期刊
SCIENCE ADVANCES
卷 8, 期 49, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.abq3970
关键词
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资金
- NSF [DGE175814]
- NIA [1F99AG068343-01, 5R01AG059566-05]
- Howard Hughes Medical Institute
- [5F32AG065381]
Aging organisms lose the ability to induce stress responses, making them vulnerable to protein toxicity and tissue damage. Neurons and glial cells can signal to induce protective stress responses in specific organelles. Understanding the role of glial cells in immune function and lifespan extension can provide valuable insights.
Aging organisms lose the ability to induce stress responses, becoming vulnerable to protein toxicity and tissue damage. Neurons can signal to peripheral tissues to induce protective organelle-specific stress responses. Recent work shows that glia can independently induce such responses. Here, we show that overexpression of heat shock factor 1 (hsf-1) in the four astrocyte-like cephalic sheath cells of Caenorhabditis elegans induces a non-cell-autonomous cytosolic unfolded protein response, also known as the heat shock response (HSR). These animals have increased lifespan and heat stress resistance and decreased protein aggregation. Glial HSR regulation is independent of canonical thermosensory circuitry and known neurotransmitters but requires the small clear vesicle release protein UNC-13. HSF-1 and the FOXO transcription factor DAF-16 are partially required in peripheral tissues for non-cell-autonomous HSR, longevity, and thermotolerance. Cephalic sheath glial hsf-1 overexpression also leads to pathogen resistance, suggesting a role for this signaling pathway in immune function.
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