakness, general malaise, fatigue, concentration impairment, and breathlessness. Approximately 37% of patients reported reduced quality of life, and 26% of studies presented evidence of reduced pulmonary function. There is an urgent need for further studies to explore the etiology, risk factors, and biomarkers of long COVID in different populations and settings.
Article
Medicine, General & Internal
Hannah E. Davis et al.
Summary: Patients with Long COVID report prolonged, multisystem involvement and significant disability. By seven months, many patients have not yet recovered (mainly from systemic and neurological/cognitive symptoms), have not returned to previous levels of work, and continue to experience significant symptom burden.
Article
Endocrinology & Metabolism
A. V. Raveendran et al.
Summary: Long COVID refers to the persistence of symptoms in individuals who have recovered from SARS-CoV-2 infection, possibly related to organ damage, post viral syndrome, etc. Clinical evaluation should focus on identifying the pathophysiology and appropriate remedial measures.
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
(2021)
Review
Endocrinology & Metabolism
Januar Wibawa Martha et al.
Summary: The meta-analysis showed that hypocalcemia in COVID-19 patients is associated with poor outcomes, with a higher post-test probability in patients with hypocalcemia compared to those without.
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
(2021)
Article
Computer Science, Information Systems
Melissa A. Haendel et al.
Summary: N3C is an open science community focused on analyzing patient-level data from multiple centers to address the challenges posed by COVID-19. By overcoming technical, regulatory, policy, and governance barriers, N3C has successfully established a secure data enclave for efficient, transparent, and reproducible collaborative analytics.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2021)
Article
Genetics & Heredity
Peter N. Robinson et al.
AMERICAN JOURNAL OF HUMAN GENETICS
(2020)
Article
Genetics & Heredity
Shiva Ganesan et al.
GENETICS IN MEDICINE
(2020)
Letter
Medical Laboratory Technology
Jenifer Gomez-Pastora et al.
CLINICA CHIMICA ACTA
(2020)
Article
Computer Science, Artificial Intelligence
Sasan Barak et al.
EXPERT SYSTEMS WITH APPLICATIONS
(2019)
Article
Health Care Sciences & Services
Xingmin Aaron Zhang et al.
NPJ DIGITAL MEDICINE
(2019)
Article
Psychology, Multidisciplinary
Kathleen M. Gates et al.
PSYCHOLOGICAL METHODS
(2019)
Article
Biochemistry & Molecular Biology
Sebastian Koehler et al.
NUCLEIC ACIDS RESEARCH
(2017)
Article
Genetics & Heredity
Tudor Groza et al.
AMERICAN JOURNAL OF HUMAN GENETICS
(2015)
Article
Computer Science, Information Systems
Erica A. Voss et al.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2015)
Article
Biochemical Research Methods
Hui Yang et al.
Article
Social Sciences, Mathematical Methods
Alexis Dinno
Article
Biochemistry & Molecular Biology
Peter N. Robinson et al.
Article
Computer Science, Software Engineering
Alexander Lex et al.
IEEE TRANSACTIONS ON VISUALIZATION AND COMPUTER GRAPHICS
(2014)
Article
Biochemistry & Molecular Biology
Sebastian Koehler et al.
NUCLEIC ACIDS RESEARCH
(2014)
Review
Genetics & Heredity
Peter N. Robinson et al.
Review
Genetics & Heredity
P. N. Robinson et al.
Article
Genetics & Heredity
Sebastian Koehler et al.
AMERICAN JOURNAL OF HUMAN GENETICS
(2009)
Review
Biochemical Research Methods
Catia Pesquita et al.
PLOS COMPUTATIONAL BIOLOGY
(2009)
Article
Genetics & Heredity
Peter N. Robinson et al.
AMERICAN JOURNAL OF HUMAN GENETICS
(2008)
Article
Statistics & Probability
Christian Hennig
JOURNAL OF MULTIVARIATE ANALYSIS
(2008)
Review
Mathematics, Interdisciplinary Applications
Douglas Steinley
BRITISH JOURNAL OF MATHEMATICAL & STATISTICAL PSYCHOLOGY
(2006)
Article
Statistics & Probability
HP Piepho
JOURNAL OF COMPUTATIONAL AND GRAPHICAL STATISTICS
(2004)
