期刊
SCIENCE ADVANCES
卷 8, 期 48, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.add3197
关键词
-
资金
- Fundamental Research Funds for the Central Universities [2021FZZX001-47]
- Foundation of National Facility for Translational Medicine (Shanghai) [TMSK-2021-410]
- Startup Package of Zhejiang University
This article describes a transdermal polymeric microneedle patch that achieves glucose-responsive closed-loop insulin and glucagon delivery for glycemic regulation with minimized risk of hypoglycemia. The patch utilizes glucose-responsive phenylboronic acid units to reversibly shift the net charge of the polymeric matrix, allowing dynamic tuning of insulin and glucagon analog release ratio to achieve glycemic homeostasis.
Insulin and glucagon secreted from the pancreas with dynamic balance play a vital role in regulating blood glucose levels. Although distinct glucose-responsive insulin delivery systems have been developed, the lack of a self-regulated glucagon release module limits their clinical applications due to the potential risk of hypoglycemia. Here, we describe a transdermal polymeric microneedle patch for glucose-responsive closed-loop insulin and glucagon delivery to achieve glycemic regulation with minimized risk of hypoglycemia. The glucose-responsive phenylboronic acid units can bind to glucose to reversibly shift the net charge (from positive to negative) of the entire polymeric matrix within microneedles. Therefore, the release ratio of the negatively charged insulin and the positively charged glucagon analog from the patch can be dynamically tuned upon the fluctuation of blood glucose levels to realize glycemic homeostasis. In both chemically induced type 1 diabetic mouse and minipig models, this glucose-responsive dual-hormone microneedle patch demonstrated tight long-term regulation in blood glucose levels (>24 hours in minipigs).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据